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David A. Largaespada - Publications

Affiliations: 
Microbiology, Immunology and Cancer Biology University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
Molecular Biology, Virology Biology, Microbiology Biology
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284 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Osum SH, Oribamise EI, Corbière SMAS, Taisto M, Jubenville T, Coutts A, Kirstein MN, Fisher J, Moertel C, Du M, Bedwell D, Largaespada DA, Watson AL. Combining nonsense mutation suppression therapy with nonsense-mediated decay inhibition in neurofibromatosis type 1. Molecular Therapy. Nucleic Acids. 33: 227-239. PMID 37520682 DOI: 10.1016/j.omtn.2023.06.018  0.638
2023 Sugita K, Onishi I, Nakayama R, Ishibashi S, Ikeda M, Inoue M, Narita R, Oshima S, Shimizu K, Saito S, Sato S, Moriarity BS, Yamamoto K, Largaespada DA, Kitagawa M, et al. Indirect CRISPR screening with photoconversion revealed key factors of drug resistance with cell-cell interactions. Communications Biology. 6: 582. PMID 37264057 DOI: 10.1038/s42003-023-04941-9  0.611
2022 Tatsumi A, Hirakochi H, Inoue S, Tanaka Y, Furuno H, Ikeda M, Ishibashi S, Taguchi T, Yamamoto K, Onishi I, Sachs Z, Largaespada DA, Kitagawa M, Kurata M. Identification of Downstream Genes with CRISPR Activation Screening. Biology. 11. PMID 36358254 DOI: 10.3390/biology11111551  0.343
2022 Becklin KL, Draper GM, Madden RA, Kluesner MG, Koga T, Huang M, Weiss WA, Spector LG, Largaespada DA, Moriarity BS, Webber BR. Developing Bottom-Up Induced Pluripotent Stem Cell Derived Solid Tumor Models Using Precision Genome Editing Technologies. The Crispr Journal. 5: 517-535. PMID 35972367 DOI: 10.1089/crispr.2022.0032  0.619
2022 Kurata M, Antony ML, Noble-Orcutt KE, Rathe SK, Lee Y, Furuno H, Ishibashi S, Ikeda M, Yamamoto K, Kitagawa M, Largaespada DA, Sachs Z. Proliferation and self-renewal are differentially sensitive NRASG12V oncogene levels in an acute myeloid leukemia cell line. Molecular Cancer Research : McR. PMID 35900472 DOI: 10.1158/1541-7786.MCR-22-0109  0.69
2021 Thomson CS, Pundavela J, Perrino MR, Coover RA, Choi K, Chaney KE, Rizvi TA, Largaespada DA, Ratner N. WNT5A inhibition alters the malignant peripheral nerve sheath tumor microenvironment and enhances tumor growth. Oncogene. PMID 34079083 DOI: 10.1038/s41388-021-01773-x  0.319
2021 Osum SH, Coutts AW, Duerre DJ, Tschida BR, Kirstein MN, Fisher J, Bell WR, Delpuech O, Smith PD, Widemann BC, Moertel CL, Largaespada DA, Watson AL. Selumetinib normalizes Ras/MAPK signaling in clinically relevant neurofibromatosis type 1 minipig tissues in vivo. Neuro-Oncology Advances. 3: vdab020. PMID 33978635 DOI: 10.1093/noajnl/vdab020  0.57
2021 Vélez-Reyes GL, Koes N, Ryu JH, Kaufmann G, Berner M, Weg MT, Wolf NK, Rathe SK, Ratner N, Moriarity BS, Largaespada DA. Transposon Mutagenesis-Guided CRISPR/Cas9 Screening Strongly Implicates Dysregulation of Hippo/YAP Signaling in Malignant Peripheral Nerve Sheath Tumor Development. Cancers. 13. PMID 33808166 DOI: 10.3390/cancers13071584  0.826
2021 Galvin R, Watson AL, Largaespada DA, Ratner N, Osum S, Moertel CL. Neurofibromatosis in the Era of Precision Medicine: Development of MEK Inhibitors and Recent Successes with Selumetinib. Current Oncology Reports. 23: 45. PMID 33721151 DOI: 10.1007/s11912-021-01032-y  0.587
2021 Osum SH, Watson AL, Largaespada DA. Spontaneous and Engineered Large Animal Models of Neurofibromatosis Type 1. International Journal of Molecular Sciences. 22. PMID 33669386 DOI: 10.3390/ijms22041954  0.634
