| Year |
Citation |
Score |
| 2023 |
Dong W, Fekete A, Chen X, Liu H, Beilhartz GL, Chen X, Bahrampour S, Xiong Y, Yang Q, Zhao H, Kong T, Morioka MS, Jung G, Kim JE, Schramek D, ... Dirks PB, et al. A designer peptide against the EAG2-Kvβ2 potassium channel targets the interaction of cancer cells and neurons to treat glioblastoma. Nature Cancer. PMID 37697045 DOI: 10.1038/s43018-023-00626-8 |
0.302 |
|
| 2023 |
Dave BM, Chen X, McCready F, Charton CS, Morley RM, Tailor JK, Ellis J, Huang X, Dirks PB. Directed differentiation of human hindbrain neuroepithelial stem cells recapitulates cerebellar granule neurogenesis. Development (Cambridge, England). PMID 37381820 DOI: 10.1242/dev.201534 |
0.329 |
|
| 2022 |
Hendrikse LD, Haldipur P, Saulnier O, Millman J, Sjoboen AH, Erickson AW, Ong W, Gordon V, Coudière-Morrison L, Mercier AL, Shokouhian M, Suárez RA, Ly M, Borlase S, Scott DS, ... ... Dirks P, et al. Failure of human rhombic lip differentiation underlies medulloblastoma formation. Nature. PMID 36131014 DOI: 10.1038/s41586-022-05215-w |
0.312 |
|
| 2022 |
Hamed AA, Kunz DJ, El-Hamamy I, Trinh QM, Subedar OD, Richards LM, Foltz W, Bullivant G, Ware M, Vladoiu MC, Zhang J, Raj AM, Pugh TJ, Taylor MD, Teichmann SA, ... ... Dirks PB, et al. A brain precursor atlas reveals the acquisition of developmental-like states in adult cerebral tumours. Nature Communications. 13: 4178. PMID 35853870 DOI: 10.1038/s41467-022-31408-y |
0.3 |
|
| 2021 |
Brooks LJ, Clements MP, Burden JJ, Kocher D, Richards L, Devesa SC, Zakka L, Woodberry M, Ellis M, Jaunmuktane Z, Brandner S, Morrison G, Pollard SM, Dirks PB, Marguerat S, et al. The white matter is a pro-differentiative niche for glioblastoma. Nature Communications. 12: 2184. PMID 33846316 DOI: 10.1038/s41467-021-22225-w |
0.311 |
|
| 2021 |
Pryszlak M, Wiggans M, Chen X, Jaramillo JE, Burns SE, Richards LM, Pugh TJ, Kaplan DR, Huang X, Dirks PB, Pearson BJ. The DEAD-box helicase DDX56 is a conserved stemness regulator in normal and cancer stem cells. Cell Reports. 34: 108903. PMID 33789112 DOI: 10.1016/j.celrep.2021.108903 |
0.384 |
|
| 2021 |
Sachamitr P, Ho JC, Ciamponi FE, Ba-Alawi W, Coutinho FJ, Guilhamon P, Kushida MM, Cavalli FMG, Lee L, Rastegar N, Vu V, Sánchez-Osuna M, Coulombe-Huntington J, Kanshin E, Whetstone H, ... ... Dirks PB, et al. PRMT5 inhibition disrupts splicing and stemness in glioblastoma. Nature Communications. 12: 979. PMID 33579912 DOI: 10.1038/s41467-021-21204-5 |
0.615 |
|
| 2021 |
Guilhamon P, Chesnelong C, Kushida MM, Nikolic A, Singhal D, MacLeod G, Madani Tonekaboni SA, Cavalli FM, Arlidge C, Rajakulendran N, Rastegar N, Hao X, Hassam R, Smith LJ, Whetstone H, ... ... Dirks PB, et al. Single-cell chromatin accessibility profiling of glioblastoma identifies an Invasive cancer stem cell population associated with lower survival. Elife. 10. PMID 33427645 DOI: 10.7554/eLife.64090 |
0.367 |
|
| 2020 |
Michealraj KA, Kumar SA, Kim LJY, Cavalli FMG, Przelicki D, Wojcik JB, Delaidelli A, Bajic A, Saulnier O, MacLeod G, Vellanki RN, Vladoiu MC, Guilhamon P, Ong W, Lee JJY, ... ... Dirks PB, et al. Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma. Cell. PMID 32445698 DOI: 10.1016/J.Cell.2020.04.047 |
0.507 |
|
| 2020 |
Selvadurai HJ, Luis E, Desai K, Lan X, Vladoiu MC, Whitley O, Galvin C, Vanner RJ, Lee L, Whetstone H, Kushida M, Nowakowski T, Diamandis P, Hawkins C, Bader G, ... ... Dirks PB, et al. Medulloblastoma Arises from the Persistence of a Rare and Transient Sox2 Granule Neuron Precursor. Cell Reports. 31: 107511. PMID 32294450 DOI: 10.1016/J.Celrep.2020.03.075 |
