| Year |
Citation |
Score |
| 2023 |
Kereliuk SM, Koch WJ. At the Crossroads of Cardiac Beta-Adrenergic Receptor Signaling and Myocardial Glucose Metabolism. Jacc. Basic to Translational Science. 8: 656-657. PMID 37426537 DOI: 10.1016/j.jacbts.2023.02.016 |
0.369 |
|
| 2023 |
Kayki-Mutlu G, Koch WJ. Novel roles for G protein-coupled receptor kinases in cardiac injury and repair. Biochemical Society Transactions. 51: 715-724. PMID 37013982 DOI: 10.1042/BST20221317 |
0.461 |
|
| 2023 |
Cannavo A, Jun S, Rengo G, Marzano F, Agrimi J, Liccardo D, Elia A, Keceli G, Altobelli GG, Marcucci L, Megighian A, Gao E, Feng N, Kammers K, Ferrara N, ... ... Koch WJ, et al. β3AR-Dependent Brain-Derived Neurotrophic Factor (BDNF) Generation Limits Chronic Postischemic Heart Failure. Circulation Research. 132: 867-881. PMID 36884028 DOI: 10.1161/CIRCRESAHA.122.321583 |
0.31 |
|
| 2022 |
Pun-García A, Clemente-Moragón A, Villena-Gutierrez R, Gómez M, Sanz-Rosa D, Díaz-Guerra A, Prados B, Medina JP, Montó F, Ivorra MD, Márquez-López C, Cannavo A, Bernal JA, Koch WJ, Fuster V, et al. Beta-3 adrenergic receptor overexpression reverses aortic stenosis-induced heart failure and restores balanced mitochondrial dynamics. Basic Research in Cardiology. 117: 62. PMID 36445563 DOI: 10.1007/s00395-022-00966-z |
0.348 |
|
| 2022 |
Ferrero KM, Koch WJ. GRK2 in cardiovascular disease and its potential as a therapeutic target. Journal of Molecular and Cellular Cardiology. 172: 14-23. PMID 35878706 DOI: 10.1016/j.yjmcc.2022.07.008 |
0.356 |
|
| 2022 |
Zhu D, Zhang Z, Zhao J, Liu D, Gan L, Lau WB, Xie D, Meng Z, Yao P, Tsukuda J, Christopher TA, Lopez BL, Gao E, Koch WJ, Wang Y, et al. Targeting Adiponectin Receptor 1 Phosphorylation Against Ischemic Heart Failure. Circulation Research. 101161CIRCRESAHA1213. PMID 35611695 DOI: 10.1161/CIRCRESAHA.121.319976 |
0.391 |
|
| 2022 |
Okyere AD, Song J, Patwa V, Carter RL, Enjamuri N, Lucchese AM, Ibetti J, de Lucia C, Schumacher SM, Koch WJ, Cheung JY, Benovic JL, Tilley DG. Pepducin ICL1-9-Mediated β2-Adrenergic Receptor-Dependent Cardiomyocyte Contractility Occurs in a G Protein/ROCK/PKD-Sensitive Manner. Cardiovascular Drugs and Therapy. PMID 34997361 DOI: 10.1007/s10557-021-07299-4 |
0.596 |
|
| 2022 |
Brinks H, Koch WJ. Targeting G protein-coupled receptor kinases (GRKs) in Heart Failure. Drug Discovery Today. Disease Mechanisms. 7: e129-e134. PMID 21218155 DOI: 10.1016/j.ddmec.2010.07.007 |
0.402 |
|
| 2022 |
Brinks H, Koch WJ. Targeting G protein-coupled receptor kinases (GRKs) in Heart Failure. Drug Discovery Today. Disease Mechanisms. 7: e129-e134. PMID 21218155 DOI: 10.1016/j.ddmec.2010.07.007 |
0.402 |
|
| 2021 |
Coleman RC, Eguchi A, Lieu M, Roy R, Barr EW, Ibetti J, Lucchese AM, Peluzzo AM, Gresham K, Chuprun JK, Koch WJ. A peptide of the N terminus of GRK5 attenuates pressure-overload hypertrophy and heart failure. Science Signaling. 14. PMID 33785612 DOI: 10.1126/scisignal.abb5968 |
0.386 |
|
| 2021 |
Marzano F, Rapacciuolo A, Ferrara N, Rengo G, Koch WJ, Cannavo A. Targeting GRK5 for Treating Chronic Degenerative Diseases. International Journal of Molecular Sciences. 22. PMID 33671974 DOI: 10.3390/ijms22041920 |
0.342 |
|
| 2021 |
de Lucia C, Grisanti LA, Borghetti G, Piedepalumbo M, Ibetti J, Maria Lucchese A, Barr EW, Roy R, Dedo Okyere A, Christine Murphy H, Gao E, Rengo G, Houser SR, Tilley DG, Koch WJ. GRK5 contributes to impaired cardiac function and immune cell recruitment in post-ischemic heart failure. Cardiovascular Research. PMID 33560342 DOI: 10.1093/cvr/cvab044 |
0.352 |
|
| 2021 |
Bledzka KM, Manaserh IH, Grondolsky J, Pfleger J, Roy R, Gao E, Chuprun JK, Koch WJ, Schumacher SM. A peptide of the amino-terminus of GRK2 induces hypertrophy and yet elicits cardioprotection after pressure overload. Journal of Molecular and Cellular Cardiology. PMID 33548241 DOI: 10.1016/j.yjmcc.2021.01.004 |
0.362 |
|
| 2021 |
Kwon JS, Schumacher SM, Gao E, Chuprun JK, Ibetti J, Roy R, Khan M, Kishore R, Koch WJ. Characterization of βARKct engineered extracellular vesicles and model specific cardioprotection. American Journal of Physiology. Heart and Circulatory Physiology. PMID 33513081 DOI: 10.1152/ajpheart.00571.2020 |
0.317 |
|
| 2021 |
Eguchi A, Coleman R, Gresham K, Gao E, Ibetti J, Chuprun JK, Koch WJ. GRK5 is a regulator of fibroblast activation and cardiac fibrosis. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33500351 DOI: 10.1073/pnas.2012854118 |
0.367 |
|
| 2021 |
Kayki-Mutlu G, Koch WJ. Nitric Oxide and S-Nitrosylation in Cardiac Regulation: G Protein-Coupled Receptor Kinase-2 and β-Arrestins as Targets. International Journal of Molecular Sciences. 22. PMID 33430208 DOI: 10.3390/ijms22020521 |
0.393 |
|
| 2020 |
Lieu M, Traynham CJ, de Lucia C, Pfleger J, Piedepalumbo M, Roy R, Petovic J, Landesberg G, Forrester SJ, Hoffman M, Grisanti LA, Yuan A, Gao E, Drosatos K, Eguchi S, ... ... Koch WJ, et al. Loss of Dynamic Regulation of G Protein-Coupled Receptor Kinase 2 by Nitric Oxide Leads to Cardiovascular Dysfunction with Aging. American Journal of Physiology. Heart and Circulatory Physiology. PMID 32216616 DOI: 10.1152/Ajpheart.00094.2020 |
0.388 |
|
| 2020 |
Kayki Mutlu G, Ferrero K, Roy R, Lucchese AM, Gao E, Koch WJ. Abstract MP122: Effects of Cardiac Beta3-Adrenoceptors on the Inhibition of G Protein-coupled Receptor Kinase 2 via S-nitrosylation Circulation Research. 127. DOI: 10.1161/res.127.suppl_1.mp122 |
0.331 |
|
| 2020 |
Ferrero KM, Kayki Mutlu G, Pfleger JM, Tilley DG, Koch WJ. Abstract 17473: GRK2 in the Mitochondria: Uncovering Novel Mechanisms in Heart Failure Circulation. 142. DOI: 10.1161/CIRC.142.SUPPL_3.17473 |
0.304 |
|
| 2019 |
Cannavo A, Marzano F, Elia A, Liccardo D, Bencivenga L, Gambino G, Perna C, Rapacciuolo A, Cittadini A, Ferrara N, Paolocci N, Koch WJ, Rengo G. Aldosterone Jeopardizes Myocardial Insulin and β-Adrenergic Receptor Signaling G Protein-Coupled Receptor Kinase 2. Frontiers in Pharmacology. 10: 888. PMID 31447681 DOI: 10.3389/fphar.2019.00888 |
0.436 |
|
| 2019 |
Beyett TS, Fraley AE, Labudde E, Patra D, Coleman RC, Eguchi A, Glukhova A, Chen Q, Williams RM, Koch WJ, Sherman DH, Tesmer JJG. Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe. Proceedings of the National Academy of Sciences of the United States of America. PMID 31337679 DOI: 10.1073/Pnas.1818547116 |
0.324 |
|
| 2019 |
Pfleger J, Gresham K, Koch WJ. G protein-coupled receptor kinases as therapeutic targets in the heart. Nature Reviews. Cardiology. PMID 31186538 DOI: 10.1038/s41569-019-0220-3 |
0.432 |
|
| 2019 |
Coleman R, Barr EW, Chuprun K, Koch WJ. Abstract 917: Actively Blocking Nuclear Localization of G Protein-Couple Receptor 5 Blunts Hypertrophy and Heart Failure After TAC Circulation Research. 125. DOI: 10.1161/res.125.suppl_1.917 |
0.365 |
|
| 2019 |
Lieu M, Traynham CJ, Petovic J, Landesberg GP, Forrester S, Gao E, Eguchi S, Scalia R, Koch WJ. Abstract 841: Loss of S-nitrosylation of G Protein-Coupled Receptor Kinase 2 Leads to Cardiovascular Dysfunction With Aging Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.841 |
0.316 |
|
| 2019 |
Okyere AD, de Lucia C, Song J, Carter RL, Benovic JL, Koch WJ, Cheung JY, Tilley DG. Abstract 757: β-arrestin-Biased β2-Adrenergic Receptor Signaling Mediates Novel Mechanisms of Cardiomyocyte Contractility Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.757 |
0.51 |
|
| 2019 |
Eguchi A, Koch WJ. Abstract 516: GRK5 Regulates Cardiac Fibroblast Differentiation and Fibrosis Circulation Research. 125. DOI: 10.1161/res.125.suppl_1.516 |
0.394 |
|
| 2018 |
Bauer R, Enns H, Jungmann A, Leuchs B, Volz C, Schinkel S, Koch WJ, Raake PW, Most P, Katus HA, Müller OJ. Various effects of AAV9-mediated βARKct gene therapy on the heart in dystrophin-deficient (mdx) mice and δ-sarcoglycan-deficient (Sgcd-/-) mice. Neuromuscular Disorders : Nmd. PMID 30782477 DOI: 10.1016/j.nmd.2018.12.006 |
0.358 |
|
| 2018 |
Grisanti LA, Thomas TP, Carter RL, de Lucia C, Gao E, Koch WJ, Benovic JL, Tilley DG. Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling. Theranostics. 8: 4664-4678. PMID 30279730 DOI: 10.7150/Thno.26619 |
0.546 |
|
| 2018 |
Grisanti LA, Schumacher SM, Tilley DG, Koch WJ. Designer Approaches for G Protein-Coupled Receptor Modulation for Cardiovascular Disease. Jacc. Basic to Translational Science. 3: 550-562. PMID 30175279 DOI: 10.1016/j.jacbts.2017.12.002 |
0.406 |
|
| 2018 |
Pfleger J, Gross P, Johnson J, Gao E, Houser SR, Koch WJ. G protein-coupled receptor kinase 2 contributes to impaired fatty acid metabolism in the failing heart. Journal of Molecular and Cellular Cardiology. PMID 30171848 DOI: 10.1016/J.Yjmcc.2018.08.025 |
0.314 |
|
| 2018 |
de Lucia C, Eguchi A, Koch WJ. New Insights in Cardiac β-Adrenergic Signaling During Heart Failure and Aging. Frontiers in Pharmacology. 9: 904. PMID 30147654 DOI: 10.3389/fphar.2018.00904 |
0.309 |
|
| 2018 |
Cheng L, Al-Owais MM, Covarrubias M, Koch WJ, Manning DR, Peers C, Riobo-Del Galdo N. Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K+ currents in cardiomyocytes and prolongs the cardiac action potential duration. The Journal of Biological Chemistry. PMID 29802197 DOI: 10.1074/Jbc.Ra118.001989 |
0.348 |
|
| 2018 |
Hayashi H, Hess DT, Zhang R, Sugi K, Gao H, Tan BL, Bowles DE, Milano CA, Jain MK, Koch WJ, Stamler JS. S-Nitrosylation of β-Arrestins Biases Receptor Signaling and Confers Ligand Independence. Molecular Cell. 70: 473-487.e6. PMID 29727618 DOI: 10.1016/J.Molcel.2018.03.034 |
0.571 |
|
| 2018 |
Yeh ST, Zambrano CM, Koch WJ, Purcell NH. PH domain leucine-rich repeat protein phosphatase 2 (PHLPP2) Regulates G-protein coupled Receptor Kinase 5 (GRK5) induced Cardiac Hypertrophy . The Journal of Biological Chemistry. PMID 29628444 DOI: 10.1074/jbc.M117.809913 |
0.367 |
|
| 2018 |
de Lucia C, Gambino G, Petraglia L, Elia A, Komici K, Femminella GD, D'Amico ML, Formisano R, Borghetti G, Liccardo D, Nolano M, Houser SR, Leosco D, Ferrara N, Koch WJ, et al. Long-Term Caloric Restriction Improves Cardiac Function, Remodeling, Adrenergic Responsiveness, and Sympathetic Innervation in a Model of Postischemic Heart Failure. Circulation. Heart Failure. 11: e004153. PMID 29535114 DOI: 10.1161/Circheartfailure.117.004153 |
0.327 |
|
| 2018 |
Grisanti LA, Thomas TP, de Lucia C, Carter RL, Gao E, Koch WJ, Benovic JL, Tilley DG. Abstract 580: A β-arrestin-Biased β2-Adrenergic Receptor-Specific Pepducin Confers Cardioprotection Circulation Research. 123. DOI: 10.1161/Res.123.Suppl_1.580 |
0.478 |
|
| 2018 |
Okyere AD, de Lucia C, Song J, Carter RL, Benovic JL, Koch WJ, Cheung JY, Tilley DG. Abstract 578: β-arrestin-Biased β2-Adrenergic Receptor Signaling Enhances Cardiomyocyte Contractility via ROCK-Dependent Signaling Circulation Research. 123. DOI: 10.1161/res.123.suppl_1.578 |
0.506 |
|
| 2018 |
Lieu M, Chuprun K, Gao E, Koch WJ. Abstract 318: MicroRNA Regulation of G Protein-Coupled Receptor Kinase 2 After Cardiac Injury Circulation Research. 123. DOI: 10.1161/RES.123.SUPPL_1.318 |
0.35 |
|
| 2018 |
Yeh S, Zambrano C, Koch W, Purcell N. Abstract 311:
