Jindrich Kopecek - Publications

Affiliations: 
1972-1986 Institute of Macromolecular Chemistry, Czechoslovak Academy of Sciences 
 1986- Bioengineering University of Utah, Salt Lake City, UT 
Area:
Biomedical Engineering, Polymer Chemistry, Nanotechnology

96/436 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Sun T, Shatalova E, Braubach O, Klymyshyn D, Holler E, Wang J, Li L, Yang J, Kopecek J, Ljubimova JY. Abstract 2869: Nano-immuno combination therapy to treat brain primary central nervous system lymphoma Cancer Research. 80: 2869-2869. DOI: 10.1158/1538-7445.Am2020-2869  0.32
2019 Radford DC, Yang J, Doan MC, Li L, Dixon AS, Owen SC, Kopeček J. Multivalent HER2-binding polymer conjugates facilitate rapid endocytosis and enhance intracellular drug delivery. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 31899273 DOI: 10.1016/J.Jconrel.2019.12.049  0.317
2016 Zhang L, Zhang R, Yang J, Wang J, Kopeček J. Indium-based and iodine-based labeling of HPMA copolymer-epirubicin conjugates: Impact of structure on the in vivo fate. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 27266365 DOI: 10.1016/j.jconrel.2016.06.004  0.303
2015 Yang J, Kopeček J. POLYMERIC BIOMATERIALS AND NANOMEDICINES. Journal of Drug Delivery Science and Technology. 30: 318-330. PMID 26688694 DOI: 10.1016/j.jddst.2015.05.012  0.307
2015 Yang J, Zhang R, Radford DC, Kopeček J. FRET-trackable biodegradable HPMA copolymer-epirubicin conjugates for ovarian carcinoma therapy. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 26410808 DOI: 10.1016/j.jconrel.2015.09.045  0.337
2015 Chu TW, Kopeček J. Drug-Free Macromolecular Therapeutics--A New Paradigm in Polymeric Nanomedicines. Biomaterials Science. 3: 908-22. PMID 26191406 DOI: 10.1039/C4Bm00442F  0.408
2014 Chu TW, Kosak KM, Shami PJ, Kopeček J. Drug-free macromolecular therapeutics induce apoptosis of patient chronic lymphocytic leukemia cells. Drug Delivery and Translational Research. 4: 389-94. PMID 25580376 DOI: 10.1007/S13346-014-0209-8  0.394
2013 Peng ZH, Sima M, Salama ME, Kopečková P, Kopeček J. Spacer length impacts the efficacy of targeted docetaxel conjugates in prostate-specific membrane antigen expressing prostate cancer. Journal of Drug Targeting. 21: 968-80. PMID 24160903 DOI: 10.3109/1061186X.2013.833207  0.327
2012 Kopeček J, Yang J. Smart self-assembled hybrid hydrogel biomaterials. Angewandte Chemie (International Ed. in English). 51: 7396-417. PMID 22806947 DOI: 10.1002/Anie.201201040  0.313
2012 Chu TW, Yang J, Kopeček J. Anti-CD20 multivalent HPMA copolymer-Fab' conjugates for the direct induction of apoptosis. Biomaterials. 33: 7174-81. PMID 22795544 DOI: 10.1016/j.biomaterials.2012.06.024  0.3
2012 Johnson RN, Kopečková P, Kopeček J. Biological activity of anti-CD20 multivalent HPMA copolymer-Fab' conjugates. Biomacromolecules. 13: 727-35. PMID 22288884 DOI: 10.1021/Bm201656K  0.498
2012 Fowers KD, Kopeček J. Targeting of multidrug-resistant human ovarian carcinoma cells with anti-P-glycoprotein antibody conjugates. Macromolecular Bioscience. 12: 502-14. PMID 22278817 DOI: 10.1002/Mabi.201100350  0.74
2012 Wu K, Yang J, Liu J, Kopeček J. Coiled-coil based drug-free macromolecular therapeutics: in vivo efficacy. Journal of Controlled Release : Official Journal of the Controlled Release Society. 157: 126-31. PMID 21843563 DOI: 10.1016/J.Jconrel.2011.08.002  0.608
2011 Wu LC, Yang J, Kopeček J. Hybrid hydrogels self-assembled from graft copolymers containing complementary β-sheets as hydroxyapatite nucleation scaffolds. Biomaterials. 32: 5341-53. PMID 21549421 DOI: 10.1016/J.Biomaterials.2011.04.014  0.489
2010 Wu K, Liu J, Johnson RN, Yang J, Kopecek J. Drug-free macromolecular therapeutics: induction of apoptosis by coiled-coil-mediated cross-linking of antigens on the cell surface. Angewandte Chemie (International Ed. in English). 49: 1451-5. PMID 20101660 DOI: 10.1002/Anie.200906232  0.686
2009 Kopeček J. HYDROGELS FROM SOFT CONTACT LENSES AND IMPLANTS TO SELF-ASSEMBLED NANOMATERIALS. Journal of Polymer Science. Part a, Polymer Chemistry. 47: 5929-5946. PMID 19918374 DOI: 10.1002/Pola.23607  0.355
2009 Radu-Wu LC, Yang J, Wu K, Kopecek J. Self-assembled hydrogels from poly[N-(2-hydroxypropyl)methacrylamide] grafted with beta-sheet peptides. Biomacromolecules. 10: 2319-27. PMID 19591463 DOI: 10.1021/Bm9005084  0.564
2009 Johnson RN, Kopecková P, Kopecek J. Synthesis and evaluation of multivalent branched HPMA copolymer-Fab' conjugates targeted to the B-cell antigen CD20. Bioconjugate Chemistry. 20: 129-37. PMID 19154157 DOI: 10.1021/Bc800351M  0.554
2008 Pan H, Sima M, Kopecková P, Wu K, Gao S, Liu J, Wang D, Miller SC, Kopecek J. Biodistribution and pharmacokinetic studies of bone-targeting N-(2-hydroxypropyl)methacrylamide copolymer-alendronate conjugates. Molecular Pharmaceutics. 5: 548-58. PMID 18505266 DOI: 10.1021/Mp800003U  0.58
2008 Yang J, Wu K, Konák C, Kopecek J. Dynamic light scattering study of self-assembly of HPMA hybrid graft copolymers. Biomacromolecules. 9: 510-7. PMID 18208316 DOI: 10.1021/Bm701001F  0.621
2008 Xu C, Kopecek J. Genetically engineered block copolymers: influence of the length and structure of the coiled-coil blocks on hydrogel self-assembly. Pharmaceutical Research. 25: 674-82. PMID 17713844 DOI: 10.1007/S11095-007-9343-Z  0.49
2008 Wu K, Yang J, Koňák Č, Kopečková P, Kopeček J. Novel Synthesis of HPMA Copolymers Containing Peptide Grafts and Their Self-Assembly Into Hybrid Hydrogels Macromolecular Chemistry and Physics. 209: 467-475. DOI: 10.1002/Macp.200700486  0.578
2007 Wang D, Miller SC, Shlyakhtenko LS, Portillo AM, Liu XM, Papangkorn K, Kopecková P, Lyubchenko Y, Higuchi WI, Kopecek J. Osteotropic Peptide that differentiates functional domains of the skeleton. Bioconjugate Chemistry. 18: 1375-8. PMID 17705416 DOI: 10.1021/Bc7002132  0.394
2006 Ding H, Prodinger WM, Kopecek J. Two-step fluorescence screening of CD21-binding peptides with one-bead one-compound library and investigation of binding properties of N-(2-hydroxypropyl)methacrylamide copolymer-peptide conjugates. Biomacromolecules. 7: 3037-46. PMID 17096529 DOI: 10.1021/Bm060508F  0.33
2006 Yang J, Xu C, Wang C, Kopecek J. Refolding hydrogels self-assembled from N-(2-hydroxypropyl)methacrylamide graft copolymers by antiparallel coiled-coil formation. Biomacromolecules. 7: 1187-95. PMID 16602737 DOI: 10.1021/Bm051002K  0.535
2006 Yang J, Xu C, Kopecková P, Kopecek J. Hybrid hydrogels self-assembled from HPMA copolymers containing peptide grafts. Macromolecular Bioscience. 6: 201-9. PMID 16514591 DOI: 10.1002/Mabi.200500208  0.5
2006 Chivukula P, Dusek K, Wang D, Dusková-Smrcková M, Kopecková P, Kopecek J. Synthesis and characterization of novel aromatic azo bond-containing pH-sensitive and hydrolytically cleavable IPN hydrogels. Biomaterials. 27: 1140-51. PMID 16098577 DOI: 10.1016/J.Biomaterials.2005.07.020  0.73
2006 Xu C, Kopeček J. Self-Assembling Hydrogels Polymer Bulletin. 58: 53-63. DOI: 10.1007/S00289-006-0597-0  0.503
2005 Merdan T, Kunath K, Petersen H, Bakowsky U, Voigt KH, Kopecek J, Kissel T. PEGylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose-dependent manner after intravenous injection into mice. Bioconjugate Chemistry. 16: 785-92. PMID 16029019 DOI: 10.1021/Bc049743Q  0.309
2005 Xu C, Breedveld V, Kopecek J. Reversible hydrogels from self-assembling genetically engineered protein block copolymers. Biomacromolecules. 6: 1739-49. PMID 15877401 DOI: 10.1021/Bm050017F  0.495
2004 Wang D, Li W, Pechar M, Kopecková P, Brömme D, Kopecek J. Cathepsin K inhibitor-polymer conjugates: potential drugs for the treatment of osteoporosis and rheumatoid arthritis. International Journal of Pharmaceutics. 277: 73-9. PMID 15158970 DOI: 10.1016/J.Ijpharm.2003.03.003  0.321
2004 David A, Kopecková P, Minko T, Rubinstein A, Kopecek J. Design of a multivalent galactoside ligand for selective targeting of HPMA copolymer-doxorubicin conjugates to human colon cancer cells. European Journal of Cancer (Oxford, England : 1990). 40: 148-57. PMID 14687799 DOI: 10.1016/J.Ejca.2003.07.001  0.328
2003 Merdan T, Callahan J, Petersen H, Kunath K, Bakowsky U, Kopecková P, Kissel T, Kopecek J. Pegylated polyethylenimine-Fab' antibody fragment conjugates for targeted gene delivery to human ovarian carcinoma cells. Bioconjugate Chemistry. 14: 989-96. PMID 13129403 DOI: 10.1021/Bc0340767  0.344
2003 Wang D, Miller S, Sima M, Kopecková P, Kopecek J. Synthesis and evaluation of water-soluble polymeric bone-targeted drug delivery systems. Bioconjugate Chemistry. 14: 853-9. PMID 13129387 DOI: 10.1021/Bc034090J  0.33
2003 Nori A, Jensen KD, Tijerina M, Kopecková P, Kopecek J. Subcellular trafficking of HPMA copolymer-Tat conjugates in human ovarian carcinoma cells. Journal of Controlled Release : Official Journal of the Controlled Release Society. 91: 53-9. PMID 12932637 DOI: 10.1016/S0168-3659(03)00213-X  0.733
2003 Tijerina M, Kopecková P, Kopecek J. Mechanisms of cytotoxicity in human ovarian carcinoma cells exposed to free Mce6 or HPMA copolymer-Mce6 conjugates. Photochemistry and Photobiology. 77: 645-52. PMID 12870851 DOI: 10.1562/0031-8655(2003)077<0645:Mociho>2.0.Co;2  0.743
2003 Tijerina M, Kopecková P, Kopecek J. Correlation of subcellular compartmentalization of HPMA copolymer-Mce6 conjugates with chemotherapeutic activity in human ovarian carcinoma cells. Pharmaceutical Research. 20: 728-37. PMID 12751627 DOI: 10.1023/A:1023425300829  0.731
2003 Peterson CM, Shiah JG, Sun Y, Kopecková P, Minko T, Straight RC, Kopecek J. HPMA copolymer delivery of chemotherapy and photodynamic therapy in ovarian cancer. Advances in Experimental Medicine and Biology. 519: 101-23. PMID 12675211 DOI: 10.1007/0-306-47932-X_7  0.36