2021 Hansen M, Cai X, Bowen S, Largaespada DA, Li MV. Flow Assisted Mutation Enrichment (FAME): A highly efficacious and efficient method to enrich Double Knockouts (DKO) after gene editing. Plos One. 16: e0247375. PMID 33661977 DOI: 10.1371/journal.pone.0247375  0.305
2021 To JC, Chiu AP, Tschida BR, Lo LH, Chiu CH, Li XX, Kuka TP, Linden MA, Amin K, Chan WC, Bell JB, Moriarity BS, Largaespada DA, Keng VW. ZBTB20 regulates WNT/CTNNB1 signalling pathway by suppressing PPARG during hepatocellular carcinoma tumourigenesis. Jhep Reports : Innovation in Hepatology. 3: 100223. PMID 33604532 DOI: 10.1016/j.jhepr.2020.100223  0.551
2020 Conboy CB, Vélez-Reyes GL, Rathe SK, Abrahante JE, Temiz NA, Burns MB, Harris RS, Starr TK, Largaespada DA. R-Spondins 2 and 3 Are Overexpressed in a Subset of Human Colon and Breast Cancers. Dna and Cell Biology. PMID 33320737 DOI: 10.1089/dna.2020.5585  0.708
2020 Watson AL, Keller BJ, Williams KA, Damle NN, Finnerty SJ, Anderson LK, Greeley AD, Keng VW, Rahrmann EP, Halfond AL, Powell NM, Collins MH, Rizvi T, Moertel CL, Ratner N, ... Largaespada DA, et al. Correction: Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity. Oncotarget. 11: 3618-3620. PMID 33062197 DOI: 10.18632/oncotarget.27349  0.802
2020 Smeester BA, Draper GM, Slipek NJ, Larsson AT, Stratton N, Pomeroy EJ, Becklin KL, Yamamoto K, Williams KB, Laoharawee K, Peterson JJ, Abrahante JE, Rathe SK, Mills LJ, Crosby MR, ... ... Largaespada DA, et al. Implication of ZNF217 in accelerating tumor development and therapeutically targeting ZNF217-induced PI3K-AKT signaling for the treatment of metastatic osteosarcoma. Molecular Cancer Therapeutics. PMID 32999043 DOI: 10.1158/1535-7163.MCT-20-0369  0.821
2020 Law EK, Levin-Klein R, Jarvis MC, Kim H, Argyris PP, Carpenter MA, Starrett GJ, Temiz NA, Larson LK, Durfee C, Burns MB, Vogel RI, Stavrou S, Aguilera AN, Wagner S, ... Largaespada DA, et al. APOBEC3A catalyzes mutation and drives carcinogenesis in vivo. The Journal of Experimental Medicine. 217. PMID 32870257 DOI: 10.1084/Jem.20200261  0.369
2020 Chaney KE, Perrino MR, Kershner LJ, Patel AV, Wu J, Choi K, Rizvi TA, Dombi E, Szabo S, Largaespada DA, Ratner N. Cdkn2a loss in a model of neurofibroma demonstrates stepwise tumor progression to atypical neurofibroma and MPNST. Cancer Research. PMID 32816910 DOI: 10.1158/0008-5472.Can-19-1429  0.398
2020 Williams KB, Largaespada DA. New Model Systems and the Development of Targeted Therapies for the Treatment of Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheath Tumors. Genes. 11. PMID 32353955 DOI: 10.3390/Genes11050477  0.442
2020 Smeester BA, Slipek NJ, Pomeroy EJ, Laoharawee K, Osum SH, Larsson AT, Williams KB, Stratton N, Yamamoto K, Peterson JJ, Rathe SK, Mills LJ, Hudson WA, Crosby MR, Wang M, ... ... Largaespada DA, et al. PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma. Bone. 115353. PMID 32251854 DOI: 10.1016/J.Bone.2020.115353  0.829
2020 Beckmann PJ, Largaespada DA. Transposon Insertion Mutagenesis in Mice for Modeling Human Cancers: Critical Insights Gained and New Opportunities. International Journal of Molecular Sciences. 21. PMID 32050713 DOI: 10.3390/Ijms21031172  0.411
2020 Kurata M, Antony ML, Noble KE, Rathe SK, Hirakouchi H, Yamamoto K, Kitagawa M, Sachs Z, Largaespada DA. Abstract 2582: Dose-dependent NRASG12V-mediated signaling controls cell cycle progression and leukemogenic signaling in a CRISPR/Cas9-modified human AML cell line Immunology. 80: 2582-2582. DOI: 10.1158/1538-7445.Am2020-2582  0.738