0.694 |
|
| 2020 |
Ryall S, Zapotocky M, Fukuoka K, Nobre L, Guerreiro Stucklin A, Bennett J, Siddaway R, Li C, Pajovic S, Arnoldo A, Kowalski PE, Johnson M, Sheth J, Lassaletta A, Tatevossian RG, ... ... Dirks P, et al. Integrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade Gliomas. Cancer Cell. 37: 569-583.e5. PMID 32289278 DOI: 10.1016/J.Ccell.2020.03.011 |
0.307 |
|
| 2020 |
Fukuoka K, Mamatjan Y, Tatevossian R, Zapotocky M, Ryall S, Stucklin AG, Bennett J, Nobre LF, Arnoldo A, Luu B, Wen J, Zhu K, Leon A, Torti D, Pugh TJ, ... ... Dirks P, et al. Clinical impact of combined epigenetic and molecular analysis of pediatric low grade gliomas. Neuro-Oncology. PMID 32242226 DOI: 10.1093/Neuonc/Noaa077 |
0.336 |
|
| 2020 |
El-Sehemy A, Selvadurai HJ, Ortin-Martinez A, Pokrajac NT, Mamatjan Y, Tachibana N, Rowland KJ, Lee L, Park NI, Aldape KD, Dirks P, Wallace VA. Norrin mediates tumor-promoting and -suppressive effects in glioblastoma via Notch and WNT. The Journal of Clinical Investigation. PMID 32182224 DOI: 10.1172/Jci128994 |
0.459 |
|
| 2019 |
Jessa S, Blanchet-Cohen A, Krug B, Vladoiu M, Coutelier M, Faury D, Poreau B, De Jay N, Hébert S, Monlong J, Farmer WT, Donovan LK, Hu Y, McConechy MK, Cavalli FMG, ... ... Dirks PB, et al. Stalled developmental programs at the root of pediatric brain tumors. Nature Genetics. PMID 31768071 DOI: 10.1038/S41588-019-0531-7 |
0.345 |
|
| 2019 |
Sachdeva R, Wu M, Smiljanic S, Kaskun O, Ghannad-Zadeh K, Celebre A, Isaev K, Morrissy AS, Guan J, Tong J, Chan J, Wilson TM, Al-Omaishi S, Munoz DG, Dirks PB, et al. ID1 Is Critical for Tumorigenesis and Regulates Chemoresistance in Glioblastoma. Cancer Research. PMID 31292163 DOI: 10.1158/0008-5472.Can-18-1357 |
0.315 |
|
| 2019 |
Huang M, Tailor J, Zhen Q, Gillmor AH, Miller ML, Weishaupt H, Chen J, Zheng T, Nash EK, McHenry LK, An Z, Ye F, Takashima Y, Clarke J, Ayetey H, ... ... Dirks P, et al. Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis. Cell Stem Cell. PMID 31204176 DOI: 10.1016/J.Stem.2019.05.013 |
0.471 |
|
| 2019 |
Vladoiu MC, El-Hamamy I, Donovan LK, Farooq H, Holgado BL, Sundaravadanam Y, Ramaswamy V, Hendrikse LD, Kumar S, Mack SC, Lee JJY, Fong V, Juraschka K, Przelicki D, Michealraj A, ... ... Dirks P, et al. Childhood cerebellar tumours mirror conserved fetal transcriptional programs. Nature. PMID 31043743 DOI: 10.1038/S41586-019-1158-7 |
0.423 |
|
| 2019 |
Hoffman M, Gillmor A, Kunz DJ, Johnston MJ, Nikolic A, Narta K, Zarrei M, King JC, Ellestad K, Dang NH, Cavalli FMG, Kushida M, Coutinho FJ, Zhu Y, Luu B, ... ... Dirks PB, et al. Intratumoral genetic and functional heterogeneity in pediatric glioblastoma. Cancer Research. PMID 30877103 DOI: 10.1158/0008-5472.Can-18-3441 |
0.318 |
|
| 2019 |
Rajakulendran N, Rowland KJ, Selvadurai HJ, Ahmadi M, Park NI, Naumenko S, Dolma S, Ward RJ, So M, Lee L, MacLeod G, Pasiliao C, Brandon C, Clarke ID, Cusimano MD, ... ... Dirks PB, et al. Wnt and Notch signaling govern self-renewal and differentiation in a subset of human glioblastoma stem cells. Genes & Development. PMID 30842215 DOI: 10.1101/Gad.321968.118 |
0.374 |
|
| 2019 |
Egan G, Hamilton J, McKeown T, Bouffet E, Tabori U, Dirks P, Bartels U. Trametinib Toxicities in Patients With Low-grade Gliomas and Diabetes Insipidus: Related Findings? Journal of Pediatric Hematology/Oncology. PMID 30676433 DOI: 10.1097/Mph.0000000000001427 |
0.311 |
|
| 2019 |