In vitro
Regulation of G-protein Coupled Receptor Kinase 5 (GRK5) Induced Cardiac Hypertrophy by a Novel Interaction With the Phosphatase PHLPP2 Circulation Research. 123. DOI: 10.1161/RES.123.SUPPL_1.311 |
0.4 |
|
| 2018 |
Pfleger JM, Gross P, Johnson J, Gao E, Houser SR, Koch WJ. Abstract 109: G Protein-coupled Receptor Kinase 2 Impairs Fatty Acid Metabolism in the Failing Heart Through Novel Mechanisms Circulation Research. 123. DOI: 10.1161/Res.123.Suppl_1.109 |
0.338 |
|
| 2018 |
Lymperopoulos A, McCrink KA, Maning J, Brill A, Desimine VL, Wertz SL, Koch W. CARVEDILOL EXERTS POSITIVE INOTROPY IN CARDIOMYOCYTES BY UNIQUELY STIMULATING BETA-ARRESTIN2-DEPENDENT SERCA2A ACTIVITY VIA THE BETA1-ADRENERGIC RECEPTOR Journal of the American College of Cardiology. 71: A933. DOI: 10.1016/S0735-1097(18)31474-8 |
0.368 |
|
| 2018 |
Pfleger JM, Gross P, Johnson J, Gao E, Houser SR, Koch WJ. G Protein-coupled receptor kinase 2 impairs fatty acid metabolism in the failing heart through novel mechanisms Journal of Molecular and Cellular Cardiology. 124: 100. DOI: 10.1016/J.Yjmcc.2018.07.055 |
0.339 |
|
| 2017 |
Cannavo A, Liccardo D, Komici K, Corbi G, de Lucia C, Femminella GD, Elia A, Bencivenga L, Ferrara N, Koch WJ, Paolocci N, Rengo G. Sphingosine Kinases and Sphingosine 1-Phosphate Receptors: Signaling and Actions in the Cardiovascular System. Frontiers in Pharmacology. 8: 556. PMID 28878674 DOI: 10.3389/fphar.2017.00556 |
0.316 |
|
| 2017 |
Jean-Charles PY, Yu SM, Abraham D, Kommaddi RP, Mao L, Strachan RT, Zhang ZS, Bowles DE, Brian L, Stiber JA, Jones SN, Koch WJ, Rockman HA, Shenoy SK. Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling. Jci Insight. 2. PMID 28878120 DOI: 10.1172/Jci.Insight.95998 |
0.819 |
|
| 2017 |
McCrink KA, Maning J, Vu A, Jafferjee M, Marrero C, Brill A, Bathgate-Siryk A, Dabul S, Koch WJ, Lymperopoulos A. β-Arrestin2 Improves Post-Myocardial Infarction Heart Failure via Sarco[endo]plasmic Reticulum Ca(2+)-ATPase-Dependent Positive Inotropy in Cardiomyocytes. Hypertension (Dallas, Tex. : 1979). PMID 28874462 DOI: 10.1161/HYPERTENSIONAHA.117.09817 |
0.365 |
|
| 2017 |
Schlegel P, Reinkober J, Meinhardt E, Tscheschner H, Gao E, Schumacher SM, Yuan A, Backs J, Most P, Wieland T, Koch WJ, Katus HA, Raake PW. G protein-coupled receptor kinase 2 promotes cardiac hypertrophy. Plos One. 12: e0182110. PMID 28759639 DOI: 10.1371/Journal.Pone.0182110 |
0.436 |
|
| 2017 |
Guo S, Carter RL, Grisanti LA, Koch WJ, Tilley DG. Impact of paroxetine on proximal β-adrenergic receptor signaling. Cellular Signalling. PMID 28711716 DOI: 10.1016/j.cellsig.2017.07.006 |
0.41 |
|
| 2017 |
Cannavo A, Rengo G, Liccardo D, Pun A, Gao E, George AJ, Gambino G, Rapacciuolo A, Leosco D, Ibanez B, Ferrara N, Paolocci N, Koch WJ. β1-Blockade Prevents Post-Ischemic Myocardial Decompensation Via β3AR-Dependent Protective Sphingosine-1 Phosphate Signaling. Journal of the American College of Cardiology. 70: 182-192. PMID 28683966 DOI: 10.1016/j.jacc.2017.05.020 |
0.31 |
|
| 2017 |
Schumacher SM, Koch WJ. Non-canonical roles of GRKs in cardiovascular signaling. Journal of Cardiovascular Pharmacology. PMID 28328744 DOI: 10.1097/FJC.0000000000000483 |
0.392 |
|
| 2017 |
Cannavo A, Koch WJ. Targeting β3-Adrenergic Receptors in the Heart: Selective Agonism and β-Blockade. Journal of Cardiovascular Pharmacology. 69: 71-78. PMID 28170359 DOI: 10.1097/FJC.0000000000000444 |
0.419 |
|
| 2017 |
Cannavo A, Koch WJ. GRK2 as negative modulator of NO bioavailability: Implications for cardiovascular disease. Cellular Signalling. PMID 28077324 DOI: 10.1016/j.cellsig.2017.01.014 |
0.342 |
|
| 2016 |
Grisanti LA, Traynham CJ, Repas AA, Gao E, Koch WJ, Tilley DG. β2-Adrenergic receptor-dependent chemokine receptor 2 expression regulates leukocyte recruitment to the heart following acute injury. Proceedings of the National Academy of Sciences of the United States of America. PMID 27956622 DOI: 10.1073/pnas.1611023114 |
0.344 |
|
| 2016 |
Woodall MC, Woodall BP, Gao E, Yuan A, Koch WJ. Cardiac Fibroblast GRK2 Deletion Enhances Contractility and Remodeling Following Ischemia/Reperfusion Injury. Circulation Research. PMID 27601479 DOI: 10.1161/CIRCRESAHA.116.309538 |
0.307 |
|
| 2016 |
Wasilewski MA, Grisanti LA, Song J, Carter RL, Repas AA, Myers VD, Gao E, Koch WJ, Cheung JY, Feldman AM, Tilley D. Vasopressin Type 1A Receptor Deletion Enhances Cardiac Contractility, β-Adrenergic Receptor Sensitivity and Acute Cardiac Injury-induced Dysfunction. Clinical Science (London, England : 1979). PMID 27589993 DOI: 10.1042/CS20160363 |
0.33 |
|
| 2016 |
Carr R, Schilling J, Song J, Carter RL, Du Y, Yoo SM, Traynham CJ, Koch WJ, Cheung JY, Tilley DG, Benovic JL. β-arrestin-biased signaling through the β2-adrenergic receptor promotes cardiomyocyte contraction. Proceedings of the National Academy of Sciences of the United States of America. PMID 27354517 DOI: 10.1073/Pnas.1606267113 |
0.516 |
|
| 2016 |
Hullmann J, Traynham CJ, Coleman RC, Koch WJ. The Expanding GRK Interactome: Implications in Cardiovascular Disease and Potential for Therapeutic Development. Pharmacological Research. PMID 27180008 DOI: 10.1016/j.phrs.2016.05.008 |
0.348 |
|
| 2016 |
Valero TR, Sturchler E, Jafferjee M, Rengo G, Magafa V, Cordopatis P, McDonald P, Koch WJ, Lymperopoulos A. Structure-activity relationship study of angiotensin II analogs in terms of β-arrestin-dependent signaling to aldosterone production. Pharmacology Research & Perspectives. 4: e00226. PMID 27069636 DOI: 10.1002/prp2.226 |
0.723 |
|
| 2016 |
Schumacher SM, Gao E, Cohen M, Lieu M, Chuprun JK, Koch WJ. A peptide of the RGS domain of GRK2 binds and inhibits Gα(q) to suppress pathological cardiac hypertrophy and dysfunction. Science Signaling. 9: ra30. PMID 27016525 DOI: 10.1126/scisignal.aae0549 |
0.397 |
|
| 2016 |
Cannavo A, Liccardo D, Eguchi A, Elliott KJ, Traynham CJ, Ibetti J, Eguchi S, Leosco D, Ferrara N, Rengo G, Koch WJ. Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases. Nature Communications. 7: 10877. PMID 26932512 DOI: 10.1038/ncomms10877 |
0.443 |
|
| 2016 |
Rengo G, Pagano G, Filardi PP, Femminella GD, Parisi V, Cannavo A, Liccardo D, Komici K, Gambino G, D'Amico ML, de Lucia C, Paolillo S, Trimarco B, Vitale DF, Ferrara N, ... Koch WJ, et al. Prognostic Value of Lymphocyte G Protein-Coupled Receptor Kinase-2 Protein Levels in Patients With Heart Failure. Circulation Research. 118: 1116-24. PMID 26884616 DOI: 10.1161/Circresaha.115.308207 |
0.374 |
|
| 2016 |
Traynham CJ, Hullmann J, Koch WJ. "Canonical and non-canonical actions of GRK5 in the heart". Journal of Molecular and Cellular Cardiology. 92: 196-202. PMID 26829117 DOI: 10.1016/j.yjmcc.2016.01.027 |
0.352 |
|
| 2016 |
Rengo G, Pagano G, Perrone-Filardi P, Daniela Femminella G, Parisi V, Cannavo A, Liccardo D, Komici K, Gambino G, Loreta D’Amico M, de Lucia C, Paolillo S, Trimarco B, Vitale DFF, Ferrara N, ... Koch WJJ, et al. Prognostic Value of Lymphocyte G Protein-Coupled Receptor Kinase-2 Protein Levels in Patients With Heart Failure Circulation Research. DOI: 10.1161/CIRCRESAHA.115.308207 |
0.341 |
|
| 2016 |
Schumacher SM, Koch WJ, VanHook AM. Science Signaling Podcast for 22 March 2016: Preventing heart failure with GRK2 Science Signaling. 9. DOI: 10.1126/Scisignal.Aaf6652 |
0.371 |
|
| 2016 |
Schumacher SM, Gao E, Cohen M, Lieu M, Chuprun JK, Koch WJ. A peptide of the RGS domain of GRK2 binds and inhibits Gαq to suppress pathological cardiac hypertrophy and dysfunction Science Signaling. 9. DOI: 10.1126/scisignal.aae0549 |
0.412 |
|
| 2015 |
Cannavo A, Liccardo D, Lymperopoulos A, Gambino G, D'amico ML, Rengo F, Koch WJ, Leosco D, Ferrara N, Rengo G. βARKct gene-therapy improves β2-adrenergic receptor-dependent neoangiogenesis following hindlimb ischemia. The Journal of Pharmacology and Experimental Therapeutics. PMID 26604244 DOI: 10.1124/jpet.115.228411 |
0.363 |
|
| 2015 |
Traynham CJ, Cannavo A, Zhou Y, Vouga A, Woodall BP, Hullmann JE, Ibetti J, Gold JI, Chuprun JK, Gao E, Koch WJ. Differential Role of G Protein-Coupled Receptor Kinase 5 in Physiological Versus Pathological Cardiac Hypertrophy. Circulation Research. PMID 26515328 DOI: 10.1161/CIRCRESAHA.115.306961 |
0.447 |
|
| 2015 |
Ritterhoff J, Völkers M, Seitz A, Spaich K, Gao E, Peppel K, Pleger ST, Zimmermann WH, Friedrich O, Fink RH, Koch WJ, Katus HA, Most P. S100A1 DNA-based Inotropic Therapy Protects Against Proarrhythmogenic Ryanodine Receptor 2 Dysfunction. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 26005840 DOI: 10.1038/mt.2015.93 |
0.674 |
|
| 2015 |
Sato PY, Chuprun JK, Schwartz M, Koch WJ. The evolving impact of g protein-coupled receptor kinases in cardiac health and disease. Physiological Reviews. 95: 377-404. PMID 25834229 DOI: 10.1152/physrev.00015.2014 |
0.418 |
|
| 2015 |
Augello MA, Berman-Booty LD, Carr R, Yoshida A, Dean JL, Schiewer MJ, Feng FY, Tomlins SA, Gao E, Koch WJ, Benovic JL, Diehl JA, Knudsen KE. Consequence of the tumor-associated conversion to cyclin D1b. Embo Molecular Medicine. 7: 628-47. PMID 25787974 DOI: 10.15252/Emmm.201404242 |
0.427 |
|
| 2015 |
Schumacher SM, Gao E, Zhu W, Chen X, Chuprun JK, Feldman AM, G Tesmer JJ, Koch WJ. Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction. Science Translational Medicine. 7: 277ra31. PMID 25739765 DOI: 10.1126/Scitranslmed.Aaa0154 |
0.364 |
|
| 2015 |
Wang Y, Gao E, Lau WB, Wang Y, Liu G, Li JJ, Wang X, Yuan Y, Koch WJ, Ma XL. G-protein-coupled receptor kinase 2-mediated desensitization of adiponectin receptor 1 in failing heart. Circulation. 131: 1392-404. PMID 25696921 DOI: 10.1161/CIRCULATIONAHA.114.015248 |
0.43 |
|
| 2015 |
Dabul S, Bathgate-Siryk A, Valero TR, Jafferjee M, Sturchler E, McDonald P, Koch WJ, Lymperopoulos A. Suppression of adrenal βarrestin1-dependent aldosterone production by ARBs: head-to-head comparison. Scientific Reports. 5: 8116. PMID 25631300 DOI: 10.1038/srep08116 |
0.739 |
|
| 2015 |
Grisanti LA, Repas AA, Talarico JA, Gold JI, Carter RL, Koch WJ, Tilley DG. Temporal and gefitinib-sensitive regulation of cardiac cytokine expression via chronic β-adrenergic receptor stimulation. American Journal of Physiology. Heart and Circulatory Physiology. 308: H316-30. PMID 25485901 DOI: 10.1152/ajpheart.00635.2014 |
0.328 |
|
| 2015 |
Trappanese DM, Liu Y, McCormick RC, Cannavo A, Nanayakkara G, Baskharoun MM, Jarrett H, Woitek FJ, Tillson DM, Dillon AR, Recchia FA, Balligand JL, Houser SR, Koch WJ, Dell'Italia LJ, et al. Chronic β1-adrenergic blockade enhances myocardial β3-adrenergic coupling with nitric oxide-cGMP signaling in a canine model of chronic volume overload: new insight into mechanisms of cardiac benefit with selective β1-blocker therapy. Basic Research in Cardiology. 110: 456. PMID 25480109 DOI: 10.1007/S00395-014-0456-3 |
0.347 |
|
| 2014 |
Lymperopoulos A, Sturchler E, Bathgate-Siryk A, Dabul S, Garcia D, Walklett K, Rengo G, McDonald P, Koch WJ. Different potencies of angiotensin receptor blockers at suppressing adrenal β-Arrestin1-dependent post-myocardial infarction hyperaldosteronism. Journal of the American College of Cardiology. 64: 2805-6. PMID 25541135 DOI: 10.1016/j.jacc.2014.09.070 |
