| Year |
Citation |
Score |
| 2023 |
Lin P, Lourenco C, Cruickshank J, Palomero L, van Leeuwen JE, Tong AHY, Chan K, El Ghamrasni S, Pujana MA, Cescon DW, Moffat J, Penn LZ. Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality. Cancer Research. OF1-OF15. PMID 37987734 DOI: 10.1158/0008-5472.CAN-22-2948 |
0.384 |
|
| 2022 |
Wei Y, Redel C, Ahlner A, Lemak A, Johansson-Åkhe I, Houliston S, Kenney TMG, Tamachi A, Morad V, Duan S, Andrews DW, Wallner B, Sunnerhagen M, Arrowsmith CH, Penn LZ. The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase. Nucleic Acids Research. PMID 35244724 DOI: 10.1093/nar/gkac138 |
0.313 |
|
| 2021 |
Lourenco C, Resetca D, Redel C, Lin P, MacDonald AS, Ciaccio R, Kenney TMG, Wei Y, Andrews DW, Sunnerhagen M, Arrowsmith CH, Raught B, Penn LZ. MYC protein interactors in gene transcription and cancer. Nature Reviews. Cancer. PMID 34188192 DOI: 10.1038/s41568-021-00367-9 |
0.342 |
|
| 2020 |
Longo J, van Leeuwen JE, Elbaz M, Branchard E, Penn LZ. Statins as anti-cancer agents in the era of precision medicine. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 32887721 DOI: 10.1158/1078-0432.Ccr-20-1967 |
0.349 |
|
| 2020 |
Longo J, Pandyra AA, Stachura P, Minden MD, Schimmer AD, Penn LZ. Cyclic AMP-hydrolyzing phosphodiesterase inhibitors potentiate statin-induced cancer cell death. Molecular Oncology. PMID 32749766 DOI: 10.1002/1878-0261.12775 |
0.441 |
|
| 2020 |
Longo J, Smirnov P, Li Z, Branchard E, van Leeuwen JE, Licht JD, Haibe-Kains B, Andrews DW, Keats JJ, Pugh TJ, Trudel S, Penn LZ. The mevalonate pathway is an actionable vulnerability of t(4;14)-positive multiple myeloma. Leukemia. PMID 32665698 DOI: 10.1038/S41375-020-0962-2 |
0.358 |
|
| 2020 |
Longo J, Hamilton RJ, Masoomian M, Khurram N, Branchard E, Mullen PJ, Elbaz M, Hersey K, Chadwick D, Ghai S, Andrews DW, Chen EX, van der Kwast TH, Fleshner NE, Penn LZ. A pilot window-of-opportunity study of preoperative fluvastatin in localized prostate cancer. Prostate Cancer and Prostatic Diseases. PMID 32203069 DOI: 10.1038/S41391-020-0221-7 |
0.32 |
|
| 2019 |
Hickman KA, Hariharan S, De Melo J, Ylanko J, Lustig LC, Penn LZ, Andrews DW. Image-Based Analysis of Protein Stability. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. PMID 31774248 DOI: 10.1002/Cyto.A.23928 |
0.353 |
|
| 2019 |
Wei Y, Resetca D, Li Z, Johansson-Åkhe I, Ahlner A, Helander S, Wallenhammar A, Morad V, Raught B, Wallner B, Kokubo T, Tong Y, Penn LZ, Sunnerhagen M. Multiple direct interactions of TBP with the MYC oncoprotein. Nature Structural & Molecular Biology. PMID 31686052 DOI: 10.1038/S41594-019-0321-Z |
0.394 |
|
| 2019 |
Lourenco C, Kalkat M, Houlahan KE, De Melo J, Longo J, Done SJ, Boutros PC, Penn LZ. Modelling the MYC-driven normal-to-tumour switch in breast cancer. Disease Models & Mechanisms. 12. PMID 31350286 DOI: 10.1242/Dmm.038083 |
0.401 |
|
| 2019 |
Longo J, Mullen PJ, Yu R, van Leeuwen JE, Masoomian M, Woon DTS, Wang Y, Chen EX, Hamilton RJ, Sweet JM, van der Kwast TH, Fleshner NE, Penn LZ. An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer. Molecular Metabolism. PMID 31023626 DOI: 10.1016/J.Molmet.2019.04.003 |
0.372 |
|
| 2018 |
Kalkat M, Resetca D, Lourenco C, Chan PK, Wei Y, Shiah YJ, Vitkin N, Tong Y, Sunnerhagen M, Done SJ, Boutros PC, Raught B, Penn LZ. MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis. Molecular Cell. PMID 30415952 DOI: 10.1016/J.Molcel.2018.09.031 |
0.428 |
|
| 2018 |
Tu WB, Shiah YJ, Lourenco C, Mullen PJ, Dingar D, Redel C, Tamachi A, Ba-Alawi W, Aman A, Al-Awar R, Cescon DW, Haibe-Kains B, Arrowsmith CH, Raught B, Boutros PC, ... Penn LZ, et al. MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis. Cancer Cell. 34: 579-595.e8. PMID 30300580 DOI: 10.1016/J.Ccell.2018.09.001 |
0.417 |
|
| 2018 |
Dingar D, Tu WB, Resetca D, Lourenco C, Tamachi A, De Melo J, Houlahan KE, Kalkat M, Chan PK, Boutros PC, Raught B, Penn LZ. MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability. Nature Communications. 9: 3502. PMID 30158517 DOI: 10.1038/S41467-018-05660-0 |
0.476 |
|
| 2018 |