Elsehemy AA, Selvadurai H, Ortin-Martinez A, Pokrajac N, Mamatjan Y, Rowland K, Aldape K, Dirks P, Wallace V. Abstract 4671: Novel biological roles of the atypical WNT ligand, Norrin, on glioblastoma stem cells segregate with ASCL1 expression Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-4671 |
0.422 |
|
| 2019 |
Richards LM, Whitley O, Cavalli FM, Safikhani Z, Coutinho F, Luchman HA, Haibe-Kains B, Weiss S, Dirks P, Bader G, Pugh TJ. Abstract 967: Single-cell transcriptomics uncovers clonal heterogeneity linked to drug response and cellular phenotype in adult brain tumor stem cells Cancer Research. 79: 967-967. DOI: 10.1158/1538-7445.Am2019-967 |
0.481 |
|
| 2019 |
Bozek D, MacLeod G, Hao X, Rajakulendran N, Ahmadi M, Dirks P, Angers S, Luchman A, Weiss S. STEM-21. INVESTIGATING DOT1L AS AN EPIGENETIC VULNERABILITY IN BRAIN TUMOR STEM CELLS Neuro-Oncology. 21: vi238-vi238. DOI: 10.1093/Neuonc/Noz175.994 |
0.529 |
|
| 2019 |
MacLeod G, Angers S, Dirks P, Rajakulendran N, Ahmadi M, Bozek D, Luchman A, Weiss S. GENE-31. IDENTIFICATION OF CORE AND CONTEXT-SPECIFIC FITNESS GENES IN GLIOBLASTOMA STEM CELLS VIA GENOME-WIDE CRISPR-Cas9 SCREENS Neuro-Oncology. 21: vi104-vi104. DOI: 10.1093/Neuonc/Noz175.433 |
0.43 |
|
| 2019 |
Bouffet E, Sudhaman S, Chung J, Campbell B, Kelly J, Coblentz A, Edwards M, Lipman T, Zhang C, Ercan AB, Sambira L, Bendel A, Bielack S, Koustenis E, Blumenthal D, ... ... Dirks P, et al. IMMU-20. IMMUNE AND TUMOR BIOMARKERS OF OUTCOME IN REPLICATION REPAIR DEFICIENT BRAIN TUMORS TREATED WITH IMMUNE CHECKPOINT INHIBITORS: UPDATES FROM THE INTERNATIONAL REPLICATION REPAIR DEFICIENCY CONSORTIUM Neuro-Oncology. 21: ii96-ii97. DOI: 10.1093/Neuonc/Noz036.139 |
0.304 |
|
| 2019 |
Nikolic A, Ellestad K, Johnston M, Dirks P, Zemp F, Gafiuk C, Mahoney D, Gallo M. Role of MacroH2A2 in the glioblastoma stem cell epigenome Canadian Journal of Neurological Sciences. 46. DOI: 10.1017/Cjn.2019.268 |
0.461 |
|
| 2018 |
Garzia L, Kijima N, Morrissy AS, De Antonellis P, Guerreiro-Stucklin A, Holgado BL, Wu X, Wang X, Parsons M, Zayne K, Manno A, Kuzan-Fischer C, Nor C, Donovan LK, Liu J, ... ... Dirks P, et al. A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases. Cell. 172: 1050-1062.e14. PMID 29474906 DOI: 10.1016/J.Cell.2018.01.038 |
0.363 |
|
| 2018 |
Campbell BB, Light N, Fabrizio D, Bouffet E, Larouche V, Samuel D, Stearns D, Cole KA, Opocher E, Thomas G, Sabel M, Dirks P, Taylor M, Malkin D, Albrecht S, et al. HGG-17. TUMOR MUTATIONAL BURDEN ANALYSIS OF PEDIATRIC TUMORS PROVIDES A DIAGNOSTIC TOOL FOR GERMLINE REPLICATION REPAIR DEFICIENCY AND PREDICT RESPONSE TO IMMUNE CHECKPOINT INHIBITION Neuro-Oncology. 20: i92-i92. DOI: 10.1093/Neuonc/Noy059.289 |
0.309 |
|
| 2017 |
Campbell BB, Light N, Fabrizio D, Zatzman M, Fuligni F, de Borja R, Davidson S, Edwards M, Elvin JA, Hodel KP, Zahurancik WJ, Suo Z, Lipman T, Wimmer K, Kratz CP, ... ... Dirks P, et al. Comprehensive Analysis of Hypermutation in Human Cancer. Cell. PMID 29056344 DOI: 10.1016/J.Cell.2017.09.048 |
0.328 |
|
| 2017 |
Park NI, Guilhamon P, Desai K, McAdam RF, Langille E, O'Connor M, Lan X, Whetstone H, Coutinho FJ, Vanner RJ, Ling E, Prinos P, Lee L, Selvadurai H, Atwal G, ... ... Dirks PB, et al. ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells. Cell Stem Cell. 21: 411. PMID 28886368 DOI: 10.1016/j.stem.2017.08.008 |
0.777 |
|
| 2017 |
Lan X, Jörg DJ, Cavalli FMG, Richards LM, Nguyen LV, Vanner RJ, Guilhamon P, Lee L, Kushida MM, Pellacani D, Park NI, Coutinho FJ, Whetstone H, Selvadurai HJ, Che C, ... ... Dirks PB, et al. Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy. Nature. PMID 28854171 DOI: 10.1038/Nature23666 |