2003 Jensen KD, Nori A, Tijerina M, Kopecková P, Kopecek J. Cytoplasmic delivery and nuclear targeting of synthetic macromolecules. Journal of Controlled Release : Official Journal of the Controlled Release Society. 87: 89-105. PMID 12618026 DOI: 10.1016/S0168-3659(02)00352-8  0.748
2003 Nori A, Jensen KD, Tijerina M, Kopecková P, Kopecek J. Tat-conjugated synthetic macromolecules facilitate cytoplasmic drug delivery to human ovarian carcinoma cells. Bioconjugate Chemistry. 14: 44-50. PMID 12526691 DOI: 10.1021/Bc0255900  0.759
2002 David A, Kopecková P, Kopecek J, Rubinstein A. The role of galactose, lactose, and galactose valency in the biorecognition of N-(2-hydroxypropyl)methacrylamide copolymers by human colon adenocarcinoma cells. Pharmaceutical Research. 19: 1114-22. PMID 12240936 DOI: 10.1023/A:1019885807067  0.395
2002 Jensen KD, Kopecková P, Kopecek J. Antisense oligonucleotides delivered to the lysosome escape and actively inhibit the hepatitis B virus. Bioconjugate Chemistry. 13: 975-84. PMID 12236779 DOI: 10.1021/Bc025559Y  0.377
2002 Luo Y, Bernshaw NJ, Lu ZR, Kopecek J, Prestwich GD. Targeted delivery of doxorubicin by HPMA copolymer-hyaluronan bioconjugates. Pharmaceutical Research. 19: 396-402. PMID 12033370 DOI: 10.1023/A:1015170907274  0.377
2002 Tang A, Kopecek J. Presentation of epitopes on genetically engineered peptides and selection of lymphoma-targeting moieties based on epitope biorecognition. Biomacromolecules. 3: 421-31. PMID 12005510 DOI: 10.1021/Bm015606+  0.337
2002 Kasuya Y, Lu ZR, Kopecková P, Tabibi SE, Kopecek J. Influence of the structure of drug moieties on the in Vitro efficacy of HPMA copolymer-geldanamycin derivative conjugates Pharmaceutical Research. 19: 115-123. PMID 11883637 DOI: 10.1023/A:1014216712820  0.302
2002 Lu ZR, Shiah JG, Sakuma S, Kopecková P, Kopecek J. Design of novel bioconjugates for targeted drug delivery. Journal of Controlled Release : Official Journal of the Controlled Release Society. 78: 165-73. PMID 11772458 DOI: 10.1016/S0168-3659(01)00495-3  0.307
2002 David A, Kopecková P, Rubinstein A, Kopecek J. Enhanced biorecognition and internalization of HPMA copolymers containing multiple or multivalent carbohydrate side-chains by human hepatocarcinoma cells. Bioconjugate Chemistry. 12: 890-9. PMID 11716678 DOI: 10.1021/bc010026v  0.323
2002 Xu C, Joss L, Wang C, Pechar M, Kopeček J. The Influence of Fusion Sequences on the Thermal Stabilities of Coiled-Coil Proteins Macromolecular Bioscience. 2: 395-401. DOI: 10.1002/1616-5195(200211)2:8<395::Aid-Mabi395>3.0.Co;2-9  0.431
2002 Pechar M, Kopečková P, Joss L, Kopeček J. Associative diblock copolymers of poly(ethylene glycol) and coiled-coil peptides Macromolecular Bioscience. 2: 199. DOI: 10.1002/1616-5195(200206)2:5<199::Aid-Mabi199>3.0.Co;2-2  0.341
2001 Jensen KD, Kopecková P, Bridge JH, Kopecek J. The cytoplasmic escape and nuclear accumulation of endocytosed and microinjected HPMA copolymers and a basic kinetic study in Hep G2 cells. Aaps Pharmsci. 3: E32. PMID 12049495 DOI: 10.1208/ps030432  0.302
2001 Fowers KD, Callahan J, Byron P, Kopecek JI. Preparation of Fab' from murine IgG2a for thiol reactive conjugation. Journal of Drug Targeting. 9: 281-94. PMID 11697031 DOI: 10.3109/10611860108997936  0.716
2001 Kasuya Y, Lu ZR, Kopečková P, Kopeček J. Improved synthesis and evaluation of 17-substituted aminoalkylgeldanamycin derivatives applicable to drug delivery systems Bioorganic and Medicinal Chemistry Letters. 11: 2089-2091. PMID 11514145 DOI: 10.1016/S0960-894X(01)00374-2  0.334
2001 Tijerina M, Kopecková P, Kopecek J. The effects of subcellular localization of N-(2-hydroxypropyl)methacrylamide copolymer-Mce(6) conjugates in a human ovarian carcinoma. Journal of Controlled Release : Official Journal of the Controlled Release Society. 74: 269-73. PMID 11489506 DOI: 10.1016/S0168-3659(01)00334-0  0.723
2001 Kasuya Y, Lu ZR, Kopečková P, Minko T, Tabibi SE, Kopeček J. Synthesis and characterization of HPMA copolymer-aminopropylgeldanamycin conjugates Journal of Controlled Release. 74: 203-211. PMID 11489496 DOI: 10.1016/S0168-3659(01)00318-2  0.304
2000 Wang D, Kopečková P, Minko T, Nanayakkara V, Kopeček J. Synthesis of starlike N-(2-hydroxypropyl)methacrylamide copolymers: Potential drug carriers Biomacromolecules. 1: 313-319. PMID 11710118 DOI: 10.1021/Bm0000236  0.332
2000 Tijerina M, Fowers KD, Kopecková P, Kopecek J. Chronic exposure of human ovarian carcinoma cells to free or HPMA copolymer-bound mesochlorin e6 does not induce P-glycoprotein-mediated multidrug resistance. Biomaterials. 21: 2203-10. PMID 10985494 DOI: 10.1016/S0142-9612(00)00161-7  0.75
2000 Lu ZR, Gao SQ, Kopecková P, Kopecek J. Synthesis of bioadhesive lectin-HPMA copolymer-cyclosporin conjugates. Bioconjugate Chemistry. 11: 3-7. PMID 10639078 DOI: 10.1021/bc990098a  0.316
1999 Lu ZR, Kopecková P, Kopecek J. Polymerizable Fab' antibody fragments for targeting of anticancer drugs. Nature Biotechnology. 17: 1101-4. PMID 10545917 DOI: 10.1038/15085  0.412
1999 Lu ZR, Kopecková P, Wu Z, Kopecek J. Functionalized semitelechelic poly[N-(2-hydroxypropyl)methacrylamide] for protein modification. Bioconjugate Chemistry. 9: 793-804. PMID 9815174 DOI: 10.1021/Bc980058R  0.366
1999 Tijerina M, Fowers K, Kopeckova P, Kopecek J. Chronic exposure to free or HPMA copolymer bound mesochlorin does not induce P-glycoprotein mediated multidrug resistance Proceedings of the Controlled Release Society. 1056-1057.  0.685
1998 Omelyanenko V, Kopecková P, Gentry C, Kopecek J. Targetable HPMA copolymer-adriamycin conjugates. Recognition, internalization, and subcellular fate. Journal of Controlled Release : Official Journal of the Controlled Release Society. 53: 25-37. PMID 9741911 DOI: 10.1016/S0168-3659(97)00235-6  0.345
1998 Omelyanenko V, Gentry C, Kopecková P, Kopecek J. HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. II. Processing in epithelial ovarian carcinoma cells in vitro. International Journal of Cancer. 75: 600-8. PMID 9466663 DOI: 10.1002/(SICI)1097-0215(19980209)75:4<600::AID-IJC18>3.0.CO;2-C  0.362
1998 Wróblewski S, Kopečková P, Říhová B, Kopeček J. Lectin-HPMA copolymer conjugates: potential oral drug carriers for targeting diseased tissues Macromolecular Chemistry and Physics. 199: 2601-2608. DOI: 10.1002/(Sici)1521-3935(19981101)199:11<2601::Aid-Macp2601>3.0.Co;2-9  0.764
1997 Kopecek J, Kopecková P, Konák C. Biorecognizable polymers: Design, structure, and bioactivity Journal of Macromolecular Science - Pure and Applied Chemistry. 34: 2103-2117. DOI: 10.1080/10601329708010328  0.369
1997 Fowers KD, Kopeček J. Development of a fibrinolytic surface: Specific and non-specific binding of plasminogen Colloids and Surfaces B: Biointerfaces. 9: 315-330. DOI: 10.1016/S0927-7765(97)00034-9  0.683
1996 Omelyanenko V, Kopecková P, Gentry C, Shiah JG, Kopecek J. HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. 1. influence of the method of synthesis on the binding affinity to OVCAR-3 ovarian carcinoma cells in vitro. Journal of Drug Targeting. 3: 357-73. PMID 8866655 DOI: 10.3109/10611869608996827  0.362
1996 Putnam DA, Shiah JG, Kopeček J. Intracellularly biorecognizable derivatives of 5-fluorouracil. Implications for site-specific delivery in the human condition Biochemical Pharmacology. 52: 957-962. PMID 8781516 DOI: 10.1016/0006-2952(96)00410-8  0.369
1995 Putnam D, Kopeček J. Enantioselective release of 5-fluorouracil from N-(2-hydroxypropyl)methacrylamide-based copolymers via lysosomal enzymes Bioconjugate Chemistry. 6: 483-492. PMID 7578369 DOI: 10.1021/Bc00034A019  0.318
1995 Gu Z, Omelyanenko V, Kopeckova P, Kopecek J, Konak C. Association of a Substituted Zinc(II) Phthalocyanine-N- (2-Hydroxypropyl)methacrylamide Copolymer Conjugate Macromolecules. 28: 8375-8380. DOI: 10.1021/Ma00128A055  0.306
1995 Kopeček J, Kopečková P, Omelyanenko VG, Rathi RC. Biorecognizable polymers: Structure-properties relationship Macromolecular Symposia. 98: 643-644. DOI: 10.1002/Masy.19950980155  0.384
1994 Chiu H, Koñák C, Kopečková P, KopeČek J. Enzymatic Degradation of Poly(ethylene glycol) Modified Dextrans Journal of Bioactive and Compatible Polymers. 9: 388-410. DOI: 10.1177/088391159400900403  0.321
1993 Chiu HC, Zalipsky S, Kopeckova P, Kopecek J. Enzymatic activity of chymotrypsin and its poly(ethylene glycol) conjugates toward low and high molecular weight substrates. Bioconjugate Chemistry. 4: 290-295. PMID 8110229 DOI: 10.1021/Bc00022A007  0.326
1992 Konak C, Kopeckova P, Kopecek J. Photoregulated association of N-(2-hydroxypropyl)methacrylamide copolymers with azobenzene-containing side chains Macromolecules. 25: 5451-5456. DOI: 10.1021/Ma00046A051  0.336
1991 Kopeček J, Řihová B, Krinick N. Targetable photoactivatable polymeric drugs Journal of Controlled Release. 16: 137-143. DOI: 10.1016/0168-3659(91)90037-E  0.39
1991 Seymour LW, Duncan R, Chytrý V, Strohalm J, Ulbrich K, Kopeček J. Intraperitoneal and subcutaneous retention of a soluble polymeric drug-carrier bearing galactose Journal of Controlled Release. 16: 255-262. DOI: 10.1016/0168-3659(91)90001-T  0.332
1989 Flanagan PA, Kopecková P, Kopecek J, Duncan R. Evaluation of protein-N-(2-hydroxypropyl)methacrylamide copolymer conjugates as targetable drug carriers. 1. Binding, pinocytic uptake and intracellular distribution of transferrin and anti-transferrin receptor antibody conjugates. Biochimica Et Biophysica Acta. 993: 83-91. PMID 2804126 DOI: 10.1016/0304-4165(89)90146-3  0.321
1988 Duncan R, Seymour LW, Ulbrich K, Kopecek J. Soluble synthetic polymers for targeting and controlled release of anticancer agents, particularly anthracycline antibiotics Journal of Bioactive and Compatible Polymers. 3: 4-15. DOI: 10.1177/088391158800300102  0.338
