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Rasheduzzaman Chowdhury - Publications

Affiliations: 
University of Oxford, Oxford, United Kingdom 
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71 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Figg WD, Fiorini G, Chowdhury R, Nakashima Y, Tumber A, McDonough MA, Schofield CJ. Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2. Proteins. PMID 37449559 DOI: 10.1002/prot.26541  0.656
2022 Islam MS, Markoulides M, Chowdhury R, Schofield CJ. Structural analysis of the 2-oxoglutarate binding site of the circadian rhythm linked oxygenase JMJD5. Scientific Reports. 12: 20680. PMID 36450832 DOI: 10.1038/s41598-022-24154-0  0.823
2022 Leissing TM, Hardy AP, Chan H, Wang Y, Tumber A, Chowdhury R, Fang P, Coleman ML, Cockman ME, Kramer HB, Berridge G, Fischer R, Kessler BM, Ratcliffe PJ, Lu X, et al. Factor inhibiting HIF can catalyse two asparaginyl-hydroxylations in VNVN motifs of ankyrin fold proteins. The Journal of Biological Chemistry. 102020. PMID 35537551 DOI: 10.1016/j.jbc.2022.102020  0.671
2022 Chowdhury R, Abboud MI, Wiley J, Tumber A, Markolovic S, Schofield CJ. Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans. Scientific Reports. 12: 6065. PMID 35410347 DOI: 10.1038/s41598-022-10028-y  0.517
2021 Brasnett A, Pfeffer I, Brewitz L, Chowdhury R, Nakashima Y, Tumber A, McDonough MA, Schofield CJ. Human Oxygenase Variants Employing a Single Protein Fe Ligand Are Catalytically Active. Angewandte Chemie (Weinheim An Der Bergstrasse, Germany). 133: 14778-14784. PMID 38505373 DOI: 10.1002/ange.202103711  0.474
2021 Islam MS, Thinnes C, Holt-Martyn J, Chowdhury R, McDonough M, Schofield C. Inhibition of JMJD6 by 2-Oxoglutarate Mimics. Chemmedchem. PMID 34581506 DOI: 10.1002/cmdc.202100398  0.606
2021 Brasnett A, Pfeffer I, Brewitz L, Chowdhury R, Nakashima Y, Tumber A, McDonough MA, Schofield C. Human oxygenase variants employing a single protein Fe(II) ligand are catalytically active. Angewandte Chemie (International Ed. in English). PMID 33887099 DOI: 10.1002/anie.202103711  0.628
2021 Figg WD, McDonough MA, Chowdhury R, Nakashima YA, Zhang ZA, Holt-Martyn JP, Krajnc A, Schofield C. Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat. Chemmedchem. PMID 33792169 DOI: 10.1002/cmdc.202100133  0.657
2020 Choi H, Hardy AP, Leissing TM, Chowdhury R, Nakashima Y, Ge W, Markoulides M, Scotti JS, Gerken PA, Thorbjornsrud H, Kang D, Hong S, Lee J, McDonough MA, Park H, et al. A human protein hydroxylase that accepts D-residues. Communications Chemistry. 3: 52. PMID 36703414 DOI: 10.1038/s42004-020-0290-5  0.77
2020 Chowdhury R, Abboud MI, McAllister TE, Banerji B, Bhushan B, Sorensen JL, Kawamura A, Schofield CJ. Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2. Scientific Reports. 10: 21964. PMID 33319810 DOI: 10.1038/s41598-020-76307-8  0.762
2020 Liu T, Abboud MI, Chowdhury R, Tumber A, Hardy AP, Lippl K, Lohans CT, Pires E, Wickens J, McDonough MA, West CM, Schofield CJ. Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii. The Journal of Biological Chemistry. PMID 32934009 DOI: 10.1074/Jbc.Ra120.013998  0.813
