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Stephan Ohnmacht - Publications

Affiliations: 
2011-2014 School of Pharmacy University College London, London, United Kingdom 
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22 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Ahmed AA, Marchetti C, Ohnmacht SA, Neidle S. A G-quadruplex-binding compound shows potent activity in human gemcitabine-resistant pancreatic cancer cells. Scientific Reports. 10: 12192. PMID 32699225 DOI: 10.1038/S41598-020-68944-W  0.528
2020 Vo T, Oxenford S, Angell R, Marchetti C, Ohnmacht SA, Wilson WD, Neidle S. Substituted Naphthalenediimide Compounds Bind Selectively to Two Human Quadruplex Structures with Parallel Topology. Acs Medicinal Chemistry Letters. 11: 991-999. PMID 32435416 DOI: 10.1021/Acsmedchemlett.0C00041  0.611
2018 Marchetti C, Zyner KG, Ohnmacht SA, Robson M, Haider SM, Morton JP, Marsico G, Vo T, Laughlin-Toth S, Ahmed AA, Di Vita G, Pazitna I, Gunaratnam M, Besser RJ, Andrade AC, et al. Targeting multiple effector pathways in pancreatic ductal adenocarcinoma with a G-quadruplex-binding small molecule. Journal of Medicinal Chemistry. PMID 29356532 DOI: 10.1021/Acs.Jmedchem.7B01781  0.603
2016 Amato J, Morigi R, Pagano B, Pagano A, Ohnmacht SA, De Magis A, Tiang YP, Capranico G, Locatelli A, Graziadio A, Leoni A, Rambaldi M, Novellino E, Neidle S, Randazzo A. Toward the development of specific G-quadruplex binders: synthesis, biophysical and biological studies of new hydrazone derivatives. Journal of Medicinal Chemistry. PMID 27223049 DOI: 10.1021/Acs.Jmedchem.6B00129  0.705
2015 Ohnmacht SA, Marchetti C, Gunaratnam M, Besser RJ, Haider SM, Di Vita G, Lowe HL, Mellinas-Gomez M, Diocou S, Robson M, Šponer J, Islam B, Pedley RB, Hartley JA, Neidle S. A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer. Scientific Reports. 5: 11385. PMID 26077929 DOI: 10.1038/Srep11385  0.585
2015 Brito H, Martins AC, Lavrado J, Mendes E, Francisco AP, Santos SA, Ohnmacht SA, Kim NS, Rodrigues CM, Moreira R, Neidle S, Borralho PM, Paulo A. Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives. Plos One. 10: e0126891. PMID 26024321 DOI: 10.1371/Journal.Pone.0126891  0.64
2015 Marchetti C, Minarini A, Tumiatti V, Moraca F, Parrotta L, Alcaro S, Rigo R, Sissi C, Gunaratnam M, Ohnmacht SA, Neidle S, Milelli A. Macrocyclic naphthalene diimides as G-quadruplex binders. Bioorganic & Medicinal Chemistry. 23: 3819-30. PMID 25935290 DOI: 10.1016/J.Bmc.2015.03.076  0.659
2015 Lavrado J, Brito H, Borralho PM, Ohnmacht SA, Kim NS, Leitão C, Pisco S, Gunaratnam M, Rodrigues CM, Moreira R, Neidle S, Paulo A. KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines. Scientific Reports. 5: 9696. PMID 25853628 DOI: 10.1038/Srep09696  0.62
2015 Lavrado J, Ohnmacht SA, Correia I, Leitão C, Pisco S, Gunaratnam M, Moreira R, Neidle S, Santos DJ, Paulo A. Indolo[3,2-c]quinoline G-quadruplex stabilizers: a structural analysis of binding to the human telomeric G-quadruplex. Chemmedchem. 10: 836-49. PMID 25820698 DOI: 10.1002/Cmdc.201500067  0.597
2015 Lavrado J, Ohnmacht SA, Correia I, Leitão C, Pisco S, Gunaratnam M, Moreira R, Neidle S, Santos DJVAD, Paulo A. Indolo[3,2-c]quinoline G-quadruplex stabilizers: A structural analysis of binding to the human telomeric G-quadruplex Chemmedchem. 10: 836-849. DOI: 10.1002/cmdc.201500067  0.57
2014 Ohnmacht SA, Neidle S. Small-molecule quadruplex-targeted drug discovery. Bioorganic & Medicinal Chemistry Letters. 24: 2602-12. PMID 24814531 DOI: 10.1016/J.Bmcl.2014.04.029  0.482