1988 Šubr V, Kopeček J, Pohl J, Baudyš M, Kostka V. Cleavage of oligopeptide side-chains in N-(2-hydroxypropyl)meth-acrylamide copolymers by mixtures of lysosomal enzymes Journal of Controlled Release. 8: 133-140. DOI: 10.1016/0168-3659(88)90039-9  0.394
1987 Seymour LW, Duncan R, Strohalm J, Kopecek J. Effect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats. Journal of Biomedical Materials Research. 21: 1341-58. PMID 3680316 DOI: 10.1002/Jbm.820211106  0.326
1987 Duncan R, Kopecková-Rejmanová P, Strohalm J, Hume I, Cable HC, Pohl J, Lloyd JB, Kopecek J. Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. I. Evaluation of daunomycin and puromycin conjugates in vitro. British Journal of Cancer. 55: 165-74. PMID 3468994 DOI: 10.1038/bjc.1987.33  0.343
1987 Seymour LW, Duncan R, Kopecková P, Kopecek J. Daunomycin- and adriamycin-N-(2-hydroxypropyl)methacrylamide copolymer conjugates; toxicity reduction by improved drug-delivery. Cancer Treatment Reviews. 14: 319-27. PMID 3326668 DOI: 10.1016/0305-7372(87)90024-7  0.372
1987 Cartlidge SA, Duncan R, Lloyd JB, Kopečková—Rejmanová P, Kopeček J. Soluble, crosslinked N-(2-hydroxypropyl)methacrylamide copolymers as potential drug carriers Journal of Controlled Release. 4: 265-278. DOI: 10.1016/0168-3659(87)90018-6  0.394
1987 Cartlidge SA, Duncan R, Lloyd JB, Kopečkova—Rejmanová P, Kopeček J. Soluble, crosslinked N-(2-hydroxypropyl)methacrylamide copolymers as potential drug carriers Journal of Controlled Release. 4: 253-264. DOI: 10.1016/0168-3659(87)90017-4  0.345
1986 Šubr V, Kopeček J, Duncan R. Degradation of Oligopeptide Sequences Connecting Poly[N-(2- hydroxypropyl)methacrylamide] Chains by Lysosomal Cysteine Proteinases Journal of Bioactive and Compatible Polymers. 1: 133-146. DOI: 10.1177/088391158600100201  0.318
1984 Duncan R, Cable HC, Rejmanová P, Kopecek J, Lloyd JB. Tyrosinamide residues enhance pinocytic capture of N-(2-hydroxypropyl)methacrylamide copolymers. Biochimica Et Biophysica Acta. 799: 1-8. PMID 6722178 DOI: 10.1016/0304-4165(84)90320-9  0.302
1982 Duncan R, Rejmanova P, Kopecek J, Lloyd JB. Pinocytic uptake and intracellular degradation of N-(2-hydroxypropyl)methacrylamide copolymers. A potential drug delivery system. Biochimica Et Biophysica Acta. 678: 143-50. PMID 7306576 DOI: 10.1016/0304-4165(81)90058-1  0.363
1981 Ulbrich K, Zacharieva EI, Obereigner B, Kopecek J. Polymers containing enzymatically degradable bonds V. Hydrophilic polymers degradable by papain. Biomaterials. 1: 199-204. PMID 7470574 DOI: 10.1016/0142-9612(80)90017-4  0.358
1978 Ulbrich K, Dušek K, Ilavský M, Kopeček J. Preparation and properties of poly-(N-butylmethacrylamide) networks European Polymer Journal. 14: 45-49. DOI: 10.1016/0014-3057(78)90150-7  0.356
1978 Strohalm J, Kopeček J. Angewandte Makromolekulare Chemie. 70: 109-118. DOI: 10.1002/Apmc.1978.050700110  0.32
1976 Ulbrich K, Kopeček J. Radical polymerization of n-substituted methacrylamides European Polymer Journal. 12: 183-187. DOI: 10.1016/0014-3057(76)90051-3  0.309
1974 Ulbrich K, Sprincl L, Kopecek J. Biocompatibility of poly(2,4 pentadiene 1 ol) Journal of Biomedical Materials Research. 8: 155-161. PMID 4133414 DOI: 10.1002/Jbm.820080205  0.338
1973 Kopecek J, Sprincl L, Lim D. New types of synthetic infusion solutions. I. Investigation of the effect of solutions of some hydrophilic polymers on blood Journal of Biomedical Materials Research. 7: 179-191. PMID 4267380 DOI: 10.1002/Jbm.820070206  0.324
1973 Kopeček J, Baẑilová H. Poly[N-(2-hydroxypropyl)methacrylamide]—I. Radical polymerization and copolymerization European Polymer Journal. 9: 7-14. DOI: 10.1016/0014-3057(73)90063-3  0.303
1969 Kopeček J, Sourirajan S. Equisorptic compositions in reverse osmosis Canadian Journal of Chemistry. 47: 3467-3469. DOI: 10.1139/v69-573  0.458
1969 Kopecek J, Sourirajan S. Performance of Porous Cellulose Acetate Membranes in Some Reverse Osmosis Experiments Industrial & Engineering Chemistry Product Research and Development. 8: 274-279. DOI: 10.1021/i360031a012  0.466
1969 Kopeček J, Sourirajan S. Structure of porous cellulose acetate membranes and a method for improving their performance in reverse osmosis Journal of Applied Polymer Science. 13: 637-657. DOI: 10.1002/app.1969.070130407  0.464
Low-probability matches (unlikely to be authored by this person)
1991 Yen H, Andrade JD, Kopeček J. Optically controlled ligand delivery. II. Copolymers containing α-methylphenacyl bonds Journal of Applied Polymer Science. 43: 1241-1252. DOI: 10.1002/App.1991.070430705  0.3
2008 Hongrapipat J, Kopecková P, Liu J, Prakongpan S, Kopecek J. Combination chemotherapy and photodynamic therapy with fab' fragment targeted HPMA copolymer conjugates in human ovarian carcinoma cells. Molecular Pharmaceutics. 5: 696-709. PMID 18729468 DOI: 10.1021/mp800006e  0.299
1971 Sprincl L, Kopecek J, Lím D. Effect of porosity of heterogeneous poly(glycol monomethacrylate) gels on the healing-in of test implants Journal of Biomedical Materials Research. 5: 447-458. PMID 5120385 DOI: 10.1002/Jbm.820050503  0.299
1991 Singh M, Rathi R, Singh A, Heller J, Talwar G, Kopecek J. Controlled release of LHRH-DT from bioerodible hydrogel microspheres International Journal of Pharmaceutics. 76: R5-R8. DOI: 10.1016/0378-5173(91)90283-T  0.299
1990 Lee JH, Kopeckova P, Kopecek J, Andrade JD. Surface properties of copolymers of alkyl methacrylates with, methoxy (polyethylene oxide) metiiacrylates and their application as protein-resistant coatings Biomaterials. 11: 455-464. PMID 2242394 DOI: 10.1016/0142-9612(90)90058-X  0.299
2015 Yang J, Kopeček J. Design Of Smart Hpma Copolymer-Based Nanomedicines. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 26437260 DOI: 10.1016/j.jconrel.2015.10.003  0.298
1989 Cassidy J, Duncan R, Morrison GJ, Strohalm J, Plocova D, Kopecek J, Kaye SB. Activity of N-(2-hydroxypropyl)methacrylamide copolymers containing daunomycin against a rat tumour model. Biochemical Pharmacology. 38: 875-9. PMID 2930589 DOI: 10.1016/0006-2952(89)90274-8  0.296
1984 Kopecek J. Controlled biodegradability of polymers--a key to drug delivery systems. Biomaterials. 5: 19-25. PMID 6375745 DOI: 10.1016/0142-9612(84)90062-0  0.296
1988 Duncan R, Kopecková P, Strohalm J, Hume IC, Lloyd JB, Kopecek J. Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. II. Evaluation of daunomycin conjugates in vivo against L1210 leukaemia. British Journal of Cancer. 57: 147-56. PMID 3358905 DOI: 10.1038/bjc.1988.31  0.295
2016 Hartley JM, Zhang R, Gudheti M, Yang J, Kopeček J. Tracking and quantifying polymer therapeutic distribution on a cellular level using 3D dSTORM. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 26855050 DOI: 10.1016/j.jconrel.2016.02.005  0.294
2008 Miller S, Pan H, Bowman M, Kopecekova P, Kopecek J. Macromolecular delivery system that can preferentially target resorption and formation surfaces and sustain the effects of an anabolic agent Bone. 43: S52. DOI: 10.1016/J.Bone.2008.08.041  0.293
2016 Zhang L, Fang Y, Yang J, Kopeček J. Drug-free macromolecular therapeutics: Impact of structure on induction of apoptosis in Raji B cells. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 28024916 DOI: 10.1016/j.jconrel.2016.12.025  0.291
2007 Malugin A, Kopecková P, Kopecek J. Liberation of doxorubicin from HPMA copolymer conjugate is essential for the induction of cell cycle arrest and nuclear fragmentation in ovarian carcinoma cells. Journal of Controlled Release : Official Journal of the Controlled Release Society. 124: 6-10. PMID 17869367 DOI: 10.1016/j.jconrel.2007.08.016  0.29
1990 Kopecek J, Kopeckova P. Targetable polymeric drugs American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. 31: 196-197.  0.29
2011 Pan H, Yang J, Kopecková P, Kopecek J. Backbone degradable multiblock N-(2-hydroxypropyl)methacrylamide copolymer conjugates via reversible addition-fragmentation chain transfer polymerization and thiol-ene coupling reaction. Biomacromolecules. 12: 247-52. PMID 21158387 DOI: 10.1021/bm101254e  0.289
2002 Merdan T, Kunath K, Fischer D, Kopecek J, Kissel T. Intracellular processing of poly(ethylene imine)/ribozyme complexes can be observed in living cells by using confocal laser scanning microscopy and inhibitor experiments. Pharmaceutical Research. 19: 140-6. PMID 11883640 DOI: 10.1023/A:1014212630566  0.289
2003 Dusek K, Dusková-Smrcková M, Ilavský M, Stewart R, Kopecek J. Swelling pressure induced phase-volume transition in hybrid biopolymer gels caused by unfolding of folded crosslinks: a model. Biomacromolecules. 4: 1818-26. PMID 14606914 DOI: 10.1021/Bm034219S  0.288
2007 Hongrapipat J, Kopecková P, Prakongpan S, Kopecek J. Enhanced antitumor activity of combinations of free and HPMA copolymer-bound drugs. International Journal of Pharmaceutics. 351: 259-70. PMID 18029122 DOI: 10.1016/j.ijpharm.2007.09.018  0.287
2017 Zhang L, Fang Y, Kopeček J, Yang J. A new construct of antibody-drug conjugates for treatment of B-cell non-Hodgkin's lymphomas. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. PMID 28249824 DOI: 10.1016/j.ejps.2017.02.034  0.286
2013 Zhang R, Luo K, Yang J, Sima M, Sun Y, Janát-Amsbury MM, Kopeček J. Synthesis and evaluation of a backbone biodegradable multiblock HPMA copolymer nanocarrier for the systemic delivery of paclitaxel. Journal of Controlled Release : Official Journal of the Controlled Release Society. 166: 66-74. PMID 23262201 DOI: 10.1016/j.jconrel.2012.12.009  0.285