2019 Holt-Martyn J, Chowdhury R, Tumber A, Yeh TL, Abboud MI, Lippl K, Lohans C, Langley G, McDonough M, Pugh C, Ratcliffe P, Schofield C. Structure-Activity Relationship and Crystallographic Studies On 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors. Chemmedchem. PMID 31751494 DOI: 10.1002/Cmdc.201900557  0.778
2019 Islam MS, McDonough MA, Chowdhury R, Gault J, Khan A, Pires E, Schofield CJ. Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6. The Journal of Biological Chemistry. PMID 31147442 DOI: 10.1074/Jbc.Ra119.008693  0.687
2019 Holt-Martyn JP, Tumber A, Rahman MZ, Lippl K, Figg W, McDonough MA, Chowdhury R, Schofield CJ. Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors. Medchemcomm. 10: 500-504. PMID 31057728 DOI: 10.1039/C8Md00548F  0.671
2018 Lippl K, Boleininger A, McDonough MA, Abboud MI, Tarhonskaya H, Chowdhury R, Loenarz C, Schofield CJ. Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal . Hypoxia (Auckland, N.Z.). 6: 57-71. PMID 30519597 DOI: 10.2147/Hp.S174655  0.774
2018 Bush JT, Leśniak RK, Yeh TL, Belle R, Kramer H, Tumber A, Chowdhury R, Flashman E, Mecinović J, Schofield CJ. Small-molecules that covalently react with a human prolyl hydroxylase - towards activity modulation and substrate capture. Chemical Communications (Cambridge, England). PMID 30452037 DOI: 10.1039/C8Cc07706A  0.802
2018 Walport LJ, Hopkinson RJ, Chowdhury R, Zhang Y, Bonnici J, Schiller R, Kawamura A, Schofield CJ. Mechanistic and Structural Studies of KDM-Catalysed Demethylation of Histone 1 Isotype 4 at Lysine 26. Febs Letters. PMID 30156264 DOI: 10.1002/1873-3468.13231  0.614
2018 Abboud M, Chowdhury R, Leung I, Lippl K, Loenarz C, Claridge TDW, Schofield C. Studies on the Substrate Selectivity of the Hypoxia-Inducible Factor Prolyl Hydroxylase 2 Catalytic Domain. Chembiochem : a European Journal of Chemical Biology. PMID 30144273 DOI: 10.1002/Cbic.201800246  0.785
2018 Markolovic S, Zhuang Q, Wilkins SE, Eaton CD, Abboud MI, Katz MJ, McNeil HE, Leśniak RK, Hall C, Struwe WB, Konietzny R, Davis S, Yang M, Ge W, Benesch JLP, ... ... Chowdhury R, et al. Publisher Correction: The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases. Nature Chemical Biology. PMID 29950663 DOI: 10.1038/S41589-018-0104-6  0.742
2018 Markolovic S, Zhuang Q, Wilkins SE, Eaton CD, Abboud MI, Katz MJ, McNeil HE, Leśniak RK, Hall C, Struwe WB, Konietzny R, Davis S, Yang M, Ge W, Benesch JLP, ... ... Chowdhury R, et al. The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases. Nature Chemical Biology. 14: 688-695. PMID 29915238 DOI: 10.1038/S41589-018-0071-Y  0.804
2018 McAllister TE, Yeh TL, Abboud MI, Leung IKH, Hookway ES, King ONF, Bhushan B, Williams ST, Hopkinson RJ, Münzel M, Loik ND, Chowdhury R, Oppermann U, Claridge TDW, Goto Y, et al. Non-competitive cyclic peptides for targeting enzyme-substrate complexes. Chemical Science. 9: 4569-4578. PMID 29899950 DOI: 10.1039/C8Sc00286J  0.734
2018 Wilkins SE, Islam MS, Gannon JM, Markolovic S, Hopkinson RJ, Ge W, Schofield CJ, Chowdhury R. Publisher Correction: JMJD5 is a human arginyl C-3 hydroxylase. Nature Communications. 9: 1675. PMID 29686330 DOI: 10.1038/S41467-018-04196-7  0.405
2018 Wilkins SE, Islam S, Gannon JM, Markolovic S, Hopkinson RJ, Ge W, Schofield CJ, Chowdhury R. JMJD5 is a human arginyl C-3 hydroxylase. Nature Communications. 9: 1180. PMID 29563586 DOI: 10.1038/S41467-018-03410-W  0.569