Melo JD, Kim SS, Lourenco C, Resetca D, Sunnerhagen M, Raught B, Penn LZ. Abstract 5423: Lysine-52 stabilizes the MYC oncoprotein through a SCFFBXW7-independent mechanism Cancer Research. 78: 5423-5423. DOI: 10.1158/1538-7445.Am2018-5423 |
0.442 |
|
| 2017 |
Yu R, Longo J, van Leeuwen JE, Mullen PJ, Ba-Alawi W, Haibe-Kains B, Penn LZ. Statin-induced cancer cell death can be mechanistically uncoupled from prenylation of RAS family proteins. Cancer Research. PMID 29229608 DOI: 10.1158/0008-5472.Can-17-1231 |
0.452 |
|
| 2017 |
Yu R, Longo J, van Leeuwen JE, Mullen PJ, Ba-Alawi W, Haibe-Kains B, Penn LZ. Statin-induced cancer cell death can be mechanistically uncoupled from prenylation of RAS family proteins. Cancer Research. PMID 29229608 DOI: 10.1158/0008-5472.CAN-17-1231 |
0.345 |
|
| 2017 |
Yu R, Longo J, van Leeuwen JE, Mullen PJ, Ba-Alawi W, Haibe-Kains B, Penn LZ. Statin-induced cancer cell death can be mechanistically uncoupled from prenylation of RAS family proteins. Cancer Research. PMID 29229608 DOI: 10.1158/0008-5472.CAN-17-1231 |
0.345 |
|
| 2017 |
De Melo J, Kim SS, Lourenco C, Penn LZ. Lysine-52 stabilizes the MYC oncoprotein through an SCF(Fbxw7)-independent mechanism. Oncogene. PMID 28806398 DOI: 10.1038/Onc.2017.268 |
0.429 |
|
| 2017 |
Lustig LC, Dingar D, Tu WB, Lourenco C, Kalkat M, Inamoto I, Ponzielli R, Chan WCW, Shin JA, Penn LZ. Inhibiting MYC binding to the E-box DNA motif by ME47 decreases tumour xenograft growth. Oncogene. PMID 28806396 DOI: 10.1038/Onc.2017.275 |
0.445 |
|
| 2017 |
Kalkat M, De Melo J, Hickman KA, Lourenco C, Redel C, Resetca D, Tamachi A, Tu WB, Penn LZ. MYC Deregulation in Primary Human Cancers. Genes. 8. PMID 28587062 DOI: 10.3390/Genes8060151 |
0.481 |
|
| 2017 |
Leeuwen Jv, Pandyra A, Goard C, Mullen PJ, Yu R, Penn LZ. Abstract 3543: Targeting the metabolic mevalonate pathway with statins as anti-breast cancer agents Cancer Research. 77: 3543-3543. DOI: 10.1158/1538-7445.Am2017-3543 |
0.785 |
|
| 2017 |
Lourenco C, Kalkat M, Dingar D, Melo JD, Yu R, Penn L. Abstract 2558: MYC-dependent transformation model of triple-negative breast cancer in vivo Cancer Research. 77: 2558-2558. DOI: 10.1158/1538-7445.Am2017-2558 |
0.332 |
|
| 2016 |
Mullen PJ, Yu R, Longo J, Archer MC, Penn LZ. The interplay between cell signalling and the mevalonate pathway in cancer. Nature Reviews. Cancer. PMID 27562463 DOI: 10.1038/Nrc.2016.76 |
0.385 |
|
| 2016 |
Stojanova A, Tu WB, Ponzielli R, Kotlyar M, Chan PK, Boutros PC, Khosravi F, Jurisica I, Raught B, Penn LZ. MYC interaction with the tumour suppressive SWI/SNF complex member INI1 regulates transcription and cellular transformation. Cell Cycle (Georgetown, Tex.). 0. PMID 27267444 DOI: 10.1080/15384101.2016.1146836 |
0.462 |
|
| 2015 |
Pandyra AA, Mullen PJ, Goard CA, Ericson E, Sharma P, Kalkat M, Yu R, Pong JT, Brown KR, Hart T, Gebbia M, Lang KS, Giaever G, Nislow C, Moffat J, ... Penn LZ, et al. Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death. Oncotarget. PMID 26353928 DOI: 10.18632/Oncotarget.4817 |
0.804 |
|
| 2015 |
Sriskanthadevan S, Jeyaraju DV, Chung TE, Prabha S, Xu W, Skrtic M, Jhas B, Hurren R, Gronda M, Wang X, Jitkova Y, Sukhai MA, Lin FH, Maclean N, Laister R, ... ... Penn LZ, et al. AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress. Blood. 125: 2120-30. PMID 25631767 DOI: 10.1182/Blood-2014-08-594408 |
0.764 |
|
| 2015 |
Dingar D, Kalkat M, Chan PK, Srikumar T, Bailey SD, Tu WB, Coyaud E, Ponzielli R, Kolyar M, Jurisica I, Huang A, Lupien M, Penn LZ, Raught B. BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors. Journal of Proteomics. 118: 95-111. PMID 25452129 DOI: 10.1016/J.Jprot.2014.09.029 |
0.384 |
|
| 2015 |
Tu WB, Helander S, Pilstål R, Hickman KA, Lourenco C, Jurisica I, Raught B, Wallner B, Sunnerhagen M, Penn LZ. Myc and its interactors take shape. Biochimica Et Biophysica Acta. 1849: 469-483. PMID 24933113 DOI: 10.1016/J.Bbagrm.2014.06.002 |
0.424 |
|
| 2015 |
Dingar D, Kalkat M, Chan P, Bailey SD, Srikumar T, Tu WB, Coyaud E, Ponzielli R, Kolyar M, Jurisica I, Huang A, Lupien M, Raught B, Penn LZ. Abstract B04: In vivo BioID identifies novel Myc interacting partners Molecular Cancer Research. 13. DOI: 10.1158/1557-3125.Myc15-B04 |