1994 Krinick NL, Sun Y, Joyner D, Spikes JD, Straight RC, Kopeček J. A polymeric drug delivery system for the simultaneous delivery of drugs activatable by enzymes and/or light Journal of Biomaterials Science, Polymer Edition. 5: 303-324. PMID 8025029 DOI: 10.1163/156856294X00040  0.284
2008 Cuchelkar V, Kopecková P, Kopecek J. Synthesis and biological evaluation of disulfide-linked HPMA copolymer-mesochlorin e6 conjugates. Macromolecular Bioscience. 8: 375-83. PMID 18215003 DOI: 10.1002/mabi.200700240  0.283
2020 Kopeček J, Yang J. Polymer nanomedicines. Advanced Drug Delivery Reviews. PMID 32735811 DOI: 10.1016/j.addr.2020.07.020  0.282
1977 Kůdela V, Vacík J, Kopeček J. pH-dependent electrochemical behaviour of hydrophilic ampholytic membranes European Polymer Journal. 13: 811-813. DOI: 10.1016/0014-3057(77)90027-1  0.282
1986 Mccormick LA, Seymour LCw, Duncan R, Kopecek J. Interaction of a Cationic N-(2-hydroxypropyl)methacrylamide Copolymer with Rat Visceral Yolk Sacs Cultured in vitro and Rat Liver in vivo Journal of Bioactive and Compatible Polymers. 1: 4-19. DOI: 10.1177/088391158600100102  0.282
2007 Ding H, Kopecková P, Kopecek J. Self-association properties of HPMA copolymers containing an amphipathic heptapeptide. Journal of Drug Targeting. 15: 465-74. PMID 17671893 DOI: 10.1080/10611860701500016  0.281
2001 Shiah JG, Dvorák M, Kopecková P, Sun Y, Peterson CM, Kopecek J. Biodistribution and antitumour efficacy of long-circulating N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates in nude mice. European Journal of Cancer (Oxford, England : 1990). 37: 131-9. PMID 11165140 DOI: 10.1016/S0959-8049(00)00374-9  0.281
2001 Lu ZR, Shiah JG, Kopecková P, Kopecek J. Preparation and biological evaluation of polymerizable antibody Fab' fragment targeted polymeric drug delivery system. Journal of Controlled Release : Official Journal of the Controlled Release Society. 74: 263-8. PMID 11489505 DOI: 10.1016/S0168-3659(01)00332-7  0.281
1987 Duncan R, Cable HC, Strohalm J, Kopecek J. Pinocytic capture and exocytosis of rat immunoglobulin IgG-N-(2-hydroxypropyl)methacrylamide copolymer conjugates by rat visceral yolk sacs cultured in vitro. Bioscience Reports. 6: 869-77. PMID 3828489 DOI: 10.1007/BF01116240  0.281
2010 Kopecek J, Kopecková P. HPMA copolymers: origins, early developments, present, and future. Advanced Drug Delivery Reviews. 62: 122-49. PMID 19919846 DOI: 10.1016/j.addr.2009.10.004  0.28
2014 Zhang R, Yang J, Sima M, Zhou Y, Kopeček J. Sequential combination therapy of ovarian cancer with degradable N-(2-hydroxypropyl)methacrylamide copolymer paclitaxel and gemcitabine conjugates. Proceedings of the National Academy of Sciences of the United States of America. 111: 12181-6. PMID 25092316 DOI: 10.1073/pnas.1406233111  0.278
2001 Varticovski L, Lu ZR, Mitchell K, de Aos I, Kopecek J. Water-soluble HPMA copolymer-wortmannin conjugate retains phosphoinositide 3-kinase inhibitory activity in vitro and in vivo. Journal of Controlled Release : Official Journal of the Controlled Release Society. 74: 275-81. PMID 11489507 DOI: 10.1016/S0168-3659(01)00349-2  0.278
1989 Lee JH, Kopecek J, Andrade JD. Protein-resistant surfaces prepared by PEO-containing block copolymer surfactants Journal of Biomedical Materials Research. 23: 351-368. PMID 2715159 DOI: 10.1002/Jbm.820230306  0.278
2000 Shen H, Spikes JD, Smith CJ, Kopeček J. Photodynamic cross-linking of proteins Journal of Photochemistry and Photobiology a: Chemistry. 130: 1-6. DOI: 10.1016/S1010-6030(99)00200-2  0.278
1989 O'Hare KB, Hume IC, Scarlett L, Chytrý V, Kopecková P, Kopecek J, Duncan R. Effect of galactose on interaction of N-(2-hydroxypropyl)methacrylamide copolymers with hepatoma cells in culture: preliminary application to an anticancer agent, daunomycin. Hepatology (Baltimore, Md.). 10: 207-14. PMID 2545589 DOI: 10.1002/hep.1840100215  0.277
2011 Giantsos-Adams K, Lopez-Quintero V, Kopeckova P, Kopecek J, Tarbell JM, Dull R. Study of the therapeutic benefit of cationic copolymer administration to vascular endothelium under mechanical stress. Biomaterials. 32: 288-94. PMID 20932573 DOI: 10.1016/J.Biomaterials.2010.08.092  0.277
2011 Yang J, Luo K, Pan H, Kopečková P, Kopeček J. Synthesis of Biodegradable Multiblock Copolymers by Click Coupling of RAFT-Generated HeterotelechelicPolyHPMA Conjugates. Reactive & Functional Polymers. 71: 294-302. PMID 21499527 DOI: 10.1016/j.reactfunctpolym.2010.10.005  0.276
1988 Kopecek J. Development of tailor-made polymeric prodrugs for systemic and oral delivery Journal of Bioactive and Compatible Polymers. 3: 16-26. DOI: 10.1177/088391158800300103  0.276
2000 Kunath K, Kopečková P, Minko T, Kopeček J. HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. 3. The effect of free and polymer-bound Adriamycin on the expression of some genes in the OVCAR-3 human ovarian carcinoma cell line European Journal of Pharmaceutics and Biopharmaceutics. 49: 11-15. PMID 10613922 DOI: 10.1016/S0939-6411(99)00033-8  0.275
2018 Yang J, Li L, Kopeček J. Biorecognition: A key to drug-free macromolecular therapeutics. Biomaterials. 190: 11-23. PMID 30391799 DOI: 10.1016/j.biomaterials.2018.10.007  0.275
1986 Rihova B, Kopecek J, Kopeckova-Rejmanova P. Bioaffinity therapy with antibodies and drugs bound to soluble synthetic polymers Journal of Chromatography - Biomedical Applications. 221-233. PMID 3519635  0.274
2006 Pan H, Kopecková P, Wang D, Yang J, Miller S, Kopecek J. Water-soluble HPMA copolymer--prostaglandin E1 conjugates containing a cathepsin K sensitive spacer. Journal of Drug Targeting. 14: 425-35. PMID 17092842 DOI: 10.1080/10611860600834219  0.274
1976 Strohalm J, Ulbrich K, Exner J, Kopeček J. Angewandte Makromolekulare Chemie. 49: 83-92. DOI: 10.1002/Apmc.1976.050490107  0.273
2000 Demoy M, Minko T, Kopečková P, Kopeček J. Time- and concentration-dependent apoptosis and necrosis induced by free and HPMA copolymer-bound doxorubicin in human ovarian carcinoma cells Journal of Controlled Release. 69: 185-196. PMID 11018556 DOI: 10.1016/S0168-3659(00)00301-1  0.272
2017 Yang J, Kopeček J. The Light at the End of the Tunnel-Second Generation HPMA Conjugates for Cancer Treatment. Current Opinion in Colloid & Interface Science. 31: 30-42. PMID 29276426 DOI: 10.1016/j.cocis.2017.07.003  0.271
2001 Shiah JG, Sun Y, Kopecková P, Peterson CM, Straight RC, Kopecek J. Combination chemotherapy and photodynamic therapy of targetable N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin/mesochlorin e(6)-OV-TL 16 antibody immunoconjugates. Journal of Controlled Release : Official Journal of the Controlled Release Society. 74: 249-53. PMID 11489502 DOI: 10.1016/S0168-3659(01)00325-X  0.27
1983 Duncan R, Kopecek J, Rejmanová P, Lloyd JB. Targeting of N-(2-hydroxypropyl)methacrylamide copolymers to liver by incorporation of galactose residues. Biochimica Et Biophysica Acta. 755: 518-21. PMID 6824743 DOI: 10.1016/0304-4165(83)90258-1  0.269
2011 Krimmer SG, Pan H, Liu J, Yang J, Kopeček J. Synthesis and characterization of poly(ε-caprolactone)-block-poly[N-(2-hydroxypropyl)methacrylamide] micelles for drug delivery. Macromolecular Bioscience. 11: 1041-51. PMID 21567954 DOI: 10.1002/mabi.201100019  0.269
2006 Gao SQ, Lu ZR, Petri B, Kopecková P, Kopecek J. Colon-specific 9-aminocamptothecin-HPMA copolymer conjugates containing a 1,6-elimination spacer. Journal of Controlled Release : Official Journal of the Controlled Release Society. 110: 323-31. PMID 16290118 DOI: 10.1016/j.jconrel.2005.10.004  0.268
2007 Gao SQ, Lu ZR, Kopecková P, Kopecek J. Biodistribution and pharmacokinetics of colon-specific HPMA copolymer--9-aminocamptothecin conjugate in mice. Journal of Controlled Release : Official Journal of the Controlled Release Society. 117: 179-85. PMID 17150276 DOI: 10.1016/j.jconrel.2006.10.024  0.263
1983 Solovsky MV, Ulbrich K, Kopecek J. Synthesis of N-(2-hydroxypr opyl) methacrylamide copolymers with antimicrobial activity Biomaterials. 4: 44-48. PMID 6301566 DOI: 10.1016/0142-9612(83)90069-8  0.261
2019 Wang J, Li L, Yang J, Clair PM, Glenn MJ, Stephens DM, Christopher Radford D, Kosak KM, Deininger MW, Shami PJ, Kopeček J. Drug-free macromolecular therapeutics induce apoptosis in cells isolated from patients with B cell malignancies with enhanced apoptosis induction by pretreatment with gemcitabine. Nanomedicine : Nanotechnology, Biology, and Medicine. PMID 30639670 DOI: 10.1016/j.nano.2018.12.011  0.258
1990 Seymour LW, Ulbrich K, Strohalm J, Kopecek J, Duncan R. The pharmacokinetics of polymer-bound adriamycin. Biochemical Pharmacology. 39: 1125-31. PMID 2322298 DOI: 10.1016/0006-2952(90)90293-T  0.258
2005 Hyde RM, Jensen K, Kopecek J, Broom AD. Confocal microscopy studies of a model oligoribonucleotide HIV inhibitor. Nucleosides, Nucleotides & Nucleic Acids. 24: 1875-84. PMID 16438054 DOI: 10.1080/15257770500268913  0.255
1992 Kopeček J, Kopečková P, Brøndsted H, Rathi R, R̆íhová B, Yeh P, Ikesue K. Polymers for colon-specific drug delivery Journal of Controlled Release. 19: 121-130. DOI: 10.1016/0168-3659(92)90070-8  0.255
1984 CARTLIDGE SA, REJMANOVÁ P, DUNCAN R, KOPEČEK J, LLOYD JB. Targeting of soluble cross-linked N-(2-hydroxypropyl)methacrylamide copolymers in vivo. A potential drug delivery system Biochemical Society Transactions. 12: 1064-1065. DOI: 10.1042/bst0121064a  0.255
2009 Segal E, Pan H, Ofek P, Udagawa T, Kopecková P, Kopecek J, Satchi-Fainaro R. Targeting angiogenesis-dependent calcified neoplasms using combined polymer therapeutics. Plos One. 4: e5233. PMID 19381291 DOI: 10.1371/Journal.Pone.0005233  0.254
2000 Hart PR, Kopecková P, Omelyanenko V, Enioutina E, Kopecek J. HPMA copolymer-modified avidin: immune response. Journal of Biomaterials Science. Polymer Edition. 11: 1-12. PMID 10680604 DOI: 10.1163/156856200743454  0.254