2018 Abboud MI, McAllister TE, Leung IKH, Chowdhury R, Jorgensen C, Domene C, Mecinović J, Lippl K, Hancock RL, Hopkinson RJ, Kawamura A, Claridge TDW, Schofield CJ. 2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2. Chemical Communications (Cambridge, England). PMID 29522057 DOI: 10.1039/C8Cc00387D  0.769
2018 Islam MS, Leissing TM, Chowdhury R, Hopkinson RJ, Schofield CJ. 2-Oxoglutarate-Dependent Oxygenases. Annual Review of Biochemistry. PMID 29494239 DOI: 10.1146/Annurev-Biochem-061516-044724  0.483
2017 Yeh TL, Leissing TM, Abboud MI, Thinnes CC, Atasoylu O, Holt-Martyn JP, Zhang D, Tumber A, Lippl K, Lohans CT, Leung IKH, Morcrette H, Clifton IJ, Claridge TDW, Kawamura A, ... ... Chowdhury R, et al. Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials. Chemical Science. 8: 7651-7668. PMID 29435217 DOI: 10.1039/C7Sc02103H  0.82
2017 Kawamura A, Münzel M, Kojima T, Yapp C, Bhushan B, Goto Y, Tumber A, Katoh T, King ON, Passioura T, Walport LJ, Hatch SB, Madden S, Müller S, Brennan PE, ... Chowdhury R, et al. Highly selective inhibition of histone demethylases by de novo macrocyclic peptides. Nature Communications. 8: 14773. PMID 28382930 DOI: 10.1038/Ncomms14773  0.739
2016 Chowdhury R, Leung IK, Tian YM, Abboud MI, Ge W, Domene C, Cantrelle FX, Landrieu I, Hardy AP, Pugh CW, Ratcliffe PJ, Claridge TD, Schofield CJ. Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nature Communications. 7: 12673. PMID 27561929 DOI: 10.1038/Ncomms12673  0.705
2016 Walport LJ, Hopkinson RJ, Chowdhury R, Schiller R, Ge W, Kawamura A, Schofield CJ. Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases. Nature Communications. 7: 11974. PMID 27337104 DOI: 10.1038/Ncomms11974  0.638
2016 Markolovic S, Leissing TM, Chowdhury R, Wilkins SE, Lu X, Schofield CJ. Structure-function relationships of human JmjC oxygenases-demethylases versus hydroxylases. Current Opinion in Structural Biology. 41: 62-72. PMID 27309310 DOI: 10.1016/J.Sbi.2016.05.013  0.5
2015 Chan MC, Atasoylu O, Hodson E, Tumber A, Leung IK, Chowdhury R, Gómez-Pérez V, Demetriades M, Rydzik AM, Holt-Martyn J, Tian YM, Bishop T, Claridge TD, Kawamura A, Pugh CW, et al. Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain. Plos One. 10: e0132004. PMID 26147748 DOI: 10.1371/Journal.Pone.0132004  0.651
2015 Böttger A, Islam MS, Chowdhury R, Schofield CJ, Wolf A. The oxygenase Jmjd6--a case study in conflicting assignments. The Biochemical Journal. 468: 191-202. PMID 25997831 DOI: 10.1042/Bj20150278  0.668
2015 Wilkins SE, Flashman E, Scotti JS, Hopkinson RJ, Chowdhury R, Schofield CJ. The role of 2-oxoglutarate-dependent oxygenases in hypoxia sensing Rsc Metallobiology. 2015: 169-209. DOI: 10.1039/9781782621959-00169  0.387
2015 Aik WS, Chowdhury R, Clifton IJ, Hopkinson RJ, Leissing T, McDonough MA, Nowak R, Schofield CJ, Walport LJ. Introduction to structural studies on 2-oxoglutarate-dependent oxygenases and related enzymes Rsc Metallobiology. 2015: 59-94. DOI: 10.1039/9781782621959-00059  0.695
2014 Gardie B, Percy MJ, Hoogewijs D, Chowdhury R, Bento C, Arsenault PR, Richard S, Almeida H, Ewing J, Lambert F, McMullin MF, Schofield CJ, Lee FS. The role of PHD2 mutations in the pathogenesis of erythrocytosis. Hypoxia (Auckland, N.Z.). 2: 71-90. PMID 27774468 DOI: 10.2147/Hp.S54455  0.503
