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Scott Neal Keeney, PhD - Publications

Affiliations: 
1997- Molecular Biology Program Memorial Sloan Kettering Cancer Center, Rockville Centre, NY, United States 
 1998- Biochemistry, Cell, and Molecular Biology Weill Cornell Medical College, New York, NY, United States 
 2008- Howard Hughes Medical Institute, Chevy Chase, MD, United States 
Area:
Molecular Biology
Website:
www.ski.edu/keeney
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Year Citation  Score
2020 Hinch AG, Becker PW, Li T, Moralli D, Zhang G, Bycroft C, Green C, Keeney S, Shi Q, Davies B, Donnelly P. The Configuration of RPA, RAD51, and DMC1 Binding in Meiosis Reveals the Nature of Critical Recombination Intermediates. Molecular Cell. PMID 32610038 DOI: 10.1016/J.Molcel.2020.06.015  0.457
2020 Murakami H, Lam I, Huang PC, Song J, van Overbeek M, Keeney S. Multilayered mechanisms ensure that short chromosomes recombine in meiosis. Nature. 582: 124-128. PMID 32494071 DOI: 10.1038/S41586-020-2248-2  0.831
2020 Acquaviva L, Boekhout M, Karasu ME, Brick K, Pratto F, Li T, van Overbeek M, Kauppi L, Camerini-Otero RD, Jasin M, Keeney S. Ensuring meiotic DNA break formation in the mouse pseudoautosomal region. Nature. PMID 32461690 DOI: 10.1038/S41586-020-2327-4  0.821
2020 Petrillo C, Barroca V, Ribeiro J, Lailler N, Livera G, Keeney S, Martini E, Jain D. shani mutation in mouse affects splicing of Spata22 and leads to impaired meiotic recombination. Chromosoma. PMID 32388826 DOI: 10.1007/S00412-020-00735-8  0.831
2020 Peterson SE, Keeney S, Jasin M. Mechanistic Insight into Crossing over during Mouse Meiosis. Molecular Cell. PMID 32362315 DOI: 10.1016/J.Molcel.2020.04.009  0.54
2020 Yamada S, Hinch AG, Kamido H, Zhang Y, Edelmann W, Keeney S. Molecular structures and mechanisms of DNA break processing in mouse meiosis. Genes & Development. PMID 32354835 DOI: 10.1101/Gad.336032.119  0.523
2019 Karasu ME, Keeney S. Cyclin B3 is dispensable for mouse spermatogenesis. Chromosoma. 128: 473-487. PMID 31446450 DOI: 10.1007/S00412-019-00725-5  0.43
2019 Boekhout M, Karasu ME, Wang J, Acquaviva L, Pratto F, Brick K, Eng DY, Xu J, Camerini-Otero RD, Patel DJ, Keeney S. REC114 Partner ANKRD31 Controls Number, Timing, and Location of Meiotic DNA Breaks. Molecular Cell. PMID 31003867 DOI: 10.1016/J.Molcel.2019.03.023  0.586
2019 Subramanian VV, Zhu X, Markowitz TE, Vale-Silva LA, San-Segundo PA, Hollingsworth NM, Keeney S, Hochwagen A. Persistent DNA-break potential near telomeres increases initiation of meiotic recombination on short chromosomes. Nature Communications. 10: 970. PMID 30814509 DOI: 10.1038/S41467-019-08875-X  0.722
2019 Karasu ME, Bouftas N, Keeney S, Wassmann K. Cyclin B3 promotes anaphase I onset in oocyte meiosis. The Journal of Cell Biology. 218: 1265-1281. PMID 30723090 DOI: 10.1083/Jcb.201808091  0.442
2018 Abreu CM, Prakash R, Romanienko PJ, Roig I, Keeney S, Jasin M. Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination. Nature Communications. 9: 3961. PMID 30305635 DOI: 10.1038/S41467-018-06384-X  0.8
2018 Pacheco S, Maldonado-Linares A, Marcet-Ortega M, Rojas C, Martínez-Marchal A, Fuentes-Lazaro J, Lange J, Jasin M, Keeney S, Fernández-Capetillo O, Garcia-Caldés M, Roig I. ATR is required to complete meiotic recombination in mice. Nature Communications. 9: 2622. PMID 29977027 DOI: 10.1038/S41467-018-04851-Z  0.845