0.476 |
|
| 2015 |
Tu WB, Stojanova A, Ponzielli R, Kotlyar M, Chan P, Boutros PC, Khosravi F, Jurisica I, Raught B, Penn LZ. Abstract A36: Interaction of the MYC oncoprotein with the tumor suppressive SWI/SNF complex member INI1 Molecular Cancer Research. 13. DOI: 10.1158/1557-3125.Myc15-A36 |
0.402 |
|
| 2015 |
Resetca D, Kalkat M, Lourenco C, Chan P, Srikumar T, Raught B, Penn L. Abstract A12: Identifying MYC post-translational modifications using a mass spectrometry-based approach Molecular Cancer Research. 13. DOI: 10.1158/1557-3125.Myc15-A12 |
0.424 |
|
| 2015 |
Lourenco C, Wasylishen A, Chan-Seng-Yue M, Bros C, Dingar D, Tu W, Kalkat M, Chan P, Mullen P, Raught B, Boutros P, Penn L. Abstract A10: The myc post-translational landscape: How novel gain-of-function mutants are revealing new stability and functional regulatory systems Molecular Cancer Research. 13. DOI: 10.1158/1557-3125.Myc15-A10 |
0.75 |
|
| 2015 |
Kalkat M, Chan P, Wasylishen AR, Srikumar T, Kim SS, Ponzielli R, Bazett-Jones DP, Raught B, Penn LZ. Abstract A08: Identification of c-MYC SUMOylation by mass spectrometry Molecular Cancer Research. 13. DOI: 10.1158/1557-3125.Myc15-A08 |
0.766 |
|
| 2014 |
Pandyra A, Penn LZ. Targeting tumor cell metabolism via the mevalonate pathway: Two hits are better than one. Molecular & Cellular Oncology. 1: e969133. PMID 27308369 DOI: 10.4161/23723548.2014.969133 |
0.41 |
|
| 2014 |
Chan PK, Srikumar T, Dingar D, Kalkat M, Penn LZ, Raught B. BioID data of c-MYC interacting protein partners in cultured cells and xenograft tumors. Data in Brief. 1: 76-8. PMID 26217692 DOI: 10.1016/J.Dib.2014.10.001 |
0.35 |
|
| 2014 |
Kalkat M, Chan PK, Wasylishen AR, Srikumar T, Kim SS, Ponzielli R, Bazett-Jones DP, Raught B, Penn LZ. Identification of c-MYC SUMOylation by mass spectrometry. Plos One. 9: e115337. PMID 25522242 DOI: 10.1371/Journal.Pone.0115337 |
0.76 |
|
| 2014 |
Pandyra A, Mullen PJ, Kalkat M, Yu R, Pong JT, Li Z, Trudel S, Lang KS, Minden MD, Schimmer AD, Penn LZ. Immediate utility of two approved agents to target both the metabolic mevalonate pathway and its restorative feedback loop. Cancer Research. 74: 4772-82. PMID 24994712 DOI: 10.1158/0008-5472.Can-14-0130 |
0.444 |
|
| 2014 |
Goard CA, Chan-Seng-Yue M, Mullen PJ, Quiroga AD, Wasylishen AR, Clendening JW, Sendorek DH, Haider S, Lehner R, Boutros PC, Penn LZ. Identifying molecular features that distinguish fluvastatin-sensitive breast tumor cells. Breast Cancer Research and Treatment. 143: 301-12. PMID 24337703 DOI: 10.1007/S10549-013-2800-Y |
0.786 |
|
| 2014 |
Wasylishen AR, Kalkat M, Kim SS, Pandyra A, Chan PK, Oliveri S, Sedivy E, Konforte D, Bros C, Raught B, Penn LZ. MYC activity is negatively regulated by a C-terminal lysine cluster. Oncogene. 33: 1066-72. PMID 23435422 DOI: 10.1038/Onc.2013.36 |
0.778 |
|
| 2014 |
Kalkat M, Wasylishen A, Chan PM, Pandyra A, Kim SS, Bros C, Raught B, Penn LZ. Abstract 3410: A novel regulatory region of the MYC oncogene decreases Myc transcriptional activity Cancer Research. 74: 3410-3410. DOI: 10.1158/1538-7445.Am2014-3410 |
0.495 |
|
| 2013 |
Wasylishen AR, Chan-Seng-Yue M, Bros C, Dingar D, Tu WB, Kalkat M, Chan PK, Mullen PJ, Huang L, Meyer N, Raught B, Boutros PC, Penn LZ. MYC phosphorylation at novel regulatory regions suppresses transforming activity. Cancer Research. 73: 6504-15. PMID 24030976 DOI: 10.1158/0008-5472.Can-12-4063 |
0.755 |
|
| 2013 |
Ponzielli R, Tu WB, Jurisica I, Penn LZ. Identifying Myc interactors. Methods in Molecular Biology (Clifton, N.J.). 1012: 51-64. PMID 24006057 DOI: 10.1007/978-1-62703-429-6_4 |
0.309 |
|
| 2013 |
Ching RW, Ahmed K, Boutros PC, Penn LZ, Bazett-Jones DP. Identifying gene locus associations with promyelocytic leukemia nuclear bodies using immuno-TRAP. The Journal of Cell Biology. 201: 325-35. PMID 23589495 DOI: 10.1083/Jcb.201211097 |
0.328 |
|
| 2013 |
Dingar D, Wasylishen AR, Chan-Seng-Yue M, Huang L, Bros C, Tu W, Meyer N, Boutros PC, Penn LZ. Abstract LB-117: Myc phosphorylation suppresses transformation through novel regulatory regions. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-117 |
