Jürgen Seibel - Publications

Affiliations: 
Julius-Maximilans-Universität Würzburg, Würzburg, Bayern, Germany 
Area:
Organic Chemistry

46 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Ortiz-Soto ME, Baier M, Brenner D, Timm M, Seibel J. Single-mutations at the galactose-binding site of enzymes GalK, GalU and LgtC enable the efficient synthesis of UDP-6-azido-6-deoxy-D-galactose and azido-functionalized Gb3 analogs. Glycobiology. PMID 37283491 DOI: 10.1093/glycob/cwad045  0.326
2020 Ortiz-Soto ME, Porras-Domínguez JR, Rodríguez-Alegría ME, Morales-Moreno LA, Díaz-Vilchis A, Rudiño-Piñera E, Beltrán-Hernandez NE, Rivera HM, Seibel J, López Munguía A. Implications of the mutation S164A on Bacillus subtilis levansucrase product specificity and insights into protein interactions acting upon levan synthesis. International Journal of Biological Macromolecules. 161: 898-908. PMID 32553967 DOI: 10.1016/J.Ijbiomac.2020.06.114  0.319
2019 Ortiz-Soto ME, Reising S, Schlosser A, Seibel J. Structural and functional role of disulphide bonds and substrate binding residues of the human beta-galactoside alpha-2,3-sialyltransferase 1 (hST3Gal1). Scientific Reports. 9: 17993. PMID 31784620 DOI: 10.1038/S41598-019-54384-8  0.321
2019 Ortiz-Soto ME, Porras-Domínguez JR, Seibel J, López-Munguía A. A close look at the structural features and reaction conditions that modulate the synthesis of low and high molecular weight fructans by levansucrases. Carbohydrate Polymers. 219: 130-142. PMID 31151510 DOI: 10.1016/J.Carbpol.2019.05.014  0.338
2019 Possiel C, Ortiz-Soto ME, Ertl J, Münch A, Vogel A, Schmiedel R, Seibel J. Exploring the sequence variability of polymerization-involved residues in the production of levan- and inulin-type fructooligosaccharides with a levansucrase. Scientific Reports. 9: 7720. PMID 31118468 DOI: 10.1038/S41598-019-44211-5  0.332
2019 Ertl J, Ortiz-Soto ME, Le TA, Bechold J, Shan J, Teßmar J, Engels B, Seibel J. Tuning the product spectrum of a glycoside hydrolase enzyme by a combination of site-directed mutagenesis and tyrosine-specific chemical modification. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 30820987 DOI: 10.1002/Chem.201900576  0.362
2019 Ertl J, Ortiz‐Soto ME, Le TA, Bechold J, Shan J, Teßmar J, Engels B, Seibel J. Cover Feature: Tuning the Product Spectrum of a Glycoside Hydrolase Enzyme by a Combination of Site‐Directed Mutagenesis and Tyrosine‐Specific Chemical Modification (Chem. Eur. J. 26/2019) Chemistry – a European Journal. 25: 6456-6456. DOI: 10.1002/Chem.201901004  0.313
2018 Ortiz-Soto ME, Ertl J, Mut J, Adelmann J, Le TA, Shan J, Teßmar J, Schlosser A, Engels B, Seibel J. Product-oriented chemical surface modification of a levansucrase (SacB) an ene-type reaction. Chemical Science. 9: 5312-5321. PMID 30009003 DOI: 10.1039/C8Sc01244J  0.377
2018 Kaiser D, Winne JM, Ortiz-Soto ME, Seibel J, Le TA, Engels B. Mechanistical insights into the bioconjugation reaction of Triazolinediones with tyrosine. The Journal of Organic Chemistry. PMID 30005167 DOI: 10.1021/Acs.Joc.8B01445  0.304
2018 Fink J, Seibel J. Click reactions with functional sphingolipids. Biological Chemistry. PMID 29908120 DOI: 10.1515/Hsz-2018-0169  0.347
2018 Gutmann M, Braun A, Seibel J, Lühmann T. Bioorthogonal Modification of Cell Derived Matrices by Metabolic Glycoengineering Acs Biomaterials Science & Engineering. 4: 1300-1306. DOI: 10.1021/Acsbiomaterials.8B00264  0.31
2017 Kraus M, Grimm C, Seibel J. Switching enzyme specificity from phosphate to resveratrol glucosylation. Chemical Communications (Cambridge, England). PMID 29057405 DOI: 10.2210/Pdb5Man/Pdb  0.345
2017 Görl J, Possiel C, Sotriffer C, Seibel J. Extending the Scope of GTFR Glucosylation Reactions with Tosylated Substrates for Rare Sugars Synthesis. Chembiochem : a European Journal of Chemical Biology. PMID 28796424 DOI: 10.1002/Cbic.201700320  0.359
2017 Elena Ortiz-Soto M, Possiel C, Görl J, Vogel A, Schmiedel R, Seibel J. Impaired coordination of nucleophile and increased hydrophobicity in the +1 subsite shift levansucrase activity towards transfructosylation. Glycobiology. PMID 28575294 DOI: 10.1093/Glycob/Cwx050  0.347
