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Refaat Hamed - Publications

Affiliations: 
University of Oxford, Oxford, United Kingdom 
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23 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Smart TJ, Hamed RB, Claridge TDW, Schofield CJ. Studies on the selectivity of proline hydroxylases reveal new substrates including bicycles. Bioorganic Chemistry. 103386. PMID 31706681 DOI: 10.1016/J.Bioorg.2019.103386  0.403
2019 Hamed RB, Gomez-Castellanos JR, Henry L, Warhaut S, Claridge TDW, Schofield CJ. Biocatalytic production of bicyclic β-lactams with three contiguous chiral centres using engineered crotonases. Communications Chemistry. 2. PMID 31157308 DOI: 10.1038/s42004-018-0106-z  0.472
2017 Lohans CT, Wang DY, Wang J, Hamed RB, Schofield CJ. Crotonases: Nature’s Exceedingly Convertible Catalysts Acs Catalysis. 7: 6587-6599. DOI: 10.1021/Acscatal.7B01699  0.666
2017 Hamed RB, Henry L, Claridge TDW, Schofield CJ. Stereoselective Production of Dimethyl-Substituted Carbapenams via Engineered Carbapenem Biosynthesis Enzymes Acs Catalysis. 7: 1279-1285. DOI: 10.1021/Acscatal.6B02509  0.458
2015 Hamed RB, Gomez-Castellanos JR, Froese DS, Krysztofinska E, Yue WW, Schofield CJ. Use of Methylmalonyl-CoA epimerase in Enhancing Crotonase Stereoselectivity. Chembiochem : a European Journal of Chemical Biology. PMID 26716911 DOI: 10.1002/Cbic.201500644  0.422
2013 Hamed RB, Henry L, Gomez-Castellanos JR, Asghar A, Brem J, Claridge TD, Schofield CJ. Stereoselective preparation of lipidated carboxymethyl-proline/pipecolic acid derivatives via coupling of engineered crotonases with an alkylmalonyl-CoA synthetase. Organic & Biomolecular Chemistry. 11: 8191-6. PMID 24108359 DOI: 10.1039/C3Ob41525B  0.441
2013 Hamed RB, Gomez-Castellanos JR, Henry L, Ducho C, McDonough MA, Schofield CJ. The enzymes of β-lactam biosynthesis. Natural Product Reports. 30: 21-107. PMID 23135477 DOI: 10.1039/C2Np20065A  0.569
2012 Ge W, Wolf A, Feng T, Ho CH, Sekirnik R, Zayer A, Granatino N, Cockman ME, Loenarz C, Loik ND, Hardy AP, Claridge TD, Hamed RB, Chowdhury R, Gong L, et al. Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. Nature Chemical Biology. 8: 960-2. PMID 23103944 DOI: 10.1038/Nchembio.1093  0.629
2012 Hamed RB, Henry L, Gomez-Castellanos JR, Mecinović J, Ducho C, Sorensen JL, Claridge TD, Schofield CJ. Crotonase catalysis enables flexible production of functionalized prolines and carbapenams. Journal of the American Chemical Society. 134: 471-9. PMID 22091817 DOI: 10.1021/Ja208318D  0.597
2012 Mantri M, Webby CJ, Loik ND, Hamed RB, Nielsen ML, McDonough MA, McCullagh JSO, Böttger A, Schofield CJ, Wolf A. Self-hydroxylation of the splicing factor lysyl hydroxylase, JMJD6 Medchemcomm. 3: 80-85. DOI: 10.1039/C1Md00225B  0.642
2011 Mantri M, Loik ND, Hamed RB, Claridge TD, McCullagh JS, Schofield CJ. The 2-oxoglutarate-dependent oxygenase JMJD6 catalyses oxidation of lysine residues to give 5S-hydroxylysine residues. Chembiochem : a European Journal of Chemical Biology. 12: 531-4. PMID 22238144 DOI: 10.1002/Cbic.201000641  0.445
2011 Hamed RB, Gomez-Castellanos JR, Thalhammer A, Harding D, Ducho C, Claridge TD, Schofield CJ. Stereoselective C-C bond formation catalysed by engineered carboxymethylproline synthases. Nature Chemistry. 3: 365-71. PMID 21505494 DOI: 10.1038/Nchem.1011  0.448