2014 Rydzik AM, Chowdhury R, Kochan GT, Williams ST, McDonough MA, Kawamura A, Schofield CJ. Modulating carnitine levels by targeting its biosynthesis pathway - selective inhibition of γ-butyrobetaine hydroxylase. Chemical Science (Royal Society of Chemistry : 2010). 5: 1765-1771. PMID 26682037 DOI: 10.1039/C4Sc00020J  0.729
2014 Williams ST, Walport LJ, Hopkinson RJ, Madden SK, Chowdhury R, Schofield CJ, Kawamura A. Studies on the catalytic domains of multiple JmjC oxygenases using peptide substrates. Epigenetics. 9: 1596-603. PMID 25625844 DOI: 10.4161/15592294.2014.983381  0.671
2014 Tarhonskaya H, Chowdhury R, Leung IK, Loik ND, McCullagh JS, Claridge TD, Schofield CJ, Flashman E. Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen. The Biochemical Journal. 463: 363-72. PMID 25120187 DOI: 10.1042/Bj20140779  0.512
2014 Thinnes CC, England KS, Kawamura A, Chowdhury R, Schofield CJ, Hopkinson RJ. Targeting histone lysine demethylases - progress, challenges, and the future. Biochimica Et Biophysica Acta. 1839: 1416-32. PMID 24859458 DOI: 10.1016/J.Bbagrm.2014.05.009  0.64
2014 Chowdhury R, Sekirnik R, Brissett NC, Krojer T, Ho CH, Ng SS, Clifton IJ, Ge W, Kershaw NJ, Fox GC, Muniz JR, Vollmar M, Phillips C, Pilka ES, Kavanagh KL, et al. Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature. 510: 422-6. PMID 24814345 DOI: 10.1038/Nature13263  0.773
2014 Tarhonskaya H, Szöllössi A, Leung IK, Bush JT, Henry L, Chowdhury R, Iqbal A, Claridge TD, Schofield CJ, Flashman E. Studies on deacetoxycephalosporin C synthase support a consensus mechanism for 2-oxoglutarate dependent oxygenases. Biochemistry. 53: 2483-93. PMID 24684493 DOI: 10.1021/Bi500086P  0.511
2014 Rydzik AM, Chowdhury R, Kochan GT, Williams ST, McDonough MA, Kawamura A, Schofield CJ. Modulating carnitine levels by targeting its biosynthesis-selective inhibition of γ-butyrobetaine hydroxylase Chemical Science. 5: 1765-1771. DOI: 10.1039/c4sc00020j  0.657
2013 Hopkinson RJ, Tumber A, Yapp C, Chowdhury R, Aik W, Che KH, Li XS, Kristensen JB, King ON, Chan MC, Yeoh KK, Choi H, Walport LJ, Thinnes CC, Bush JT, et al. 5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation. Chemical Science (Royal Society of Chemistry : 2010). 4: 3110-3117. PMID 26682036 DOI: 10.1039/C3Sc51122G  0.808
2013 Chowdhury R, Candela-Lena JI, Chan MC, Greenald DJ, Yeoh KK, Tian YM, McDonough MA, Tumber A, Rose NR, Conejo-Garcia A, Demetriades M, Mathavan S, Kawamura A, Lee MK, van Eeden F, et al. Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. Acs Chemical Biology. 8: 1488-96. PMID 23683440 DOI: 10.1021/Cb400088Q  0.782
2013 Yang M, Hardy AP, Chowdhury R, Loik ND, Scotti JS, McCullagh JS, Claridge TD, McDonough MA, Ge W, Schofield CJ. Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor. Angewandte Chemie (International Ed. in English). 52: 1700-4. PMID 23296631 DOI: 10.1002/Anie.201208046  0.728
2013 Yeoh KK, Chan MC, Thalhammer A, Demetriades M, Chowdhury R, Tian YM, Stolze I, McNeill LA, Lee MK, Woon EC, Mackeen MM, Kawamura A, Ratcliffe PJ, Mecinović J, Schofield CJ. Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion. Organic & Biomolecular Chemistry. 11: 732-45. PMID 23151668 DOI: 10.1039/C2Ob26648B  0.799