0.738 |
|
| 2014 |
Hullmann JE, Grisanti LA, Makarewich CA, Gao E, Gold JI, Chuprun JK, Tilley DG, Houser SR, Koch WJ. GRK5-mediated exacerbation of pathological cardiac hypertrophy involves facilitation of nuclear NFAT activity. Circulation Research. 115: 976-85. PMID 25332207 DOI: 10.1161/Circresaha.116.304475 |
0.449 |
|
| 2014 |
Lucas E, Jurado-Pueyo M, Fortuño MA, Fernández-Veledo S, Vila-Bedmar R, Jiménez-Borreguero LJ, Lazcano JJ, Gao E, Gómez-Ambrosi J, Frühbeck G, Koch WJ, Díez J, Mayor F, Murga C. Downregulation of G protein-coupled receptor kinase 2 levels enhances cardiac insulin sensitivity and switches on cardioprotective gene expression patterns. Biochimica Et Biophysica Acta. 1842: 2448-56. PMID 25239306 DOI: 10.1016/J.Bbadis.2014.09.004 |
0.572 |
|
| 2014 |
Tilley DG, Zhu W, Myers VD, Barr LA, Gao E, Li X, Song J, Carter RL, Makarewich CA, Yu D, Troupes CD, Grisanti LA, Coleman RC, Koch WJ, Houser SR, et al. β-adrenergic receptor-mediated cardiac contractility is inhibited via vasopressin type 1A-receptor-dependent signaling. Circulation. 130: 1800-11. PMID 25205804 DOI: 10.1161/Circulationaha.114.010434 |
0.395 |
|
| 2014 |
Carbe CJ, Cheng L, Addya S, Gold JI, Gao E, Koch WJ, Riobo NA. Gi proteins mediate activation of the canonical hedgehog pathway in the myocardium. American Journal of Physiology. Heart and Circulatory Physiology. 307: H66-72. PMID 24816261 DOI: 10.1152/ajpheart.00166.2014 |
0.332 |
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| 2014 |
Woodall MC, Ciccarelli M, Woodall BP, Koch WJ. G protein-coupled receptor kinase 2: a link between myocardial contractile function and cardiac metabolism. Circulation Research. 114: 1661-70. PMID 24812353 DOI: 10.1161/Circresaha.114.300513 |
0.665 |
|
| 2014 |
Scimia MC, Blass BE, Koch WJ. Apelin receptor: its responsiveness to stretch mechanisms and its potential for cardiovascular therapy. Expert Review of Cardiovascular Therapy. 12: 733-41. PMID 24794045 DOI: 10.1586/14779072.2014.911661 |
0.377 |
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| 2014 |
Huang ZM, Gao E, Chuprun JK, Koch WJ. GRK2 in the heart: a GPCR kinase and beyond. Antioxidants & Redox Signaling. 21: 2032-43. PMID 24702056 DOI: 10.1089/ars.2014.5876 |
0.392 |
|
| 2014 |
Carter RL, Grisanti LA, Yu JE, Repas AA, Woodall M, Ibetti J, Koch WJ, Jacobson MA, Tilley DG. Dynamic mass redistribution analysis of endogenous β-adrenergic receptor signaling in neonatal rat cardiac fibroblasts. Pharmacology Research & Perspectives. 2. PMID 24683488 DOI: 10.1002/prp2.24 |
0.387 |
|
| 2014 |
Bathgate-Siryk A, Dabul S, Pandya K, Walklett K, Rengo G, Cannavo A, De Lucia C, Liccardo D, Gao E, Leosco D, Koch WJ, Lymperopoulos A. Negative impact of β-arrestin-1 on post-myocardial infarction heart failure via cardiac and adrenal-dependent neurohormonal mechanisms. Hypertension. 63: 404-12. PMID 24218435 DOI: 10.1161/HYPERTENSIONAHA.113.02043 |
0.375 |
|
| 2014 |
Khan M, Mohsin S, Toko H, Alkatib M, Nguyen J, Truffa S, Gude N, Chuprun K, Tilley DG, Koch WJ, Sussman MA. Cardiac progenitor cells engineered with βARKct have enhanced β-adrenergic tolerance. Molecular Therapy : the Journal of the American Society of Gene Therapy. 22: 178-85. PMID 24002692 DOI: 10.1038/Mt.2013.200 |
0.31 |
|
| 2014 |
Rengo G, Galasso G, Femminella GD, Parisi V, Zincarelli C, Pagano G, De Lucia C, Cannavo A, Liccardo D, Marciano C, Vigorito C, Giallauria F, Ferrara N, Furgi G, Filardi PP, ... Koch WJ, et al. Reduction of lymphocyte G protein-coupled receptor kinase-2 (GRK2) after exercise training predicts survival in patients with heart failure. European Journal of Preventive Cardiology. 21: 4-11. PMID 23689525 DOI: 10.1177/2047487313491656 |
0.358 |
|
| 2013 |
Huang ZM, Gao E, Fonseca FV, Hayashi H, Shang X, Hoffman NE, Chuprun JK, Tian X, Tilley DG, Madesh M, Lefer DJ, Stamler JS, Koch WJ. Convergence of G protein-coupled receptor and S-nitrosylation signaling determines the outcome to cardiac ischemic injury. Science Signaling. 6: ra95. PMID 24170934 DOI: 10.1126/Scisignal.2004225 |
0.358 |
|
| 2013 |
Cannavo A, Liccardo D, Koch WJ. Targeting cardiac β-adrenergic signaling via GRK2 inhibition for heart failure therapy. Frontiers in Physiology. 4: 264. PMID 24133451 DOI: 10.3389/fphys.2013.00264 |
0.42 |
|
| 2013 |
Salazar NC, Vallejos X, Siryk A, Rengo G, Cannavo A, Liccardo D, De Lucia C, Gao E, Leosco D, Koch WJ, Lymperopoulos A. GRK2 blockade with βARKct is essential for cardiac β2-adrenergic receptor signaling towards increased contractility. Cell Communication and Signaling : Ccs. 11: 64. PMID 23984976 DOI: 10.1186/1478-811X-11-64 |
0.468 |
|
| 2013 |
Cannavo A, Rengo G, Liccardo D, Pagano G, Zincarelli C, De Angelis MC, Puglia R, Di Pietro E, Rabinowitz JE, Barone MV, Cirillo P, Trimarco B, Palmer TM, Ferrara N, Koch WJ, et al. β1-adrenergic receptor and sphingosine-1-phosphate receptor 1 (S1PR1) reciprocal downregulation influences cardiac hypertrophic response and progression to heart failure: protective role of S1PR1 cardiac gene therapy. Circulation. 128: 1612-22. PMID 23969695 DOI: 10.1161/Circulationaha.113.002659 |
0.444 |
|
| 2013 |
Brailoiu GC, Benamar K, Arterburn JB, Gao E, Rabinowitz JE, Koch WJ, Brailoiu E. Aldosterone increases cardiac vagal tone via G protein-coupled oestrogen receptor activation. The Journal of Physiology. 591: 4223-35. PMID 23878371 DOI: 10.1113/Jphysiol.2013.257204 |
0.315 |
|
| 2013 |
Fan Q, Chen M, Zuo L, Shang X, Huang MZ, Ciccarelli M, Raake P, Brinks H, Chuprun KJ, Dorn GW, Koch WJ, Gao E. Myocardial Ablation of G Protein-Coupled Receptor Kinase 2 (GRK2) Decreases Ischemia/Reperfusion Injury through an Anti-Intrinsic Apoptotic Pathway. Plos One. 8: e66234. PMID 23805205 DOI: 10.1371/Journal.Pone.0066234 |
0.592 |
|
| 2013 |
Gold JI, Martini JS, Hullmann J, Gao E, Chuprun JK, Lee L, Tilley DG, Rabinowitz JE, Bossuyt J, Bers DM, Koch WJ. Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process. Plos One. 8: e57324. PMID 23472081 DOI: 10.1371/Journal.Pone.0057324 |
0.381 |
|
| 2013 |
Chen M, Sato PY, Chuprun JK, Peroutka RJ, Otis NJ, Ibetti J, Pan S, Sheu SS, Gao E, Koch WJ. Prodeath signaling of G protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting. Circulation Research. 112: 1121-34. PMID 23467820 DOI: 10.1161/Circresaha.112.300754 |
0.338 |
|
| 2013 |
Swain JD, Fargnoli AS, Katz MG, Tomasulo CE, Sumaroka M, Richardville KC, Koch WJ, Rabinowitz JE, Bridges CR. MCARD-mediated gene transfer of GRK2 inhibitor in ovine model of acute myocardial infarction. Journal of Cardiovascular Translational Research. 6: 253-62. PMID 23208013 DOI: 10.1007/S12265-012-9418-Z |
0.352 |
|
| 2013 |
Most P, Lerchenmüller C, Rengo G, Mahlmann A, Ritterhoff J, Rohde D, Goodman C, Busch CJ, Laube F, Heissenberg J, Pleger ST, Weiss N, Katus HA, Koch WJ, Peppel K. S100A1 deficiency impairs postischemic angiogenesis via compromised proangiogenic endothelial cell function and nitric oxide synthase regulation. Circulation Research. 112: 66-78. PMID 23048072 DOI: 10.1161/CIRCRESAHA.112.275156 |
0.621 |
|
| 2013 |
Pu J, Yuan A, Shan P, Gao E, Wang X, Wang Y, Lau WB, Koch W, Ma XL, He B. Cardiomyocyte-expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischaemia/reperfusion injury. European Heart Journal. 34: 1834-45. PMID 22307460 DOI: 10.1093/eurheartj/ehs011 |
0.334 |
|
| 2013 |
Raake PW, Schlegel P, Ksienzyk J, Reinkober J, Barthelmes J, Schinkel S, Pleger S, Mier W, Haberkorn U, Koch WJ, Katus HA, Most P, Müller OJ. AAV6.βARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model. European Heart Journal. 34: 1437-47. PMID 22261894 DOI: 10.1093/eurheartj/ehr447 |
0.351 |
|
| 2013 |
Koch WJ, VanHook AM. Science signaling podcast: 29 october 2013 Science Signaling. 6: pc28. DOI: 10.1126/Scisignal.2004842 |
0.335 |
|
| 2013 |
Rengo G, Pagano G, Galasso G, Femminella GD, Liccardo D, De Lucia C, Cannavo A, Koch WJ, Ferrara N, Leosco D. Lymphocyte G-protein coupled receptor kinase 2 and cardiac mortality in heart failure European Heart Journal. 34: P1486-P1486. DOI: 10.1093/EURHEARTJ/EHT308.P1486 |
0.38 |
|
| 2013 |
Reinkober J, Tscheschner H, Schlegel P, Wieland T, Backs J, Koch W, Katus H, Most P, Raake P. G-protein coupled receptor kinase 2 (GRK-2), a new regulator in the pathological cardiac hypertrophy by interacting NFAT signaling European Heart Journal. 34: 39-39. DOI: 10.1093/Eurheartj/Eht307.39 |
0.395 |
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| 2013 |
Lymperopoulos A, Rengo G, Gao E, Ebert SN, Dorn GW, Koch WJ. Adrenal-Specific G Protein-Coupled Receptor Kinase (GRK)-2 Deficiency Reduces Circulating Catecholamine Levels and Improves Cardiac Function after Myocardial Infarction Catecholamine Research in the 21st Century: Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012. 207. DOI: 10.1016/B978-0-12-800044-1.00186-0 |
0.387 |
|
| 2012 |
Schumacher-Bass SM, Traynham CJ, Koch WJ. G protein-coupled Receptor Kinase 2 as a Therapeutic Target for Heart Failure. Drug Discovery Today. Therapeutic Strategies. 9: e155-e162. PMID 24839449 DOI: 10.1016/j.ddstr.2014.01.002 |
0.318 |
|
| 2012 |
Thal DM, Homan KT, Chen J, Wu EK, Hinkle PM, Huang ZM, Chuprun JK, Song J, Gao E, Cheung JY, Sklar LA, Koch WJ, Tesmer JJ. Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility. Acs Chemical Biology. 7: 1830-9. PMID 22882301 DOI: 10.1021/Cb3003013 |
0.364 |
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| 2012 |
Gold JI, Gao E, Shang X, Premont RT, Koch WJ. Determining the absolute requirement of G protein-coupled receptor kinase 5 for pathological cardiac hypertrophy: short communication. Circulation Research. 111: 1048-53. PMID 22859683 DOI: 10.1161/Circresaha.112.273367 |
0.648 |
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| 2012 |
Seqqat R, Guo X, Rafiq K, Kolpakov MA, Guo J, Koch WJ, Houser SR, Dell'italia LJ, Sabri A. Beta1-adrenergic receptors promote focal adhesion signaling downregulation and myocyte apoptosis in acute volume overload. Journal of Molecular and Cellular Cardiology. 53: 240-9. PMID 22609523 DOI: 10.1016/J.Yjmcc.2012.05.004 |
0.354 |
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| 2012 |
Reinkober J, Tscheschner H, Pleger ST, Most P, Katus HA, Koch WJ, Raake PW. Targeting GRK2 by gene therapy for heart failure: benefits above β-blockade. Gene Therapy. 19: 686-93. PMID 22336718 DOI: 10.1038/gt.2012.9 |
0.34 |
|
| 2012 |
Wang Y, Wang X, Jasmin JF, Lau WB, Li R, Yuan Y, Yi W, Chuprun K, Lisanti MP, Koch WJ, Gao E, Ma XL. Essential role of caveolin-3 in adiponectin signalsome formation and adiponectin cardioprotection. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 934-42. PMID 22328772 DOI: 10.1161/Atvbaha.111.242164 |
0.337 |
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| 2012 |
Lymperopoulos A, Rengo G, Koch WJ. GRK2 inhibition in heart failure: something old, something new. Current Pharmaceutical Design. 18: 186-91. PMID 22229578 DOI: 10.2174/138161212799040510 |
0.449 |
|
| 2012 |