1993 Gu Z, Spikes JD, Kopečková P, Kopeček J. Synthesis and Photoproperties of a Substituted Zinc(II) Phthalocyanine-N-(2-hydroxypropyl)methacrylamide Copolymer Conjugate Collection of Czechoslovak Chemical Communications. 58: 2321-2336. DOI: 10.1135/Cccc19932321  0.253
1984 Lloyd JB, Duncan R, Kopecek J. Synthetic polymers as targetable carries for drugs Pure and Applied Chemistry. 56: 1301-1304. DOI: 10.1351/pac198456101301  0.253
1993 Říhová B, Krinick NL, Kopeček J. Targetable photoactivalable drugs. 3. In vitro efficacy of polymer bound chlorin e6 toward human hepatocarcinoma cell line (PLC/PRF/5) targeted with galactosamine and to mouse splenocytes targeted with anti-Thy 1.2 antibodies Journal of Controlled Release. 25: 71-87. DOI: 10.1016/0168-3659(93)90096-N  0.253
1991 Grim Y, Kopecek J. Bioadhesive water-soluble polymeric drug carriers for site-specific oral drug delivery. Synthesis, characterization, and release of 5-aminosalicylic acid by Streptococcus faecium in vitro New Polymeric Materials. 3: 49-59.  0.253
1985 Rejmanová P, Kopecek J, Duncan R, Lloyd JB. Stability in rat plasma and serum of lysosomally degradable oligopeptide sequences in N-(2-hydroxypropyl) methacrylamide copolymers. Biomaterials. 6: 45-8. PMID 3971018 DOI: 10.1016/0142-9612(85)90037-7  0.252
2014 Duangjai A, Luo K, Zhou Y, Yang J, Kopeček J. Combination cytotoxicity of backbone degradable HPMA copolymer gemcitabine and platinum conjugates toward human ovarian carcinoma cells. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 87: 187-96. PMID 24316339 DOI: 10.1016/j.ejpb.2013.11.008  0.252
2014 Chu TW, Yang J, Zhang R, Sima M, Kopeček J. Cell surface self-assembly of hybrid nanoconjugates via oligonucleotide hybridization induces apoptosis. Acs Nano. 8: 719-30. PMID 24308267 DOI: 10.1021/nn4053827  0.252
1995 Kamei S, Kopecek J. Prolonged blood circulation in rats of nanospheres surface-modified with semitelechelic poly[N-(2-hydroxypropyl)methacrylamide]. Pharmaceutical Research. 12: 663-8. PMID 7479550 DOI: 10.1023/A:1016247206531  0.252
1987 Seymour L, Duncan R, Kopecková P, Kopeček J. Potential of Sugar Residues Attached to N-(2- Hydroxypropyl)methacryl amide Copolymers as Targeting Groups for the Selective Delivery of Drugs Journal of Bioactive and Compatible Polymers. 2: 97-119. DOI: 10.1177/088391158700200201  0.252
1994 Kopečková P, Rathi R, Takada S, Říhová B, Berenson M, Kopeček J. Bioadhesive N-(2-hydroxypropyl) methacrylamide copolymers for colon-specific drug delivery Journal of Controlled Release. 28: 211-222. DOI: 10.1016/0168-3659(94)90168-6  0.251
1999 Dvorák M, Kopecková P, Kopecek J. High-molecular weight HPMA copolymer-adriamycin conjugates. Journal of Controlled Release : Official Journal of the Controlled Release Society. 60: 321-32. PMID 10425337 DOI: 10.1016/S0168-3659(99)00087-5  0.251
1993 Spikes JD, Krinick NL, Kopec̆ek J. Photoproperties of a mesochlorin e6—N-(2-hydroxypropyl)methacrylamide copolymer conjugate Journal of Photochemistry and Photobiology a: Chemistry. 70: 163-170. DOI: 10.1016/1010-6030(93)85037-9  0.251
2001 Sakuma S, Lu ZR, Kopecková P, Kopecek J. Biorecognizable HPMA copolymer-drug conjugates for colon-specific delivery of 9-aminocamptothecin. Journal of Controlled Release : Official Journal of the Controlled Release Society. 75: 365-79. PMID 11489323 DOI: 10.1016/S0168-3659(01)00405-9  0.251
1996 Omelyanenko V, Kopeckova P, Gentry C, Kopecek J. Performance of HPMA copolymer-drug conjugate antibody targeted to ovarian carcinoma cells Proceedings of the Controlled Release Society. 633-634.  0.25
2016 Zhang R, Yang J, Zhou Y, Shami PJ, Kopeček J. N-(2-Hydroxypropyl)methacrylamide Copolymer-Drug Conjugates for Combination Chemotherapy of Acute Myeloid Leukemia. Macromolecular Bioscience. 16: 121-8. PMID 26222892 DOI: 10.1002/mabi.201500193  0.249
2020 Li Y, Li L, Wang J, Radford DC, Gu Z, Kopeček J, Yang J. Dendronized polymer conjugates with amplified immunogenic cell death for oncolytic immunotherapy. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 33098912 DOI: 10.1016/j.jconrel.2020.10.041  0.249
1986 Cartlidge SA, Duncan R, Lloyd JB, Rejmanová P, Kopeček J. Soluble, crosslinked N-(2-hydroxypropyl)methacrylamide copolymers as potential drug carriers Journal of Controlled Release. 3: 55-66. DOI: 10.1016/0168-3659(86)90064-7  0.248
2000 Kopeček J, Kopečková P, Minko T, Lu ZR. HPMA copolymer-anticancer drug conjugates: Design, activity, and mechanism of action European Journal of Pharmaceutics and Biopharmaceutics. 50: 61-81. PMID 10840193 DOI: 10.1016/S0939-6411(00)00075-8  0.248
2014 Yang J, Kopeček J. Macromolecular therapeutics. Journal of Controlled Release : Official Journal of the Controlled Release Society. 190: 288-303. PMID 24747162 DOI: 10.1016/j.jconrel.2014.04.013  0.245
1999 Fowers K, Kopeckova P, Kopecek J. Targeting of HPMA copolymer-drug conjugates to A2780/AD ovarian cancer cells using anti-P-glycoprotein antibodies or fragments Proceedings of the Controlled Release Society. 527-528.  0.244
2001 Kopeček J, Kopečková P, Minko T, Lu ZR, Peterson CM. Water soluble polymers in tumor targeted delivery Journal of Controlled Release. 74: 147-158. PMID 11489491 DOI: 10.1016/S0168-3659(01)00330-3  0.244
1997 Chiu HC, Kopecková P, Deshmane SS, Kopecek J. Lysosomal degradability of poly(alpha-amino acids). Journal of Biomedical Materials Research. 34: 381-92. PMID 9086408 DOI: 10.1002/(SICI)1097-4636(19970305)34:3<381::AID-JBM13>3.0.CO;2-J  0.244
2002 Sakuma S, Lu Z, Pecharová B, Kopečková P, Kopeček J. N-(2-Hydroxypropyl)methacrylamide Copolymer-9-Aminocamptothecin Conjugate: Colon-Specific Drug Delivery in Rats Journal of Bioactive and Compatible Polymers. 17: 305-319. DOI: 10.1177/0883911502017005557  0.243
2011 Luo K, Yang J, Kopečková P, Kopeček J. Biodegradable Multiblock Poly[N-(2-hydroxypropyl)methacrylamide] via Reversible Addition-Fragmentation Chain Transfer Polymerization and Click Chemistry. Macromolecules. 44: 2481-2488. PMID 21552355 DOI: 10.1021/ma102574e  0.243
2013 Kopeček J. Polymer-drug conjugates: origins, progress to date and future directions. Advanced Drug Delivery Reviews. 65: 49-59. PMID 23123294 DOI: 10.1016/j.addr.2012.10.014  0.242
2018 Li L, Yang J, Soodvilai S, Wang J, Opanasopit P, Kopeček J. Drug-free albumin-triggered sensitization of cancer cells to anticancer drugs. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 30465822 DOI: 10.1016/j.jconrel.2018.11.015  0.241
1999 Minko T, Kopečková P, Kopeček J. Comparison of the anticancer effect of free and HPMA copolymer-bound adriamycin in human ovarian carcinoma cells Pharmaceutical Research. 16: 986-996. PMID 10450921 DOI: 10.1023/A:1018959029186  0.241
1981 Lääne A, Chytrý V, Haga M, Sikk P, Aaviksaar A, Kopeček J. Covalent attachment of chymotrypsin to poly[N-(2-hydroxypropyl)methacrylamide] Collection of Czechoslovak Chemical Communications. 46: 1466-1473. DOI: 10.1135/cccc19811466  0.241
2005 Nori A, Kopecek J. Intracellular targeting of polymer-bound drugs for cancer chemotherapy. Advanced Drug Delivery Reviews. 57: 609-36. PMID 15722167 DOI: 10.1016/j.addr.2004.10.006  0.241
2001 Tang A, Wang C, Stewart RJ, Kopecek J. The coiled coils in the design of protein-based constructs: hybrid hydrogels and epitope displays. Journal of Controlled Release : Official Journal of the Controlled Release Society. 72: 57-70. PMID 11389985 DOI: 10.1016/S0168-3659(01)00262-0  0.241
2017 Yang J, Zhang R, Pan H, Li Y, Fang Y, Zhang L, Kopecek J. Backbone Degradable HPMA Copolymer Conjugates with Gemcitabine and Paclitaxel: Impact of Molecular Weight on Activity toward Human Ovarian Carcinoma Xenografts. Molecular Pharmaceutics. PMID 28094954 DOI: 10.1021/acs.molpharmaceut.6b01005  0.24
1999 Shiah JJ, Sun Y, Peterson CM, Kopecek J. Biodistribution of free and N-(2-hydroxypropyl)methacrylamide copolymer-bound mesochlorin e(6) and adriamycin in nude mice bearing human ovarian carcinoma OVCAR-3 xenografts. Journal of Controlled Release : Official Journal of the Controlled Release Society. 61: 145-57. PMID 10469911 DOI: 10.1016/S0168-3659(99)00113-3  0.239
2001 Minko T, Kopečková P, Kopeček J. Mechanisms of anticancer action of HPMA copolymer-bound doxorubicin Macromolecular Symposia. 172: 35-48. DOI: 10.1002/1521-3900(200107)172:1<35::Aid-Masy35>3.0.Co;2-N  0.238
1993 Brøndsted H, Kopecek J. Hydrogels for site-specific drug delivery to the colon: in vitro and in vivo degradation. Pharmaceutical Research. 9: 1540-5. PMID 1488395 DOI: 10.1023/A:1015847921435  0.236
2023 Gambles MT, Sborov D, Shami P, Yang J, Kopeček J. Obinutuzumab-Based Drug-Free Macromolecular Therapeutics Synergizes with Topoisomerase Inhibitors. Macromolecular Bioscience. e2300375. PMID 37838941 DOI: 10.1002/mabi.202300375  0.236
1989 Rihova B, Bilej M, Vetvicka V, Ulbrich K, Strohalm J, Kopecek J, Duncan R. Biocompatibility of N-(2-hydroxypropyl) methacrylamide copolymers containing adriamycin. Immunogenicity, and effect on haematopoietic stem cells in bone marrow in vivo and mouse splenocytes and human peripheral blood lymphocytes in vitro. Biomaterials. 10: 335-42. PMID 2765631 DOI: 10.1016/0142-9612(89)90075-6  0.235
1997 Ghandehari H, Kopečkové P, Kopeček J. In vitro degradation of pH-sensitive hydrogels containing aromatic azo bonds Biomaterials. 18: 861-872. PMID 9184750 DOI: 10.1016/S0142-9612(97)00007-0  0.234
2016 Zhang R, Yang J, Radford DC, Fang Y, Kopeček J. FRET Imaging of Enzyme-Responsive HPMA Copolymer Conjugate. Macromolecular Bioscience. PMID 27198936 DOI: 10.1002/mabi.201600125  0.233
2013 Pan H, Sima M, Yang J, Kopeček J. Synthesis of long-circulating, backbone degradable HPMA copolymer-doxorubicin conjugates and evaluation of molecular-weight-dependent antitumor efficacy. Macromolecular Bioscience. 13: 155-60. PMID 23339052 DOI: 10.1002/mabi.201200353  0.233