0.482 |
|
| 2013 |
Pong J, Pandyra A, Goard C, Ericson E, Brown K, Ylanko J, Andrews D, Nislow C, Moffat J, Penn L. Abstract PR12: A genome-wide shRNA screen reveals that inhibiting kinases potentiates the anti-breast cancer activity of fluvastatin Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Pms-Pr12 |
0.384 |
|
| 2012 |
Andresen C, Helander S, Lemak A, Farès C, Csizmok V, Carlsson J, Penn LZ, Forman-Kay JD, Arrowsmith CH, Lundström P, Sunnerhagen M. Transient structure and dynamics in the disordered c-Myc transactivation domain affect Bin1 binding. Nucleic Acids Research. 40: 6353-66. PMID 22457068 DOI: 10.1093/Nar/Gks263 |
0.402 |
|
| 2012 |
Clendening JW, Penn LZ. Targeting tumor cell metabolism with statins Oncogene. 31: 4967-4978. PMID 22310279 DOI: 10.1038/Onc.2012.6 |
0.387 |
|
| 2012 |
Sriskanthadevan S, Chung TE, Skrtic M, Jhas B, Hurren R, Gronda M, Wang XM, Jitkova Y, Sukhai MA, Lin F, Maclean N, Laister RC, Mullen P, Xie S, Penn L, et al. AML Cells Have Altered Mitochondrial Biogenesis and Low Spare Reserve Capacity in Their Respiratory Chain That Renders Them Susceptible to Oxidative Metabolic Stress. Blood. 120: 2581-2581. DOI: 10.1182/Blood.V120.21.2581.2581 |
0.387 |
|
| 2011 |
Hakem A, Bohgaki M, Lemmers B, Tai E, Salmena L, Matysiak-Zablocki E, Jung YS, Karaskova J, Kaustov L, Duan S, Madore J, Boutros P, Sheng Y, Chesi M, Bergsagel PL, ... ... Penn L, et al. Role of Pirh2 in mediating the regulation of p53 and c-Myc. Plos Genetics. 7: e1002360. PMID 22125490 DOI: 10.1371/Journal.Pgen.1002360 |
0.402 |
|
| 2011 |
Wasylishen AR, Stojanova A, Oliveri S, Rust AC, Schimmer AD, Penn LZ. New model systems provide insights into Myc-induced transformation. Oncogene. 30: 3727-34. PMID 21441954 DOI: 10.1038/Onc.2011.88 |
0.759 |
|
| 2011 |
Kalkat M, Wasylishen AR, Kim SS, Penn L. More than MAX: Discovering the Myc interactome. Cell Cycle (Georgetown, Tex.). 10: 374-5. PMID 21270515 DOI: 10.4161/Cc.10.3.14645 |
0.731 |
|
| 2011 |
Sriskanthadevan S, Marko S, Livak B, Jitkova Y, Hurren R, Gronda M, Laister R, Mullen P, Penn L, Minden MD, Schimmer AD. AML Cells Have Increased Mitochondrial Mass but Less Reserve in Their Respiratory Chain Complexes Leading to Heightened Sensitivity to Inhibition of Mitochondrial Protein Translation, Blood. 118: 3585-3585. DOI: 10.1182/Blood.V118.21.3585.3585 |
0.362 |
|
| 2011 |
Pandyra A, Sobol P, Sharmeen S, Schimmer A, Penn L. Abstract C170: The combination of statins and dipyridamole is effective preclinically in AML, MM, and breast cancer. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-C170 |
0.485 |
|
| 2011 |
Mullen PJ, Goard CA, Wasylishen AR, Pandyra A, Penn LZ. Abstract C165: Breast cancer, statins, and 3-D cell culture. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-C165 |
0.792 |
|
| 2010 |
Wasylishen AR, Penn LZ. Myc: the beauty and the beast. Genes & Cancer. 1: 532-41. PMID 21779457 DOI: 10.1177/1947601910378024 |
0.714 |
|
| 2010 |
Goard CA, Mather RG, Vinepal B, Clendening JW, Martirosyan A, Boutros PC, Sharom FJ, Penn LZ. Differential interactions between statins and P-glycoprotein: implications for exploiting statins as anticancer agents. International Journal of Cancer. 127: 2936-48. PMID 21351272 DOI: 10.1002/Ijc.25295 |
0.754 |
|
| 2010 |
Luoto KR, Meng AX, Wasylishen AR, Zhao H, Coackley CL, Penn LZ, Bristow RG. Tumor cell kill by c-MYC depletion: role of MYC-regulated genes that control DNA double-strand break repair. Cancer Research. 70: 8748-59. PMID 20940401 DOI: 10.1158/0008-5472.Can-10-0944 |
0.754 |
|
| 2010 |
Clendening JW, Pandyra A, Boutros PC, El Ghamrasni S, Khosravi F, Trentin GA, Martirosyan A, Hakem A, Hakem R, Jurisica I, Penn LZ. Dysregulation of the mevalonate pathway promotes transformation. Proceedings of the National Academy of Sciences of the United States of America. 107: 15051-6. PMID 20696928 DOI: 10.1073/Pnas.0910258107 |
0.427 |
|
| 2010 |