0.389 |
|
| 2017 |
Park NI, Guilhamon P, Desai K, McAdam RF, Langille E, O'Connor M, Lan X, Whetstone H, Coutinho FJ, Vanner RJ, Ling E, Prinos P, Lee L, Selvadurai H, Atwal G, ... ... Dirks PB, et al. ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells. Cell Stem Cell. PMID 28712938 DOI: 10.1016/J.Stem.2017.06.004 |
0.789 |
|
| 2017 |
Parada LF, Dirks PB, Wechsler-Reya RJ. Brain Tumor Stem Cells Remain in Play. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO2017739540. PMID 28640710 DOI: 10.1200/Jco.2017.73.9540 |
0.366 |
|
| 2017 |
Morrissy AS, Cavalli FM, Remke M, Ramaswamy V, Shih DJ, Holgado BL, Farooq H, Donovan LK, Garzia L, Agnihotri S, Kiehna EN, Mercier E, Mayoh C, Papillon-Cavanagh S, Nikbakht H, ... ... Dirks P, et al. Spatial heterogeneity in medulloblastoma. Nature Genetics. PMID 28394352 DOI: 10.1038/Ng.3838 |
0.311 |
|
| 2017 |
Zapotocky M, Ryall S, Mistry M, Arnoldo A, Lassaletta A, Stucklin AG, Krishnatry R, Fukuoka K, Dirks P, Ramaswamy V, Bartels U, Huang A, Zhukova N, Bouffet E, Tabori U, et al. Lgg-18. Molecular Alterations Predict Response To Chemotherapy And Outcome Of Pediatric Low-Grade Glioma Neuro-Oncology. 19. DOI: 10.1093/Neuonc/Nox083.151 |
0.323 |
|
| 2016 |
Dolma S, Selvadurai HJ, Lan X, Lee L, Kushida M, Voisin V, Whetstone H, So M, Aviv T, Park N, Zhu X, Xu C, Head R, Rowland KJ, Bernstein M, ... ... Dirks PB, et al. Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell. 29: 859-873. PMID 27300435 DOI: 10.1016/J.Ccell.2016.05.002 |
0.566 |
|
| 2016 |
Rajakulendran N, Selvadurai H, Rowland K, Park N, Batada N, Dirks P, Angers S. Abstract B14: Wnt signaling circuits in glioblastoma multiforme Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Devbiolca15-B14 |
0.443 |
|
| 2016 |
Campbell B, Bouffet E, Larouche V, Mason G, Reddy A, Osborne M, Magimairajan V, Merico D, Borja Rd, Chung B, Galati M, Aronson M, Durno C, Krueger J, Cabric V, ... ... Dirks P, et al. PDCT-09. HYPERMUTATION AND NEOANTIGEN FORMATION IS DIAGNOSTIC AND PREDICT RESPONSE TO IMMUNE CHECKPOINT INHIBITION IN CHILDHOOD BIALLELIC MISMATCH REPAIR DEFICIENT BRAIN TUMORS Neuro-Oncology. 18: vi147-vi147. DOI: 10.1093/Neuonc/Now212.613 |
0.317 |
|
| 2015 |
Hart T, Chandrashekhar M, Aregger M, Steinhart Z, Brown KR, MacLeod G, Mis M, Zimmermann M, Fradet-Turcotte A, Sun S, Mero P, Dirks P, Sidhu S, Roth FP, Rissland OS, et al. High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities. Cell. PMID 26627737 DOI: 10.1016/J.Cell.2015.11.015 |
0.345 |
|
| 2015 |
Faria CC, Agnihotri S, Mack SC, Golbourn BJ, Diaz RJ, Olsen S, Bryant M, Bebenek M, Wang X, Bertrand KC, Kushida M, Head R, Clark I, Dirks P, Smith CA, et al. Identification of alsterpaullone as a novel small molecule inhibitor to target group 3 medulloblastoma. Oncotarget. PMID 26061748 DOI: 10.18632/Oncotarget.4304 |
0.322 |
|
| 2015 |
Shlien A, Campbell BB, de Borja R, Alexandrov LB, Merico D, Wedge D, Van Loo P, Tarpey PS, Coupland P, Behjati S, Pollett A, Lipman T, Heidari A, Deshmukh S, Avitzur N, ... ... Dirks P, et al. Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers. Nature Genetics. 47: 257-62. PMID 25642631 DOI: 10.1038/Ng.3202 |
0.311 |
|
| 2015 |