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1984 Duncan R, Kopecek J, Lloyd JB. Drug targeting to lysosomes Biochemical Society Transactions. 12: 913-915. PMID 6530039  0.169
2005 Miller SC, Wang D, Kopecková P, Kopecek J. Biopolymer-based delivery systems for advanced imaging and skeletal tissue-specific therapeutics. Journal of Bone and Mineral Metabolism. 23: 103-8. PMID 15984424  0.169
2011 Segal E, Pan H, Benayoun L, Kopečková P, Shaked Y, Kopeček J, Satchi-Fainaro R. Enhanced anti-tumor activity and safety profile of targeted nano-scaled HPMA copolymer-alendronate-TNP-470 conjugate in the treatment of bone malignances. Biomaterials. 32: 4450-63. PMID 21429572 DOI: 10.1016/J.Biomaterials.2011.02.059  0.168
1980 Duncan R, Lloyd JB, Kopecek J. Degradation of side chains of N-(2-hydroxypropyl) methacrylamide copolymers by lysosomal enzymes. Biochemical and Biophysical Research Communications. 94: 284-90. PMID 7387696 DOI: 10.1016/S0006-291X(80)80218-X  0.168
1981 Hrouz J, Ilavský M, Ulbrich K, Kopeček J. The photoelastic behaviour of dry and swollen networks of poly (N,N-diethylacrylamide) and of its copolymer with N-tert.butylacrylamide European Polymer Journal. 17: 361-366. DOI: 10.1016/0014-3057(81)90137-3  0.168
2017 Li L, Yang J, Wang J, Kopeček J. Drug-Free Macromolecular Therapeutics Induce Apoptosis via Calcium Influx and Mitochondrial Signaling Pathway. Macromolecular Bioscience. PMID 28805013 DOI: 10.1002/mabi.201700196  0.168
2005 Wang D, Miller SC, Kopecek J. Targeted drug delivery for musculoskeletal diseases. Advanced Drug Delivery Reviews. 57: 935-7. PMID 15876395 DOI: 10.1016/j.addr.2004.12.012  0.167
1987 Kopeček J, Duncan R. Targetable polymeric prodrugs Journal of Controlled Release. 6: 315-327. DOI: 10.1016/0168-3659(87)90085-X  0.166
2012 Journo-Gershfeld G, Kapp D, Shamay Y, Kopeček J, David A. Hyaluronan oligomers-HPMA copolymer conjugates for targeting paclitaxel to CD44-overexpressing ovarian carcinoma. Pharmaceutical Research. 29: 1121-33. PMID 22350800 DOI: 10.1007/s11095-012-0672-1  0.166
1979 Ilavsky M, Dusek K, Vacik J, Kopecek J. DEFORMATIONAL, SWELLING, AND POTENTIOMETRIC BEHAVIOR OF IONIZED GELS OF 2-HYDROXYETHYL METHACRYLATE-METHACRYLIC ACID COPOLYMERS J Appl Polym Sci. 23: 2073-2082. DOI: 10.1002/app.1979.070230717  0.166
1981 DUNCAN R, CABLE H, REJMANOVA P, KOPECEK J, LLOYD J. Design of synthetic copolymer side-chains to facilitate their degradation in lysosomes Cell Biology International Reports. 5: 14. DOI: 10.1016/0309-1651(81)90059-X  0.165
2010 Kopecek J. Biomaterials and drug delivery: past, present, and future. Molecular Pharmaceutics. 7: 922-5. PMID 20672864 DOI: 10.1021/mp1001813  0.165
2006 Ding H, Prodinger WM, Kopecek J. Identification of CD21-binding peptides with phage display and investigation of binding properties of HPMA copolymer-peptide conjugates. Bioconjugate Chemistry. 17: 514-23. PMID 16536485 DOI: 10.1021/bc0503162  0.164
1991 Říhová B, Krinick NL, Kopeček J. Targetable photoactivatable drugs Journal of Materials Science: Materials in Medicine. 2: 238-242. DOI: 10.1007/BF00703378  0.164
2006 Callahan J, Kopecek J. Semitelechelic HPMA copolymers functionalized with triphenylphosphonium as drug carriers for membrane transduction and mitochondrial localization. Biomacromolecules. 7: 2347-56. PMID 16903681 DOI: 10.1021/bm060336m  0.164
1992 Crepon B, Jozefonvicz J, Chytry V, Rihová B, Kopecek J. Enzymatic degradation and immunogenic properties of derivatized dextrans. Biomaterials. 12: 550-4. PMID 1723000 DOI: 10.1016/0142-9612(91)90049-G  0.161
1977 Ulbrich K, Ilavský M, Dušek K, Kopeček J. Preparation and properties of poly(N-ethylmethacrylamide) networks European Polymer Journal. 13: 579-585. DOI: 10.1016/0014-3057(77)90184-7  0.16
2015 Zhou Y, Yang J, Zhang R, Kopeček J. Combination therapy of prostate cancer with HPMA copolymer conjugates containing PI3K/mTOR inhibitor and docetaxel. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 89: 107-15. PMID 25481033 DOI: 10.1016/j.ejpb.2014.11.025  0.159
1978 Kálal J, Drobnik J, Kopeček J, Exner J. Water Soluble Polymers for Medicine British Polymer Journal. 10: 111-114. DOI: 10.1002/pi.4980100204  0.159
2008 Miller SC, Pan H, Wang D, Bowman BM, Kopecková P, Kopecek J. Feasibility of using a bone-targeted, macromolecular delivery system coupled with prostaglandin E(1) to promote bone formation in aged, estrogen-deficient rats. Pharmaceutical Research. 25: 2889-95. PMID 18758923 DOI: 10.1007/s11095-008-9706-0  0.159
2012 Liu J, Kopečková P, Pan H, Sima M, Bühler P, Wolf P, Elsässer-Beile U, Kopeček J. Prostate-cancer-targeted N-(2-hydroxypropyl)methacrylamide copolymer/docetaxel conjugates. Macromolecular Bioscience. 12: 412-22. PMID 22493797 DOI: 10.1002/mabi.201100340  0.158
1997 Shiah J, Koňák Č, Spikes JD, Kopeček J. Solution and Photoproperties ofN-(2-Hydroxypropyl)methacrylamide Copolymer−Meso-chlorin e6Conjugates The Journal of Physical Chemistry B. 101: 6803-6809. DOI: 10.1021/Jp970360H  0.158
2000 Chen L, Kopeček J, Stewart RJ. Responsive hybrid hydrogels with volume transitions modulated by a titin immunoglobulin module Bioconjugate Chemistry. 11: 734-740. PMID 10995218 DOI: 10.1021/Bc000046H  0.156
2007 Pan H, Kopecková P, Liu J, Wang D, Miller SC, Kopecek J. Stability in plasmas of various species of HPMA copolymer-PGE1 conjugates. Pharmaceutical Research. 24: 2270-80. PMID 17899324 DOI: 10.1007/s11095-007-9449-3  0.156
1981 Duncan R, Kopeček J, Lloyd JB. THE EFFECT OF SYNTHETIC COPOLYMER SIDE-CHAIN COMPOSITION ON SUSCEPTIBILITY TO LYSOSOMAL HYDROLYSIS Biochemical Society Transactions. 9: 261P-261P. DOI: 10.1042/bst009261pc  0.155
1998 Kopecek J. Otto Wichterle (1913-98) Nature. 395: 332. PMID 9759721 DOI: 10.1038/26369  0.154
2007 Ulbrich K, Kopeček J. Cross-linked copolymers of N,N-diethylacrylamide with improved mechanical properties Journal of Polymer Science: Polymer Symposia. 66: 209-219. DOI: 10.1002/polc.5070660122  0.154
2010 Kasuya Y, Lu Z, Kopeckova P, Kopecek J. ChemInform Abstract: Improved Synthesis and Evaluation of 17-Substituted Aminoalkylgeldanamycin Derivatives Applicable to Drug Delivery Systems. Cheminform. 32: no-no. DOI: 10.1002/chin.200145246  0.153
1998 Dvorak M, Kopeckova P, Kopecek J. Novel synthesis of long-circulating HPMA copolymer - adriamycin conjugates Proceedings of the Controlled Release Society. 884-885.  0.153
2009 Gao SQ, Sun Y, Kopecková P, Peterson CM, Kopecek J. Antitumor efficacy of colon-specific HPMA copolymer/9-aminocamptothecin conjugates in mice bearing human-colon carcinoma xenografts. Macromolecular Bioscience. 9: 1135-42. PMID 19685500 DOI: 10.1002/mabi.200900147  0.152
2008 Gao SQ, Sun Y, Kopecková P, Peterson CM, Kopecek J. Pharmacokinetic modeling of absorption behavior of 9-aminocamptothecin (9-AC) released from colon-specific HPMA copolymer-9-AC conjugate in rats. Pharmaceutical Research. 25: 218-26. PMID 17929146 DOI: 10.1007/s11095-007-9465-3  0.151
1993 Chiu H, Zalipsky S, Kopeckova P, Kopecek J. Correction - Enzymatic Activity of Chymotrypsin and Its Poly(Ethylene Glycol) Conjugates Toward Low and High Molecular Weight Substrates Bioconjugate Chemistry. 4: 410-410. DOI: 10.1021/bc00023a601  0.149
1990 Flanagan P, Duncan R, Rihova B, ŠUbr V, Kopeček J. Immunogenicity of Protein-N-(2-Hydroxypropyl)methacrylamide Copolymer Conjugates in A/J and B10 Mice Journal of Bioactive and Compatible Polymers. 5: 151-166. DOI: 10.1177/088391159000500201  0.149
1993 Kopeček J. Azo functional polymers: Functional group approach in macromolecular design Journal of Controlled Release. 26: 59. DOI: 10.1016/0168-3659(93)90209-N  0.148
2023 Gambles MT, Yang J, Kopeček J. Multi-targeted immunotherapeutics to treat B cell malignancies. Journal of Controlled Release : Official Journal of the Controlled Release Society. 358: 232-258. PMID 37121515 DOI: 10.1016/j.jconrel.2023.04.048  0.148
2007 Obereigner B, Burešová M, Vrána A, Kopeček J. Preparation of polymerizable derivatives of N-(4-aminobenzenesulfonyl)-n′-butylurea Journal of Polymer Science: Polymer Symposia. 66: 41-52. DOI: 10.1002/polc.5070660107  0.147
2006 Wang D, Sima M, Mosley RL, Davda JP, Tietze N, Miller SC, Gwilt PR, Kopecková P, Kopecek J. Pharmacokinetic and biodistribution studies of a bone-targeting drug delivery system based on N-(2-hydroxypropyl)methacrylamide copolymers. Molecular Pharmaceutics. 3: 717-25. PMID 17140259 DOI: 10.1021/mp0600539  0.147
2007 Kopeček J, Rejmanová P. Reactive copolymers of N-(2-hydroxypropyl) methacrylamide with N-methacryloylated derivatives of l-leucine and l-phenylalanine. II. Reaction with the polymeric amine and stability of cross-links towards chymotrypsin in vitro Journal of Polymer Science: Polymer Symposia. 66: 15-32. DOI: 10.1002/polc.5070660105  0.147
1985 Tlaskalová-Hogenová H, Kopeček J, Ulbrich K, Rypáček F, Pospíšil M. In vivo and in vitro immunogenicity of water-soluble haptenated copolymers for mouse and human lymphocytes Die Makromolekulare Chemie. 9: 137-143. DOI: 10.1002/macp.1985.020091985118  0.146
2018 Li L, Yang J, Wang J, Kopecek J. Amplification of CD20 Crosslinking in Rituximab Resistant B-Lymphoma Cells Enhances Apoptosis Induction by Drug-Free Macromolecular Therapeutics. Acs Nano. PMID 29595951 DOI: 10.1021/acsnano.8b00797  0.146
1973 Kopeček J, Vacík J. Effect of the hydrophilic character of the polymeric backbone on membrane permeability Collection of Czechoslovak Chemical Communications. 38: 854-860. DOI: 10.1135/cccc19730854  0.145