Zhu W, Petrashevskaya N, Ren S, Zhao A, Chakir K, Gao E, Chuprun JK, Wang Y, Talan M, Dorn GW, Lakatta EG, Koch WJ, Feldman AM, Xiao RP. Gi-biased β2AR signaling links GRK2 upregulation to heart failure. Circulation Research. 110: 265-74. PMID 22179058 DOI: 10.1161/Circresaha.111.253260 |
0.412 |
|
| 2012 |
Wei Z, Hurtt R, Ciccarelli M, Koch WJ, Doria C. Growth inhibition of human hepatocellular carcinoma cells by overexpression of G-protein-coupled receptor kinase 2 Journal of Cellular Physiology. 227: 2371-2377. PMID 21826651 DOI: 10.1002/Jcp.22972 |
0.536 |
|
| 2011 |
Cheng H, Kari G, Dicker AP, Rodeck U, Koch WJ, Force T. A novel preclinical strategy for identifying cardiotoxic kinase inhibitors and mechanisms of cardiotoxicity Circulation Research. 109: 1401-1409. PMID 21998323 DOI: 10.1161/Circresaha.111.255695 |
0.316 |
|
| 2011 |
Li X, Mikhalkova D, Gao E, Zhang J, Myers V, Zincarelli C, Lei Y, Song J, Koch WJ, Peppel K, Cheung JY, Feldman AM, Chan TO. Myocardial injury after ischemia-reperfusion in mice deficient in Akt2 is associated with increased cardiac macrophage density American Journal of Physiology - Heart and Circulatory Physiology. 301: H1932-H1940. PMID 21890689 DOI: 10.1152/ajpheart.00755.2010 |
0.671 |
|
| 2011 |
Zhang Y, Matkovich SJ, Duan X, Gold JI, Koch WJ, Dorn GW. Nuclear effects of G-protein receptor kinase 5 on histone deacetylase 5-regulated gene transcription in heart failure. Circulation. Heart Failure. 4: 659-68. PMID 21768220 DOI: 10.1161/Circheartfailure.111.962563 |
0.382 |
|
| 2011 |
Li X, Chan TO, Myers V, Chowdhury I, Zhang XQ, Song J, Zhang J, Andrel J, Funakoshi H, Robbins J, Koch WJ, Hyslop T, Cheung JY, Feldman AM. Controlled and cardiac-restricted overexpression of the arginine vasopressin V1A receptor causes reversible left ventricular dysfunction through Gαq-mediated cell signaling. Circulation. 124: 572-81. PMID 21747049 DOI: 10.1161/Circulationaha.111.021352 |
0.426 |
|
| 2011 |
Huang ZM, Gold JI, Koch WJ. G protein-coupled receptor kinases in normal and failing myocardium. Frontiers in Bioscience (Landmark Edition). 16: 3047-60. PMID 21622221 DOI: 10.2741/3898 |
0.458 |
|
| 2011 |
Ciccarelli M, Chuprun JK, Rengo G, Gao E, Wei Z, Peroutka RJ, Gold JI, Gumpert A, Chen M, Otis NJ, Dorn GW, Trimarco B, Iaccarino G, Koch WJ. G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia. Circulation. 123: 1953-62. PMID 21518983 DOI: 10.1161/Circulationaha.110.988642 |
0.821 |
|
| 2011 |
Raake PW, Koch WJ, Most P. Polymorphisms present in G-protein-coupled receptor kinases and their effect on β-blocker treatment Pharmacogenomics. 12: 295-297. PMID 21449665 DOI: 10.2217/pgs.11.13 |
0.313 |
|
| 2011 |
Lymperopoulos A, Rengo G, Zincarelli C, Kim J, Koch WJ. Adrenal beta-arrestin 1 inhibition in vivo attenuates post-myocardial infarction progression to heart failure and adverse remodeling via reduction of circulating aldosterone levels. Journal of the American College of Cardiology. 57: 356-65. PMID 21232674 DOI: 10.1016/j.jacc.2010.08.635 |
0.345 |
|
| 2011 |
Völkers M, Weidenhammer C, Herzog N, Qiu G, Spaich K, von Wegner F, Peppel K, Müller OJ, Schinkel S, Rabinowitz JE, Hippe HJ, Brinks H, Katus HA, Koch WJ, Eckhart AD, et al. The inotropic peptide βARKct improves βAR responsiveness in normal and failing cardiomyocytes through G(βγ)-mediated L-type calcium current disinhibition. Circulation Research. 108: 27-39. PMID 21106943 DOI: 10.1161/CIRCRESAHA.110.225201 |
0.744 |
|
| 2011 |
Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou RH, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G. Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors British Journal of Pharmacology. 162: 712-721. PMID 20958287 DOI: 10.1111/J.1476-5381.2010.01078.X |
0.771 |
|
| 2011 |
Rengo G, Lymperopoulos A, Leosco D, Koch WJ. GRK2 as a novel gene therapy target in heart failure Journal of Molecular and Cellular Cardiology. 50: 785-792. PMID 20800067 DOI: 10.1016/j.yjmcc.2010.08.014 |
0.36 |
|
| 2011 |
Lymperopoulos A, Rengo G, Gao E, Koch WJ. The GRK2 Inhibitor βARKct Enhances β2-Adrenergic Receptor-Dependent Cardiac Contractility In Vivo by Opposing Receptor Interaction with Phosphodiesterase Type 4D Journal of Cardiac Failure. 17: S7. DOI: 10.1016/J.CARDFAIL.2011.06.022 |
0.337 |
|
| 2010 |
Brinks H, Boucher M, Gao E, Chuprun JK, Pesant S, Raake PW, Huang ZM, Wang X, Qiu G, Gumpert A, Harris DM, Eckhart AD, Most P, Koch WJ. Level of G protein-coupled receptor kinase-2 determines myocardial ischemia/reperfusion injury via pro- and anti-apoptotic mechanisms. Circulation Research. 107: 1140-9. PMID 20814022 DOI: 10.1161/CIRCRESAHA.110.221010 |
0.363 |
|
| 2010 |
Brinks H, Koch WJ. βaRKct: A therapeutic approach for improved adrenergic signaling and function in heart disease Journal of Cardiovascular Translational Research. 3: 499-506. PMID 20623214 DOI: 10.1007/s12265-010-9206-6 |
0.472 |
|
| 2010 |
Zhou J, Lal H, Chen X, Shang X, Song J, Li Y, Kerkela R, Doble BW, MacAulay K, DeCaul M, Koch WJ, Farber J, Woodgett J, Gao E, Force T. GSK-3α directly regulates β-adrenergic signaling and the response of the heart to hemodynamic stress in mice Journal of Clinical Investigation. 120: 2280-2291. PMID 20516643 DOI: 10.1172/Jci41407 |
0.416 |
|
| 2010 |
Lymperopoulos A, Rengo G, Gao E, Ebert SN, Dorn GW, Koch WJ. Reduction of sympathetic activity via adrenal-targeted GRK2 gene deletion attenuates heart failure progression and improves cardiac function after myocardial infarction Journal of Biological Chemistry. 285: 16378-16386. PMID 20351116 DOI: 10.1074/Jbc.M109.077859 |
0.385 |
|
| 2010 |
Ciccarelli M, Chuprun JK, Koch WJ. β-adrenoceptors in cardiovascular and respiratory diseases G Protein-Coupled Receptors: Structure, Signaling, and Physiology. 287-320. DOI: 10.1017/CBO9780511760334.016 |
0.457 |
|
| 2009 |
Zhou RH, Pesant S, Cohn HI, Soltys S, Koch WJ, Eckhart AD. Negative regulation of VEGF signaling in human coronary artery endothelial cells by G protein-coupled receptor kinase 5 Clinical and Translational Science. 2: 57-61. PMID 20443868 DOI: 10.1111/j.1752-8062.2008.00058.x |
0.365 |
|
| 2009 |
Rengo G, Lymperopoulos A, Koch WJ. Future g protein-coupled receptor targets for treatment of heart failure. Current Treatment Options in Cardiovascular Medicine. 11: 328-38. PMID 19627665 DOI: 10.1007/s11936-009-0033-5 |
0.403 |
|
| 2009 |
Rengo G, Lymperopoulos A, Koch WJ. Future g protein-coupled receptor targets for treatment of heart failure. Current Treatment Options in Cardiovascular Medicine. 11: 328-38. PMID 19627665 DOI: 10.1007/s11936-009-0033-5 |
0.403 |
|
| 2009 |
Lymperopoulos A, Rengo G, Zincarelli C, Kim J, Soltys S, Koch WJ. An adrenal beta-arrestin 1-mediated signaling pathway underlies angiotensin II-induced aldosterone production in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. 106: 5825-30. PMID 19289825 DOI: 10.1073/pnas.0811706106 |
0.38 |
|
| 2009 |
Rengo G, Lymperopoulos A, Zincarelli C, Donniacuo M, Soltys S, Rabinowitz JE, Koch WJ. Myocardial adeno-associated virus serotype 6-βARKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failure Circulation. 119: 89-98. PMID 19103992 DOI: 10.1161/CIRCULATIONAHA.108.803999 |
0.447 |
|
| 2009 |
Harris DM, Chen X, Pesant S, Cohn HI, MacDonnell SM, Boucher M, Vinge LE, Raake P, Moraca SR, Li D, Most P, Houser SR, Koch WJ, Eckhart AD. Inhibition of angiotensin II Gq signaling augments β-adrenergic receptor mediated effects in a renal artery stenosis model of high blood pressure Journal of Molecular and Cellular Cardiology. 46: 100-107. PMID 18930063 DOI: 10.1016/J.Yjmcc.2008.09.708 |
0.361 |
|
| 2009 |
Bonita RE, Raake PW, Otis NJ, Chuprun KJ, Dasgupta A, Koch WJ, Mather PJ. G-Protein Coupled Receptor Kinase Expression in Lymphocytes – A Novel Biomarker of Left Ventricular Systolic Function in Heart Failure Patients Journal of Cardiac Failure. 15: S9. DOI: 10.1016/J.CARDFAIL.2009.06.407 |
0.377 |
|
| 2008 |
Cohn HI, Harris DM, Pesant S, Pfeiffer M, Zhou RH, Koch WJ, Dorn GW, Eckhart AD. Inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances alpha1D-adrenergic receptor constriction. American Journal of Physiology. Heart and Circulatory Physiology. 295: H1695-704. PMID 18723764 DOI: 10.1152/ajpheart.00564.2008 |
0.405 |
|
| 2008 |
Martini JS, Raake P, Vinge LE, DeGeorge BR, DeGeorge B, Chuprun JK, Harris DM, Gao E, Eckhart AD, Pitcher JA, Koch WJ. Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes. Proceedings of the National Academy of Sciences of the United States of America. 105: 12457-62. PMID 18711143 DOI: 10.1073/pnas.0803153105 |
0.761 |
|
| 2008 |
Raake PW, Vinge LE, Gao E, Boucher M, Rengo G, Chen X, Degeorge BR, Matkovich S, Houser SR, Most P, Eckhart AD, Dorn GW, Koch WJ. G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure Circulation Research. 103: 413-422. PMID 18635825 DOI: 10.1161/Circresaha.107.168336 |
0.431 |
|
| 2008 |
Augustus AS, Buchanan J, Addya S, Rengo G, Pestell RG, Fortina P, Koch WJ, Bensadoun A, Abel ED, Lisanti MP. Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts American Journal of Physiology - Heart and Circulatory Physiology. 295: H657-H666. PMID 18552160 DOI: 10.1152/Ajpheart.00387.2008 |
0.369 |
|
| 2008 |
Liggett SB, Cresci S, Kelly RJ, Syed FM, Matkovich SJ, Hahn HS, Diwan A, Martini JS, Sparks L, Parekh RR, Spertus JA, Koch WJ, Kardia SL, Dorn GW. A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure. Nature Medicine. 14: 510-7. PMID 18425130 DOI: 10.1038/Nm1750 |
0.651 |
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| 2008 |
DeGeorge BR, Gao E, Boucher M, Vinge LE, Martini JS, Raake PW, Chuprun JK, Harris DM, Kim GW, Soltys S, Eckhart AD, Koch WJ. Targeted inhibition of cardiomyocyte Gi signaling enhances susceptibility to apoptotic cell death in response to ischemic stress Circulation. 117: 1378-1387. PMID 18316484 DOI: 10.1161/CIRCULATIONAHA.107.752618 |
0.307 |
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| 2008 |
Lymperopoulos A, Rengo G, Zincarelli C, Soltys S, Koch WJ. Modulation of adrenal catecholamine secretion by in vivo gene transfer and manipulation of G protein-coupled receptor kinase-2 activity Molecular Therapy. 16: 302-307. PMID 18223549 DOI: 10.1038/sj.mt.6300371 |
0.328 |
|
| 2008 |
Vinge LE, von Lueder TG, Aasum E, Qvigstad E, Gravning JA, How OJ, Edvardsen T, Bjørnerheim R, Ahmed MS, Mikkelsen BW, Oie E, Attramadal T, Skomedal T, Smiseth OA, Koch WJ, et al. Cardiac-restricted expression of the carboxyl-terminal fragment of GRK3 Uncovers Distinct Functions of GRK3 in regulation of cardiac contractility and growth: GRK3 controls cardiac alpha1-adrenergic receptor responsiveness. The Journal of Biological Chemistry. 283: 10601-10. PMID 18165681 DOI: 10.1074/jbc.M708912200 |
0.691 |
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| 2008 |
Leosco D, Rengo G, Iaccarino G, Golino L, Marchese M, Fortunato F, Zincarelli C, Sanzari E, Ciccarelli M, Galasso G, Altobelli GG, Conti V, Matrone G, Cimini V, Ferrara N, ... ... Koch WJ, et al. Exercise promotes angiogenesis and improves beta-adrenergic receptor signalling in the post-ischaemic failing rat heart. Cardiovascular Research. 78: 385-94. PMID 18093988 DOI: 10.1093/Cvr/Cvm109 |
