| Year |
Citation |
Score |
| 2019 |
Belluzo BS, Abriata LA, Giannini E, Mihovilcevic D, Dal Peraro M, Llarrull LI. An experiment-informed signal transduction model for the role of the Staphylococcus aureus MecR1 protein in β-lactam resistance. Scientific Reports. 9: 19558. PMID 31862951 DOI: 10.1038/s41598-019-55923-z |
0.311 |
|
| 2018 |
Palacios AR, Mojica MF, Giannini E, Taracila MA, Bethel CR, Alzari PM, Otero LH, Klinke S, Llarrull LI, Bonomo RA, Vila AJ. THE REACTION MECHANISM OF METALLO-β-LACTAMASES IS TUNED BY THE CONFORMATION OF AN ACTIVE SITE MOBILE LOOP. Antimicrobial Agents and Chemotherapy. PMID 30348667 DOI: 10.1128/Aac.01754-18 |
0.656 |
|
| 2017 |
Lisa MN, Palacios AR, Aitha M, González MM, Moreno DM, Crowder MW, Bonomo RA, Spencer J, Tierney DL, Llarrull LI, Vila AJ. A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamases. Nature Communications. 8: 538. PMID 28912448 DOI: 10.1038/S41467-017-00601-9 |
0.652 |
|
| 2016 |
Hinchliffe P, González MM, Mojica MF, González JM, Castillo V, Saiz C, Kosmopoulou M, Tooke CL, Llarrull LI, Mahler G, Bonomo RA, Vila AJ, Spencer J. Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes. Proceedings of the National Academy of Sciences of the United States of America. PMID 27303030 DOI: 10.1073/Pnas.1601368113 |
0.601 |
|
| 2015 |
González MM, Kosmopoulou M, Mojica MF, Castillo V, Hinchliffe P, Pettinati I, Brem J, Schofield CJ, Mahler G, Bonomo RA, Llarrull LI, Spencer J, Vila AJ. Bisthiazolidines: A Substrate-Mimicking Scaffold as an Inhibitor of the NDM-1 Carbapenemase. Acs Infectious Diseases. 1: 544-54. PMID 27623409 DOI: 10.1021/Acsinfecdis.5B00046 |
0.632 |
|
| 2015 |
Meini MR, Llarrull LI, Vila AJ. Overcoming differences: The catalytic mechanism of metallo-β-lactamases. Febs Letters. 589: 3419-32. PMID 26297824 DOI: 10.1016/J.Febslet.2015.08.015 |
0.659 |
|
| 2015 |
Mojica MF, Mahler SG, Bethel CR, Taracila MA, Kosmopoulou M, Papp-Wallace KM, Llarrull LI, Wilson BM, Marshall SH, Wallace CJ, Villegas MV, Harris ME, Vila AJ, Spencer J, Bonomo RA. Exploring the Role of Residue 228 in Substrate and Inhibitor Recognition by VIM Metallo-β-lactamases. Biochemistry. 54: 3183-96. PMID 25915520 DOI: 10.1021/Acs.Biochem.5B00106 |
0.585 |
|
| 2014 |
Meini MR, Llarrull LI, Vila AJ. Evolution of Metallo-β-lactamases: Trends Revealed by Natural Diversity and in vitro Evolution. Antibiotics (Basel, Switzerland). 3: 285-316. PMID 25364574 |
0.609 |
|
| 2013 |
Otero LH, Rojas-Altuve A, Llarrull LI, Carrasco-López C, Kumarasiri M, Lastochkin E, Fishovitz J, Dawley M, Hesek D, Lee M, Johnson JW, Fisher JF, Chang M, Mobashery S, Hermoso JA. How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function. Proceedings of the National Academy of Sciences of the United States of America. 110: 16808-13. PMID 24085846 DOI: 10.1073/Pnas.1300118110 |
0.356 |
|
| 2012 |
Breece RM, Llarrull LI, Tioni MF, Vila AJ, Tierney DL. X-ray absorption spectroscopy of metal site speciation in the metallo-β-lactamase BcII from Bacillus cereus. Journal of Inorganic Biochemistry. 111: 182-6. PMID 22381913 DOI: 10.1016/J.Jinorgbio.2011.12.013 |
0.607 |
|
| 2009 |
Llarrull LI, Fisher JF, Mobashery S. Molecular basis and phenotype of methicillin resistance in Staphylococcus aureus and insights into new beta-lactams that meet the challenge. Antimicrobial Agents and Chemotherapy. 53: 4051-63. PMID 19470504 DOI: 10.1128/Aac.00084-09 |
0.326 |
|
| 2008 |
Tioni MF, Llarrull LI, Poeylaut-Palena AA, Martí MA, Saggu M, Periyannan GR, Mata EG, Bennett B, Murgida DH, Vila AJ. Trapping and characterization of a reaction intermediate in carbapenem hydrolysis by B. cereus metallo-beta-lactamase. Journal of the American Chemical Society. 130: 15852-63. PMID 18980308 DOI: 10.1021/Ja801169J |
0.66 |
|
| 2008 |
Llarrull LI, Tioni MF, Vila AJ. Metal content and localization during turnover in B. cereus metallo-beta-lactamase. Journal of the American Chemical Society. 130: 15842-51. PMID 18980306 DOI: 10.1021/Ja801168R |
0.696 |
|
| 2008 |
Abriata LA, González LJ, Llarrull LI, Tomatis PE, Myers WK, Costello AL, Tierney DL, Vila AJ. Engineered mononuclear variants in Bacillus cereus metallo-beta-lactamase BcII are inactive. Biochemistry. 47: 8590-9. PMID 18652482 DOI: 10.1021/Bi8006912 |
0.649 |
|
| 2007 |
Llarrull LI, Tioni MF, Kowalski J, Bennett B, Vila AJ. Evidence for a dinuclear active site in the metallo-beta-lactamase BcII with substoichiometric Co(II). A new model for metal uptake. The Journal of Biological Chemistry. 282: 30586-95. PMID 17715135 DOI: 10.1074/Jbc.M704613200 |
0.683 |
|
| 2007 |
Llarrull LI, Fabiane SM, Kowalski JM, Bennett B, Sutton BJ, Vila AJ. Asp-120 locates Zn2 for optimal metallo-beta-lactamase activity. The Journal of Biological Chemistry. 282: 18276-85. PMID 17426028 DOI: 10.1074/Jbc.M700742200 |
0.688 |
|
| 2006 |
Schujman GE, Guerin M, Buschiazzo A, Schaeffer F, Llarrull LI, Reh G, Vila AJ, Alzari PM, de Mendoza D. Structural basis of lipid biosynthesis regulation in Gram-positive bacteria. The Embo Journal. 25: 4074-83. PMID 16932747 DOI: 10.1038/Sj.Emboj.7601284 |
0.514 |
|
| 2004 |
Dal Peraro M, Llarrull LI, Rothlisberger U, Vila AJ, Carloni P. Water-assisted reaction mechanism of monozinc beta-lactamases. Journal of the American Chemical Society. 126: 12661-8. PMID 15453800 DOI: 10.1021/Ja048071B |
0.574 |
|
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