2016 Mertsch A, Letschert S, Memmel E, Sauer M, Seibel J. Synthesis and application of water-soluble, photoswitchable cyanine dyes for bioorthogonal labeling of cell-surface carbohydrates. Zeitschrift Fur Naturforschung. C, Journal of Biosciences. 71: 347-354. PMID 27564698 DOI: 10.1515/Znc-2016-0123  0.313
2016 Ortiz-Soto ME, Seibel J. Expression of Functional Human Sialyltransferases ST3Gal1 and ST6Gal1 in Escherichia coli. Plos One. 11: e0155410. PMID 27166796 DOI: 10.1371/Journal.Pone.0155410  0.371
2016 Gutmann M, Memmel E, Braun AC, Seibel J, Meinel L, Lühmann T. Biocompatible Azide-Alkyne "Click" Reactions for Surface Decoration of Glyco-Engineered Cells. Chembiochem : a European Journal of Chemical Biology. 17: 866-75. PMID 26818821 DOI: 10.1002/Cbic.201500582  0.316
2015 Fleck C, Memmel E, Fölsing M, Poll B, Hackl T, Seibel J, Maison W. Synthesis and evaluation of neoglycoconjugates based on adamantyl scaffolds European Journal of Organic Chemistry. 2015: 1696-1710. DOI: 10.1002/Ejoc.201403517  0.345
2014 Bornscheuer U, Buchholz K, Seibel J. Enzymatic degradation of (ligno)cellulose. Angewandte Chemie (International Ed. in English). 53: 10876-93. PMID 25136976 DOI: 10.1002/Anie.201309953  0.333
2013 Timm M, Görl J, Kraus M, Kralj S, Hellmuth H, Beine R, Buchholz K, Dijkhuizen L, Seibel J. An unconventional glycosyl transfer reaction: glucansucrase GTFA functions as an allosyltransferase enzyme. Chembiochem : a European Journal of Chemical Biology. 14: 2423-6. PMID 24227695 DOI: 10.1002/Cbic.201300392  0.358
2012 Görl J, Timm M, Seibel J. Mechanism-oriented redesign of an isomaltulose synthase to an isomelezitose synthase by site-directed mutagenesis. Chembiochem : a European Journal of Chemical Biology. 13: 149-56. PMID 22124943 DOI: 10.1002/Cbic.201100576  0.356
2010 Seibel J, Buchholz K. Tools in oligosaccharide synthesis current research and application. Advances in Carbohydrate Chemistry and Biochemistry. 63: 101-38. PMID 20381705 DOI: 10.1016/S0065-2318(10)63004-1  0.326
2010 Seibel J, Jördening HJ, Buchholz K. Extending synthetic routes for oligosaccharides by enzyme, substrate and reaction engineering. Advances in Biochemical Engineering/Biotechnology. 120: 163-93. PMID 20182930 DOI: 10.1007/10_2009_54  0.39
2009 Homann A, Seibel J. Chemo-enzymatic synthesis and functional analysis of natural and modified glycostructures. Natural Product Reports. 26: 1555-71. PMID 19936386 DOI: 10.1039/B909990P  0.334
2009 Homann A, Seibel J. Towards tailor-made oligosaccharides-chemo-enzymatic approaches by enzyme and substrate engineering. Applied Microbiology and Biotechnology. 83: 209-16. PMID 19357843 DOI: 10.1007/S00253-009-1989-5  0.394
2009 Beine R, Valente AR, Biedendieck R, Jahn D, Seibel J. Directed optimization of biocatalytic transglycosylation processes by the integration of genetic algorithms and fermentative approaches into a kinetic model Process Biochemistry. 44: 1103-1114. DOI: 10.1016/J.Procbio.2009.06.001  0.336
2008 Beine R, Moraru R, Nimtz M, Na'amnieh S, Pawlowski A, Buchholz K, Seibel J. Synthesis of novel fructooligosaccharides by substrate and enzyme engineering. Journal of Biotechnology. 138: 33-41. PMID 18775456 DOI: 10.1016/J.Jbiotec.2008.07.1998  0.381
2008 Hellmuth H, Wittrock S, Kralj S, Dijkhuizen L, Hofer B, Seibel J. Engineering the glucansucrase GTFR enzyme reaction and glycosidic bond specificity: toward tailor-made polymer and oligosaccharide products. Biochemistry. 47: 6678-84. PMID 18512955 DOI: 10.1021/Bi800563R  0.399
2008 Buchholz K, Seibel J. Industrial carbohydrate biotransformations Carbohydrate Research. 343: 1966-1979. PMID 18353291 DOI: 10.1016/J.Carres.2008.02.007  0.334
2008 Zuccaro A, Götze S, Kneip S, Dersch P, Seibel J. Tailor-made fructooligosaccharides by a combination of substrate and genetic engineering. Chembiochem : a European Journal of Chemical Biology. 9: 143-9. PMID 18058889 DOI: 10.1002/Cbic.200700486  0.347