2018 Widger A, Mahadevaiah SK, Lange J, ElInati E, Zohren J, Hirota T, Pacheco S, Maldonado-Linares A, Stanzione M, Ojarikre O, Maciulyte V, de Rooij DG, Tóth A, Roig I, Keeney S, et al. ATR is a multifunctional regulator of male mouse meiosis. Nature Communications. 9: 2621. PMID 29976923 DOI: 10.1038/S41467-018-04850-0  0.855
2018 Lukaszewicz A, Lange J, Keeney S, Jasin M. Control of meiotic double-strand-break formation by ATM: local and global views. Cell Cycle (Georgetown, Tex.). 1-18. PMID 29963942 DOI: 10.1080/15384101.2018.1464847  0.578
2018 Mimitou EP, Keeney S. S1-seq Assay for Mapping Processed DNA Ends. Methods in Enzymology. 601: 309-330. PMID 29523237 DOI: 10.1016/Bs.Mie.2017.11.031  0.552
2018 Jain D, Puno MR, Meydan C, Lailler N, Mason CE, Lima CD, Anderson KV, Keeney S. ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2. Elife. 7. PMID 29360036 DOI: 10.7554/Elife.30919  0.401
2017 Kniewel R, Murakami H, Liu Y, Ito M, Ohta K, Hollingsworth NM, Keeney S. Histone H3 Threonine 11 Phosphorylation Is Catalyzed Directly by the Meiosis-Specific Kinase Mek1 and Provides a Molecular Readout of Mek1 Activity in Vivo. Genetics. PMID 28986445 DOI: 10.1534/Genetics.117.300359  0.79
2017 Jain D, Meydan C, Lange J, Claeys Bouuaert C, Mason CE, Anderson KV, Keeney S. rahu is a mutant allele of Dnmt3c, encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline. Plos Genetics. 13: e1006964. PMID 28854222 DOI: 10.1371/Journal.Pgen.1006964  0.504
2017 Yamada S, Kim S, Tischfield SE, Jasin M, Lange J, Keeney S. Genomic and chromatin features shaping meiotic double-strand break formation and repair in mice. Cell Cycle (Georgetown, Tex.). 0. PMID 28820351 DOI: 10.1080/15384101.2017.1361065  0.832
2017 Marcet-Ortega M, Pacheco S, Martínez-Marchal A, Castillo H, Flores E, Jasin M, Keeney S, Roig I. p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes. Plos Genetics. 13: e1006845. PMID 28617799 DOI: 10.1371/Journal.Pgen.1006845  0.798
2017 Claeys Bouuaert C, Keeney S. Distinct DNA-binding surfaces in the ATPase and linker domains of MutLγ determine its substrate specificities and exert separable functions in meiotic recombination and mismatch repair. Plos Genetics. 13: e1006722. PMID 28505149 DOI: 10.1371/Journal.Pgen.1006722  0.532
2017 Lam I, Mohibullah N, Keeney S. Sequencing Spo11 Oligonucleotides for Mapping Meiotic DNA Double-Strand Breaks in Yeast. Methods in Molecular Biology (Clifton, N.J.). 1471: 51-98. PMID 28349390 DOI: 10.1007/978-1-4939-6340-9_3  0.803
2017 Mimitou EP, Yamada S, Keeney S. A global view of meiotic double-strand break end resection. Science (New York, N.Y.). 355: 40-45. PMID 28059759 DOI: 10.1126/Science.Aak9704  0.466
2017 Jain D, Puno MR, Meydan C, Lailler N, Mason CE, Lima CD, Anderson KV, Keeney S. Author response: ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2 Elife. DOI: 10.7554/Elife.30919.049  0.302
2017 Prakash R, Abreu CM, Keeney S, Jasin M. Abstract A07: The RAD51 paralog complex SWS1-SWSAP1 is critical for homologous recombination in the mouse Molecular Cancer Research. 15. DOI: 10.1158/1557-3125.Dnarepair16-A07  0.543
2016 Mohibullah N, Keeney S. Numerical and spatial patterning of yeast meiotic DNA breaks by Tel1. Genome Research. PMID 27923845 DOI: 10.1101/Gr.213587.116  0.583
2016 Lange J, Yamada S, Tischfield SE, Pan J, Kim S, Zhu X, Socci ND, Jasin M, Keeney S. The Landscape of Mouse Meiotic Double-Strand Break Formation, Processing, and Repair. Cell. PMID 27745971 DOI: 10.1016/J.Cell.2016.09.035  0.847
2016 Stanzione M, Baumann M, Papanikos F, Dereli I, Lange J, Ramlal A, Tränkner D, Shibuya H, de Massy B, Watanabe Y, Jasin M, Keeney S, Tóth A. Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice. Nature Cell Biology. PMID 27723721 DOI: 10.1038/Ncb3417  0.638