2013 Hopkinson RJ, Tumber A, Yapp C, Chowdhury R, Aik W, Che KH, Li XS, Kristensen JBL, King ONF, Chan MC, Yeoh KK, Choi H, Walport LJ, Thinnes CC, Bush JT, et al. 8-Hydroxyquinoline-5-Carboxylic Acid is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation Chemical Reviews. 4: 3110. DOI: 10.2210/Pdb4Bio/Pdb  0.701
2013 Hopkinson RJ, Tumber A, Yapp C, Chowdhury R, Aik W, Che KH, Li XS, Kristensen JBL, King ONF, Chan MC, Yeoh KK, Choi H, Walport LJ, Thinnes CC, Bush JT, et al. 5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation Chemical Science. 4: 3110-3117. DOI: 10.1039/c3sc51122g  0.774
2012 Aik W, McDonough MA, Thalhammer A, Chowdhury R, Schofield CJ. Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases. Current Opinion in Structural Biology. 22: 691-700. PMID 23142576 DOI: 10.1016/J.Sbi.2012.10.001  0.671
2012 Ge W, Wolf A, Feng T, Ho CH, Sekirnik R, Zayer A, Granatino N, Cockman ME, Loenarz C, Loik ND, Hardy AP, Claridge TD, Hamed RB, Chowdhury R, Gong L, et al. Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. Nature Chemical Biology. 8: 960-2. PMID 23103944 DOI: 10.1038/Nchembio.1093  0.786
2012 Rose NR, Woon EC, Tumber A, Walport LJ, Chowdhury R, Li XS, King ON, Lejeune C, Ng SS, Krojer T, Chan MC, Rydzik AM, Hopkinson RJ, Che KH, Daniel M, et al. Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. Journal of Medicinal Chemistry. 55: 6639-43. PMID 22724510 DOI: 10.1021/Jm300677J  0.788
2012 Demetriades M, Leung IK, Chowdhury R, Chan MC, McDonough MA, Yeoh KK, Tian YM, Claridge TD, Ratcliffe PJ, Woon EC, Schofield CJ. Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors. Angewandte Chemie (International Ed. in English). 51: 6672-5. PMID 22639232 DOI: 10.1002/Anie.201202000  0.752
2011 Iqbal A, Clifton IJ, Chowdhury R, Ivison D, Domene C, Schofield CJ. Structural and biochemical analyses reveal how ornithine acetyl transferase binds acidic and basic amino acid substrates. Organic & Biomolecular Chemistry. 9: 6219-25. PMID 21796301 DOI: 10.1039/C1Ob05554B  0.66
2011 Chowdhury R, Flashman E, Mecinović J, Kramer HB, Kessler BM, Frapart YM, Boucher JL, Clifton IJ, McDonough MA, Schofield CJ. Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1). Journal of Molecular Biology. 410: 268-79. PMID 21601578 DOI: 10.1016/J.Jmb.2011.04.075  0.729
2011 Chowdhury R, Yeoh KK, Tian YM, Hillringhaus L, Bagg EA, Rose NR, Leung IK, Li XS, Woon EC, Yang M, McDonough MA, King ON, Clifton IJ, Klose RJ, Claridge TD, et al. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. Embo Reports. 12: 463-9. PMID 21460794 DOI: 10.1038/Embor.2011.43  0.753
2011 Yang M, Chowdhury R, Ge W, Hamed RB, McDonough MA, Claridge TD, Kessler BM, Cockman ME, Ratcliffe PJ, Schofield CJ. Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains. The Febs Journal. 278: 1086-97. PMID 21251231 DOI: 10.1111/J.1742-4658.2011.08022.X  0.77
2011 Yang M, Ge W, Chowdhury R, Claridge TD, Kramer HB, Schmierer B, McDonough MA, Gong L, Kessler BM, Ratcliffe PJ, Coleman ML, Schofield CJ. Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor. The Journal of Biological Chemistry. 286: 7648-60. PMID 21177872 DOI: 10.1074/Jbc.M110.193540  0.702
2011 Astuti D, Ricketts CJ, Chowdhury R, McDonough MA, Gentle D, Kirby G, Schlisio S, Kenchappa RS, Carter BD, Kaelin WG, Ratcliffe PJ, Schofield CJ, Latif F, Maher ER. Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility. Endocrine-Related Cancer. 18: 73-83. PMID 20959442 DOI: 10.1677/Erc-10-0113  0.613
