| Year |
Citation |
Score |
| 2023 |
Nordio G, Piazzola F, Cozza G, Rossetto M, Cervelli M, Minarini A, Basagni F, Tassinari E, Dalla Via L, Milelli A, Di Paolo ML. From Monoamine Oxidase Inhibition to Antiproliferative Activity: New Biological Perspectives for Polyamine Analogs. Molecules (Basel, Switzerland). 28. PMID 37687158 DOI: 10.3390/molecules28176329 |
0.311 |
|
| 2023 |
Guardigni M, Pruccoli L, Santini A, Simone A, Bersani M, Spyrakis F, Frabetti F, Uliassi E, Andrisano V, Pagliarani B, Fernández-Gómez P, Palomo V, Bolognesi ML, Tarozzi A, Milelli A. PROTAC-Induced Glycogen Synthase Kinase 3β Degradation as a Potential Therapeutic Strategy for Alzheimer's Disease. Acs Chemical Neuroscience. PMID 37218653 DOI: 10.1021/acschemneuro.3c00096 |
0.53 |
|
| 2022 |
Espinoza-Chávez RM, Salerno A, Liuzzi A, Ilari A, Milelli A, Uliassi E, Bolognesi ML. Targeted Protein Degradation for Infectious Diseases: from Basic Biology to Drug Discovery. Acs Bio & Med Chem Au. 3: 32-45. PMID 37101607 DOI: 10.1021/acsbiomedchemau.2c00063 |
0.516 |
|
| 2022 |
Salerno A, Seghetti F, Caciolla J, Uliassi E, Testi E, Guardigni M, Roberti M, Milelli A, Bolognesi ML. Enriching Proteolysis Targeting Chimeras with a Second Modality: When Two Are Better Than One. Journal of Medicinal Chemistry. 65: 9507-9530. PMID 35816671 DOI: 10.1021/acs.jmedchem.2c00302 |
0.515 |
|
| 2020 |
De Simone A, Tumiatti V, Andrisano V, Milelli A. Glycogen Synthase Kinase 3β: A New Gold Rush in Anti-Alzheimer's Disease Multitarget Drug Discovery? Journal of Medicinal Chemistry. PMID 33346659 DOI: 10.1021/acs.jmedchem.0c00931 |
0.311 |
|
| 2020 |
Catanzaro E, Betari N, Arencibia JM, Montanari S, Sissi C, De Simone A, Vassura I, Santini A, Andrisano V, Tumiatti V, De Vivo M, Krysko DV, Rocchi MBL, Fimognari C, Milelli A. Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer. European Journal of Medicinal Chemistry. 202: 112504. PMID 32712536 DOI: 10.1016/j.ejmech.2020.112504 |
0.308 |
|
| 2019 |
Di Paolo ML, Cozza G, Milelli A, Zonta F, Sarno S, Minniti E, Ursini F, Rosini M, Minarini A. Benextramine and derivatives as novel human monoamine oxidases inhibitors: an integrated approach. The Febs Journal. 286: 4995-5015. PMID 31291696 DOI: 10.1111/febs.14994 |
0.306 |
|
| 2019 |
De Simone A, La Pietra V, Betari N, Petragnani N, Conte M, Daniele S, Pietrobono D, Martini C, Petralla S, Casadei R, Davani L, Frabetti F, Russomanno P, Novellino E, Montanari S, ... ... Milelli A, et al. Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease. Acs Medicinal Chemistry Letters. 10: 469-474. PMID 30996781 DOI: 10.1021/acsmedchemlett.8b00507 |
0.338 |
|
| 2017 |
Pasini A, Marchetti C, Sissi C, Cortesi M, Giordano E, Minarini A, Milelli A. Novel Polyamine-Naphthalene Diimide Conjugates Targeting Histone Deacetylases and DNA for Cancer Phenotype Reprogramming Acs Medicinal Chemistry Letters. 8: 1218-1223. PMID 29259737 DOI: 10.1021/Acsmedchemlett.7B00289 |
0.343 |
|
| 2017 |
Milelli A, De Simone A, Ticchi N, Chen HH, Betari N, Andrisano V, Tumiatti V. Tacrine-based Multifunctional Agents in Alzheimer's Disease: an Old Story in Continuous Development. Current Medicinal Chemistry. PMID 28294041 DOI: 10.2174/0929867324666170309123920 |
0.38 |
|
| 2016 |
Milelli A, Turrini E, Catanzaro E, Maffei F, Fimognari C. Perspectives in Designing Multifunctional Molecules in Antipsychotic Drug Discovery Drug Development Research. 77: 437-443. PMID 27539712 DOI: 10.1002/Ddr.21334 |