Shlien A, Campbell BB, Borja Rd, Alexandrov LB, Merico D, Wedge D, Loo PV, Tarpey PS, Coupland P, Pollett A, Lipman T, Heidari A, Deshmukh S, Gerstung M, Merino D, ... ... Dirks P, et al. Abstract B09: DNA polymerase mutations trigger rapid onset of ultra-hypermutant malignant brain tumors in children with biallelic mismatch repair deficiency Brain. 75. DOI: 10.1158/1538-7445.Brain15-B09 |
0.351 |
|
| 2015 |
Shlien A, Campbell BB, de Borja R, Alexandrov LB, Merino DM, Remke M, Bakry D, Dirks P, Huang A, Grundy RG, Durno C, Aronson M, Taylor MD, Pursell ZF, Pearson CE, et al. GE-09 * COMBINED HEREDITARY AND SOMATIC MUTATIONS OF REPLICATION ERROR REPAIR GENES RESULT IN RAPID ONSET OF ULTRA-HYPERMUTATED MALIGNANT BRAIN TUMORS IN CHILDREN Neuro-Oncology. 17: iii9-iii9. DOI: 10.1093/Neuonc/Nov061.33 |
0.327 |
|
| 2014 |
Wee S, Niklasson M, Marinescu VD, Segerman A, Schmidt L, Hermansson A, Dirks P, Forsberg-Nilsson K, Westermark B, Uhrbom L, Linnarsson S, Nelander S, Andäng M. Selective calcium sensitivity in immature glioma cancer stem cells. Plos One. 9: e115698. PMID 25531110 DOI: 10.1371/Journal.Pone.0115698 |
0.378 |
|
| 2014 |
Gedye CA, Hussain A, Paterson J, Smrke A, Saini H, Sirskyj D, Pereira K, Lobo N, Stewart J, Go C, Ho J, Medrano M, Hyatt E, Yuan J, Lauriault S, ... ... Dirks P, et al. Cell surface profiling using high-throughput flow cytometry: a platform for biomarker discovery and analysis of cellular heterogeneity. Plos One. 9: e105602. PMID 25170899 DOI: 10.1371/Journal.Pone.0105602 |
0.345 |
|
| 2014 |
Vanner RJ, Remke M, Gallo M, Selvadurai HJ, Coutinho F, Lee L, Kushida M, Head R, Morrissy S, Zhu X, Aviv T, Voisin V, Clarke ID, Li Y, Mungall AJ, ... ... Dirks PB, et al. Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma. Cancer Cell. 26: 33-47. PMID 24954133 DOI: 10.1016/J.Ccr.2014.05.005 |
0.341 |
|
| 2014 |
Kleinman CL, Gerges N, Papillon-Cavanagh S, Sin-Chan P, Pramatarova A, Quang DA, Adoue V, Busche S, Caron M, Djambazian H, Bemmo A, Fontebasso AM, Spence T, Schwartzentruber J, Albrecht S, ... ... Dirks P, et al. Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR. Nature Genetics. 46: 39-44. PMID 24316981 DOI: 10.1038/Ng.2849 |
0.397 |
|
| 2014 |
Mistry M, Zhukova N, Merico D, Rakopoulos P, Krishnatry R, Shago M, Stavropoulos J, Pole J, Ray P, Remke M, Buczkowicz P, Ramaswamy V, Shlien A, Rutka J, Dirks P, et al. Bi-21Braf Mutation And Cdkn2A Deletions Define A Clinically Distinct Subgroup Of Childhood Secondary High Grade Glioma Neuro-Oncology. 17. DOI: 10.1093/Neuonc/Nov061.70 |
0.32 |
|
| 2014 |
Dolma S, So M, Voisin V, Zhu X, Head R, Clarke I, Bader G, Tyers M, Dirks P. SC-05 * DOPAMINE RECEPTOR ANTAGONISTS ARE SELECTIVE INHIBITORS OF GLIOBLASTOMA STEM CELLS THROUGH IMPAIRMENT OF AUTOPHAGY Neuro-Oncology. 16: v198-v198. DOI: 10.1093/Neuonc/Nou275.5 |
0.64 |
|
| 2014 |
Park N, Vaner R, Ling E, Lee L, Dirks P. SC-25 * INVESTIGATING THE ROLE OF ASCL1 IN REGULATING DIFFERENTIATION OF GLIOBLASTOMA PRECURSOR CELLS Neuro-Oncology. 16: v202-v202. DOI: 10.1093/Neuonc/Nou275.25 |
0.785 |
|
| 2013 |
Saleh M, Carter MT, Latino GA, Dirks P, Ratjen F. Brain arteriovenous malformations in patients with hereditary hemorrhagic telangiectasia: clinical presentation and anatomical distribution. Pediatric Neurology. 49: 445-50. PMID 24080277 DOI: 10.1016/J.Pediatrneurol.2013.07.021 |
0.305 |
|
| 2013 |
Stricker SH, Feber A, Engström PG, Carén H, Kurian KM, Takashima Y, Watts C, Way M, Dirks P, Bertone P, Smith A, Beck S, Pollard SM. Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner. Genes & Development. 27: 654-69. PMID 23512659 DOI: 10.1101/Gad.212662.112 |
0.474 |
|
| 2013 |