0.805 |
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| 2008 |
Martini JS, Raake P, Vinge LE, DeGeorge BR, Chuprun JK, Harris DM, Gao E, Eckhart AD, Pitcher JA, Koch WJ. Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes (Proceedings of the National Academy of Sciences of the United States of America (2008) 105, (12457-12462) DOI: 10.1073/pnas.0803153105) Proceedings of the National Academy of Sciences of the United States of America. 105: 17206. DOI: 10.1073/pnas.0808974105 |
0.704 |
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| 2007 |
Lymperopoulos A, Rengo G, Koch WJ. Adrenal adrenoceptors in heart failure: fine-tuning cardiac stimulation Trends in Molecular Medicine. 13: 503-511. PMID 17981507 DOI: 10.1016/j.molmed.2007.10.005 |
0.333 |
|
| 2007 |
MacDonnell SM, Kubo H, Harris DM, Chen X, Berretta R, Barbe MF, Kolwicz S, Reger PO, Eckhart A, Renna BF, Koch WJ, Houser SR, Libonati JR. Calcineurin inhibition normalizes beta-adrenergic responsiveness in the spontaneously hypertensive rat. American Journal of Physiology. Heart and Circulatory Physiology. 293: H3122-9. PMID 17827263 DOI: 10.1152/Ajpheart.00687.2007 |
0.375 |
|
| 2007 |
Force T, Woulfe K, Koch WJ, Kerkelä R. Molecular scaffolds regulate bidirectional crosstalk between Wnt and classical seven-transmembrane-domain receptor signaling pathways. Science Signaling. 2007. PMID 17666710 DOI: 10.1126/Stke.3972007Pe41 |
0.322 |
|
| 2007 |
Pleger ST, Boucher M, Most P, Koch WJ. Targeting myocardial beta-adrenergic receptor signaling and calcium cycling for heart failure gene therapy. Journal of Cardiac Failure. 13: 401-14. PMID 17602988 DOI: 10.1016/J.CARDFAIL.2007.01.003 |
0.362 |
|
| 2007 |
Vinge LE, Andressen KW, Attramadal T, Andersen GØ, Ahmed MS, Peppel K, Koch WJ, Freedman NJ, Levy FO, Skomedal T, Osnes JB, Attramadal H. Substrate specificities of g protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function. Molecular Pharmacology. 72: 582-91. PMID 17573483 DOI: 10.1124/mol.107.035766 |
0.853 |
|
| 2007 |
Leosco D, Rengo G, Iaccarino G, Filippelli A, Lymperopoulos A, Zincarelli C, Fortunato F, Golino L, Marchese M, Esposito G, Rapacciuolo A, Rinaldi B, Ferrara N, Koch WJ, Rengo F. Exercise training and beta-blocker treatment ameliorate age-dependent impairment of beta-adrenergic receptor signaling and enhance cardiac responsiveness to adrenergic stimulation. American Journal of Physiology. Heart and Circulatory Physiology. 293: H1596-603. PMID 17557919 DOI: 10.1152/Ajpheart.00308.2007 |
0.777 |
|
| 2007 |
Leosco D, Rengo G, Iaccarino G, Sanzari E, Golino L, De Lisa G, Zincarelli C, Fortunato F, Ciccarelli M, Cimini V, Altobelli GG, Piscione F, Galasso G, Trimarco B, Koch WJ, et al. Prior exercise improves age-dependent vascular endothelial growth factor downregulation and angiogenesis responses to hind-limb ischemia in old rats. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 62: 471-80. PMID 17522350 DOI: 10.1093/Gerona/62.5.471 |
0.732 |
|
| 2007 |
Whalen EJ, Foster MW, Matsumoto A, Ozawa K, Violin JD, Que LG, Nelson CD, Benhar M, Keys JR, Rockman HA, Koch WJ, Daaka Y, Lefkowitz RJ, Stamler JS. Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2. Cell. 129: 511-22. PMID 17482545 DOI: 10.1016/J.Cell.2007.02.046 |
0.836 |
|
| 2007 |
Most P, Remppis A, Pleger ST, Katus HA, Koch WJ. S100A1: a novel inotropic regulator of cardiac performance. Transition from molecular physiology to pathophysiological relevance. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 293: R568-77. PMID 17459908 DOI: 10.1152/AJPREGU.00075.2007 |
0.311 |
|
| 2007 |
Funakoshi H, Zacharia LC, Tang Z, Zhang J, Lee LL, Good JC, Herrmann DE, Higuchi Y, Koch WJ, Jackson EK, Chan TO, Feldman AM. A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction. Circulation. 115: 2307-15. PMID 17438146 DOI: 10.1161/Circulationaha.107.694596 |
0.326 |
|
| 2007 |
Lymperopoulos A, Rengo G, Funakoshi H, Eckhart AD, Koch WJ. Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure. Nature Medicine. 13: 315-23. PMID 17322894 DOI: 10.1038/nm1553 |
0.367 |
|
| 2007 |
Leosco D, Fortunato F, Rengo G, Iaccarino G, Sanzari E, Golino L, Zincarelli C, Canonico V, Marchese M, Koch WJ, Rengo F. Lymphocyte G-protein-coupled receptor kinase-2 is upregulated in patients with Alzheimer's disease. Neuroscience Letters. 415: 279-82. PMID 17276003 DOI: 10.1016/J.Neulet.2007.01.034 |
0.725 |
|
| 2007 |
DeGeorge BR, Koch WJ. Beta blocker specificity: a building block toward personalized medicine. The Journal of Clinical Investigation. 117: 86-9. PMID 17200711 DOI: 10.1172/JCI30476 |
0.34 |
|
| 2007 |
Zhu W, Chakir K, Koch WJ, Xiao R. Ark1-directed β2-adrenergic receptor coupling to Gi signaling leads to heart failure Journal of Molecular and Cellular Cardiology. 42: S145. DOI: 10.1016/J.YJMCC.2007.03.473 |
0.33 |
|
| 2007 |
Martini JS, Raake P, Vinge LE, DeGeorge BR, Chuprun JK, Harris DM, Eckhart AE, Pitcher JA, Koch WJ. A Novel Nuclear Function for GRK5 and Its Potential Role in the Hypertrophic Response Journal of Cardiac Failure. 13: S71. DOI: 10.1016/j.cardfail.2007.06.311 |
0.644 |
|
| 2006 |
Matkovich SJ, Diwan A, Klanke JL, Hammer DJ, Marreez Y, Odley AM, Brunskill EW, Koch WJ, Schwartz RJ, Dorn GW. Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-adrenergic signaling. Circulation Research. 99: 996-1003. PMID 17008600 DOI: 10.1161/01.Res.0000247932.71270.2C |
0.457 |
|
| 2006 |
Hata JA, Williams ML, Schroder JN, Lima B, Keys JR, Blaxall BC, Petrofski JA, Jakoi A, Milano CA, Koch WJ. Lymphocyte levels of GRK2 (betaARK1) mirror changes in the LVAD-supported failing human heart: lower GRK2 associated with improved beta-adrenergic signaling after mechanical unloading. Journal of Cardiac Failure. 12: 360-8. PMID 16762799 DOI: 10.1016/j.cardfail.2006.02.011 |
0.629 |
|
| 2006 |
Hu A, Jiao X, Gao E, Koch WJ, Sharifi-Azad S, Grunwald Z, Ma XL, Sun JZ. Chronic beta-adrenergic receptor stimulation induces cardiac apoptosis and aggravates myocardial ischemia/reperfusion injury by provoking inducible nitric-oxide synthase-mediated nitrative stress. The Journal of Pharmacology and Experimental Therapeutics. 318: 469-75. PMID 16574780 DOI: 10.1124/jpet.106.102160 |
0.343 |
|
| 2006 |
Iaccarino G, Campanile A, Santulli G, Zuppieri F, Koch WJ. G protein-coupled receptor kinases and hypertension: A review of disease mechanisms High Blood Pressure and Cardiovascular Prevention. 13: 151-158. DOI: 10.2165/00151642-200613040-00002 |
0.662 |
|
| 2006 |
Liggett SB, Kelly R, Matkovich SJ, Hahn HS, Syed FM, Marreez Y, Case KL, McGuire N, Brunskill EW, Odley AM, Parekh R, Sparks L, Koch WJ, Freeman GL, Kardia SL, et al. G-Protein Receptor Kinase-5 Polymorphism Influences Therapeutic Efficacy of β-Blockers in Heart Failure Journal of Cardiac Failure. 12: S39. DOI: 10.1016/J.Cardfail.2006.06.138 |
0.599 |
|
| 2005 |
Petrofski JA, Hata JA, Williams ML, Parsa CJ, Thompson RB, Hanish SI, Gehrig TR, Koch WJ, Milano CA. A Gbetagamma inhibitor reduces intimal hyperplasia in aortocoronary saphenous vein grafts. The Journal of Thoracic and Cardiovascular Surgery. 130: 1683-90. PMID 16308016 DOI: 10.1016/j.jtcvs.2005.01.024 |
0.512 |
|
| 2005 |
Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, ... Koch WJ, et al. Ischemic neoangiogenesis enhanced by beta2-adrenergic receptor overexpression: a novel role for the endothelial adrenergic system. Circulation Research. 97: 1182-9. PMID 16239589 DOI: 10.1161/01.Res.0000191541.06788.Bb |
0.823 |
|
| 2005 |
Iaccarino G, Barbato E, Cipolletta E, De Amicis V, Margulies KB, Leosco D, Trimarco B, Koch WJ. Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure. European Heart Journal. 26: 1752-8. PMID 16055494 DOI: 10.1093/Eurheartj/Ehi429 |
0.798 |
|
| 2005 |
MacDonnell SM, Kubo H, Crabbe DL, Renna BF, Reger PO, Mohara J, Smithwick LA, Koch WJ, Houser SR, Libonati JR. Improved myocardial beta-adrenergic responsiveness and signaling with exercise training in hypertension. Circulation. 111: 3420-8. PMID 15967848 DOI: 10.1161/CIRCULATIONAHA.104.505784 |
0.413 |
|
| 2005 |
Tevaearai HT, Walton GB, Keys JR, Koch WJ, Eckhart AD. Acute ischemic cardiac dysfunction is attenuated via gene transfer of a peptide inhibitor of the beta-adrenergic receptor kinase (betaARK1). The Journal of Gene Medicine. 7: 1172-7. PMID 15880449 DOI: 10.1002/jgm.770 |
0.339 |
|
| 2005 |
Tachibana H, Naga Prasad SV, Lefkowitz RJ, Koch WJ, Rockman HA. Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure. Circulation. 111: 591-7. PMID 15668342 DOI: 10.1161/01.Cir.0000142291.70954.Df |
0.645 |
|
| 2005 |
Koch WJ. Genetic and phenotypic targeting of beta-adrenergic signaling in heart failure. Molecular and Cellular Biochemistry. 263: 5-9. PMID 15524162 |
0.375 |
|
| 2005 |
Tevaearai HT, Koch WJ. Molecular restoration of beta-adrenergic receptor signaling improves contractile function of failing hearts. Trends in Cardiovascular Medicine. 14: 252-6. PMID 15451518 DOI: 10.1016/J.TCM.2004.07.002 |
0.499 |
|
| 2004 |
Jones JM, Petrofski JA, Wilson KH, Steenbergen C, Koch WJ, Milano CA. beta2 adrenoceptor gene therapy ameliorates left ventricular dysfunction following cardiac surgery. European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association For Cardio-Thoracic Surgery. 26: 1161-8. PMID 15541978 DOI: 10.1016/J.Ejcts.2004.08.028 |
0.532 |
|
| 2004 |
Jones JM, Wilson KH, Steenbergen C, Koch WJ, Milano CA. Dose dependent effects of cardiac beta2 adrenoceptor gene therapy. The Journal of Surgical Research. 122: 113-20. PMID 15522323 DOI: 10.1016/j.jss.2004.06.009 |
0.52 |
|
| 2004 |
Schroder JN, Williams ML, Koch WJ. Gene delivery approaches to heart failure treatment. Expert Opinion On Biological Therapy. 4: 1413-22. PMID 15335309 DOI: 10.1517/14712598.4.9.1413 |
0.315 |
|
| 2004 |
Hata JA, Williams ML, Koch WJ. Genetic manipulation of myocardial beta-adrenergic receptor activation and desensitization. Journal of Molecular and Cellular Cardiology. 37: 11-21. PMID 15242731 DOI: 10.1016/j.yjmcc.2004.03.014 |
0.487 |
|
| 2004 |
Williams ML, Hata JA, Schroder J, Rampersaud E, Petrofski J, Jakoi A, Milano CA, Koch WJ. Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts. Circulation. 109: 1590-3. PMID 15051637 DOI: 10.1161/01.CIR.0000125521.40985.28 |
0.639 |
|
| 2004 |
Tong H, Rockman HA, Koch WJ, Steenbergen C, Murphy E. G protein-coupled receptor internalization signaling is required for cardioprotection in ischemic preconditioning. Circulation Research. 94: 1133-41. PMID 15031261 DOI: 10.1161/01.Res.0000126048.32383.6B |
0.371 |
|
| 2004 |
Emani SM, Shah AS, Bowman MK, White DC, Emani S, Glower DD, Koch WJ. Right ventricular targeted gene transfer of a beta-adrenergic receptor kinase inhibitor improves ventricular performance after pulmonary artery banding. The Journal of Thoracic and Cardiovascular Surgery. 127: 787-93. PMID 15001908 DOI: 10.1016/S0022-5223(03)01189-9 |
0.343 |
|
| 2004 |