Wong WW, Boutros PC, Wasylishen AR, Guckert KD, O'Brien EM, Griffiths R, Martirosyan AR, Bros C, Jurisica I, Langler RF, Penn LZ. Characterization of the apoptotic response of human leukemia cells to organosulfur compounds. Bmc Cancer. 10: 351. PMID 20598143 DOI: 10.1186/1471-2407-10-351 |
0.73 |
|
| 2010 |
Clendening JW, Pandyra A, Li Z, Boutros PC, Martirosyan A, Lehner R, Jurisica I, Trudel S, Penn LZ. Exploiting the mevalonate pathway to distinguish statin-sensitive multiple myeloma. Blood. 115: 4787-97. PMID 20360469 DOI: 10.1182/Blood-2009-07-230508 |
0.455 |
|
| 2010 |
Martirosyan A, Clendening JW, Goard CA, Penn LZ. Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance. Bmc Cancer. 10: 103. PMID 20298590 DOI: 10.1186/1471-2407-10-103 |
0.788 |
|
| 2009 |
Radziszewska A, Schroer SA, Choi D, Tajmir P, Radulovich N, Ho JC, Wang L, Liadis N, Hakem R, Tsao MS, Penn LZ, Evan GI, Woo M. Absence of caspase-3 protects pancreatic {beta}-cells from c-Myc-induced apoptosis without leading to tumor formation. The Journal of Biological Chemistry. 284: 10947-56. PMID 19213729 DOI: 10.1074/Jbc.M806960200 |
0.446 |
|
| 2009 |
Boutros PC, Lau SK, Pintilie M, Liu N, Shepherd FA, Der SD, Tsao MS, Penn LZ, Jurisica I. Prognostic gene signatures for non-small-cell lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 106: 2824-8. PMID 19196983 DOI: 10.1073/Pnas.0809444106 |
0.325 |
|
| 2009 |
Penn LZ, Clendening JW, Pandyra A, Boutros PC, Trentin GA, Martirosyan A, Trudel S, Jurisica I. Abstract B99: Dysregulation of HMGCR and the mevalonate pathway in human cancers Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-B99 |
0.446 |
|
| 2009 |
Collins T, Wasylishen A, Penn L, Andrews D. Abstract A170: High‐content screening for inhibitors of oncogenic transcription by c‐Myc Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-A170 |
0.423 |
|
| 2008 |
Meyer N, Penn LZ. Reflecting on 25 years with MYC. Nature Reviews. Cancer. 8: 976-90. PMID 19029958 DOI: 10.1038/Nrc2231 |
0.358 |
|
| 2008 |
Beheshti Zavareh R, Lau KS, Hurren R, Datti A, Ashline DJ, Gronda M, Cheung P, Simpson CD, Liu W, Wasylishen AR, Boutros PC, Shi H, Vengopal A, Jurisica I, Penn LZ, et al. Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function. Cancer Research. 68: 6688-97. PMID 18701493 DOI: 10.1158/0008-5472.Can-07-6833 |
0.715 |
|
| 2008 |
Ray JB, Arab S, Deng Y, Liu P, Penn L, Courtman DW, Ward ME. Oxygen regulation of arterial smooth muscle cell proliferation and survival. American Journal of Physiology. Heart and Circulatory Physiology. 294: H839-52. PMID 18055518 DOI: 10.1152/Ajpheart.00587.2007 |
0.385 |
|
| 2007 |
Lau SK, Boutros PC, Pintilie M, Blackhall FH, Zhu CQ, Strumpf D, Johnston MR, Darling G, Keshavjee S, Waddell TK, Liu N, Lau D, Penn LZ, Shepherd FA, Jurisica I, et al. Three-gene prognostic classifier for early-stage non small-cell lung cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 25: 5562-9. PMID 18065728 DOI: 10.1200/Jco.2007.12.0352 |
0.312 |
|
| 2007 |
Kim SS, Shago M, Kaustov L, Boutros PC, Clendening JW, Sheng Y, Trentin GA, Barsyte-Lovejoy D, Mao DY, Kay R, Jurisica I, Arrowsmith CH, Penn LZ. CUL7 is a novel antiapoptotic oncogene. Cancer Research. 67: 9616-22. PMID 17942889 DOI: 10.1158/0008-5472.Can-07-0644 |
0.463 |
|
| 2007 |
Zhu CQ, Popova SN, Brown ER, Barsyte-Lovejoy D, Navab R, Shih W, Li M, Lu M, Jurisica I, Penn LZ, Gullberg D, Tsao MS. Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 11754-9. PMID 17600088 DOI: 10.1073/Pnas.0703040104 |
0.325 |
|
| 2007 |
Wong WW, Clendening JW, Martirosyan A, Boutros PC, Bros C, Khosravi F, Jurisica I, Stewart AK, Bergsagel PL, Penn LZ. Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma. Molecular Cancer Therapeutics. 6: 1886-97. PMID 17575117 DOI: 10.1158/1535-7163.Mct-06-0745 |
0.477 |
|
| 2007 |
Zhu C, Popova S, Brown ER, Barsyte-Lovejoy D, Navab R, Shih W, Li M, Penn L, Gullberg D, Tsao M. P2-036: Novel mechanism of collagen-tumor cell interaction by integrin alpha-11 expression by cancer associated fibroblasts in non-small cell lung cancer cells Journal of Thoracic Oncology. 2: S496. DOI: 10.1097/01.Jto.0000283478.00088.2C |
0.391 |
|
| 2006 |
