| Year |
Citation |
Score |
| 2023 |
O'Brien DP, Jones HB, Guenther F, Murphy EJ, England KS, Vendrell I, Anderson M, Brennan P, Davis JB, Pinto-Fernández A, Turnbull AP, Kessler BM. Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides. Molecular & Cellular Proteomics : McP. 100609. PMID 37385347 DOI: 10.1016/j.mcpro.2023.100609 |
0.37 |
|
| 2021 |
Mathea S, Salah E, Tallant C, Chatterjee D, Berger BT, Konietzny R, Müller-Knapp S, Kessler BM, Knapp S. Conformational plasticity of the ULK3 kinase domain. The Biochemical Journal. PMID 34190988 DOI: 10.1042/BCJ20210257 |
0.483 |
|
| 2020 |
Ward JA, Pinto-Fernandez A, Cornelissen L, Bonham S, Díaz-Sáez L, Riant O, Huber KVM, Kessler BM, Feron O, Tate EW. Re-evaluating the mechanism of action of α,β-unsaturated carbonyl DUB inhibitors b-AP15 and VLX1570: a paradigmatic example of unspecific protein crosslinking with Michael acceptor motif-containing drugs. Journal of Medicinal Chemistry. PMID 32109059 DOI: 10.1021/Acs.Jmedchem.0C00144 |
0.324 |
|
| 2018 |
D'Ascenzio M, Pugh KM, Konietzny R, Berridge G, Tallant C, Hashem S, Monteiro O, Thomas JR, Schirle M, Knapp S, Marsden B, Fedorov O, Bountra C, Kessler BM, Brennan PE. An Activity-Based Probe Targeting Non-Catalytic, Highly Conserved Amino Acid Residues within Bromodomains. Angewandte Chemie (International Ed. in English). PMID 30589164 DOI: 10.1002/Anie.201807825 |
0.541 |
|
| 2018 |
Vazquez-Rodriguez S, Wright M, Rogers CM, Cribbs A, Velupillai S, Philpott M, Lee H, Dunford JE, Huber KVM, Robers MB, Vasta JD, Thezenas ML, Bonham S, Kessler B, Bennett J, et al. Design, Synthesis and Characterization of Covalent KDM5 Inhibitors. Angewandte Chemie (International Ed. in English). PMID 30431220 DOI: 10.1002/Anie.201810179 |
0.38 |
|
| 2017 |
Turnbull AP, Ioannidis S, Krajewski WW, Pinto-Fernandez A, Heride C, Martin ACL, Tonkin LM, Townsend EC, Buker SM, Lancia DR, Caravella JA, Toms AV, Charlton TM, Lahdenranta J, Wilker E, ... ... Kessler BM, et al. Molecular basis of USP7 inhibition by selective small-molecule inhibitors. Nature. PMID 29045389 DOI: 10.1038/Nature24451 |
0.402 |
|
| 2017 |
Schuller M, Riedel K, Gibbs-Seymour I, Uth K, Sieg C, Gehring AP, Ahel I, Bracher F, Kessler BM, Elkins JM, Knapp S. Discovery of a selective allosteric inhibitor targeting macrodomain 2 of poly-adenosine-diphosphate-ribose polymerases 14. Acs Chemical Biology. PMID 28991428 DOI: 10.1021/Acschembio.7B00445 |
0.582 |
|
| 2017 |
Nicholson J, Jevons S, Groselj B, Ellermann S, Konietzny R, Kerr M, Kessler BM, Kiltie AE. E3 ligase cIAP2 mediates downregulation of MRE11 and radiosensitization in response to HDAC inhibition in bladder cancer. Cancer Research. PMID 28363998 DOI: 10.1158/0008-5472.CAN-16-3232 |
0.327 |
|
| 2016 |
Olzscha H, Fedorov O, Kessler BM, Knapp S, La Thangue NB. CBP/p300 Bromodomains Regulate Amyloid-like Protein Aggregation upon Aberrant Lysine Acetylation. Cell Chemical Biology. PMID 27989401 DOI: 10.1016/j.chembiol.2016.11.009 |
0.456 |
|
| 2016 |
Lu M, Breyssens H, Salter V, Zhong S, Hu Y, Baer C, Ratnayaka I, Sullivan A, Brown NR, Endicott J, Knapp S, Kessler BM, Middleton MR, Siebold C, Jones EY, et al. Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP. Cancer Cell. 30: 822-823. PMID 27846394 DOI: 10.1016/j.ccell.2016.09.019 |
0.441 |
|
| 2016 |
New M, Sheikh S, Bekheet M, Olzscha H, Thezenas ML, Care MA, Fotheringham S, Tooze RM, Kessler BM, La Thangue NB. TLR adaptor protein MYD88 mediates sensitivity to HDAC inhibitors via a cytokine-dependent mechanism. Cancer Research. PMID 27733371 DOI: 10.1158/0008-5472.CAN-16-0504 |