0.323 |
|
| 2016 |
Tarozzi A, Marchetti C, Nicolini B, D'Amico M, Ticchi N, Pruccoli L, Tumiatti V, Simoni E, Lodola A, Mor M, Milelli A, Minarini A. Combined inhibition of the EGFR/AKT pathways by a novel conjugate of quinazoline with isothiocyanate. European Journal of Medicinal Chemistry. 117: 283-91. PMID 27135370 DOI: 10.1016/J.Ejmech.2016.04.002 |
0.35 |
|
| 2016 |
D'Urzo A, De Simone A, Fiori J, Naldi M, Milelli A, Andrisano V. Direct determination of GSK-3β activity and inhibition by UHPLC-UV-vis diode arrays detector (DAD). Journal of Pharmaceutical and Biomedical Analysis. 124: 104-111. PMID 26942334 DOI: 10.1016/J.Jpba.2016.02.029 |
0.398 |
|
| 2015 |
Zuccari G, Milelli A, Pastorino F, Loi M, Petretto A, Parise A, Marchetti C, Minarini A, Cilli M, Emionite L, Di Paolo D, Brignole C, Piaggio F, Perri P, Tumiatti V, et al. Tumor vascular targeted liposomal-bortezomib minimizes side effects and increases therapeutic activity in human neuroblastoma. Journal of Controlled Release : Official Journal of the Controlled Release Society. 211: 44-52. PMID 26031842 DOI: 10.1016/J.Jconrel.2015.05.286 |
0.321 |
|
| 2015 |
Marchetti C, Minarini A, Tumiatti V, Moraca F, Parrotta L, Alcaro S, Rigo R, Sissi C, Gunaratnam M, Ohnmacht SA, Neidle S, Milelli A. Macrocyclic naphthalene diimides as G-quadruplex binders. Bioorganic & Medicinal Chemistry. 23: 3819-30. PMID 25935290 DOI: 10.1016/J.Bmc.2015.03.076 |
0.356 |
|
| 2015 |
De Gianni E, Turrini E, Milelli A, Maffei F, Carini M, Minarini A, Tumiatti V, Ros TD, Prato M, Fimognari C. Study of the cytotoxic effects of the new synthetic Isothiocyanate CM9 and its fullerene derivative on human T-leukemia cells. Toxins. 7: 535-52. PMID 25679371 DOI: 10.3390/Toxins7020535 |
0.396 |
|
| 2014 |
Milelli A, Fimognari C, Ticchi N, Neviani P, Minarini A, Tumiatti V. Isothiocyanate synthetic analogs: biological activities, structure-activity relationships and synthetic strategies. Mini-Reviews in Medicinal Chemistry. 14: 963-977. PMID 25373847 DOI: 10.2174/1389557514666141106131909 |
0.358 |
|
| 2014 |
Rosini M, Simoni E, Milelli A, Minarini A, Melchiorre C. Oxidative stress in Alzheimer's disease: are we connecting the dots? Journal of Medicinal Chemistry. 57: 2821-31. PMID 24131448 DOI: 10.1021/Jm400970M |
0.577 |
|
| 2014 |
Minarini A, Milelli A, Fimognari C, Simoni E, Turrini E, Tumiatti V. Exploring the effects of isothiocyanates on chemotherapeutic drugs Expert Opinion On Drug Metabolism & Toxicology. 10: 25-38. PMID 24087843 DOI: 10.1517/17425255.2013.843668 |
0.332 |
|
| 2013 |
Bonaiuto E, Milelli A, Cozza G, Tumiatti V, Marchetti C, Agostinelli E, Fimognari C, Hrelia P, Minarini A, Di Paolo ML. Novel polyamine analogues: From substrates towards potential inhibitors of monoamine oxidases European Journal of Medicinal Chemistry. 70: 88-101. PMID 24140951 DOI: 10.1016/J.Ejmech.2013.07.005 |
0.379 |
|
| 2013 |
Minarini A, Milelli A, Simoni E, Rosini M, Bolognesi ML, Marchetti C, Tumiatti V. Multifunctional tacrine derivatives in Alzheimer's disease. Current Topics in Medicinal Chemistry. 13: 1771-86. PMID 23931443 DOI: 10.2174/15680266113139990136 |
0.639 |
|
| 2013 |