2016 Barchi M, Cohen P, Keeney S. Special issue on "recent advances in meiotic chromosome structure, recombination and segregation". Chromosoma. PMID 27022980 DOI: 10.1007/S00412-016-0586-5  0.474
2016 Bouuaert CC, Keeney S. DNA. Breaking DNA. Science (New York, N.Y.). 351: 916-7. PMID 26917753 DOI: 10.1126/Science.Aaf2509  0.406
2016 Kim S, Peterson SE, Jasin M, Keeney S. Mechanisms of germ line genome instability. Seminars in Cell & Developmental Biology. PMID 26880205 DOI: 10.1016/J.Semcdb.2016.02.019  0.589
2016 Thacker D, Keeney S. Homologous recombination during meiosis Dna Replication, Recombination, and Repair: Molecular Mechanisms and Pathology. 131-151. DOI: 10.1007/978-4-431-55873-6_6  0.76
2015 Vincenten N, Kuhl LM, Lam I, Oke A, Kerr AR, Hochwagen A, Fung J, Keeney S, Vader G, Marston AL. The kinetochore prevents centromere-proximal crossover recombination during meiosis. Elife. 4. PMID 26653857 DOI: 10.7554/Elife.10850  0.831
2015 Lam I, Keeney S. Nonparadoxical evolutionary stability of the recombination initiation landscape in yeast. Science (New York, N.Y.). 350: 932-7. PMID 26586758 DOI: 10.1126/Science.Aad0814  0.773
2015 de Boer E, Jasin M, Keeney S. Local and sex-specific biases in crossover vs. noncrossover outcomes at meiotic recombination hot spots in mice. Genes & Development. 29: 1721-33. PMID 26251527 DOI: 10.1101/Gad.265561.115  0.45
2015 Zhu X, Keeney S. High-Resolution Global Analysis of the Influences of Bas1 and Ino4 Transcription Factors on Meiotic DNA Break Distributions in Saccharomyces cerevisiae. Genetics. 201: 525-42. PMID 26245832 DOI: 10.1534/Genetics.115.178293  0.621
2015 Pacheco S, Marcet-Ortega M, Lange J, Jasin M, Keeney S, Roig I. The ATM signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes. Plos Genetics. 11: e1005017. PMID 25768017 DOI: 10.1371/Journal.Pgen.1005017  0.813
2015 Lam I, Keeney S. Mechanism and regulation of meiotic recombination initiation. Cold Spring Harbor Perspectives in Biology. 7: a016634. PMID 25324213 DOI: 10.1101/Cshperspect.A016634  0.82
2015 Vincenten N, Kuhl L, Lam I, Oke A, Kerr AR, Hochwagen A, Fung J, Keeney S, Vader G, Marston AL. Author response: The kinetochore prevents centromere-proximal crossover recombination during meiosis Elife. DOI: 10.7554/Elife.10850.036  0.757
2014 Murakami H, Keeney S. DDK links replication and recombination in meiosis. Cell Cycle (Georgetown, Tex.). 13: 3621-2. PMID 25483055 DOI: 10.4161/15384101.2014.986626  0.58
2014 Keeney S, Lange J, Mohibullah N. Self-organization of meiotic recombination initiation: general principles and molecular pathways. Annual Review of Genetics. 48: 187-214. PMID 25421598 DOI: 10.1146/Annurev-Genet-120213-092304  0.558
2014 Cole F, Baudat F, Grey C, Keeney S, de Massy B, Jasin M. Mouse tetrad analysis provides insights into recombination mechanisms and hotspot evolutionary dynamics. Nature Genetics. 46: 1072-80. PMID 25151354 DOI: 10.1038/Ng.3068  0.458
2014 Murakami H, Keeney S. Temporospatial coordination of meiotic DNA replication and recombination via DDK recruitment to replisomes. Cell. 158: 861-73. PMID 25126790 DOI: 10.1016/J.Cell.2014.06.028  0.541
2014 Fowler KR, Sasaki M, Milman N, Keeney S, Smith GR. Evolutionarily diverse determinants of meiotic DNA break and recombination landscapes across the genome. Genome Research. 24: 1650-64. PMID 25024163 DOI: 10.1101/Gr.172122.114  0.704