Hata JA, Koch WJ. Phosphorylation of G protein-coupled receptors: GPCR kinases in heart disease. Molecular Interventions. 3: 264-72. PMID 14993440 DOI: 10.1124/MI.3.5.264 |
0.516 |
|
| 2004 |
Petrofski JA, Hata JA, Gehrig TR, Hanish SI, Williams ML, Thompson RB, Parsa CJ, Koch WJ, Milano CA. Gene delivery to aortocoronary saphenous vein grafts in a large animal model of intimal hyperplasia. The Journal of Thoracic and Cardiovascular Surgery. 127: 27-33. PMID 14752409 DOI: 10.1016/j.jtcvs.2003.07.032 |
0.365 |
|
| 2004 |
Keys JR, Koch WJ. The adrenergic pathway and heart failure Recent Progress in Hormone Research. 59: 13-30. PMID 14749495 DOI: 10.1210/rp.59.1.13 |
0.381 |
|
| 2004 |
Petrofski JA, Koch WJ. The beta-adrenergic receptor kinase in heart failure. Journal of Molecular and Cellular Cardiology. 35: 1167-74. PMID 14519424 DOI: 10.1016/S0022-2828(03)00243-8 |
0.481 |
|
| 2004 |
Iaccarino G, Koch WJ. In vivo adenoviral-mediated gene transfer of the beta ARKct to study the role of G beta gamma in arterial restenosis Methods in Molecular Biology (Clifton, N.J.). 237: 181-192. PMID 14501050 DOI: 10.1385/1-59259-430-1:181 |
0.768 |
|
| 2004 |
Parsa CJ, Koch WJ. Gene interventions in the beta-adrenergic system for treating heart failure. Seminars in Thoracic and Cardiovascular Surgery. 15: 259-67. PMID 12973703 DOI: 10.1016/S1043-0679(03)70005-7 |
0.331 |
|
| 2004 |
Iaccarino G, Cerullo V, Ciccarelli M, Galasso G, Sorriento D, Koch WJ, Piscione F, Pastore L, Salvatore F, Trimarco B. 386. Intra-Arterial Adenoviral Mediated |[beta]|2Adrenergic Receptor (AR) Gene Delivery Induces Neoangiogenesis in Rat Ischemic Hindlimb Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.323 |
0.773 |
|
| 2003 |
Iaccarino G, Koch WJ. Transgenic mice targeting the heart unveil G protein-coupled receptor kinases as therapeutic targets Assay Drug Dev Technol. 1: 347-355. PMID 15090200 DOI: 10.1089/154065803321204484 |
0.769 |
|
| 2003 |
Foerster K, Groner F, Matthes J, Koch WJ, Birnbaumer L, Herzig S. Cardioprotection specific for the G protein Gi2 in chronic adrenergic signaling through beta 2-adrenoceptors. Proceedings of the National Academy of Sciences of the United States of America. 100: 14475-80. PMID 14612574 DOI: 10.1073/Pnas.1936026100 |
0.384 |
|
| 2003 |
Bookout AL, Finney AE, Guo R, Peppel K, Koch WJ, Daaka Y. Targeting Gbetagamma signaling to inhibit prostate tumor formation and growth. The Journal of Biological Chemistry. 278: 37569-73. PMID 12869546 DOI: 10.1074/jbc.M306276200 |
0.757 |
|
| 2003 |
Keys JR, Greene EA, Cooper CJ, Naga Prasad SV, Rockman HA, Koch WJ. Cardiac hypertrophy and altered beta-adrenergic signaling in transgenic mice that express the amino terminus of beta-ARK1. American Journal of Physiology. Heart and Circulatory Physiology. 285: H2201-11. PMID 12869383 DOI: 10.1152/Ajpheart.00112.2003 |
0.426 |
|
| 2003 |
Blaxall BC, Spang R, Rockman HA, Koch WJ. Differential myocardial gene expression in the development and rescue of murine heart failure. Physiological Genomics. 15: 105-14. PMID 12865503 DOI: 10.1152/Physiolgenomics.00087.2003 |
0.313 |
|
| 2003 |
Most P, Remppis A, Pleger ST, Löffler E, Ehlermann P, Bernotat J, Kleuss C, Heierhorst J, Ruiz P, Witt H, Karczewski P, Mao L, Rockman HA, Duncan SJ, Katus HA, ... Koch WJ, et al. Transgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance. The Journal of Biological Chemistry. 278: 33809-17. PMID 12777394 DOI: 10.1074/Jbc.M301788200 |
0.355 |
|
| 2003 |
Blaxall BC, Tschannen-Moran BM, Milano CA, Koch WJ. Differential gene expression and genomic patient stratification following left ventricular assist device support. Journal of the American College of Cardiology. 41: 1096-106. PMID 12679207 DOI: 10.1016/S0735-1097(03)00043-3 |
0.429 |
|
| 2003 |
Rau T, Nose M, Remmers U, Weil J, Weissmüller A, Davia K, Harding S, Peppel K, Koch WJ, Eschenhagen T. Overexpression of wild-type Galpha(i)-2 suppresses beta-adrenergic signaling in cardiac myocytes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 523-5. PMID 12631586 DOI: 10.1096/Fj.02-0660Fje |
0.744 |
|
| 2003 |
Tevaearai HT, Koch WJ. Modification of in vivo cardiac performance by intracoronary gene transfer of beta-adrenergic receptor signaling components. Methods in Molecular Biology (Clifton, N.J.). 219: 219-32. PMID 12597012 DOI: 10.1385/1-59259-350-X:219 |
0.411 |
|
| 2003 |
Koch WJ. Gene transfer of beta-adrenergic signaling components for heart failure. Journal of Cardiac Failure. 8: S526-31. PMID 12555169 DOI: 10.1054/JCAF.2002.129287 |
0.421 |
|
| 2003 |
Hata JA, Keyes JR, Blaxall BC, Petrofski JA, Hanish SI, Williams ML, Felker G, Milano CA, Koch WJ. Differential expression of G-protein coupled receptor kinases after mechanical unloading in the failing human heart Journal of Cardiac Failure. 9: S46. DOI: 10.1016/S1071-9164(03)00518-9 |
0.575 |
|
| 2002 |
Tevaearai HT, Walton GB, Eckhart AD, Keys JR, Koch WJ. Donor heart contractile dysfunction following prolonged ex vivo preservation can be prevented by gene-mediated beta-adrenergic signaling modulation. European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association For Cardio-Thoracic Surgery. 22: 733-7. PMID 12414039 DOI: 10.1016/S1010-7940(02)00466-9 |
0.423 |
|
| 2002 |
Keys JR, Greene EA, Koch WJ, Eckhart AD. Gq-coupled receptor agonists mediate cardiac hypertrophy via the vasculature Hypertension. 40: 660-666. PMID 12411459 DOI: 10.1161/01.HYP.0000035397.73223.CE |
0.394 |
|
| 2002 |
Iaccarino G, Cipolletta E, Fiorillo A, Annecchiarico M, Ciccarelli M, Cimini V, Koch WJ, Trimarco B. Beta(2)-adrenergic receptor gene delivery to the endothelium corrects impaired adrenergic vasorelaxation in hypertension. Circulation. 106: 349-55. PMID 12119252 DOI: 10.1161/01.Cir.0000022690.55143.56 |
0.8 |
|
| 2002 |
Tevaearai HT, Eckhart AD, Walton GB, Keys JR, Wilson K, Koch WJ. Myocardial gene transfer and overexpression of beta2-adrenergic receptors potentiates the functional recovery of unloaded failing hearts. Circulation. 106: 124-9. PMID 12093781 DOI: 10.1161/01.CIR.0000020220.79105.FD |
0.408 |
|
| 2002 |
Jones JM, Wilson KH, Koch WJ, Milano CA. Adenoviral gene transfer to the heart during cardiopulmonary bypass: effect of myocardial protection technique on transgene expression. European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association For Cardio-Thoracic Surgery. 21: 847-52. PMID 12062273 DOI: 10.1016/S1010-7940(02)00078-7 |
0.477 |
|
| 2002 |
Eckhart AD, Fentzke RC, Lepore J, Lang R, Lin H, Lefkowitz RJ, Koch WJ, Leiden JM. Inhibition of betaARK1 restores impaired biochemical beta-adrenergic receptor responsiveness but does not rescue CREB(A133) induced cardiomyopathy. Journal of Molecular and Cellular Cardiology. 34: 669-77. PMID 12054854 DOI: 10.1006/jmcc.2002.2007 |
0.642 |
|
| 2002 |
Kim J, Eckhart AD, Eguchi S, Koch WJ. Beta-adrenergic receptor-mediated DNA synthesis in cardiac fibroblasts is dependent on transactivation of the epidermal growth factor receptor and subsequent activation of extracellular signal-regulated kinases. The Journal of Biological Chemistry. 277: 32116-23. PMID 12048215 DOI: 10.1074/jbc.M204895200 |
0.442 |
|
| 2002 |
Feldman DS, Zamah AM, Pierce KL, Miller WE, Kelly F, Rapacciuolo A, Rockman HA, Koch WJ, Luttrell LM. Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus. The Journal of Biological Chemistry. 277: 28631-40. PMID 12036966 DOI: 10.1074/Jbc.M204753200 |
0.834 |
|
| 2002 |
Gong H, Sun H, Koch WJ, Rau T, Eschenhagen T, Ravens U, Heubach JF, Adamson DL, Harding SE. Specific beta(2)AR blocker ICI 118,551 actively decreases contraction through a G(i)-coupled form of the beta(2)AR in myocytes from failing human heart. Circulation. 105: 2497-503. PMID 12034656 DOI: 10.1161/01.Cir.0000017187.61348.95 |
0.382 |
|
| 2002 |
Tevaearai HT, Walton GB, Koch WJ. [Gene therapy and benefits in modulating of system beta-adrenergic in cardiac insufficiency]. Revue MéDicale De La Suisse Romande. 122: 149-53. PMID 12014253 |
0.307 |
|
| 2002 |
Eckhart AD, Ozaki T, Tevaearai H, Rockman HA, Koch WJ. Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates β-adrenergic receptor signaling and increases resting blood pressure Molecular Pharmacology. 61: 749-758. PMID 11901213 DOI: 10.1124/Mol.61.4.749 |
0.364 |
|
| 2002 |
Rockman HA, Koch WJ, Lefkowitz RJ. Seven-transmembrane-spanning receptors and heart function. Nature. 415: 206-12. PMID 11805844 DOI: 10.1038/415206A |
0.644 |
|
| 2002 |
Eckhart AD, Koch WJ. Expression of a beta-adrenergic receptor kinase inhibitor reverses dysfunction in failing cardiomyocytes. Molecular Therapy : the Journal of the American Society of Gene Therapy. 5: 74-9. PMID 11786048 DOI: 10.1006/mthe.2001.0508 |
0.411 |
|
| 2002 |
Lewis CJ, Gong H, Koch WJ, Brown MJ, Sian HE. The putative beta four-adrenergic receptor is a novel state of the beta one-adrenergic receptor Journal of the American College of Cardiology. 39: 165. DOI: 10.1016/S0735-1097(02)80731-8 |
0.372 |
|
| 2002 |
Khouri SJ, Binkley P, Koch W, Kolattukudy P. Myocardial overexpression of the cardiac b-adrenergic receptor kinase-1 inhibitor (BARKI) delay the development of cardiomyopathy induced by myocardial expression of monocyte chemo-tactic protein-1 (MCP-1) Journal of the American College of Cardiology. 39: 164. DOI: 10.1016/S0735-1097(02)80726-4 |
0.364 |
|
| 2002 |
Rau T, Janssen PM, Peppel K, Hasenfuss G, Koch W, Eschenhagen T. Adenoviral gi-protein overexpression: Impact on beta-adrenergic signaling in cardiac myocytes and intact trabeculae Journal of Molecular and Cellular Cardiology. 34: A53. DOI: 10.1016/S0022-2828(02)90935-1 |
0.735 |
|
| 2001 |
Davidson MJ, Koch WJ. Genetic manipulation of beta-adrenergic signalling in heart failure. Acta Physiologica Scandinavica. 173: 145-50. PMID 11678737 DOI: 10.1046/J.1365-201X.2001.00900.X |
0.355 |
|
| 2001 |
Tevaearai HT, Eckhart AD, Shotwell KF, Wilson K, Koch WJ. Ventricular dysfunction after cardioplegic arrest is improved after myocardial gene transfer of a beta-adrenergic receptor kinase inhibitor. Circulation. 104: 2069-74. PMID 11673348 DOI: 10.1161/HC4201.097188 |
0.48 |
|
| 2001 |
Iaccarino G, Barbato E, Cipolleta E, Esposito A, Fiorillo A, Koch WJ, Trimarco B. Cardiac βARK1 Upregulation Induced by Chronic Salt Deprivation in Rats Hypertension. 38: 255-260. PMID 11509486 DOI: 10.1161/01.Hyp.38.2.255 |
0.739 |
|
| 2001 |
Iaccarino G, Keys JR, Rapacciuolo A, Shotwell KF, Lefkowitz RJ, Rockman HA, Koch WJ. Regulation of myocardial betaARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing alpha1B-adrenergic receptors. Journal of the American College of Cardiology. 38: 534-40. PMID 11499749 DOI: 10.1016/S0735-1097(01)01396-1 |
0.803 |
|
| 2001 |
Davidson MJ, Jones JM, Emani SM, Wilson KH, Jaggers J, Koch WJ, Milano CA. Cardiac gene delivery with cardiopulmonary bypass Circulation. 104: 131-133. PMID 11447073 DOI: 10.1161/01.CIR.104.2.131 |
0.477 |
|
| 2001 |
Harding VB, Jones LR, Lefkowitz RJ, Koch WJ, Rockman HA. Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure. Proceedings of the National Academy of Sciences of the United States of America. 98: 5809-14. PMID 11331748 DOI: 10.1073/Pnas.091102398 |