2008 Kralj S, Buchholz K, Dijkhuizen L, Seibel J. Fructansucrase enzymes and sucrose analogues: A new approach for the synthesis of unique fructo-oligosaccharides Biocatalysis and Biotransformation. 26: 32-41. DOI: 10.1080/10242420701789478  0.408
2007 Homann A, Biedendieck R, Götze S, Jahn D, Seibel J. Insights into polymer versus oligosaccharide synthesis: mutagenesis and mechanistic studies of a novel levansucrase from Bacillus megaterium. The Biochemical Journal. 407: 189-98. PMID 17608626 DOI: 10.1042/Bj20070600  0.368
2007 Biedendieck R, Beine R, Gamer M, Jordan E, Buchholz K, Seibel J, Dijkhuizen L, Malten M, Jahn D. Export, purification, and activities of affinity tagged Lactobacillus reuteri levansucrase produced by Bacillus megaterium Applied Microbiology and Biotechnology. 74: 1062-1073. PMID 17245578 DOI: 10.1007/S00253-006-0756-0  0.313
2007 Hellmuth H, Hillringhaus L, Höbbel S, Kralj S, Dijkhuizen L, Seibel J. Highly efficient chemoenzymatic synthesis of novel branched thiooligosaccharides by substrate direction with glucansucrases. Chembiochem : a European Journal of Chemical Biology. 8: 273-6. PMID 17219452 DOI: 10.1002/Cbic.200600444  0.693
2006 Seibel J, Moraru R, Götze S, Buchholz K, Na'amnieh S, Pawlowski A, Hecht HJ. Synthesis of sucrose analogues and the mechanism of action of Bacillus subtilis fructosyltransferase (levansucrase). Carbohydrate Research. 341: 2335-49. PMID 16870166 DOI: 10.1016/J.Carres.2006.07.001  0.358
2006 Seibel J, Hellmuth H, Hofer B, Kicinska AM, Schmalbruch B. Identification of new acceptor specificities of glycosyltransferase R with the aid of substrate microarrays. Chembiochem : a European Journal of Chemical Biology. 7: 310-20. PMID 16416490 DOI: 10.1002/Cbic.200500350  0.371
2006 Seibel J, Macdonald SJ, Schofield CJ. Synthesis of δ-Lactam (2-Oxopiperazine) Inhibitors of Elastase. Cheminform. 37. DOI: 10.3184/030823405775146951  0.497
2006 Seibel J, Jördening H, Buchholz K. Glycosylation with activated sugars using glycosyltransferases and transglycosidases Biocatalysis and Biotransformation. 24: 311-342. DOI: 10.1080/10242420600986811  0.435
2006 Seibel J, Beine R, Moraru R, Behringer C, Buchholz K. A new pathway for the synthesis of oligosaccharides by the use of non-Leloir glycosyltransferases Biocatalysis and Biotransformation. 24: 157-165. DOI: 10.1080/10242420500538274  0.378
2005 Baciu I-, Jördening H-, Seibel J, Buchholz K. Investigations of the transfructosylation reaction by fructosyltransferase from B. subtilis NCIMB 11871 for the synthesis of the sucrose analogue galactosyl-fructoside. Journal of Biotechnology. 116: 347-357. PMID 15748761 DOI: 10.1016/J.Jbiotec.2004.10.019  0.366
2005 Seibel J, Hillringhaus L, Moraru R. Microwave-assisted glycosylation for the synthesis of glycopeptides. Carbohydrate Research. 340: 507-11. PMID 15680608 DOI: 10.1016/J.Carres.2004.12.014  0.689
2005 Seibel J, Moraru R, Götze S. Biocatalytic and chemical investigations in the synthesis of sucrose analogues Tetrahedron. 61: 7081-7086. DOI: 10.1016/J.Tet.2005.05.063  0.446
2003 Turnbull JJ, Nagle MJ, Seibel JF, Welford RW, Grant GH, Schofield CJ. The C-4 stereochemistry of leucocyanidin substrates for anthocyanidin synthase affects product selectivity. Bioorganic & Medicinal Chemistry Letters. 13: 3853-7. PMID 14552794 DOI: 10.1016/S0960-894X(03)00711-X  0.358
2003 Seibel J, Brown D, Amour A, Macdonald SJ, Oldham NJ, Schofield CJ. Synthesis and evaluation of delta-lactams (piperazones) as elastase inhibitors. Bioorganic & Medicinal Chemistry Letters. 13: 387-9. PMID 12565935 DOI: 10.1016/S0960-894X(02)00995-2  0.47
2003 Elkins JM, Hewitson KS, McNeill LA, Seibel JF, Schlemminger I, Pugh CW, Ratcliffe PJ, Schofield CJ. Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha. The Journal of Biological Chemistry. 278: 1802-6. PMID 12446723 DOI: 10.1074/Jbc.C200644200  0.334
2002 McNeill LA, Hewitson KS, Claridge TD, Seibel JF, Horsfall LE, Schofield CJ. Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803. The Biochemical Journal. 367: 571-5. PMID 12215170 DOI: 10.1042/Bj20021162  0.337
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