2014 Zhu X, Keeney S. Zip it up to shut it down. Cell Cycle (Georgetown, Tex.). 13: 2157-8. PMID 24967581 DOI: 10.4161/Cc.29747  0.747
2014 Thacker D, Mohibullah N, Zhu X, Keeney S. Homologue engagement controls meiotic DNA break number and distribution. Nature. 510: 241-6. PMID 24717437 DOI: 10.1038/Nature13120  0.825
2014 Roset R, Inagaki A, Hohl M, Brenet F, Lafrance-Vanasse J, Lange J, Scandura JM, Tainer JA, Keeney S, Petrini JH. The Rad50 hook domain regulates DNA damage signaling and tumorigenesis. Genes & Development. 28: 451-62. PMID 24532689 DOI: 10.1101/Gad.236745.113  0.436
2014 Ontoso D, Kauppi L, Keeney S, San-Segundo PA. Dynamics of DOT1L localization and H3K79 methylation during meiotic prophase I in mouse spermatocytes. Chromosoma. 123: 147-64. PMID 24105599 DOI: 10.1007/S00412-013-0438-5  0.745
2013 Dowdle JA, Mehta M, Kass EM, Vuong BQ, Inagaki A, Egli D, Jasin M, Keeney S. Mouse BAZ1A (ACF1) is dispensable for double-strand break repair but is essential for averting improper gene expression during spermatogenesis. Plos Genetics. 9: e1003945. PMID 24244200 DOI: 10.1371/Journal.Pgen.1003945  0.847
2013 Sasaki M, Tischfield SE, van Overbeek M, Keeney S. Meiotic recombination initiation in and around retrotransposable elements in Saccharomyces cerevisiae. Plos Genetics. 9: e1003732. PMID 24009525 DOI: 10.1371/Journal.Pgen.1003732  0.839
2013 Kauppi L, Jasin M, Keeney S. How much is enough? Control of DNA double-strand break numbers in mouse meiosis. Cell Cycle (Georgetown, Tex.). 12: 2719-20. PMID 23966150 DOI: 10.4161/Cc.26079  0.828
2013 Kauppi L, Barchi M, Lange J, Baudat F, Jasin M, Keeney S. Numerical constraints and feedback control of double-strand breaks in mouse meiosis. Genes & Development. 27: 873-86. PMID 23599345 DOI: 10.1101/Gad.213652.113  0.807
2013 de Boer E, Jasin M, Keeney S. Analysis of recombinants in female mouse meiosis. Methods in Molecular Biology (Clifton, N.J.). 957: 19-45. PMID 23138942 DOI: 10.1007/978-1-62703-191-2_2  0.531
2012 Cole F, Keeney S, Jasin M. Preaching about the converted: how meiotic gene conversion influences genomic diversity. Annals of the New York Academy of Sciences. 1267: 95-102. PMID 22954222 DOI: 10.1111/J.1749-6632.2012.06595.X  0.454
2012 Kauppi L, Jasin M, Keeney S. The tricky path to recombining X and Y chromosomes in meiosis. Annals of the New York Academy of Sciences. 1267: 18-23. PMID 22954211 DOI: 10.1111/J.1749-6632.2012.06593.X  0.779
2012 Globus ST, Keeney S. The joy of six: how to control your crossovers. Cell. 149: 11-2. PMID 22464316 DOI: 10.1016/J.Cell.2012.03.011  0.814
2012 Tischfield SE, Keeney S. Scale matters: the spatial correlation of yeast meiotic DNA breaks with histone H3 trimethylation is driven largely by independent colocalization at promoters. Cell Cycle (Georgetown, Tex.). 11: 1496-503. PMID 22433953 DOI: 10.4161/Cc.19733  0.834
2012 Cole F, Kauppi L, Lange J, Roig I, Wang R, Keeney S, Jasin M. Homeostatic control of recombination is implemented progressively in mouse meiosis. Nature Cell Biology. 14: 424-30. PMID 22388890 DOI: 10.1038/Ncb2451  0.841
2011 Lange J, Pan J, Cole F, Thelen MP, Jasin M, Keeney S. ATM controls meiotic double-strand-break formation. Nature. 479: 237-40. PMID 22002603 DOI: 10.1038/Nature10508  0.605
2011 Thacker D, Lam I, Knop M, Keeney S. Exploiting spore-autonomous fluorescent protein expression to quantify meiotic chromosome behaviors in Saccharomyces cerevisiae. Genetics. 189: 423-39. PMID 21840861 DOI: 10.1534/Genetics.111.131326  0.83