Gallo M, Ho J, Coutinho FJ, Vanner R, Lee L, Head R, Ling EK, Clarke ID, Dirks PB. A tumorigenic MLL-homeobox network in human glioblastoma stem cells. Cancer Research. 73: 417-27. PMID 23108137 DOI: 10.1158/0008-5472.CAN-12-1881 |
0.795 |
|
| 2013 |
Lan X, Meyer M, Reimand J, Zhu X, Kushida M, Head R, Clarke I, Bader G, Dirks P. Abstract B29: Defining subclonal signaling heterogeneity in glioblastoma multiforme (GBM) Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-B29 |
0.419 |
|
| 2012 |
Nguyen LV, Vanner R, Dirks P, Eaves CJ. Cancer stem cells: an evolving concept. Nature Reviews. Cancer. 12: 133-43. PMID 22237392 DOI: 10.1038/Nrc3184 |
0.412 |
|
| 2012 |
Walker EJ, Zhang C, Castelo-Branco P, Hawkins C, Wilson W, Zhukova N, Alon N, Novokmet A, Baskin B, Ray P, Knobbe C, Dirks P, Taylor MD, Croul S, Malkin D, et al. Monoallelic expression determines oncogenic progression and outcome in benign and malignant brain tumors. Cancer Research. 72: 636-44. PMID 22144470 DOI: 10.1158/0008-5472.Can-11-2266 |
0.354 |
|
| 2012 |
Fried I, Hawkins C, Scheinemann K, Tsangaris E, Hesselson L, Bartels U, Huang A, Laperriere N, Dirks P, Bouffet E, Tabori U. Favorable outcome with conservative treatment for children with low grade brainstem tumors. Pediatric Blood & Cancer. 58: 556-60. PMID 21618421 DOI: 10.1002/Pbc.23200 |
0.303 |
|
| 2011 |
Persaud A, Alberts P, Hayes M, Guettler S, Clarke I, Sicheri F, Dirks P, Ciruna B, Rotin D. Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function. The Embo Journal. 30: 3259-73. PMID 21765395 DOI: 10.1038/Emboj.2011.234 |
0.341 |
|
| 2011 |
Scheinemann K, Bartels U, Tsangaris E, Hawkins C, Huang A, Dirks P, Fried I, Bouffet E, Tabori U. Feasibility and efficacy of repeated chemotherapy for progressive pediatric low-grade gliomas. Pediatric Blood & Cancer. 57: 84-8. PMID 21557457 DOI: 10.1002/Pbc.22917 |
0.331 |
|
| 2011 |
Venere M, Fine HA, Dirks PB, Rich JN. Cancer stem cells in gliomas: identifying and understanding the apex cell in cancer's hierarchy. Glia. 59: 1148-54. PMID 21547954 DOI: 10.1002/Glia.21185 |
0.398 |
|
| 2011 |
Agnihotri S, Wolf A, Munoz DM, Smith CJ, Gajadhar A, Restrepo A, Clarke ID, Fuller GN, Kesari S, Dirks PB, McGlade CJ, Stanford WL, Aldape K, Mischel PS, Hawkins C, et al. A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas. The Journal of Experimental Medicine. 208: 689-702. PMID 21464220 DOI: 10.1084/Jem.20102099 |
0.301 |
|
| 2011 |
Castelo-Branco P, Zhang C, Lipman T, Fujitani M, Hansford L, Clarke I, Harley CB, Tressler R, Malkin D, Walker E, Kaplan DR, Dirks P, Tabori U. Neural tumor-initiating cells have distinct telomere maintenance and can be safely targeted for telomerase inhibition. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 111-21. PMID 21208905 DOI: 10.1158/1078-0432.Ccr-10-2075 |
0.502 |
|
| 2010 |
Dirks PB. Brain tumor stem cells: the cancer stem cell hypothesis writ large. Molecular Oncology. 4: 420-30. PMID 20801091 DOI: 10.1016/j.molonc.2010.08.001 |
0.393 |
|
| 2010 |
Dirks P. Cancer stem cells: Invitation to a second round. Nature. 466: 40-1. PMID 20596007 DOI: 10.1038/466040A |
0.436 |
|
| 2010 |
Mondal S, Dirks P, Rutka JT. Immunolocalization of fascin, an actin-bundling protein and glial fibrillary acidic protein in human astrocytoma cells. Brain Pathology (Zurich, Switzerland). 20: 190-9. PMID 19170683 DOI: 10.1111/J.1750-3639.2008.00261.X |
0.327 |
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| 2009 |