Bachtiary B, Boutros PC, Pintilie M, Shi W, Bastianutto C, Li JH, Schwock J, Zhang W, Penn LZ, Jurisica I, Fyles A, Liu FF. Gene expression profiling in cervical cancer: an exploration of intratumor heterogeneity. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 5632-40. PMID 17020965 DOI: 10.1158/1078-0432.Ccr-06-0357 |
0.328 |
|
| 2006 |
Meyer N, Kim SS, Penn LZ. The Oscar-worthy role of Myc in apoptosis. Seminars in Cancer Biology. 16: 275-87. PMID 16945552 DOI: 10.1016/J.Semcancer.2006.07.011 |
0.451 |
|
| 2006 |
Barsyte-Lovejoy D, Lau SK, Boutros PC, Khosravi F, Jurisica I, Andrulis IL, Tsao MS, Penn LZ. The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis. Cancer Research. 66: 5330-7. PMID 16707459 DOI: 10.1158/0008-5472.Can-06-0037 |
0.434 |
|
| 2006 |
Zhang W, Hirschler-Laszkiewicz I, Tong Q, Conrad K, Sun SC, Penn L, Barber DL, Stahl R, Carey DJ, Cheung JY, Miller BA. TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage. American Journal of Physiology. Cell Physiology. 290: C1146-59. PMID 16306129 DOI: 10.1152/Ajpcell.00205.2005 |
0.357 |
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| 2005 |
Ponzielli R, Katz S, Barsyte-Lovejoy D, Penn LZ. Cancer therapeutics: targeting the dark side of Myc. European Journal of Cancer (Oxford, England : 1990). 41: 2485-501. PMID 16243519 DOI: 10.1016/J.Ejca.2005.08.017 |
0.496 |
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| 2005 |
Tomlin JL, Guinn BA, Penn LZ, Berinstein NL. Bcl-2 and c-Myc co-operate in the Epstein-Barr virus-immortalized human B-cell line GM607 but do not confer tumorigenicity. Leukemia & Lymphoma. 46: 581-92. PMID 16019487 DOI: 10.1080/10428190400019867 |
0.44 |
|
| 2005 |
Huang A, Ho CS, Ponzielli R, Barsyte-Lovejoy D, Bouffet E, Picard D, Hawkins CE, Penn LZ. Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells. Cancer Research. 65: 5607-19. PMID 15994933 DOI: 10.1158/0008-5472.Can-05-0500 |
0.664 |
|
| 2005 |
Pineda-Lucena A, Ho CS, Mao DY, Sheng Y, Laister RC, Muhandiram R, Lu Y, Seet BT, Katz S, Szyperski T, Penn LZ, Arrowsmith CH. A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants. Journal of Molecular Biology. 351: 182-94. PMID 15992821 DOI: 10.1016/J.Jmb.2005.05.046 |
0.628 |
|
| 2005 |
Annis MG, Soucie EL, Dlugosz PJ, Cruz-Aguado JA, Penn LZ, Leber B, Andrews DW. Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis. The Embo Journal. 24: 2096-103. PMID 15920484 DOI: 10.1038/Sj.Emboj.7600675 |
0.757 |
|
| 2005 |
Griffiths R, Wong WWL, Fletcher SP, Penn LZ, Langler RF. Novel disulfides with antitumour efficacy and specificity Australian Journal of Chemistry. 58: 128-136. DOI: 10.1071/Ch03105 |
0.38 |
|
| 2005 |
Soucie EL, Evan G, Penn LZ. Apoptosis and cancer Apoptosis in Health and Disease: Clinical and Therapeutic Aspects. 75-95. DOI: 10.1017/CBO9780511663543.004 |
0.77 |
|
| 2004 |
Wu J, Wong WW, Khosravi F, Minden MD, Penn LZ. Blocking the Raf/MEK/ERK pathway sensitizes acute myelogenous leukemia cells to lovastatin-induced apoptosis. Cancer Research. 64: 6461-8. PMID 15374955 DOI: 10.1158/0008-5472.Can-04-0866 |
0.417 |
|
| 2004 |
Mao DY, Barsyte-Lovejoy D, Ho CS, Watson JD, Stojanova A, Penn LZ. Promoter-binding and repression of PDGFRB by c-Myc are separable activities. Nucleic Acids Research. 32: 3462-8. PMID 15226411 DOI: 10.1093/Nar/Gkh669 |
0.632 |
|
| 2004 |
Stojanova A, Caro C, Jarjour RJ, Oster SK, Penn LZ, Germinario RJ. Repression of the human immunodeficiency virus type-1 long terminal repeat by the c-Myc oncoprotein. Journal of Cellular Biochemistry. 92: 400-13. PMID 15108364 DOI: 10.1002/Jcb.20065 |
0.78 |
|
| 2004 |
Barsyte-Lovejoy D, Mao DY, Penn LZ. c-Myc represses the proximal promoters of GADD45a and GADD153 by a post-RNA polymerase II recruitment mechanism. Oncogene. 23: 3481-6. PMID 15021909 DOI: 10.1038/Sj.Onc.1207487 |
0.423 |
|
| 2003 |
Janumyan YM, Sansam CG, Chattopadhyay A, Cheng N, Soucie EL, Penn LZ, Andrews D, Knudson CM, Yang E. Bcl-xL/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry. The Embo Journal. 22: 5459-70. PMID 14532118 DOI: 10.1093/Emboj/Cdg533 |
0.76 |
|
| 2003 |