2011 Churchman ML, Roig I, Jasin M, Keeney S, Sherr CJ. Expression of arf tumor suppressor in spermatogonia facilitates meiotic progression in male germ cells. Plos Genetics. 7: e1002157. PMID 21811412 DOI: 10.1371/Journal.Pgen.1002157  0.711
2011 Yin Y, Lin C, Kim ST, Roig I, Chen H, Liu L, Veith GM, Jin RU, Keeney S, Jasin M, Moley K, Zhou P, Ma L. The E3 ubiquitin ligase Cullin 4A regulates meiotic progression in mouse spermatogenesis. Developmental Biology. 356: 51-62. PMID 21624359 DOI: 10.1016/J.Ydbio.2011.05.661  0.776
2011 Daniel K, Lange J, Hached K, Fu J, Anastassiadis K, Roig I, Cooke HJ, Stewart AF, Wassmann K, Jasin M, Keeney S, Tóth A. Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1. Nature Cell Biology. 13: 599-610. PMID 21478856 DOI: 10.1038/Ncb2213  0.786
2011 Pan J, Sasaki M, Kniewel R, Murakami H, Blitzblau HG, Tischfield SE, Zhu X, Neale MJ, Jasin M, Socci ND, Hochwagen A, Keeney S. A hierarchical combination of factors shapes the genome-wide topography of yeast meiotic recombination initiation. Cell. 144: 719-31. PMID 21376234 DOI: 10.1016/J.Cell.2011.02.009  0.835
2011 Kauppi L, Barchi M, Baudat F, Romanienko PJ, Keeney S, Jasin M. Distinct properties of the XY pseudoautosomal region crucial for male meiosis. Science (New York, N.Y.). 331: 916-20. PMID 21330546 DOI: 10.1126/Science.1195774  0.8
2011 Dray E, Dunlop MH, Kauppi L, San Filippo J, Wiese C, Tsai MS, Begovic S, Schild D, Jasin M, Keeney S, Sung P. Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1). Proceedings of the National Academy of Sciences of the United States of America. 108: 3560-5. PMID 21307306 DOI: 10.1073/Pnas.1016454108  0.829
2011 Dray E, Dunlop MH, Kauppi L, Filippo JSS, Wiese C, Tsai M, Begovic S, Schild D, Jasin M, Keeney S, Sung P. Molecular Basis for Enhancement of the Meiotic DMCI Recombinase by RAD51AP1 Lawrence Berkeley National Laboratory. DOI: 10.2172/1011037  0.827
2010 Cole F, Keeney S, Jasin M. Comprehensive, fine-scale dissection of homologous recombination outcomes at a hot spot in mouse meiosis. Molecular Cell. 39: 700-10. PMID 20832722 DOI: 10.1016/J.Molcel.2010.08.017  0.529
2010 Roig I, Dowdle JA, Toth A, de Rooij DG, Jasin M, Keeney S. Mouse TRIP13/PCH2 is required for recombination and normal higher-order chromosome structure during meiosis. Plos Genetics. 6. PMID 20711356 DOI: 10.1371/Journal.Pgen.1001062  0.847
2010 Cole F, Keeney S, Jasin M. Evolutionary conservation of meiotic DSB proteins: more than just Spo11. Genes & Development. 24: 1201-7. PMID 20551169 DOI: 10.1101/Gad.1944710  0.494
2010 Sasaki M, Lange J, Keeney S. Genome destabilization by homologous recombination in the germ line. Nature Reviews. Molecular Cell Biology. 11: 182-95. PMID 20164840 DOI: 10.1038/Nrm2849  0.694
2010 Kidane D, Jonason AS, Gorton TS, Mihaylov I, Pan J, Keeney S, de Rooij DG, Ashley T, Keh A, Liu Y, Banerjee U, Zelterman D, Sweasy JB. DNA polymerase beta is critical for mouse meiotic synapsis. The Embo Journal. 29: 410-23. PMID 20019666 DOI: 10.1038/Emboj.2009.357  0.419
2009 Wojtasz L, Daniel K, Roig I, Bolcun-Filas E, Xu H, Boonsanay V, Eckmann CR, Cooke HJ, Jasin M, Keeney S, McKay MJ, Toth A. Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase. Plos Genetics. 5: e1000702. PMID 19851446 DOI: 10.1371/Journal.Pgen.1000702  0.811
2009 Pan J, Keeney S. Detection of SPO11-oligonucleotide complexes from mouse testes. Methods in Molecular Biology (Clifton, N.J.). 557: 197-207. PMID 19799184 DOI: 10.1007/978-1-59745-527-5_13  0.439