Minarini A, Zini M, Milelli A, Tumiatti V, Marchetti C, Nicolini B, Falconi M, Farruggia G, Cappadone C, Stefanelli C. Synthetic polyamines activating autophagy: effects on cancer cell death. European Journal of Medicinal Chemistry. 67: 359-366. PMID 23887056 DOI: 10.1016/J.Ejmech.2013.06.044 |
0.337 |
|
| 2013 |
Saiki R, Yoshizawa Y, Minarini A, Milelli A, Marchetti C, Tumiatti V, Toida T, Kashiwagi K, Igarashi K. In vitro and in vivo evaluation of polymethylene tetraamine derivatives as NMDA receptor channel blockers. Bioorganic & Medicinal Chemistry Letters. 23: 3901-4. PMID 23692871 DOI: 10.1016/J.Bmcl.2013.04.063 |
0.321 |
|
| 2012 |
Milelli A, Tumiatti V, Micco M, Rosini M, Zuccari G, Raffaghello L, Bianchi G, Pistoia V, Fernando Díaz J, Pera B, Trigili C, Barasoain I, Musetti C, Toniolo M, Sissi C, et al. Structure-activity relationships of novel substituted naphthalene diimides as anticancer agents. European Journal of Medicinal Chemistry. 57: 417-28. PMID 22819507 DOI: 10.1016/J.Ejmech.2012.06.045 |
0.399 |
|
| 2012 |
Minarini A, Milelli A, Tumiatti V, Ferruzzi L, Marton M, Turrini E, Hrelia P, Fimognari C. Design, synthesis and biological evaluation of new naphtalene diimides bearing isothiocyanate functionality. European Journal of Medicinal Chemistry. 48: 124-131. PMID 22200402 DOI: 10.1016/J.Ejmech.2011.12.003 |
0.359 |
|
| 2012 |
Minarini A, Milelli A, Tumiatti V, Rosini M, Simoni E, Bolognesi ML, Andrisano V, Bartolini M, Motori E, Angeloni C, Hrelia S. Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment. Neuropharmacology. 62: 997-1003. PMID 22032870 DOI: 10.1016/J.Neuropharm.2011.10.007 |
0.658 |
|
| 2012 |
Emanuela B, Minarini A, Tumiatti V, Milelli A, Lunelli M, Pegoraro M, Rizzoli V, Paolo MLD. Synthetic polyamines as potential amine oxidase inhibitors: a preliminary study. Amino Acids. 42: 913-928. PMID 21858471 DOI: 10.1007/S00726-011-1006-Z |
0.401 |
|
| 2011 |
Rosini M, Simoni E, Bartolini M, Tarozzi A, Matera R, Milelli A, Hrelia P, Andrisano V, Bolognesi ML, Melchiorre C. Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease European Journal of Medicinal Chemistry. 46: 5435-5442. PMID 21924801 DOI: 10.1016/J.Ejmech.2011.09.001 |
0.701 |
|
| 2011 |
Bolognesi ML, Bartolini M, Tarozzi A, Morroni F, Lizzi F, Milelli A, Minarini A, Rosini M, Hrelia P, Andrisano V, Melchiorre C. Multitargeted drugs discovery: Balancing anti-amyloid and anticholinesterase capacity in a single chemical entity Bioorganic and Medicinal Chemistry Letters. 21: 2655-2658. PMID 21236667 DOI: 10.1016/J.Bmcl.2010.12.093 |
0.713 |
|
| 2010 |
Bolognesi ML, Bartolini M, Mancini F, Chiriano G, Ceccarini L, Rosini M, Milelli A, Tumiatti V, Andrisano V, Melchiorre C. Bis(7)-tacrine derivatives as multitarget-directed ligands: Focus on anticholinesterase and antiamyloid activities. Chemmedchem. 5: 1215-20. PMID 20486153 DOI: 10.1002/Cmdc.201000086 |
0.662 |
|
| 2010 |
Tumiatti V, Minarini A, Bolognesi ML, Milelli A, Rosini M, Melchiorre C. Tacrine derivatives and Alzheimer's disease. Current Medicinal Chemistry. 17: 1825-38. PMID 20345341 DOI: 10.2174/092986710791111206 |
0.705 |
|
| 2010 |
Minarini A, Milelli A, Tumiatti V, Rosini M, Bolognesi ML, Melchiorre C. Synthetic polyamines: an overview of their multiple biological activities. Amino Acids. 38: 383-92. PMID 20012115 DOI: 10.1007/S00726-009-0430-9 |
0.634 |
|
| 2009 |