Mao DY, Watson JD, Yan PS, Barsyte-Lovejoy D, Khosravi F, Wong WW, Farnham PJ, Huang TH, Penn LZ. Analysis of Myc bound loci identified by CpG island arrays shows that Max is essential for Myc-dependent repression. Current Biology : Cb. 13: 882-6. PMID 12747840 DOI: 10.1016/S0960-9822(03)00297-5 |
0.466 |
|
| 2003 |
Oster SK, Mao DY, Kennedy J, Penn LZ. Functional analysis of the N-terminal domain of the Myc oncoprotein. Oncogene. 22: 1998-2010. PMID 12673205 DOI: 10.1038/Sj.Onc.1206228 |
0.808 |
|
| 2003 |
Janumyan YM, Sansam CG, Chattopadhyay A, Cheng N, Soucie EL, Penn LZ, Andrews D, Knudson CM, Yang E. Bcl-xL/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry Embo Journal. 22: 5459-5470. DOI: 10.1093/emboj/cdg533 |
0.772 |
|
| 2002 |
Watson JD, Oster SK, Shago M, Khosravi F, Penn LZ. Identifying genes regulated in a Myc-dependent manner. The Journal of Biological Chemistry. 277: 36921-30. PMID 12145275 DOI: 10.1074/Jbc.M201493200 |
0.803 |
|
| 2002 |
Dimitroulakos J, Marhin WH, Tokunaga J, Irish J, Gullane P, Penn LZ, Kamel-Reid S. Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas. Neoplasia (New York, N.Y.). 4: 337-46. PMID 12082550 DOI: 10.1038/Sj.Neo.7900247 |
0.491 |
|
| 2002 |
Wong WWL, Dimitroulakos J, Minden MD, Penn LZ. HMG-CoA reductase inhibitors and the malignant cell: The statin family of drugs as triggers of tumor-specific apoptosis Leukemia. 16: 508-519. PMID 11960327 DOI: 10.1038/Sj.Leu.2402476 |
0.429 |
|
| 2002 |
Oster SK, Ho CS, Soucie EL, Penn LZ. The myc oncogene: MarvelouslY Complex. Advances in Cancer Research. 84: 81-154. PMID 11885563 DOI: 10.1016/S0065-230X(02)84004-0 |
0.801 |
|
| 2001 |
Penn LZ. Apoptosis modulators as cancer therapeutics Current Opinion in Investigational Drugs. 2: 684-692. PMID 11569948 |
0.346 |
|
| 2001 |
Xia Z, Tan MM, Wei-Lynn Wong W, Dimitroulakos J, Minden MD, Penn LZ. Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells Leukemia. 15: 1398-1407. PMID 11516100 DOI: 10.1038/Sj.Leu.2402196 |
0.437 |
|
| 2001 |
Wong WW, Tan MM, Xia Z, Dimitroulakos J, Minden MD, Penn LZ. Cerivastatin triggers tumor-specific apoptosis with higher efficacy than lovastatin. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 7: 2067-75. PMID 11448925 |
0.307 |
|
| 2001 |
Hirst M, Ho C, Sabourin L, Rudnicki M, Penn L, Sadowski I. A two-hybrid system for transactivator bait proteins Proceedings of the National Academy of Sciences of the United States of America. 98: 8726-8731. PMID 11447261 DOI: 10.1073/Pnas.141413598 |
0.595 |
|
| 2001 |
Dimitroulakos J, Thai S, Wasfy GH, Hedley DW, Minden MD, Penn LZ. Lovastatin induces a pronounced differentiation response in acute myeloid leukemias Leukemia and Lymphoma. 40: 167-178. PMID 11426618 DOI: 10.3109/10428190009054894 |
0.406 |
|
| 2001 |
Minden MD, Dimitroulakos J, Nohynek D, Penn LZ. Lovastatin induced control of blast cell growth in an elderly patient with acute myeloblastic leukemia Leukemia and Lymphoma. 40: 659-662. PMID 11426537 DOI: 10.3109/10428190109097663 |
0.345 |
|
| 2001 |
Soucie EL, Annis MG, Sedivy J, Filmus J, Leber B, Andrews DW, Penn LZ. Myc potentiates apoptosis by stimulating Bax activity at the mitochondria. Molecular and Cellular Biology. 21: 4725-36. PMID 11416148 DOI: 10.1128/Mcb.21.14.4725-4736.2001 |
0.796 |
|
| 2001 |
Annis MG, Zamzami N, Zhu W, Penn LZ, Kroemer G, Leber B, Andrews DW. Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event. Oncogene. 20: 1939-52. PMID 11360178 DOI: 10.1038/Sj.Onc.1204288 |
0.393 |
|
| 2001 |
Dimitroulakos J, Ye LY, Benzaquen M, Moore MJ, Kamel-Reid S, Freedman MH, Yeger H, Penn LZ. Differential sensitivity of various pediatric cancers and squamous cell carcinomas to lovastatin-induced apoptosis: Therapeutic implications Clinical Cancer Research. 7: 158-167. PMID 11205904 |
0.394 |
|
| 2000 |
Fang X, Yu S, LaPushin R, Lu Y, Furui T, Penn LZ, Stokoe D, Erickson JR, Bast RC, Mills GB. Lysophosphatidic acid prevents apoptosis in fibroblasts via G(i)-protein-mediated activation of mitogen-activated protein kinase. The Biochemical Journal. 352: 135-43. PMID 11062066 DOI: 10.1042/0264-6021:3520135 |
