| Year |
Citation |
Score |
| 2021 |
Brem J, Panduwawala T, Hansen JU, Hewitt J, Liepins E, Donets P, Espina L, Farley AJM, Shubin K, Campillos GG, Kiuru P, Shishodia S, Krahn D, Leśniak RK, Schmidt Adrian J, et al. Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors. Nature Chemistry. PMID 34903857 DOI: 10.1038/s41557-021-00831-x |
0.631 |
|
| 2021 |
Newman H, Krajnc A, Bellini D, Eyermann CJ, Boyle GA, Paterson NG, McAuley KE, Lesniak R, Gangar M, von Delft F, Brem J, Chibale K, Schofield CJ, Dowson CG. High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes. Journal of Medicinal Chemistry. PMID 34337941 DOI: 10.1021/acs.jmedchem.1c00717 |
0.546 |
|
| 2019 |
Leśniak RK, Rydzik AM, Kamps JJAG, Kahn A, Claridge TDW, Schofield CJ. F NMR studies on γ-butyrobetaine hydroxylase provide mechanistic insights and suggest a dual inhibition mode. Chemical Communications (Cambridge, England). PMID 31702759 DOI: 10.1039/C9Cc06466D |
0.423 |
|
| 2018 |
Bush JT, Leśniak RK, Yeh TL, Belle R, Kramer H, Tumber A, Chowdhury R, Flashman E, Mecinović J, Schofield CJ. Small-molecules that covalently react with a human prolyl hydroxylase - towards activity modulation and substrate capture. Chemical Communications (Cambridge, England). PMID 30452037 DOI: 10.1039/C8Cc07706A |
0.682 |
|
| 2018 |
Markolovic S, Zhuang Q, Wilkins SE, Eaton CD, Abboud MI, Katz MJ, McNeil HE, Leśniak RK, Hall C, Struwe WB, Konietzny R, Davis S, Yang M, Ge W, Benesch JLP, et al. Publisher Correction: The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases. Nature Chemical Biology. PMID 29950663 DOI: 10.1038/S41589-018-0104-6 |
0.491 |
|
| 2018 |
Markolovic S, Zhuang Q, Wilkins SE, Eaton CD, Abboud MI, Katz MJ, McNeil HE, Leśniak RK, Hall C, Struwe WB, Konietzny R, Davis S, Yang M, Ge W, Benesch JLP, et al. The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases. Nature Chemical Biology. 14: 688-695. PMID 29915238 DOI: 10.1038/S41589-018-0071-Y |
0.604 |
|
| 2017 |
Li GB, Brem J, Lesniak R, Abboud MI, Lohans CT, Clifton IJ, Yang SY, Jiménez-Castellanos JC, Avison MB, Spencer J, McDonough MA, Schofield CJ. Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-β-lactamase inhibition. Chemical Communications (Cambridge, England). PMID 28470248 DOI: 10.1039/C7Cc02394D |
0.668 |
|
| 2016 |
Leśniak RK, Markolovic S, Tars K, Schofield CJ. Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-N(ε)-trimethyllysine. Chemical Communications (Cambridge, England). PMID 27965989 DOI: 10.1039/C6Cc08381A |
0.335 |
|
| 2016 |
Khan A, Leśniak RK, Brem J, Rydzik AM, Choi H, Leung IKH, McDonough MA, Schofield CJ, Claridge TDW. Development and application of ligand-based NMR screening assays for γ-butyrobetaine hydroxylase Medchemcomm. 7: 873-880. DOI: 10.1039/C6Md00004E |
0.588 |
|
| 2016 |
Kamps JJAG, Khan A, Choi H, Lesniak RK, Brem J, Rydzik AM, McDonough MA, Schofield CJ, Claridge TDW, Mecinović J. Frontispiece: Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis Chemistry - a European Journal. 22. DOI: 10.1002/Chem.201680462 |
0.662 |
|
| 2015 |
Kamps JJ, Khan A, Choi H, Lesniak RK, Brem J, Rydzik AM, McDonough MA, Schofield CJ, Claridge TD, Mecinović J. Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 26660433 DOI: 10.1002/Chem.201503761 |
0.682 |
|
| 2015 |
Chen P, Chaikuad A, Bamborough P, Bantscheff M, Bountra C, Chung CW, Fedorov O, Grandi P, Jung D, Lesniak R, Lindon M, Müller S, Philpott M, Prinjha R, Rogers C, et al. Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B. Journal of Medicinal Chemistry. PMID 25799074 DOI: 10.1021/Acs.Jmedchem.5B00209 |
0.684 |
|
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