Tumiatti V, Milelli A, Minarini A, Micco M, Gasperi Campani A, Roncuzzi L, Baiocchi D, Marinello J, Capranico G, Zini M, Stefanelli C, Melchiorre C. Design, synthesis, and biological evaluation of substituted naphthalene imides and diimides as anticancer agent. Journal of Medicinal Chemistry. 52: 7873-7. PMID 19954251 DOI: 10.1021/Jm901131M |
0.518 |
|
| 2009 |
Zini M, Passariello CL, Gottardi D, Cetrullo S, Flamigni F, Pignatti C, Minarini A, Tumiatti V, Milelli A, Melchiorre C, Stefanelli C. Cytotoxicity of methoctramine and methoctramine-related polyamines. Chemico-Biological Interactions. 181: 409-16. PMID 19576191 DOI: 10.1016/J.Cbi.2009.06.015 |
0.583 |
|
| 2009 |
Aleman J, Milelli A, Cabrera S, Reyes E, Joergensen KA. ChemInform Abstract: Asymmetric 1,4-Addition of Oxazolones to Nitroalkenes by Bifunctional Cinchona Alkaloid Thiourea Organocatalysts: Synthesis of α,α-Disubstituted α-Amino Acids. Cheminform. 40. DOI: 10.1002/CHIN.200916122 |
0.449 |
|
| 2009 |
Cabrera S, Reyes E, Aleman J, Milelli A, Kobbelgaard S, Joergensen KA. ChemInform Abstract: Organocatalytic Asymmetric Synthesis of α,α-Disubstituted α-Amino Acids and Derivatives. Cheminform. 40. DOI: 10.1002/chin.200904064 |
0.45 |
|
| 2008 |
Alemán J, Milelli A, Cabrera S, Reyes E, Jørgensen KA. Asymmetric 1,4-addition of oxazolones to nitroalkenes by bifunctional cinchona alkaloid thiourea organocatalysts: synthesis of alpha,alpha-disubstituted alpha-amino acids. Chemistry (Weinheim An Der Bergstrasse, Germany). 14: 10958-66. PMID 18979472 DOI: 10.1002/Chem.200802030 |
0.497 |
|
| 2008 |
Tumiatti V, Milelli A, Minarini A, Rosini M, Bolognesi ML, Micco M, Andrisano V, Bartolini M, Mancini F, Recanatini M, Cavalli A, Melchiorre C. Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer. Journal of Medicinal Chemistry. 51: 7308-12. PMID 18954037 DOI: 10.1021/Jm8009684 |
0.683 |
|
| 2008 |
Cabrera S, Reyes E, Alemán J, Milelli A, Kobbelgaard S, Jørgensen KA. Organocatalytic asymmetric synthesis of alpha,alpha-disubstituted alpha-amino acids and derivatives. Journal of the American Chemical Society. 130: 12031-7. PMID 18698775 DOI: 10.1021/Ja804567H |
0.509 |
|
| 2008 |
Tumiatti V, Bolognesi ML, Minarini A, Rosini M, Milelli A, Matera R, Melchiorre C. Progress in acetylcholinesterase inhibitors for Alzheimer's disease: an update Expert Opinion On Therapeutic Patents. 18: 387-401. DOI: 10.1517/13543776.18.4.387 |
0.702 |
|
| 2008 |
Reyes E, Jiang H, Milelli A, Elsner P, Hazell RG, Jørgensen KA. Generation of Five Stereocenters in an Organocatalytic Cascade Reaction Synfacts. 2008: 89-89. DOI: 10.1055/S-2007-991420 |
0.327 |
|
| 2008 |
Jørgensen K, Cabrera S, Reyes E, Alemán J, Milelli A, Kobbelgaard S. Quaternary α-Amino Acids and Derivatives Synfacts. 2008: 1220-1220. DOI: 10.1055/S-0028-1083383 |
0.549 |
|
| 2007 |
Reyes E, Jiang H, Milelli A, Elsner P, Hazell RG, Jørgensen KA. How to make five contiguous stereocenters in one reaction: Asymmetric organocatalytic synthesis of pentasubstituted cyclohexanes Angewandte Chemie - International Edition. 46: 9202-9205. PMID 17985337 DOI: 10.1002/Anie.200704454 |
0.42 |
|
| 2007 |
Tumiatti V, Minarini A, Milelli A, Rosini M, Buccioni M, Marucci G, Ghelardini C, Bellucci C, Melchiorre C. Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: effect of replacing the inner polymethylene chain with cyclic moieties. Bioorganic & Medicinal Chemistry. 15: 2312-21. PMID 17276075 DOI: 10.1016/J.Bmc.2007.01.022 |
0.558 |
|
| Show low-probability matches. |