Alexander CM, Puchalski J, Klos KS, Badders N, Ailles L, Kim CF, Dirks P, Smalley MJ. Separating stem cells by flow cytometry: reducing variability for solid tissues. Cell Stem Cell. 5: 579-83. PMID 19951686 DOI: 10.1016/J.Stem.2009.11.008 |
0.41 |
|
| 2009 |
Zhou BB, Zhang H, Damelin M, Geles KG, Grindley JC, Dirks PB. Tumour-initiating cells: challenges and opportunities for anticancer drug discovery. Nature Reviews. Drug Discovery. 8: 806-23. PMID 19794444 DOI: 10.1038/nrd2137 |
0.332 |
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| 2009 |
Rastegar M, Hotta A, Pasceri P, Makarem M, Cheung AY, Elliott S, Park KJ, Adachi M, Jones FS, Clarke ID, Dirks P, Ellis J. MECP2 isoform-specific vectors with regulated expression for Rett syndrome gene therapy. Plos One. 4: e6810. PMID 19710912 DOI: 10.1371/Journal.Pone.0006810 |
0.352 |
|
| 2009 |
Dirks PB. MicroRNAs and parallel stem cell lives. Cell. 138: 423-4. PMID 19665962 DOI: 10.1016/j.cell.2009.07.025 |
0.356 |
|
| 2009 |
Pollard SM, Yoshikawa K, Clarke ID, Danovi D, Stricker S, Russell R, Bayani J, Head R, Lee M, Bernstein M, Squire JA, Smith A, Dirks P. Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. Cell Stem Cell. 4: 568-80. PMID 19497285 DOI: 10.1016/J.Stem.2009.03.014 |
0.516 |
|
| 2009 |
Ward RJ, Lee L, Graham K, Satkunendran T, Yoshikawa K, Ling E, Harper L, Austin R, Nieuwenhuis E, Clarke ID, Hui CC, Dirks PB. Multipotent CD15+ cancer stem cells in patched-1-deficient mouse medulloblastoma. Cancer Research. 69: 4682-90. PMID 19487286 DOI: 10.1158/0008-5472.Can-09-0342 |
0.79 |
|
| 2009 |
King J, Cusimano M, Hawkins C, Dirks P. Extradural middle fossa approach to a clear cell meningioma in a child. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 36: 257-61. PMID 19378726 DOI: 10.1017/S0317167100120311 |
0.305 |
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| 2009 |
Diamandis P, Sacher AG, Tyers M, Dirks PB. New drugs for brain tumors? Insights from chemical probing of neural stem cells. Medical Hypotheses. 72: 683-7. PMID 19261391 DOI: 10.1016/J.Mehy.2008.10.034 |
0.749 |
|
| 2009 |
Pollard S, Clarke ID, Smith A, Dirks P. Brain Cancer Stem Cells: A Level Playing Field Cell Stem Cell. 5: 468-469. DOI: 10.1016/J.Stem.2009.10.016 |
0.301 |
|
| 2008 |
Kim CF, Dirks PB. Cancer and stem cell biology: how tightly intertwined? Cell Stem Cell. 3: 147-50. PMID 18682238 DOI: 10.1016/J.Stem.2008.07.012 |
0.366 |
|
| 2008 |
Dirks PB. Brain tumor stem cells: bringing order to the chaos of brain cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 26: 2916-24. PMID 18539973 DOI: 10.1200/JCO.2008.17.6792 |
0.41 |
|
| 2008 |
Dirks PB. Brain tumour stem cells: the undercurrents of human brain cancer and their relationship to neural stem cells. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 363: 139-52. PMID 17309866 DOI: 10.1098/rstb.2006.2017 |
0.338 |
|
| 2007 |
Ward RJ, Dirks PB. Cancer stem cells: at the headwaters of tumor development. Annual Review of Pathology. 2: 175-89. PMID 18039097 DOI: 10.1146/annurev.pathol.2.010506.091847 |
0.37 |
|
| 2007 |
Dirks P. Bmi1 and cell of origin determinants of brain tumor phenotype. Cancer Cell. 12: 295-7. PMID 17936553 DOI: 10.1016/J.Ccr.2007.10.003 |
0.465 |
|
| 2007 |
Diamandis P, Wildenhain J, Clarke ID, Sacher AG, Graham J, Bellows DS, Ling EK, Ward RJ, Jamieson LG, Tyers M, Dirks PB. Chemical genetics reveals a complex functional ground state of neural stem cells. Nature Chemical Biology. 3: 268-73. PMID 17417631 DOI: 10.25011/Cim.V31I4.4797 |
0.748 |
|
| 2007 |