2020 Li L, Li Y, Yang CH, Radford DC, Wang J, Janát-Amsbury M, Kopeček J, Yang J. Inhibition of Immunosuppressive Tumors by Polymer-Assisted Inductions of Immunogenic Cell Death and Multivalent PD-L1 Crosslinking. Advanced Functional Materials. 30. PMID 33071706 DOI: 10.1002/adfm.201908961  0.144
1986 Paluska E, Hrubá A, Stěrba O, Kopecek J. Effect of a synthetic poly N-(2-hydroxypropyl)methacrylamide (Duxon) on haemopoiesis and graft-versus-host reaction Folia Biologica. 32: 91-102. PMID 3721017  0.143
2003 Nishiyama N, Nori A, Malugin A, Kasuya Y, Kopecková P, Kopecek J. Free and N-(2-hydroxypropyl)methacrylamide copolymer-bound geldanamycin derivative induce different stress responses in A2780 human ovarian carcinoma cells. Cancer Research. 63: 7876-82. PMID 14633716  0.142
2002 Merdan T, Kopecek J, Kissel T. Prospects for cationic polymers in gene and oligonucleotide therapy against cancer. Advanced Drug Delivery Reviews. 54: 715-58. PMID 12204600 DOI: 10.1016/S0169-409X(02)00046-7  0.141
2000 Shen H, Spikes JD, Smith CJ, Kopeček J. Photodynamic cross-linking of proteins Journal of Photochemistry and Photobiology a: Chemistry. 133: 115-122. DOI: 10.1016/S1010-6030(00)00228-8  0.14
2004 Senter PD, Kopecek J. Drug carriers in medicine and biology. Molecular Pharmaceutics. 1: 395-8. PMID 16028350  0.139
2004 Wang D, Miller SC, Sima M, Parker D, Buswell H, Goodrich KC, Kopecková P, Kopecek J. The arthrotropism of macromolecules in adjuvant-induced arthritis rat model: a preliminary study. Pharmaceutical Research. 21: 1741-9. PMID 15553217 DOI: 10.1023/B:Pham.0000045232.18134.E9  0.139
2010 Liu J, Bauer H, Callahan J, Kopecková P, Pan H, Kopecek J. Endocytic uptake of a large array of HPMA copolymers: Elucidation into the dependence on the physicochemical characteristics. Journal of Controlled Release : Official Journal of the Controlled Release Society. 143: 71-9. PMID 20043962 DOI: 10.1016/j.jconrel.2009.12.022  0.139
1995 Koňák Č, Tuzar Z, Kopečková P, Andrade JD, Kopeček J. Association of Graft Copolymers of Alkyl Methacrylates with α-Methyl-ω-hydroxy-poly(oxyethylene) ethacrylates Collection of Czechoslovak Chemical Communications. 60: 1971-1985. DOI: 10.1135/Cccc19951971  0.136
1971 Kopeček J, Lím D. Mechanism of three-dimensional polymerization of glycol methacrylates. III. Contribution to the polymerization kinetics of the system diglycol monomethacrylate-glycol dimethacrylates-water Collection of Czechoslovak Chemical Communications. 36: 2703-2707. DOI: 10.1135/cccc19712703  0.135
2009 Liu J, Kopecková P, Bühler P, Wolf P, Pan H, Bauer H, Elsässer-Beile U, Kopecek J. Biorecognition and subcellular trafficking of HPMA copolymer-anti-PSMA antibody conjugates by prostate cancer cells. Molecular Pharmaceutics. 6: 959-70. PMID 19344119 DOI: 10.1021/mp8002682  0.134
1978 Vacík J, Ulbrich K, Exner J, Kopeček J. Permeability of hydrophilic membranes based on N-substituted (meth)acrylamides Collection of Czechoslovak Chemical Communications. 43: 1221-1226. DOI: 10.1135/cccc19781221  0.134
1988 Andrade JD, Herron J, Lin JN, Yen H, Kopecek J, Kopeckova P. On-line sensors for coagulation proteins: concept and progress report. Biomaterials. 9: 76-9. PMID 3280041 DOI: 10.1016/0142-9612(88)90074-9  0.129
1976 Kola[rcirc]ik J, Kopeĉek J, Vacík J, Janáĉek J. Relaxation Behavior of Poly(N-monosubstituted Methacrylamides) International Journal of Polymeric Materials. 5: 89-97. DOI: 10.1080/00914037608072391  0.127
1997 Koňák Č, Rathi RC, Kopečková P, Kopeček J. Photoregulated Association of Water-Soluble Copolymers with Spirobenzopyran-Containing Side Chains Macromolecules. 30: 5553-5556. DOI: 10.1021/ma970499q  0.127
2002 Wang D, Dušek K, Kopečková P, Dušková-Smrčková M, Kopeček J. Novel Aromatic Azo-Containing pH-Sensitive Hydrogels:  Synthesis and Characterization Macromolecules. 35: 7791-7803. DOI: 10.1021/ma020745k  0.126
2012 Kopecek J, Yang J. ChemInform Abstract: Smart Self-Assembled Hybrid Hydrogel Biomaterials Cheminform. 43: no-no. DOI: 10.1002/chin.201247271  0.124
2003 Kopecek J. Smart and genetically engineered biomaterials and drug delivery systems. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 20: 1-16. PMID 13678788  0.124
1973 Sprincl L, Vacík J, Kopecek J. Biological tolerance of ionogenic hydrophilic gels Journal of Biomedical Materials Research. 7: 123-136. PMID 4691155  0.123
1998 Koňák Č, Rathi RC, Kopečková P, Kopeček J. Photoassociation of water-soluble copolymers containing photochromic spirobenzopyran moieties Polymers For Advanced Technologies. 9: 641-648. DOI: 10.1002/(SICI)1099-1581(1998100)9:10/11<641::AID-PAT812>3.0.CO;2-W  0.121
1976 Janáĉek J, Kola[rcirc];ík J, Vacík J, Kopeĉek J. Mechanical Responses of 2-Hydroxyethyl Methacrylate-Methacrylonitrile and 2-Hydroxyethyl Methacrylate-Acrylonitrile Copolymer Networks International Journal of Polymeric Materials. 5: 59-70. DOI: 10.1080/00914037608072389  0.121
1986 Šubr V, Duncan R, Hanada K, Cable H, Kopeček J. A lysosomotropic polymeric inhibitor of cysteine proteinases Journal of Controlled Release. 4: 63-68. DOI: 10.1016/0168-3659(86)90034-9  0.12
1992 Kopečková P, Ikesue K, Kopeček J. Die Makromolekulare Chemie. 193: 2605-2619. DOI: 10.1002/macp.1992.021931010  0.12
1990 Kopečková P, Kopeček J. Die Makromolekulare Chemie. 191: 2037-2045. DOI: 10.1002/macp.1990.021910906  0.12
1990 Přádný M, Kopeček J. Die Makromolekulare Chemie. 191: 1887-1897. DOI: 10.1002/macp.1990.021910814  0.12
1989 Solovskij MV, Ulbrich K, Nazarova OV, Zubko NV, Panarin EF, Kopeček J. Die Makromolekulare Chemie. 190: 2245-2254. DOI: 10.1002/macp.1989.021900925  0.12
1987 Ulbrich K, Zacharieva EI, Kopeček J, Hume IC, Duncan R. Die Makromolekulare Chemie. 188: 2497-2509. DOI: 10.1002/macp.1987.021881101  0.12
1987 Ulbrich K, Koňák Č, Tuzar Z, Kopeček J. Die Makromolekulare Chemie. 188: 1261-1272. DOI: 10.1002/macp.1987.021880604  0.12
1986 Ulbrich K, Strohalm J, Kopeček J. Die Makromolekulare Chemie. 187: 1131-1144. DOI: 10.1002/macp.1986.021870510  0.12
1984 Pató J, Azori M, Ulbrich K, Kopeček J. Die Makromolekulare Chemie. 185: 231-237. DOI: 10.1002/macp.1984.021850201  0.12
1983 Rejmanová P, Kopeček J, Pohl J, Baudyš M, Kostka V. Die Makromolekulare Chemie. 184: 2009-2020. DOI: 10.1002/macp.1983.021841006  0.12
1983 Duncan R, Cable HC, Lloyd JB, Rejmanová P, Kopeček J. Die Makromolekulare Chemie. 184: 1997-2008. DOI: 10.1002/macp.1983.021841005  0.12
1983 Chytrý V, Kopeček J. Die Makromolekulare Chemie. 184: 1345-1353. DOI: 10.1002/macp.1983.021840703  0.12
1983 Lääne A, Haga M, Aaviksaar A, Chytrý V, Kopeček J. Die Makromolekulare Chemie. 184: 1339-1344. DOI: 10.1002/macp.1983.021840702  0.12
1982 Chytrý V, Kopeček J, Sikk P, Sinijärv R, Aaviksaar A. Die Makromolekulare Chemie, Rapid Communications. 3: 11-15. DOI: 10.1002/marc.1982.030030103  0.12
1981 Kopeček J, Cífková I, Rejmanová P, Strohalm J, Obereigner B, Ulbrich K. Die Makromolekulare Chemie. 182: 2941-2949. DOI: 10.1002/macp.1981.021821102  0.12
1981 Rejmanová P, Obereigner B, Kopeček J. Die Makromolekulare Chemie. 182: 1899-1915. DOI: 10.1002/macp.1981.021820703  0.12
1981 Kopeček J, Rejmanová P, Chytrý V. Die Makromolekulare Chemie. 182: 799-809. DOI: 10.1002/macp.1981.021820310  0.12
1978 Chytrý V, Vrána A, Kopeček J. Die Makromolekulare Chemie. 179: 329-336. DOI: 10.1002/macp.1978.021790207  0.12
1977 Kopeček J. Die Makromolekulare Chemie. 178: 2169-2183. DOI: 10.1002/macp.1977.021780804  0.12
1977 Rejmanová P, Labský J, Kopeček J. Die Makromolekulare Chemie. 178: 2159-2168. DOI: 10.1002/macp.1977.021780803  0.12
1976 Drobník J, Kopeček J, Labský J, Rejmanová P, Exner J, Saudek V, Kálal J. Die Makromolekulare Chemie. 177: 2833-2848. DOI: 10.1002/macp.1976.021771003  0.12
2013 Zhou Y, Kopeček J. Biological rationale for the design of polymeric anti-cancer nanomedicines. Journal of Drug Targeting. 21: 1-26. PMID 23009337 DOI: 10.3109/1061186X.2012.723213  0.119
2003 Lu Z, Kopečková P, Kopeček J. Antigen Responsive Hydrogels Based on Polymerizable Antibody Fab′ Fragment Macromolecular Bioscience. 3: 296-300. DOI: 10.1002/mabi.200390039  0.118
2021 Li L, Wang J, Radford DC, Kopeček J, Yang J. Combination treatment with immunogenic and anti-PD-L1 polymer-drug conjugates of advanced tumors in a transgenic MMTV-PyMT mouse model of breast cancer. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 33607175 DOI: 10.1016/j.jconrel.2021.02.011  0.117
1995 Kopeček J. Polymeric site-specific pharmacotherapy Journal of Controlled Release. 34: 273-274. DOI: 10.1016/S0168-3659(95)90051-9  0.116
1994 Koňák Č, Kopečková P, Kopeček J. Photoregulated Adsorption and Association of Amphiphilic Copolymers Containing Azobenzene Side Chains Journal of Colloid and Interface Science. 168: 235-241. DOI: 10.1006/jcis.1994.1414  0.116
2007 Kopeček J, Yang J. Hydrogels as smart biomaterials Polymer International. 56: 1078-1098. DOI: 10.1002/pi.2253  0.116
2022 Peng ZH, Jogdeo CM, Li J, Xie Y, Wang Y, Sheinin YM, Kopeček J, Oupický D. Tumor Microenvironment-Responsive Polymeric iRGD and Doxorubicin Conjugates Reduce Spontaneous Lung Metastasis in an Orthotopic Breast Cancer Model. Pharmaceutics. 14. PMID 36015351 DOI: 10.3390/pharmaceutics14081725  0.115
2014 Peng ZH, Kopeček J. HPMA Copolymer CXCR4 Antagonist Conjugates Substantially Inhibited the Migration of Prostate Cancer Cells. Acs Macro Letters. 3: 1240-1243. PMID 25621190 DOI: 10.1021/mz5006537  0.114
1981 Duncan R, Kopeček J, Lloyd JB. UPTAKE AND DEGRADATION OF A SYNTHETIC COPOLYMER BY RAT VISCERAL YOLK SACS CULTURED IN VITRO Biochemical Society Transactions. 9: 261P-261P. DOI: 10.1042/bst009261pd  0.112
2008 Yuan W, Yang J, Kopecková P, Kopecek J. Smart hydrogels containing adenylate kinase: translating substrate recognition into macroscopic motion. Journal of the American Chemical Society. 130: 15760-1. PMID 18980321 DOI: 10.1021/ja805634x  0.112