2014 Ohnmacht SA, Varavipour E, Nanjunda R, Pazitna I, Di Vita G, Gunaratnam M, Kumar A, Ismail MA, Boykin DW, Wilson WD, Neidle S. Discovery of new G-quadruplex binding chemotypes. Chemical Communications (Cambridge, England). 50: 960-3. PMID 24302123 DOI: 10.1039/C3Cc48616H  0.627
2013 Altieri A, Alvino A, Ohnmacht S, Ortaggi G, Neidle S, Nocioni D, Franceschin M, Bianco A. Xanthene and xanthone derivatives as G-quadruplex stabilizing ligands Molecules. 18: 13446-13470. PMID 24177701 DOI: 10.3390/Molecules181113446  0.688
2013 Ohnmacht SA, Ciancimino C, Vignaroli G, Gunaratnam M, Neidle S. Optimization of anti-proliferative activity using a screening approach with a series of bis-heterocyclic G-quadruplex ligands Bioorganic and Medicinal Chemistry Letters. 23: 5351-5355. PMID 23972440 DOI: 10.1016/J.Bmcl.2013.07.057  0.608
2013 Lavrado J, Borralho PM, Ohnmacht SA, Castro RE, Rodrigues CM, Moreira R, dos Santos DJ, Neidle S, Paulo A. Synthesis, G-quadruplex stabilisation, docking studies, and effect on cancer cells of indolo[3,2-b]quinolines with one, two, or three basic side chains. Chemmedchem. 8: 1648-61. PMID 23960016 DOI: 10.1002/Cmdc.201300288  0.669
2013 Mpima S, Ohnmacht SA, Barletta M, Husby J, Pett LC, Gunaratnam M, Hilton ST, Neidle S. The influence of positional isomerism on G-quadruplex binding and anti-proliferative activity of tetra-substituted naphthalene diimide compounds. Bioorganic & Medicinal Chemistry. 21: 6162-70. PMID 23769166 DOI: 10.1016/J.Bmc.2013.05.027  0.677
2013 Micco M, Collie GW, Dale AG, Ohnmacht SA, Pazitna I, Gunaratnam M, Reszka AP, Neidle S. Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells. Journal of Medicinal Chemistry. 56: 2959-74. PMID 23514618 DOI: 10.1021/Jm301899Y  0.709
2013 Mitchell T, Ramos-Montoya A, Di Antonio M, Murat P, Ohnmacht S, Micco M, Jurmeister S, Fryer L, Balasubramanian S, Neidle S, Neal DE. Downregulation of androgen receptor transcription by promoter g-quadruplex stabilization as a potential alternative treatment for castrate-resistant prostate cancer. Biochemistry. 52: 1429-36. PMID 23363071 DOI: 10.1021/Bi301349C  0.614
2013 Mitchell T, Ramos-Montoya A, Di Antonio M, Murat P, Ohnmacht S, Micco M, Fryer L, Balasubramanian S, Neidle S, Neal D. 823 Transcriptional down-regulation of the androgen receptor by promoter G-quadruplex stabilisation; a potential alternative treatment in castrate-resistant prostate cancer European Urology Supplements. 12: e823-e824. DOI: 10.1016/S1569-9056(13)61303-2  0.507
2013 Lavrado J, Borralho PM, Ohnmacht SA, Castro RE, Rodrigues CMP, Moreira R, Dos Santos DJVA, Neidle S, Paulo A. Synthesis, G-quadruplex stabilisation, docking studies, and effect on cancer cells of indolo[3,2-b]quinolines with one, two, or three basic side chains Chemmedchem. 8: 1648-1661. DOI: 10.1002/cmdc.201300288  0.545
2012 Ohnmacht SA, Micco M, Petrucci V, Todd AK, Reszka AP, Gunaratnam M, Carvalho MA, Zloh M, Neidle S. Sequences in the HSP90 promoter form G-quadruplex structures with selectivity for disubstituted phenyl bis-oxazole derivatives Bioorganic and Medicinal Chemistry Letters. 22: 5930-5935. PMID 22892119 DOI: 10.1016/J.Bmcl.2012.07.065  0.568
2004 Werstuck GH, Kim AJ, Brenstrum T, Ohnmacht SA, Panna E, Capretta A. Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds. Bioorganic & Medicinal Chemistry Letters. 14: 5465-7. PMID 15482904 DOI: 10.1016/j.bmcl.2004.09.013  0.332
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