0.318 |
|
| 2016 |
Miranda F, Mannion D, Liu S, Zheng Y, Mangala LS, Redondo C, Herrero-Gonzalez S, Xu R, Taylor C, Chedom DF, Karaminejadranjbar M, Albukhari A, Jiang D, Pradeep S, Rodriguez-Aguayo C, ... ... Kessler BM, et al. Salt-Inducible Kinase 2 Couples Ovarian Cancer Cell Metabolism with Survival at the Adipocyte-Rich Metastatic Niche. Cancer Cell. PMID 27478041 DOI: 10.1016/J.Ccell.2016.06.020 |
0.447 |
|
| 2016 |
Mathea S, Abdul Azeez KR, Salah E, Tallant C, Wolfreys F, Konietzny R, Fischer R, Lou HJ, Brennan PE, Schnapp G, Pautsch A, Kessler BM, Turk BE, Knapp S. Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib. Acs Chemical Biology. PMID 26999302 DOI: 10.1021/Acschembio.6B00043 |
0.539 |
|
| 2016 |
Ghari F, Quirke AM, Munro S, Kawalkowska J, Picaud S, McGouran J, Subramanian V, Muth A, Williams R, Kessler B, Thompson PR, Fillipakopoulos P, Knapp S, Venables PJ, La Thangue NB. Citrullination-acetylation interplay guides E2F-1 activity during the inflammatory response. Science Advances. 2: e1501257. PMID 26989780 DOI: 10.1126/Sciadv.1501257 |
0.461 |
|
| 2013 |
New M, Olzscha H, Liu G, Khan O, Stimson L, McGouran J, Kerr D, Coutts A, Kessler B, Middleton M, La Thangue NB. A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors. Cell Death and Differentiation. 20: 1306-16. PMID 23703321 DOI: 10.1038/cdd.2013.47 |
0.321 |
|
| 2013 |
Lu M, Breyssens H, Salter V, Zhong S, Hu Y, Baer C, Ratnayaka I, Sullivan A, Brown NR, Endicott J, Knapp S, Kessler BM, Middleton MR, Siebold C, Jones EY, et al. Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP. Cancer Cell. 23: 618-33. PMID 23623661 DOI: 10.1016/j.ccr.2013.03.013 |
0.465 |
|
| 2011 |
Altun M, Kramer HB, Willems LI, McDermott JL, Leach CA, Goldenberg SJ, Kumar KG, Konietzny R, Fischer R, Kogan E, Mackeen MM, McGouran J, Khoronenkova SV, Parsons JL, Dianov GL, ... ... Kessler BM, et al. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Chemistry & Biology. 18: 1401-12. PMID 22118674 DOI: 10.1016/j.chembiol.2011.08.018 |
0.36 |
|
| 2011 |
Rotili D, Altun M, Kawamura A, Wolf A, Fischer R, Leung IK, Mackeen MM, Tian YM, Ratcliffe PJ, Mai A, Kessler BM, Schofield CJ. A photoreactive small-molecule probe for 2-oxoglutarate oxygenases. Chemistry & Biology. 18: 642-54. PMID 21609845 DOI: 10.1016/J.Chembiol.2011.03.007 |
0.335 |
|
| 2007 |
van Swieten PF, Samuel E, Hernández RO, van den Nieuwendijk AM, Leeuwenburgh MA, van der Marel GA, Kessler BM, Overkleeft HS, Kisselev AF. A cell-permeable inhibitor and activity-based probe for the caspase-like activity of the proteasome. Bioorganic & Medicinal Chemistry Letters. 17: 3402-5. PMID 17442566 DOI: 10.1016/j.bmcl.2007.03.092 |
0.312 |
|
| 2005 |
Borodovsky A, Ovaa H, Meester WJ, Venanzi ES, Bogyo MS, Hekking BG, Ploegh HL, Kessler BM, Overkleeft HS. Small-molecule inhibitors and probes for ubiquitin- and ubiquitin-like-specific proteases. Chembiochem : a European Journal of Chemical Biology. 6: 287-91. PMID 15651044 DOI: 10.1002/Cbic.200400236 |
0.304 |
|
| 2004 |
Bogyo M, Baruch A, Jeffery DA, Greenbaum D, Borodovsky A, Ovaa H, Kessler B. Applications for chemical probes of proteolytic activity. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Unit 21.17. PMID 18429259 DOI: 10.1002/0471140864.Ps2117S36 |
0.328 |
|
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