2009 Neale MJ, Keeney S. End-labeling and analysis of Spo11-oligonucleotide complexes in Saccharomyces cerevisiae. Methods in Molecular Biology (Clifton, N.J.). 557: 183-95. PMID 19799183 DOI: 10.1007/978-1-59745-527-5_12  0.779
2009 Murakami H, Borde V, Nicolas A, Keeney S. Gel electrophoresis assays for analyzing DNA double-strand breaks in Saccharomyces cerevisiae at various spatial resolutions. Methods in Molecular Biology (Clifton, N.J.). 557: 117-42. PMID 19799180 DOI: 10.1007/978-1-59745-527-5_9  0.54
2009 Thacker D, Keeney S. PCH'ing together an understanding of crossover control. Plos Genetics. 5: e1000576. PMID 19629169 DOI: 10.1371/Journal.Pgen.1000576  0.787
2009 Kniewel R, Keeney S. Histone methylation sets the stage for meiotic DNA breaks. The Embo Journal. 28: 81-3. PMID 19158660 DOI: 10.1038/Emboj.2008.277  0.817
2008 Keeney S. Spo11 and the Formation of DNA Double-Strand Breaks in Meiosis. Genome Dynamics and Stability. 2: 81-123. PMID 21927624 DOI: 10.1007/7050_2007_026  0.444
2008 Roig I, Keeney S. Probing meiotic recombination decisions. Developmental Cell. 15: 331-2. PMID 18804427 DOI: 10.1016/J.Devcel.2008.08.009  0.696
2008 Barchi M, Roig I, Di Giacomo M, de Rooij DG, Keeney S, Jasin M. ATM promotes the obligate XY crossover and both crossover control and chromosome axis integrity on autosomes. Plos Genetics. 4: e1000076. PMID 18497861 DOI: 10.1371/Journal.Pgen.1000076  0.803
2008 Murakami H, Keeney S. Regulating the formation of DNA double-strand breaks in meiosis. Genes & Development. 22: 286-92. PMID 18245442 DOI: 10.1101/Gad.1642308  0.588
2007 Pan J, Keeney S. Molecular cartography: mapping the landscape of meiotic recombination. Plos Biology. 5: e333. PMID 18092891 DOI: 10.1371/Journal.Pbio.0050333  0.301
2007 Kauppi L, Jasin M, Keeney S. Meiotic crossover hotspots contained in haplotype block boundaries of the mouse genome. Proceedings of the National Academy of Sciences of the United States of America. 104: 13396-401. PMID 17690247 DOI: 10.1073/Pnas.0701965104  0.739
2007 Maleki S, Neale MJ, Arora C, Henderson KA, Keeney S. Interactions between Mei4, Rec114, and other proteins required for meiotic DNA double-strand break formation in Saccharomyces cerevisiae. Chromosoma. 116: 471-86. PMID 17558514 DOI: 10.1007/S00412-007-0111-Y  0.826
2006 Liebe B, Petukhova G, Barchi M, Bellani M, Braselmann H, Nakano T, Pandita TK, Jasin M, Fornace A, Meistrich ML, Baarends WM, Schimenti J, de Lange T, Keeney S, Camerini-Otero RD, et al. Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages. Experimental Cell Research. 312: 3768-81. PMID 17010969 DOI: 10.1016/J.Yexcr.2006.07.019  0.495
2006 Martini E, Diaz RL, Hunter N, Keeney S. Crossover homeostasis in yeast meiosis. Cell. 126: 285-95. PMID 16873061 DOI: 10.1016/J.Cell.2006.05.044  0.845
2006 Keeney S, Neale MJ. Initiation of meiotic recombination by formation of DNA double-strand breaks: Mechanism and regulation Biochemical Society Transactions. 34: 523-525. PMID 16856850 DOI: 10.1042/Bst0340523  0.825
2006 Neale MJ, Keeney S. Clarifying the mechanics of DNA strand exchange in meiotic recombination. Nature. 442: 153-8. PMID 16838012 DOI: 10.1038/Nature04885  0.832
2006 Henderson KA, Kee K, Maleki S, Santini PA, Keeney S. Cyclin-dependent kinase directly regulates initiation of meiotic recombination. Cell. 125: 1321-32. PMID 16814718 DOI: 10.1016/J.Cell.2006.04.039  0.828
2005 Henderson KA, Keeney S. Synaptonemal complex formation: where does it start? Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 27: 995-8. PMID 16163735 DOI: 10.1002/Bies.20310  0.646