2011 Yang M, Chowdhury R, Ge W, Hamed RB, McDonough MA, Claridge TD, Kessler BM, Cockman ME, Ratcliffe PJ, Schofield CJ. Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains. The Febs Journal. 278: 1086-97. PMID 21251231 DOI: 10.1111/J.1742-4658.2011.08022.X  0.642
2011 Rotili D, Altun M, Hamed RB, Loenarz C, Thalhammer A, Hopkinson RJ, Tian YM, Ratcliffe PJ, Mai A, Kessler BM, Schofield CJ. Photoactivable peptides for identifying enzyme-substrate and protein-protein interactions. Chemical Communications (Cambridge, England). 47: 1488-90. PMID 21152646 DOI: 10.1039/C0Cc04457A  0.677
2010 Flashman E, Hoffart LM, Hamed RB, Bollinger JM, Krebs C, Schofield CJ. Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen. The Febs Journal. 277: 4089-99. PMID 20840591 DOI: 10.1111/J.1742-4658.2010.07804.X  0.395
2010 Hamed RB, Mecinović J, Ducho C, Claridge TD, Schofield CJ. Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles. Chemical Communications (Cambridge, England). 46: 1413-5. PMID 20162132 DOI: 10.1039/B924519G  0.354
2010 Hopkinson RJ, Hamed RB, Rose NR, Claridge TD, Schofield CJ. Monitoring the activity of 2-oxoglutarate dependent histone demethylases by NMR spectroscopy: direct observation of formaldehyde. Chembiochem : a European Journal of Chemical Biology. 11: 506-10. PMID 20095001 DOI: 10.1002/Cbic.200900713  0.526
2009 Ducho C, Hamed RB, Batchelar ET, Sorensen JL, Odell B, Schofield CJ. Synthesis of regio- and stereoselectively deuterium-labelled derivatives of L-glutamate semialdehyde for studies on carbapenem biosynthesis. Organic & Biomolecular Chemistry. 7: 2770-9. PMID 19532994 DOI: 10.1039/B903312B  0.562
2009 Mecinović J, Hamed RB, Schofield CJ. Iron-mediated cleavage of C-C bonds in vicinal tricarbonyl compounds in water. Angewandte Chemie (International Ed. in English). 48: 2796-800. PMID 19280617 DOI: 10.1002/Anie.200806296  0.385
2009 Hamed RB, Batchelar ET, Mecinović J, Claridge TD, Schofield CJ. Evidence that thienamycin biosynthesis proceeds via C-5 epimerization: ThnE catalyzes the formation of (2S,5S)-trans-carboxymethylproline. Chembiochem : a European Journal of Chemical Biology. 10: 246-50. PMID 19090510 DOI: 10.1002/Cbic.200800652  0.42
2009 Hamed RB, Batchelar ET, Mecinović J, Claridge TDW, Schofield CJ. Cover Picture: Evidence that Thienamycin Biosynthesis Proceeds via C-5 Epimerization: ThnE Catalyzes the Formation of (2S,5S)-trans-Carboxymethylproline (ChemBioChem 2/2009) Chembiochem. 10: 189-189. DOI: 10.1002/Cbic.200990000  0.624
2008 Batchelar ET, Hamed RB, Ducho C, Claridge TD, Edelmann MJ, Kessler B, Schofield CJ. Thioester hydrolysis and C-C bond formation by carboxymethylproline synthase from the crotonase superfamily. Angewandte Chemie (International Ed. in English). 47: 9322-5. PMID 18972478 DOI: 10.1002/Anie.200803906  0.391
2008 Hamed RB, Batchelar ET, Clifton IJ, Schofield CJ. Mechanisms and structures of crotonase superfamily enzymes--how nature controls enolate and oxyanion reactivity. Cellular and Molecular Life Sciences : Cmls. 65: 2507-27. PMID 18470480 DOI: 10.1007/S00018-008-8082-6  0.617
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