1974 Sprinel L, Kopecek J, Lím D. Effect of the structure of poly(glycol monomethacrylate) gel on the calcification of implants. Calcified Tissue Research. 13: 63-72. PMID 4750794 DOI: 10.1007/BF02015397  0.111
1978 Ulbrich K, Kopeček J. Polymerisationskinetik von N-Äthylacrylamid Colloid and Polymer Science. 256: 601-601. DOI: 10.1007/BF01639211  0.111
1971 Kopeček J, Lím D. Mechanism of three-dimensional polymerization of glycol methacrylates. IV. The system triglycol monomethacrylate-glycol dimethacrylates-water Collection of Czechoslovak Chemical Communications. 36: 3394-3398. DOI: 10.1135/cccc19713394  0.109
1995 Putnam D, Kopecek J. Enantioselecttve release of 5-fluorouracil from HPMA based copolymers via lysosomal enzymes Proceedings of the Controlled Release Society. 596-597.  0.109
1999 Shiah JG, Sun Y, Peterson CM, Kopecek J. Combinational, efficacy of HPMA copolymer-Mce6/adriamycin conjugates in cancer therapy Proceedings of the Controlled Release Society. 1058-1059.  0.108
1975 Vacík J, Kopeček J. Specific resistances of hydrophilic membranes containing ionogenic groups Journal of Applied Polymer Science. 19: 3029-3044. DOI: 10.1002/app.1975.070191108  0.108
2014 Peng ZH, Kopeček J. Synthesis and activity of tumor-homing peptide iRGD and histone deacetylase inhibitor valproic acid conjugate. Bioorganic & Medicinal Chemistry Letters. 24: 1928-33. PMID 24656564 DOI: 10.1016/j.bmcl.2014.03.006  0.107
2009 Callahan J, Kopečkov P, Kopeček J. Intracellular trafficking and subcellular distribution of a large array of HPMA copolymers. Biomacromolecules. 10: 1704-14. PMID 21197960 DOI: 10.1021/bm801514x  0.106
1999 Wang C, Kopecek J, Stewart RJ. Hybrid hydrogels undergo volume transition due to temperature-induced conformatonal change of coiled-coil protein crosslinks Proceedings of the Controlled Release Society. 157-158.  0.105
1997 Kopecek J. Carriers for active and passive targeting Proceedings of the Controlled Release Society. 151-152.  0.105
1998 Tully CP, Kopeckova P, Kopecek J. Antibody mediated control of hydrogel thermal volume transitions Proceedings of the Controlled Release Society. 892-893.  0.104
1999 Minko T, Kopeckova P, Kopecek J. EPR effect, multidrug resistance and the efficacy of HPMA copolymer-bound adriamycin in solid tumors with high vascularization Proceedings of the Controlled Release Society. 46-47.  0.103
1975 Vacik J, Kůdela V, Kopeĉek J. Concentration potentials of hydrophilic membranes containing ionogenic groups European Polymer Journal. 11: 331-335. DOI: 10.1016/0014-3057(75)90045-2  0.103
2007 Kopecek J. Hydrogel biomaterials: a smart future? Biomaterials. 28: 5185-92. PMID 17697712 DOI: 10.1016/j.biomaterials.2007.07.044  0.103
1974 Kopecek J, Sprincl L. Relationship between the structure and biocompatibility of hydrophilic gels Polimery W Medycynie. 4: 109-117. PMID 4468387  0.1
2015 Low SA, Galliford CV, Yang J, Low PS, Kopeček J. Biodistribution of Fracture-Targeted GSK3β Inhibitor-Loaded Micelles for Improved Fracture Healing. Biomacromolecules. PMID 26331790 DOI: 10.1021/Acs.Biomac.5B00777  0.096
1976 Korcakova L, Paluska E, Haskova V, Kopecek J. A simple test for immunogenicity of colloidal infusion solutions; the draining lymph node activation Zeitschrift Fur Immunitatsforschung. 151: 219-223. PMID 134540  0.094
1998 Lu ZR, Kopeckova P, Kopecek J. Polymerizable Fab' antibody fragments Proceedings of the Controlled Release Society. 788-789.  0.092
1979 Větvicka V, Viklický V, Jarosková L, Kopecek J. Comparison of the functional activity of normal and stimulated peritoneal exudate cells in suspension and after adherence to the substrate Folia Biologica. 25: 403-404. PMID 533687  0.089
1998 Jensen KD, Kopeckova P, Kopecek J. Study of the internalization and subcellular trafficking of model antisense compounds in Hep G2 cells Proceedings of the Controlled Release Society. 352-353.  0.087
1985 Kirstein D, Braselmann H, Vacik J, Kopecek J. Influence of medium and matrix composition on diffusivities in charged membranes Biotechnology and Bioengineering. 27: 1382-1384.  0.085
1979 Shatayeva LK, Samsonov GV, Vacík J, Kopeček J, Kálal J. Permeability of heterogeneous membranes based on methacrylic acid Journal of Applied Polymer Science. 23: 2245-2251. DOI: 10.1002/app.1979.070230803  0.084
1980 Kůdela V, Vacík J, Kopeček J. Strong-acid membranes with enhanced hydrophilicity Journal of Membrane Science. 6: 123-131. DOI: 10.1016/S0376-7388(00)82155-9  0.082
2017 Pelaz B, Alexiou C, Alvarez-Puebla RA, Alves F, Andrews AM, Ashraf S, Balogh LP, Ballerini L, Bestetti A, Brendel C, Bosi S, Carril M, Chan WC, Chen C, Chen X, et al. Diverse Applications of Nanomedicine. Acs Nano. PMID 28290206 DOI: 10.1021/Acsnano.6B06040  0.081
1971 Kopeček J, Vacík J, Lím D. Permeability of membranes containing ionogenic groups Journal of Polymer Science Part a-1: Polymer Chemistry. 9: 2801-2815. DOI: 10.1002/pol.1971.150091005  0.08
1977 Vacík J, Czaková M, Exner J, Kálal J, Kopeček J. Permeability of metabolites through hydrophilic membranes Collection of Czechoslovak Chemical Communications. 42: 2786-2790. DOI: 10.1135/cccc19772786  0.078
2000 Minko T, Kopeckova P, Pozharov V, Jensen KD, Kopecek J. The influence of cytotoxicity of macromolecules and of VEGF gene modulated vascular permeability on the enhanced permeability and retention effect in resistant solid tumors. Pharmaceutical Research. 17: 505-14. PMID 10888300 DOI: 10.1023/A:1007500412442  0.077
1985 Větvicka V, Fornůsek L, Ríhová B, Kopecek J. Properties of macrophages from low- and high-responder strains of mice. I. Effect of antigenic stimulation Folia Biologica. 31: 20-33. PMID 3972142  0.074
1968 Jokl J, Kopeček J, Lím D. Mechanism of three-dimensional polymerization of the system methyl methacrylate–glycol dimethacrylate. I. Determination of the structure of the three-dimensional product Journal of Polymer Science Part a-1: Polymer Chemistry. 6: 3041-3048. DOI: 10.1002/pol.1968.150061108  0.07
1994 Yen HR, Oscarsson S, Ulbrich K, Kopecek J. Adsorption and activation of zymogens at solid-liquid interfaces. I. Chymotrypsinogen on alkylamino modified silica derivatives. Journal of Biomedical Materials Research. 28: 247-57. PMID 8207038 DOI: 10.1002/jbm.820280216  0.068
2010 Fangueiro R, Lima M, Kopecek J, Velosa J. Mechanical properties of composite materials reinforced by an innovative multiaxial woven fabric Proceedings of the 10th International Conference On Textile Composites - Texcomp 10: Recent Advances in Textile Composites. 263-270.  0.065
2017 Low SA, Galliford CV, Jones-Hall YL, Roy J, Yang J, Low PS, Kopeček J. Healing efficacy of fracture-targeted GSK3β inhibitor-loaded micelles for improved fracture repair. Nanomedicine (London, England). PMID 28093944 DOI: 10.2217/Nnm-2016-0340  0.061
1980 Braselmann H, Vacík J, Kopeček J, Kirstein D. Regulation of transport in artificial membranes by environmental hydrogen-ion concentration European Polymer Journal. 16: 431-435. DOI: 10.1016/0014-3057(80)90149-4  0.059
1970 Kopecek J. Performance of Porous Cellulose Acetate Membranes for the Reverse Osmosis Separation of Mixtures of Organic Liquids Industrial & Engineering Chemistry Process Design and Development. 9: 5-12. DOI: 10.1021/i260033a002  0.059
1975 Voldrich Z, Tomanek Z, Vacik J, Kopecek J. Long term experience with poly(glycol monomethacrylate) gel in plastic operations of the nose Journal of Biomedical Materials Research. 9: 675-685. PMID 1184613  0.056
1993 Ikesue K, Kopečkovà P, Kopeček J. Degradation of proteins by guinea pig intestinal enzymes International Journal of Pharmaceutics. 95: 171-179. DOI: 10.1016/0378-5173(93)90404-4  0.053
1997 Shen HR, Spikes JD, Kopeckova P, Kopecek J. Photodynamic crosslinking of macromolecules: Implications for the mechanism of photodynamic therapy Proceedings of the Controlled Release Society. 134-135.  0.05
1985 Fornusek L, Vetvicka V, Kopecek J, Pesek M. New method for the determination of phagocytic activity of leukocytes from peripheral blood Cesko-Slovenska Epidemiologie Mikrobiologie Imunologie. 34: 234-238. PMID 3161637  0.041
1972 KOPECEK J, LIM D. ChemInform Abstract: MECHANISMUS DER DREIDIMENSIONALEN POLYMERISATION VON GLYKOLMETHACRYLATEN 4. MITT. SYST. TRIGLYKOLMONOMETHACRYLAT-GLYKOLDIMETHACRYLAT-WASSER Chemischer Informationsdienst. 3. DOI: 10.1002/chin.197201126  0.034
1967 Kopeček J, Jokl J, Lím D. Mechanismus der Dreidimensionalen Polymerisation von Glykolmethacrylaten Journal of Polymer Science Part C: Polymer Symposia. 16: 3877-3889. DOI: 10.1002/polc.5070160727  0.03
1983 Kopecek J, Polak R, Folk I. Shaft Vibrations in Steam Turbines Der Maschinenschaden Berlin. 56: 169-173.  0.03
1971 KOPECEK J, LIM D. ChemInform Abstract: MECHANISMUS DER DREIDIMENSIONALEN POLYMERISIERUNG VON GLYKOLMETHACRYLATEN 3. MITT. KINETIK DER POLYMERISIERUNG VON SYST. DIGLYKOLMONOMETHACRYLAT-GLYKOLDIMETHACRYLAT-WASSER Chemischer Informationsdienst. Organische Chemie. 2. DOI: 10.1002/chin.197146162  0.02
1993 KOPECEK J. Guest editorialProfessor Otto Wichterle's 80th birthday Biomaterials. 14: 1043-1044. DOI: 10.1016/0142-9612(93)90201-C  0.012
2014 Kopeček J, Stanwix H. Interview with Professor Jindřich Kopeček. Nanomedicine (London, England). 9: 577-9. PMID 24827841 DOI: 10.2217/nnm.14.20  0.01
2012 Kopeček J, Yang J. “Intelligente” Biomaterialien durch Selbstorganisation von Hybridhydrogelen Angewandte Chemie. 124: 7512-7535. DOI: 10.1002/ange.201201040  0.01
1996 Sung Wan Kim, Kopecek J, Anderson J. Preface Journal of Controlled Release. 39: 119. DOI: 10.1016/S0168-3659(96)90014-0  0.01
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