0.643 |
|
| 2001 |
Chen EP, Bittner HB, Akhter SA, Koch WJ, Davis RD. Myocardial function in hearts with transgenic overexpression of the G protein-coupled receptor kinase 5. The Annals of Thoracic Surgery. 71: 1320-4. PMID 11308180 DOI: 10.1016/S0003-4975(00)01754-9 |
0.737 |
|
| 2001 |
Freeman K, Lerman I, Kranias EG, Bohlmeyer T, Bristow MR, Lefkowitz RJ, Iaccarino G, Koch WJ, Leinwand LA. Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. The Journal of Clinical Investigation. 107: 967-74. PMID 11306600 DOI: 10.1172/Jci12083 |
0.813 |
|
| 2001 |
Esposito G, Naga Prasad SV, Rapacciuolo A, Mao L, Koch WJ, Rockman HA. Cardiac overexpression of a Gq inhibitor blocks induction of extracellular signal-regulated kinase and c-Jun NH2-terminal kinase activity in in vivo pressure overload Circulation. 103: 1453-1458. PMID 11245652 DOI: 10.1161/01.Cir.103.10.1453 |
0.366 |
|
| 2001 |
Shah AS, White DC, Emani S, Kypson AP, Lilly RE, Wilson K, Glower DD, Lefkowitz RJ, Koch WJ. In vivo ventricular gene delivery of a beta-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction. Circulation. 103: 1311-6. PMID 11238278 DOI: 10.1161/01.Cir.103.9.1311 |
0.656 |
|
| 2001 |
Zhu WZ, Zheng M, Koch WJ, Lefkowitz RJ, Kobilka BK, Xiao RP. Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America. 98: 1607-12. PMID 11171998 DOI: 10.1073/Pnas.98.4.1607 |
0.723 |
|
| 2001 |
Freeman K, Colon-Rivera C, Olsson MC, Moore RL, Weinberger HD, Grupp IL, Vikstrom KL, Iaccarino G, Koch WJ, Leinwand LA. Progression from hypertrophic to dilated cardiomyopathy in mice that express a mutant myosin transgene. American Journal of Physiology. Heart and Circulatory Physiology. 280: H151-9. PMID 11123229 DOI: 10.1152/Ajpheart.2001.280.1.H151 |
0.702 |
|
| 2001 |
Gong H, Adamson DL, Ranu HK, Koch WJ, Heubach JF, Ravens U, Zolk O, Harding SE. The effect of Gi-protein inactivation on basal, and beta(1)- and beta(2)AR-stimulated contraction of myocytes from transgenic mice overexpressing the beta(2)-adrenoceptor. British Journal of Pharmacology. 131: 594-600. PMID 11015312 DOI: 10.1038/sj.bjp.0703591 |
0.382 |
|
| 2000 |
Eckhart AD, Koch WJ. Beta-Adrenergic gene therapy for cardiovascular disease. Current Controlled Trials in Cardiovascular Medicine. 1: 131-134. PMID 11714426 DOI: 10.1186/cvm-1-3-131 |
0.421 |
|
| 2000 |
Manning BS, Shotwell K, Mao L, Rockman HA, Koch WJ. Physiological induction of a β-adrenergic receptor kinase inhibitor transgene preserves β-adrenergic responsiveness in pressure-overload cardiac hypertrophy Circulation. 102: 2751-2757. PMID 11094043 DOI: 10.1161/01.Cir.102.22.2751 |
0.383 |
|
| 2000 |
Gaballa MA, Eckhart AD, Koch WJ, Goldman S. Vascular beta-adrenergic receptor adenylyl cyclase system in maturation and aging. Journal of Molecular and Cellular Cardiology. 32: 1745-55. PMID 10966835 DOI: 10.1006/JMCC.2000.1210 |
0.313 |
|
| 2000 |
Shah AS, White DC, Tai O, Hata JA, Wilson KH, Pippen A, Kypson AP, Glower DD, Lefkowitz RJ, Koch WJ. Adenovirus-mediated genetic manipulation of the myocardial beta-adrenergic signaling system in transplanted hearts. The Journal of Thoracic and Cardiovascular Surgery. 120: 581-8. PMID 10962422 DOI: 10.1067/Mtc.2000.107519 |
0.668 |
|
| 2000 |
Shah AS, Atkins BZ, Hata JA, Tai O, Kypson AP, Lilly RE, Koch WJ, Glower DD. Early effects of right ventricular volume overload on ventricular performance and beta-adrenergic signaling. The Journal of Thoracic and Cardiovascular Surgery. 120: 342-9. PMID 10917952 DOI: 10.1067/MTC.2000.107278 |
0.323 |
|
| 2000 |
Koch WJ, Lefkowitz RJ, Rockman HA. Functional consequences of altering myocardial adrenergic receptor signaling. Annual Review of Physiology. 62: 237-60. PMID 10845091 DOI: 10.1146/Annurev.Physiol.62.1.237 |
0.647 |
|
| 2000 |
Zhang SJ, Cheng H, Zhou YY, Wang DJ, Zhu W, Ziman B, Spurgoen H, Lefkowitz RJ, Lakatta EG, Koch WJ, Xiao RP. Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor. The Journal of Biological Chemistry. 275: 21773-9. PMID 10787424 DOI: 10.1074/Jbc.M909484199 |
0.66 |
|
| 2000 |
White DC, Hata JA, Shah AS, Glower DD, Lefkowitz RJ, Koch WJ. Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction. Proceedings of the National Academy of Sciences of the United States of America. 97: 5428-33. PMID 10779554 DOI: 10.1073/pnas.090091197 |
0.649 |
|
| 2000 |
Lefkowitz RJ, Rockman HA, Koch WJ. Catecholamines, cardiac beta-adrenergic receptors, and heart failure. Circulation. 101: 1634-7. PMID 10758041 DOI: 10.1161/01.Cir.101.14.1634 |
0.619 |
|
| 2000 |
Naga Prasad SV, Esposito G, Mao L, Koch WJ, Rockman HA. Gβγ-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy Journal of Biological Chemistry. 275: 4693-4698. PMID 10671499 DOI: 10.1074/Jbc.275.7.4693 |
0.368 |
|
| 2000 |
Shah AS, Lilly RE, Kypson AP, Tai O, Hata JA, Pippen A, Silvestry SC, Lefkowitz RJ, Glower DD, Koch WJ. Intracoronary adenovirus-mediated delivery and overexpression of the beta(2)-adrenergic receptor in the heart : prospects for molecular ventricular assistance. Circulation. 101: 408-14. PMID 10653833 DOI: 10.1161/01.Cir.101.4.408 |
0.683 |
|
| 2000 |
Eckhart AD, Duncan SJ, Penn RB, Benovic JL, Lefkowitz RJ, Koch WJ. Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart. Circulation Research. 86: 43-50. PMID 10625304 DOI: 10.1161/01.Res.86.1.43 |
0.727 |
|
| 2000 |
Davidson MJ, Shah AS, Jaggers J, Koch WJ, Milano CA. Intracoronary transgene delivery during cardiopulmonary bypass results in transmural cardiac-specific gene expression in neonatal pigs Journal of the American College of Surgeons. 191: S11. DOI: 10.1016/S1072-7515(00)00401-4 |
0.458 |
|
| 1999 |
Iaccarino G, Koch WJ. Gβγ-mediated signaling: New therapeutic target for proliferative vascular disease Iubmb Life. 48: 257-261. PMID 10690635 DOI: 10.1080/713803509 |
0.745 |
|
| 1999 |
Koch WJ, Rockman HA. Exploring the role of the β-adrenergic receptor kinase in cardiac disease using gene-targeted mice Trends in Cardiovascular Medicine. 9: 77-81. PMID 10578521 DOI: 10.1016/S1050-1738(99)00009-2 |
0.406 |
|
| 1999 |
Cross HR, Steenbergen C, Lefkowitz RJ, Koch WJ, Murphy E. Overexpression of the cardiac beta(2)-adrenergic receptor and expression of a beta-adrenergic receptor kinase-1 (betaARK1) inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury. Circulation Research. 85: 1077-84. PMID 10571539 DOI: 10.1161/01.RES.85.11.1077 |
0.668 |
|
| 1999 |
Iaccarino G, Lefkowitz RJ, Koch WJ. Myocardial G protein-coupled receptor kinases: implications for heart failure therapy. Proceedings of the Association of American Physicians. 111: 399-405. PMID 10519160 |
0.783 |
|
| 1999 |
Maurice JP, Koch WJ. Potential future therapies for heart failure: gene transfer of beta-adrenergic signaling components. Coronary Artery Disease. 10: 401-5. PMID 10474791 DOI: 10.1097/00019501-199909000-00009 |
0.335 |
|
| 1999 |
Kypson AP, Hendrickson SC, Akhter SA, Wilson K, McDonald PH, Lilly RE, Dolber PC, Glower DD, Lefkowitz RJ, Koch WJ. Adenovirus-mediated gene transfer of the β2-adrenergic receptor to donor hearts enhances cardiac function Gene Therapy. 6: 1298-1304. PMID 10455439 DOI: 10.1038/sj.gt.3300940 |
0.732 |
|
| 1999 |
Akhter SA, Eckhart AD, Rockman HA, Shotwell K, Lefkowitz RJ, Koch WJ. In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function. Circulation. 100: 648-53. PMID 10441103 DOI: 10.1161/01.Cir.100.6.648 |
0.803 |
|
| 1999 |
Heubach JF, Trebess I, Wettwer E, Himmel HM, Michel MC, Kaumann AJ, Koch WJ, Harding SE, Ravens U. L-type calcium current and contractility in ventricular myocytes from mice overexpressing the cardiac beta 2-adrenoceptor. Cardiovascular Research. 42: 173-82. PMID 10435008 DOI: 10.1016/S0008-6363(98)00262-4 |
0.37 |
|
| 1999 |
Cho MC, Rapacciuolo A, Koch WJ, Kobayashi Y, Jones LR, Rockman HA. Defective β-adrenergic receptor signaling precedes the development of dilated cardiomyopathy in transgenic mice with calsequestrin overexpression Journal of Biological Chemistry. 274: 22251-22256. PMID 10428792 DOI: 10.1074/Jbc.274.32.22251 |
0.351 |
|
| 1999 |
Maurice JP, Hata JA, Shah AS, White DC, McDonald PH, Dolber PC, Wilson KH, Lefkowitz RJ, Glower DD, Koch WJ. Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery. The Journal of Clinical Investigation. 104: 21-9. PMID 10393695 DOI: 10.1172/JCI6026 |
0.67 |
|
| 1999 |
Dorn GW, Tepe NM, Lorenz JN, Koch WJ, Liggett SB. Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice. Proceedings of the National Academy of Sciences of the United States of America. 96: 6400-5. PMID 10339599 DOI: 10.1073/Pnas.96.11.6400 |
0.64 |
|
| 1999 |
Cho MC, Rao M, Koch WJ, Thomas SA, Palmiter RD, Rockman HA. Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine. Circulation. 99: 2702-7. PMID 10338466 DOI: 10.1161/01.Cir.99.20.2702 |
0.473 |
|
| 1999 |
Chen EP, Akhter SA, Bittner HB, Koch WJ, Davis RD, Van Trigt P. Molecular and functional mechanisms of right ventricular adaptation in chronic pulmonary hypertension. The Annals of Thoracic Surgery. 67: 1053-8. PMID 10320250 DOI: 10.1016/S0003-4975(99)00142-3 |
0.523 |
|
| 1999 |
Iaccarino G, Smithwick LA, Lefkowitz RJ, Koch WJ. Targeting Gbeta gamma signaling in arterial vascular smooth muscle proliferation: a novel strategy to limit restenosis. Proceedings of the National Academy of Sciences of the United States of America. 96: 3945-50. PMID 10097143 DOI: 10.1073/Pnas.96.7.3945 |
0.788 |
|
| 1999 |
Zeiders JL, Seidler FJ, Iaccarino G, Koch WJ, Slotkin TA. Ontogeny of cardiac β-adrenoceptor desensitization mechanisms: Agonist treatment enhances receptor/G-protein transduction rather than eliciting uncoupling Journal of Molecular and Cellular Cardiology. 31: 413-423. PMID 10093053 DOI: 10.1006/Jmcc.1998.0875 |
0.749 |
|
| 1999 |
Anderson KM, Eckhart AD, Willette RN, Koch WJ. The myocardial beta-adrenergic system in spontaneously hypertensive heart failure (SHHF) rats. Hypertension (Dallas, Tex. : 1979). 33: 402-7. PMID 9931137 DOI: 10.1161/01.HYP.33.1.402 |
0.386 |
|
| 1999 |
Iaccarino G, Dolber PC, Lefkowitz RJ, Koch WJ. Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation. Hypertension. 33: 396-401. PMID 9931136 DOI: 10.1161/01.Hyp.33.1.396 |
0.838 |
|
| 1999 |
Xiao RP, Avdonin P, Zhou YY, Cheng H, Akhter SA, Eschenhagen T, Lefkowitz RJ, Koch WJ, Lakatta EG. Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes. Circulation Research. 84: 43-52. PMID 9915773 DOI: 10.1161/01.Res.84.1.43 |
0.789 |
|
| 1999 |
Iaccarino G, Koch WJ. Therapeutic potential of G-protein coupled receptor kinases in the heart Expert Opinion On Investigational Drugs. 8: 545-554. DOI: 10.1517/13543784.8.5.545 |
0.781 |
|
| 1999 |
Shah AS, Eric Lilly R, Tai O, Hata JA, Glower DD, Koch WJ. Percutaneous intracoronary adenoviral-mediated delivery and overexpression of the β2-adrenergic receptor in the normal and failing heart Journal of Cardiac Failure. 5: 22. DOI: 10.1016/S1071-9164(99)91422-7 |
0.337 |
|
| 1999 |
Huynh TTT, Iaccarino G, Davies MG, Safi HJ, Koch WJ, Hagen PO. External support modulates G protein expression and receptor coupling in experimental vein grafts. Surgery. 126: 127-134. DOI: 10.1016/S0039-6060(99)70145-5 |