2005 Neale MJ, Pan J, Keeney S. Endonucleolytic processing of covalent protein-linked DNA double-strand breaks. Nature. 436: 1053-7. PMID 16107854 DOI: 10.1038/Nature03872  0.795
2005 Barchi M, Mahadevaiah S, Di Giacomo M, Baudat F, de Rooij DG, Burgoyne PS, Jasin M, Keeney S. Surveillance of different recombination defects in mouse spermatocytes yields distinct responses despite elimination at an identical developmental stage. Molecular and Cellular Biology. 25: 7203-15. PMID 16055729 DOI: 10.1128/Mcb.25.16.7203-7215.2005  0.52
2005 Ahn SH, Henderson KA, Keeney S, Allis CD. H2B (Ser10) phosphorylation is induced during apoptosis and meiosis in S. cerevisiae Cell Cycle. 4: 780-783. PMID 15970663 DOI: 10.4161/Cc.4.6.1745  0.656
2005 Okada T, Keeney S. Homologous recombination: needing to have my say. Current Biology : Cb. 15: R200-2. PMID 15797011 DOI: 10.1016/J.Cub.2005.03.009  0.531
2005 Di Giacomo M, Barchi M, Baudat F, Edelmann W, Keeney S, Jasin M. Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants. Proceedings of the National Academy of Sciences of the United States of America. 102: 737-42. PMID 15640358 DOI: 10.1073/Pnas.0406212102  0.543
2004 Maleki S, Keeney S. Modifying histones and initiating meiotic recombination; new answers to an old question. Cell. 118: 404-6. PMID 15315752 DOI: 10.1016/J.Cell.2004.08.008  0.526
2004 Kauppi L, Jeffreys AJ, Keeney S. Where the crossovers are: recombination distributions in mammals. Nature Reviews. Genetics. 5: 413-24. PMID 15153994 DOI: 10.1038/Nrg1346  0.798
2004 Henderson KA, Keeney S. Tying synaptonemal complex initiation to the formation and programmed repair of DNA double-strand breaks. Proceedings of the National Academy of Sciences of the United States of America. 101: 4519-24. PMID 15070750 DOI: 10.1073/Pnas.0400843101  0.73
2004 Kee K, Protacio RU, Arora C, Keeney S. Spatial organization and dynamics of the association of Rec102 and Rec104 with meiotic chromosomes. The Embo Journal. 23: 1815-24. PMID 15044957 DOI: 10.1038/Sj.Emboj.7600184  0.847
2004 Arora C, Kee K, Maleki S, Keeney S. Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism. Molecular Cell. 13: 549-59. PMID 14992724 DOI: 10.1016/S1097-2765(04)00063-2  0.82
2002 Martini E, Keeney S. Sex and the single (double-strand) break. Molecular Cell. 9: 700-2. PMID 11983162 DOI: 10.1016/S1097-2765(02)00512-9  0.837
2002 Martini EM, Keeney S, Osley MA. A role for histone H2B during repair of UV-induced DNA damage in Saccharomyces cerevisiae. Genetics. 160: 1375-87. PMID 11973294  0.805
2002 Diaz RL, Alcid AD, Berger JM, Keeney S. Identification of residues in yeast Spo11p critical for meiotic DNA double-strand break formation. Molecular and Cellular Biology. 22: 1106-15. PMID 11809802 DOI: 10.1128/Mcb.22.4.1106-1115.2002  0.488
2002 Klein U, Esposito G, Baudat F, Keeney S, Jasin M. Mice deficient for the type II topoisomerase-like DNA transesterase Spo11 show normal immunoglobulin somatic hypermutation and class switching. European Journal of Immunology. 32: 316-21. PMID 11807770 DOI: 10.1002/1521-4141(200202)32:2<316::Aid-Immu316>3.0.Co;2-P  0.4
2002 Kee K, Keeney S. Functional interactions between SPO11 and REC102 during initiation of meiotic recombination in Saccharomyces cerevisiae. Genetics. 160: 111-22. PMID 11805049  0.718
2001 Keeney S. Mechanism and control of meiotic recombination initiation Current Topics in Developmental Biology. 52: 1-53. PMID 11529427 DOI: 10.1016/S0070-2153(01)52008-6  0.523