2010 McDonough MA, Loenarz C, Chowdhury R, Clifton IJ, Schofield CJ. Structural studies on human 2-oxoglutarate dependent oxygenases. Current Opinion in Structural Biology. 20: 659-72. PMID 20888218 DOI: 10.1016/J.Sbi.2010.08.006  0.806
2010 Iqbal A, Arunlanantham H, Brown T, Chowdhury R, Clifton IJ, Kershaw NJ, Hewitson KS, McDonough MA, Schofield CJ. Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway. Proteins. 78: 1398-407. PMID 20014241 DOI: 10.1002/Prot.22653  0.756
2009 Mecinović J, Loenarz C, Chowdhury R, Schofield CJ. 2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2. Bioorganic & Medicinal Chemistry Letters. 19: 6192-5. PMID 19775891 DOI: 10.1016/J.Bmcl.2009.09.005  0.77
2009 Chowdhury R, McDonough MA, Mecinović J, Loenarz C, Flashman E, Hewitson KS, Domene C, Schofield CJ. Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases. Structure (London, England : 1993). 17: 981-9. PMID 19604478 DOI: 10.1016/J.Str.2009.06.002  0.81
2009 Mecinović J, Chowdhury R, Flashman E, Schofield CJ. Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2. Analytical Biochemistry. 393: 215-21. PMID 19563769 DOI: 10.1016/J.Ab.2009.06.029  0.496
2009 Loenarz C, Mecinović J, Chowdhury R, McNeill LA, Flashman E, Schofield CJ. Evidence for a stereoelectronic effect in human oxygen sensing. Angewandte Chemie (International Ed. in English). 48: 1784-7. PMID 19180614 DOI: 10.1002/Anie.200805427  0.757
2008 Hewitson KS, Holmes SL, Ehrismann D, Hardy AP, Chowdhury R, Schofield CJ, McDonough MA. Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH). The Journal of Biological Chemistry. 283: 25971-8. PMID 18611856 DOI: 10.1074/Jbc.M804999200  0.737
2008 Chowdhury R, Hardy A, Schofield CJ. The human oxygen sensing machinery and its manipulation. Chemical Society Reviews. 37: 1308-19. PMID 18568157 DOI: 10.1039/B701676J  0.655
2008 Flashman E, Bagg EA, Chowdhury R, Mecinović J, Loenarz C, McDonough MA, Hewitson KS, Schofield CJ. Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases. The Journal of Biological Chemistry. 283: 3808-15. PMID 18063574 DOI: 10.1074/Jbc.M707411200  0.804
2008 Mecinović J, Chowdhury R, Liénard BM, Flashman E, Buck MR, Oldham NJ, Schofield CJ. ESI-MS studies on prolyl hydroxylase domain 2 reveal a new metal binding site. Chemmedchem. 3: 569-72. PMID 18058781 DOI: 10.1002/Cmdc.200700233  0.456
2008 Loenarz C, Chowdhury R, Schofield CJ, Flashman E. Oxygenases for oxygen sensing Pure and Applied Chemistry. 80: 1837-1847. DOI: 10.1351/Pac200880081837  0.77
2008 Mecinović J, Chowdhury R, Liénard BM, Flashman E, Buck M, Oldham N, Schofield C. Cover Picture: ESI-MS Studies on Prolyl Hydroxylase Domain 2 Reveal a New Metal Binding Site (ChemMedChem 4/2008) Chemmedchem. 3: 509-509. DOI: 10.1002/Cmdc.200890014  0.669
2006 McDonough MA, Li V, Flashman E, Chowdhury R, Mohr C, Liénard BM, Zondlo J, Oldham NJ, Clifton IJ, Lewis J, McNeill LA, Kurzeja RJ, Hewitson KS, Yang E, Jordan S, et al. Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2). Proceedings of the National Academy of Sciences of the United States of America. 103: 9814-9. PMID 16782814 DOI: 10.1073/Pnas.0601283103  0.767
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