0.712 |
|
| 1998 |
Iaccarino G, Rockman HA, Shotwell KF, Tomhave ED, Koch WJ. Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs. American Journal of Physiology. Heart and Circulatory Physiology. 275: H1298-H1306. PMID 29586850 DOI: 10.1152/ajpheart.1998.275.4.H1298 |
0.612 |
|
| 1998 |
Iaccarino G, Tomhave ED, Lefkowitz RJ, Koch WJ. Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade. Circulation. 98: 1783-9. PMID 9788834 DOI: 10.1161/01.Cir.98.17.1783 |
0.851 |
|
| 1998 |
Davies MG, Huynh TT, Fulton GJ, Lefkowitz RJ, Svendsen E, Hagen PO, Koch WJ. G protein signaling and vein graft intimal hyperplasia: reduction of intimal hyperplasia in vein grafts by a Gbetagamma inhibitor suggests a major role of G protein signaling in lesion development. Arteriosclerosis, Thrombosis, and Vascular Biology. 18: 1275-80. PMID 9714134 DOI: 10.1161/01.ATV.18.8.1275 |
0.607 |
|
| 1998 |
Rockman HA, Choi DJ, Akhter SA, Jaber M, Giros B, Lefkowitz RJ, Caron MG, Koch WJ. Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice. The Journal of Biological Chemistry. 273: 18180-4. PMID 9660778 DOI: 10.1074/Jbc.273.29.18180 |
0.806 |
|
| 1998 |
Rockman HA, Chien KR, Choi DJ, Iaccarino G, Hunter JJ, Ross J, Lefkowitz RJ, Koch WJ. Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. Proceedings of the National Academy of Sciences of the United States of America. 95: 7000-5. PMID 9618528 DOI: 10.1073/Pnas.95.12.7000 |
0.83 |
|
| 1998 |
Gaballa MA, Peppel K, Lefkowitz RJ, Aguirre M, Dolber PC, Pennock GD, Koch WJ, Goldman S. Enhanced vasorelaxation by overexpression of beta 2-adrenergic receptors in large arteries. Journal of Molecular and Cellular Cardiology. 30: 1037-45. PMID 9618244 DOI: 10.1006/jmcc.1998.0668 |
0.773 |
|
| 1998 |
Akhter SA, Luttrell LM, Rockman HA, Iaccarino G, Lefkowitz RJ, Koch WJ. Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. Science (New York, N.Y.). 280: 574-7. PMID 9554846 DOI: 10.1126/Science.280.5363.574 |
0.834 |
|
| 1998 |
Kypson AP, Peppel K, Akhter SA, Lilly RE, Glower DD, Lefkowitz RJ, Koch WJ. Ex vivo adenovirus-mediated gene transfer to the adult rat heart. The Journal of Thoracic and Cardiovascular Surgery. 115: 623-30. PMID 9535450 DOI: 10.1016/S0022-5223(98)70327-7 |
0.838 |
|
| 1998 |
Xiao RP, Tomhave ED, Wang DJ, Ji X, Boluyt MO, Cheng H, Lakatta EG, Koch WJ. Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinases. Journal of Clinical Investigation. 101: 1273-1282. PMID 9502768 DOI: 10.1172/Jci1335 |
0.396 |
|
| 1998 |
Iaccarino G, Rockman HA, Shotwell KF, Tomhave ED, Koch WJ. Myocardial overexpression of GRK3 in transgenic mice: Evidence for in vivo selectivity of GRKs American Journal of Physiology - Heart and Circulatory Physiology. 44. DOI: 10.1152/Ajpheart.1998.275.4.H1298 |
0.77 |
|
| 1998 |
Huynh TTT, Iaccarino G, Davies MG, Svendsen E, Koch WJ, Hagen P. Adenoviral-mediated inhibition of Gβγ signaling limits the hyperplastic response in experimental vein grafts Surgery. 124: 177-186. DOI: 10.1016/S0039-6060(98)70118-7 |
0.733 |
|
| 1997 |
Peppel K, Koch WJ, Lefkowitz RJ. Gene transfer strategies for augmenting cardiac function. Trends in Cardiovascular Medicine. 7: 145-50. PMID 21235878 DOI: 10.1016/S1050-1738(97)00028-5 |
0.738 |
|
| 1997 |
Akhter SA, Skaer CA, Kypson AP, McDonald PH, Peppel KC, Glower DD, Lefkowitz RJ, Koch WJ. Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer. Proceedings of the National Academy of Sciences of the United States of America. 94: 12100-5. PMID 9342369 DOI: 10.1073/pnas.94.22.12100 |
0.844 |
|
| 1997 |
Akhter SA, Milano CA, Shotwell KF, Cho MC, Rockman HA, Lefkowitz RJ, Koch WJ. Transgenic mice with cardiac overexpression of alpha1B-adrenergic receptors. In vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signaling. The Journal of Biological Chemistry. 272: 21253-9. PMID 9261135 DOI: 10.1074/Jbc.272.34.21253 |
0.812 |
|
| 1997 |
Choi DJ, Koch WJ, Hunter JJ, Rockman HA. Mechanism of β-adrenergic receptor desensitization in cardiac hypertrophy is increased β-adrenergic receptor kinase Journal of Biological Chemistry. 272: 17223-17229. PMID 9202046 DOI: 10.1074/Jbc.272.27.17223 |
0.409 |
|
| 1997 |
Rockman HA, Koch WJ, Lefkowitz RJ. Cardiac function in genetically engineered mice with altered adrenergic receptor signaling. The American Journal of Physiology. 272: H1553-9. PMID 9139936 DOI: 10.1152/Ajpheart.1997.272.4.H1553 |
0.679 |
|
| 1997 |
Korzick DH, Xiao RP, Ziman BD, Koch WJ, Lefkowitz RJ, Lakatta EG. Transgenic manipulation of beta-adrenergic receptor kinase modifies cardiac myocyte contraction to norepinephrine. The American Journal of Physiology. 272: H590-6. PMID 9038983 DOI: 10.1152/Ajpheart.1997.272.1.H590 |
0.64 |
|
| 1997 |
Koch WJ, Lefkowitz RJ, Milano CA, Akhter SA, Rockmad HA. Myocarondial Overexpression of Adrenergic Receptors and Receptor Kinases Advances in Pharmacology. 42: 502-506. DOI: 10.1016/S1054-3589(08)60799-1 |
0.744 |
|
| 1996 |
Lembo G, Rockman HA, Hunter JJ, Steinmetz H, Koch WJ, Ma L, Prinz MP, Ross J, Chien KR, Powell-Braxton L. Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency Journal of Clinical Investigation. 98: 2648-2655. PMID 8958230 DOI: 10.1172/Jci119086 |
0.518 |
|
| 1996 |
Jaber M, Koch WJ, Rockman H, Smith B, Bond RA, Sulik KK, Ross J, Lefkowitz RJ, Caron MG, Giros B. Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. Proceedings of the National Academy of Sciences of the United States of America. 93: 12974-9. PMID 8917529 DOI: 10.1073/Pnas.93.23.12974 |
0.748 |
|
| 1996 |
Rockman HA, Koch WJ, Milano CA, Lefkowitz RJ. Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice. Journal of Molecular Medicine (Berlin, Germany). 74: 489-95. PMID 8892053 DOI: 10.1007/Bf00204974 |
0.716 |
|
| 1996 |
Pitcher JA, Fredericks ZL, Stone WC, Premont RT, Stoffel RH, Koch WJ, Lefkowitz RJ. Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies. The Journal of Biological Chemistry. 271: 24907-13. PMID 8798768 DOI: 10.1074/Jbc.271.40.24907 |
0.816 |
|
| 1996 |
Rockman HA, Choi DJ, Rahman NU, Akhter SA, Lefkowitz RJ, Koch WJ. Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 93: 9954-9. PMID 8790438 DOI: 10.1073/Pnas.93.18.9954 |
0.797 |
|
| 1996 |
Koch WJ, Milano CA, Lefkowitz RJ. Transgenic manipulation of myocardial G protein-coupled receptors and receptor kinases. Circulation Research. 78: 511-6. PMID 8635207 DOI: 10.1161/01.Res.78.4.511 |
0.673 |
|
| 1996 |
van Biesen T, Hawes BE, Raymond JR, Luttrell LM, Koch WJ, Lefkowitz RJ. G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism. The Journal of Biological Chemistry. 271: 1266-9. PMID 8576109 DOI: 10.1074/jbc.271.3.1266 |
0.747 |
|
| 1995 |
Koch WJ, Hawes BE, Allen LF, Lefkowitz RJ. Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras. Proceedings of the National Academy of Sciences of the United States of America. 91: 12706-10. PMID 7809106 DOI: 10.1073/PNAS.91.26.12706 |
0.665 |
|
| 1995 |
Inglese J, Koch WJ, Touhara K, Lefkowitz RJ. G beta gamma interactions with PH domains and Ras-MAPK signaling pathways. Trends in Biochemical Sciences. 20: 151-6. PMID 7770915 DOI: 10.1016/S0968-0004(00)88992-6 |
0.746 |
|
| 1995 |
Luttrell LM, Hawes BE, Touhara K, van Biesen T, Koch WJ, Lefkowitz RJ. Effect of cellular expression of pleckstrin homology domains on Gi-coupled receptor signaling. The Journal of Biological Chemistry. 270: 12984-9. PMID 7768889 DOI: 10.1074/JBC.270.22.12984 |
0.785 |
|
| 1995 |
Koch WJ, Rockman HA, Samama P, Hamilton RA, Bond RA, Milano CA, Lefkowitz RJ. Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. Science (New York, N.Y.). 268: 1350-3. PMID 7761854 DOI: 10.1126/Science.7761854 |
0.841 |
|
| 1995 |
Nair LA, Inglese J, Stoffel R, Koch WJ, Lefkowitz RJ, Kwatra MM, Grant AO. Cardiac muscarinic potassium channel activity is attenuated by inhibitors of G beta gamma. Circulation Research. 76: 832-8. PMID 7729000 DOI: 10.1161/01.Res.76.5.832 |
0.821 |
|
| 1995 |
Touhara K, Koch WJ, Hawes BE, Lefkowitz RJ. Mutational analysis of the pleckstrin homology domain of the beta-adrenergic receptor kinase. Differential effects on G beta gamma and phosphatidylinositol 4,5-bisphosphate binding. The Journal of Biological Chemistry. 270: 17000-5. PMID 7622521 DOI: 10.1074/JBC.270.28.17000 |
0.722 |
|
| 1995 |
Luttrell LM, van Biesen T, Hawes BE, Koch WJ, Touhara K, Lefkowitz RJ. G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor. The Journal of Biological Chemistry. 270: 16495-8. PMID 7622449 DOI: 10.1074/JBC.270.28.16495 |
0.805 |
|
| 1995 |
Hawes BE, van Biesen T, Koch WJ, Luttrell LM, Lefkowitz RJ. Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation. The Journal of Biological Chemistry. 270: 17148-53. PMID 7615510 DOI: 10.1074/JBC.270.29.17148 |
0.77 |
|
| 1995 |
Ferguson SS, Ménard L, Barak LS, Koch WJ, Colapietro AM, Caron MG. Role of phosphorylation in agonist-promoted beta 2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by beta ARK1. The Journal of Biological Chemistry. 270: 24782-9. PMID 7559596 DOI: 10.1074/JBC.270.42.24782 |
0.374 |
|
| 1995 |
Rockman HA, Hamilton R, Milano CA, Mao L, Lefkowitz RJ, Koch WJ. 718-3 Cardiac Overexpression of βARK in Transgenic Mice Inhibits Isoproterenol Stimulated Contractility In Vivo Journal of the American College of Cardiology. 25: 91A. DOI: 10.1016/0735-1097(95)91830-Q |
0.61 |
|
| 1994 |
Inglese J, Luttrell LM, Iñiguez-Lluhi JA, Touhara K, Koch WJ, Lefkowitz RJ. Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase. Proceedings of the National Academy of Sciences of the United States of America. 91: 3637-41. PMID 8170960 DOI: 10.1073/PNAS.91.9.3637 |
0.806 |
|
| 1994 |
Boekhoff I, Inglese J, Schleicher S, Koch W, Lefkowitz R, Breer H. Olfactory desensitization requires membrane targeting of receptor kinase mediated by beta gamma-subunits of heterotrimeric G proteins. Journal of Biological Chemistry. 269: 37-40. DOI: 10.1016/s0021-9258(17)42306-4 |
0.384 |
|
| 1994 |
Ishii K, Chen J, Ishii M, Koch W, Freedman N, Lefkowitz R, Coughlin S. Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases. Journal of Biological Chemistry. 269: 1125-1130. DOI: 10.1016/s0021-9258(17)42230-7 |
0.701 |
|
| 1994 |
Koch W, Hawes B, Inglese J, Luttrell L, Lefkowitz R. Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling. Journal of Biological Chemistry. 269: 6193-6197. DOI: 10.1016/s0021-9258(17)37587-7 |
0.427 |
|
| 1993 |
Lefkowitz RJ, Inglese J, Koch WJ, Pitcher J, Attramadal H, Caron MG. G-protein-coupled receptors: regulatory role of receptor kinases and arrestin proteins. Cold Spring Harbor Symposia On Quantitative Biology. 57: 127-33. PMID 1339651 DOI: 10.1101/Sqb.1992.057.01.016 |
0.821 |
|
| 1993 |
Koch W, Inglese J, Stone W, Lefkowitz R. The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase. Journal of Biological Chemistry. 268: 8256-8260. DOI: 10.1016/s0021-9258(18)53090-8 |
0.393 |
|
| 1992 |
Inglese J, Koch WJ, Caron MG, Lefkowitz RJ. Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases. Nature. 359: 147-50. PMID 1522899 DOI: 10.1038/359147A0 |
0.727 |
|
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