2001 Mahadevaiah SK, Turner JM, Baudat F, Rogakou EP, de Boer P, Blanco-Rodríguez J, Jasin M, Keeney S, Bonner WM, Burgoyne PS. Recombinational DNA double-strand breaks in mice precede synapsis. Nature Genetics. 27: 271-6. PMID 11242108 DOI: 10.1038/85830  0.529
2001 Baudat F, Keeney S. Meiotic recombination: Making and breaking go hand in hand Current Biology. 11. PMID 11231139 DOI: 10.1016/S0960-9822(01)00013-6  0.59
2000 Baudat F, Manova K, Yuen JP, Jasin M, Keeney S. Chromosome synapsis defects and sexually dimorphic meiotic progression in mice lacking Spo11. Molecular Cell. 6: 989-98. PMID 11106739 DOI: 10.1016/S1097-2765(00)00098-8  0.544
2000 Cha RS, Weiner BM, Keeney S, Dekker J, Kleckner N. Progression of meiotic DNA replication is modulated by interchromosomal interaction proteins, negatively by Spo11p and positively by Rec8p. Genes & Development. 14: 493-503. PMID 10691741  0.836
2000 Cha RS, Weiner BM, Keeney S, Dekker J, Kleckner N. Progression of meiotic DNA replication is modulated by interchromosomal interaction proteins, negatively by Spo11p and positively by Rec8p Genes & Development. 14: 493-503. DOI: 10.1101/Gad.14.4.493  0.84
1999 Keeney S, Baudat F, Angeles M, Zhou ZH, Copeland NG, Jenkins NA, Manova K, Jasin M. A mouse homolog of the Saccharomyces cerevisiae meiotic recombination DNA transesterase Spo11p. Genomics. 61: 170-82. PMID 10534402 DOI: 10.1006/Geno.1999.5956  0.533
1997 Keeney S, Giroux CN, Kleckner N. Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family. Cell. 88: 375-84. PMID 9039264 DOI: 10.1016/S0092-8674(00)81876-0  0.7
1996 Keeney S, Kleckner N. Communication between homologous chromosomes: genetic alterations at a nuclease-hypersensitive site can alter mitotic chromatin structure at that site both in cis and in trans. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 1: 475-89. PMID 9078379 DOI: 10.1046/J.1365-2443.1996.D01-257.X  0.708
1996 Vaisman A, Keeney S, Nichols AF, Linn S, Chaney SG. Cisplatin-induced alterations in the expression of the mRNAs for UV-damage recognition protein. Oncology Research. 8: 7-12. PMID 8704286  0.579
1995 Dualan R, Brody T, Keeney S, Nichols AF, Admon A, Linn S. Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein. Genomics. 29: 62-9. PMID 8530102 DOI: 10.1006/Geno.1995.1215  0.631
1995 Keeney S, Kleckner N. Covalent protein-DNA complexes at the 5' strand termini of meiosis-specific double-strand breaks in yeast. Proceedings of the National Academy of Sciences of the United States of America. 92: 11274-8. PMID 7479978 DOI: 10.1073/Pnas.92.24.11274  0.706
1994 Keeney S, Eker APM, Brody T, Vermeulen W, Bootsma D, Hoeijmaker JHJ, Linn S. Correction of the DNA repair defect in xeroderma pigmentosum group E by injection of a DNA damage-binding protein Proceedings of the National Academy of Sciences of the United States of America. 91: 4053-4056. PMID 8171034 DOI: 10.1073/Pnas.91.9.4053  0.661
1993 Keeney S, Chang GJ, Linn S. Characterization of a human DNA damage binding protein implicated in xeroderma pigmentosum E Journal of Biological Chemistry. 268: 21293-21300. PMID 8407967  0.601
1992 Keeney S, Wein H, Linn S. Biochemical heterogeneity in xeroderma pigmentosum complementation group E Mutation Research-Dna Repair. 273: 49-56. PMID 1376435 DOI: 10.1016/0921-8777(92)90049-9  0.599
1990 Keeney S, Linn S. A critical review of permeabilized cell systems for studying mammalian DNA repair Mutation Research-Dna Repair. 236: 239-252. PMID 2119002 DOI: 10.1016/0921-8777(90)90008-S  0.646
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