0.352 |
|
| 2000 |
Oster SK, Marhin WW, Asker C, Facchini LM, Dion PA, Funa K, Post M, Sedivy JM, Penn LZ. Myc is an essential negative regulator of platelet-derived growth factor beta receptor expression. Molecular and Cellular Biology. 20: 6768-78. PMID 10958674 DOI: 10.1128/Mcb.20.18.6768-6778.2000 |
0.781 |
|
| 2000 |
Wong WWL, Macdonald S, Langler RF, Penn LZ. Novel synthetic organosulfur compounds induce apoptosis of human leukemic cells Anticancer Research. 20: 1367-1374. PMID 10928045 DOI: 10.5167/Uzh-58183 |
0.388 |
|
| 2000 |
Landay M, Oster SK, Khosravi F, Grove LE, Yin X, Sedivy J, Penn LZ, Prochownik EV. Promotion of growth and apoptosis in c-myc nullizygous fibroblasts by other members of the myc oncoprotein family. Cell Death and Differentiation. 7: 697-705. PMID 10918443 DOI: 10.1038/Sj.Cdd.4400701 |
0.813 |
|
| 1999 |
Lee ST, Hoeflich KP, Wasfy GW, Woodgett JR, Leber B, Andrews DW, Hedley DW, Penn LZ. Bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by Myc but not etoposide in Rat-1 fibroblasts. Oncogene. 18: 3520-8. PMID 10376530 DOI: 10.1038/Sj.Onc.1202716 |
0.401 |
|
| 1999 |
Dimitroulakos J, Nohynek D, Backway KL, Medley DW, Yeger H, Freedman MH, Minden MD, Penn LZ. Increased sensitivity of acute myeloid leukemias to lovastatin-induced apoptosis: A potential therapeutic approach Blood. 93: 1308-1318. PMID 9949174 DOI: 10.1182/Blood.V93.4.1308.404K08_1308_1318 |
0.439 |
|
| 1998 |
Amundson SA, Zhan Q, Penn LZ, Fornace AJ. Myc suppresses induction of the growth arrest genes gadd34, gadd45, and gadd153 by DNA-damaging agents Oncogene. 17: 2149-2154. PMID 9811446 |
0.342 |
|
| 1998 |
Gonzalez AD, Kaya M, Shi W, Song H, Testa JR, Penn LZ, Filmus J. OCI-5/GPC3, a glypican encoded by a gene that is mutated in the Simpson- Golabi-Behmel overgrowth syndrome, induces apoptosis in a cell line-specific manner Journal of Cell Biology. 141: 1407-1414. PMID 9628896 DOI: 10.1083/Jcb.141.6.1407 |
0.45 |
|
| 1998 |
Facchini LM, Penn LZ. The molecular role of Myc in growth and transformation: Recent discoveries lead to new insights Faseb Journal. 12: 633-651. PMID 9619443 DOI: 10.1096/Fasebj.12.9.633 |
0.485 |
|
| 1998 |
Penn LZ. Advances in the understanding of apoptosis Leukemia and Lymphoma. 30: 59-60. DOI: 10.3109/10428199809058638 |
0.335 |
|
| 1997 |
Marhin WW, Chen S, Facchini LM, Fornace AJ, Penn LZ. Myc represses the growth arrest gene gadd45 Oncogene. 14: 2825-2834. PMID 9190899 DOI: 10.1038/Sj.Onc.1201138 |
0.483 |
|
| 1997 |
Screaton RA, Penn LZ, Stanners CP. Carcinoembryonic antigen, a human tumor marker, cooperates with Myc and Bcl-2 in cellular transformation. The Journal of Cell Biology. 137: 939-52. PMID 9151695 DOI: 10.1083/Jcb.137.4.939 |
0.456 |
|
| 1997 |
Facchini LM, Chen S, Marhin WW, Lear JN, Penn LZ. The Myc negative autoregulation mechanism requires Myc-Max association and involves the c-myc P2 minimal promoter Molecular and Cellular Biology. 17: 100-114. PMID 8972190 DOI: 10.1128/Mcb.17.1.100 |
0.478 |
|
| 1996 |
Zhu W, Cowie A, Wasfy GW, Penn LZ, Leber B, Andrews DW. Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types. The Embo Journal. 15: 4130-41. PMID 8861942 DOI: 10.1002/J.1460-2075.1996.Tb00788.X |
0.419 |
|
| 1996 |
Zhu W, Cowie A, Wasfy GW, Penn LZ, Leber B, Andrews DW. BCL-2 mutants with restricted sub-cellular location reveal spatially distinct pathways for apoptosis in different cell types Faseb Journal. 10. |
0.301 |
|
| 1995 |
Shi Y, Frankel A, Mills GB, Radvanyi LG, Miller RG, Penn LZ. Rapamycin Enhances Apoptosis and Increases Sensitivity to Cisplatin in Vitro Cancer Research. 55: 1982-1988. PMID 7728769 |
0.38 |
|
| 1992 |
Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, Waters CM, Penn LZ, Hancock DC. Induction of apoptosis in fibroblasts by c-myc protein Cell. 69: 119-128. PMID 1555236 DOI: 10.1016/0092-8674(92)90123-T |
0.468 |
|
| 1990 |
Penn L, Brooks M, Laufer E, Land H. Negative autoregulation of c-myc transcription. The Embo Journal. 9: 1113-1121. DOI: 10.1002/J.1460-2075.1990.Tb08217.X |
0.346 |
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