Singh S, Dirks PB. Brain tumor stem cells: identification and concepts. Neurosurgery Clinics of North America. 18: 31-8, viii. PMID 17244552 DOI: 10.1016/j.nec.2006.10.014 |
0.41 |
|
| 2007 |
Behie L, Clarke I, Basik M, Dirks P, Youn B, Sen A. Bioprocessing of Cancer Stem Cells Bioprocessing Journal. 6: 21-29. DOI: 10.12665/J62.Behie |
0.45 |
|
| 2006 |
Dirks PB. Cancer: stem cells and brain tumours. Nature. 444: 687-8. PMID 17151644 DOI: 10.1038/444687a |
0.351 |
|
| 2006 |
Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, Visvader J, Weissman IL, Wahl GM. Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Research. 66: 9339-44. PMID 16990346 DOI: 10.1158/0008-5472.Can-06-3126 |
0.362 |
|
| 2006 |
Balenci L, Clarke ID, Dirks PB, Assard N, Ducray F, Jouvet A, Belin MF, Honnorat J, Baudier J. IQGAP1 protein specifies amplifying cancer cells in glioblastoma multiforme. Cancer Research. 66: 9074-82. PMID 16982749 DOI: 10.1158/0008-5472.Can-06-0761 |
0.396 |
|
| 2006 |
Hansford L, Smith K, Datti A, Wrana J, Irwin M, Gerstle T, Dirks P, Thorner P, Miller F, Kaplan D. Tumor initiating cells from neuroblastoma, a neural crest-derived tumor International Journal of Developmental Neuroscience. 24: 489. DOI: 10.1016/J.Ijdevneu.2006.09.047 |
0.36 |
|
| 2006 |
Dirks P. Brain tumor initiating cells: Implications for neural stem cell biology and cancer International Journal of Developmental Neuroscience. 24: 488. DOI: 10.1016/J.Ijdevneu.2006.09.045 |
0.505 |
|
| 2005 |
Dirks PB. Brain tumor stem cells. Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. 11: 12-3. PMID 15682168 DOI: 10.1016/j.bbmt.2004.11.004 |
0.361 |
|
| 2004 |
Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, Hide T, Henkelman RM, Cusimano MD, Dirks PB. Identification of human brain tumour initiating cells. Nature. 432: 396-401. PMID 15549107 DOI: 10.1038/Nature03128 |
0.326 |
|
| 2004 |
Singh SK, Clarke ID, Hide T, Dirks PB. Cancer stem cells in nervous system tumors. Oncogene. 23: 7267-73. PMID 15378086 DOI: 10.1038/sj.onc.1207946 |
0.375 |
|
| 2003 |
Singh SK, Clarke ID, Terasaki M, Bonn VE, Hawkins C, Squire J, Dirks PB. Identification of a cancer stem cell in human brain tumors. Cancer Research. 63: 5821-8. PMID 14522905 |
0.372 |
|
| 2000 |
Rutka JT, Taylor M, Mainprize T, Langlois A, Ivanchuk S, Mondal S, Dirks P. Molecular biology and neurosurgery in the third millennium. Neurosurgery. 46: 1034-51. PMID 10807235 DOI: 10.1097/00006123-200005000-00002 |
0.345 |
|
| 1999 |
Rutka JT, Ivanchuk S, Mondal S, Taylor M, Sakai K, Dirks P, Jun P, Jung S, Becker LE, Ackerley C. Co-expression of nestin and vimentin intermediate filaments in invasive human astrocytoma cells. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 17: 503-15. PMID 10571412 DOI: 10.1016/S0736-5748(99)00049-0 |
0.348 |
|
| 1998 |
Arab S, Murakami M, Dirks P, Boyd B, Hubbard SL, Lingwood CA, Rutka JT. Verotoxins inhibit the growth of and induce apoptosis in human astrocytoma cells. Journal of Neuro-Oncology. 40: 137-50. PMID 9892096 DOI: 10.1023/A:1006010019064 |
0.357 |
|
| 1997 |
Tsugu A, Dirks P, Jung S, Kurimoto M, Jay V, Murakami M, Rutka JT. Cell cycle control in pediatric neuro-oncology. Pediatric Neurosurgery. 26: 226-35. PMID 9440492 DOI: 10.1159/000121197 |
0.307 |
|
| 1995 |
Muller M, Hubbard SL, Fukuyama K, Dirks P, Matsuzawa K, Rutka JT. Characterization of a pineal region malignant rhabdoid tumor. Towards understanding brain tumor cell invasion. Pediatric Neurosurgery. 22: 204-9. PMID 7619721 DOI: 10.1159/000120902 |
0.38 |
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