2019 Sachs K, Sarver AL, Noble-Orcutt KE, LaRue RS, Antony ML, Chang D, Lee Y, Navis CM, Hillesheim AL, Nykaza IR, Ha NA, Hansen CJ, Karadag FK, Bergerson RJ, Verneris MR, ... ... Largaespada DA, et al. Single-cell gene expression analyses reveal distinct self-renewing and proliferating subsets in the leukemia stem cell compartment in acute myeloid leukemia. Cancer Research. PMID 31784425 DOI: 10.1158/0008-5472.Can-18-2932  0.791
2019 Xiong Z, Ampudia Mesias E, Pluhar GE, Rathe SK, Largaespada DA, Sham YY, Moertel CL, Olin MR. CD200 Checkpoint Reversal:A Novel Approach to Immunotherapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31624103 DOI: 10.1158/1078-0432.Ccr-19-2234  0.7
2019 Smeester BA, Slipek NJ, Pomeroy EJ, Bomberger HE, Shamsan GA, Peterson JJ, Crosby MR, Draper GM, Becklin KL, Rahrmann EP, McCarthy JB, Odde DJ, Wood DK, Largaespada DA, Moriarity BS. SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis. Oncogene. PMID 31582836 DOI: 10.1038/S41388-019-1041-X  0.818
2019 Huang M, Tailor J, Zhen Q, Gillmor AH, Miller ML, Weishaupt H, Chen J, Zheng T, Nash EK, McHenry LK, An Z, Ye F, Takashima Y, Clarke J, Ayetey H, ... ... Largaespada DA, et al. Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis. Cell Stem Cell. PMID 31204176 DOI: 10.1016/J.Stem.2019.05.013  0.668
2019 Chiu AP, Tschida BR, Sham TT, Lo LH, Moriarity BS, Li XX, Lo RC, Hinton DE, Rowlands DK, Chan CO, Mok DK, Largaespada DA, Warner N, Keng VW. HBx-K130M/V131I promotes liver cancer in transgenic mice via AKT/FOXO1 signaling pathway and arachidonic acid metabolism. Molecular Cancer Research : McR. PMID 30975706 DOI: 10.1158/1541-7786.Mcr-18-1127  0.634
2019 Ramkissoon A, Chaney KE, Milewski D, Williams KB, Williams RL, Choi K, Miller AA, Kalin TV, Pressey JG, Szabo S, Azam M, Largaespada DA, Ratner N. Targeted inhibition of the dual specificity phosphatases DUSP1 and DUSP6 suppress MPNST growth via JNK. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30936125 DOI: 10.1158/1078-0432.Ccr-18-3224  0.404
2019 Rathe SK, Popescu FE, Johnson JE, Watson AL, Marko TA, Moriarity BS, Ohlfest JR, Largaespada DA. Identification of candidate neoantigens produced by fusion transcripts in human osteosarcomas. Scientific Reports. 9: 358. PMID 30674975 DOI: 10.1038/S41598-018-36840-Z  0.802
2019 Beckmann PJ, Larson JD, Larsson AT, Ostergaard JP, Wagner S, Rahrmann EP, Shamsan GA, Otto GM, Williams RL, Wang J, Lee C, Tschida BR, Das P, Dubuc AM, Moriarity BS, ... ... Largaespada DA, et al. Sleeping Beauty insertional mutagenesis reveals important genetic drivers of central nervous system embryonal tumors. Cancer Research. PMID 30674530 DOI: 10.1158/0008-5472.Can-18-1261  0.823
2019 Slipek NJ, Varshney J, Largaespada DA. CRISPR/Cas9-Based Positive Screens for Cancer-Related Traits. Methods in Molecular Biology (Clifton, N.J.). 1907: 137-144. PMID 30542997 DOI: 10.1007/978-1-4939-8967-6_11  0.313
2019 Beckmann P, Krebs R, Larson J, Largaespada D. PDTM-19. MYC AND FAK/SRC COMBINATION TREATMENT OF FOXR2-HIGH BRAIN TUMORS Neuro-Oncology. 21: vi191-vi191. DOI: 10.1093/Neuonc/Noz175.795  0.653
2019 Osum S, Stemmer-Rachamimov A, Widemann B, Dombi E, Vitte J, Dahiya S, Rizvi T, Ratner N, Messiaen L, Gutmann D, Giovannini M, Moertel C, Largaespada D, Watson A. TMOD-23. PRECLINICAL DRUG EVALUATION IN A GENETICALLY ENGINEERED MINIPIG MODEL OF NEUROFIBROMATOSIS TYPE 1 Neuro-Oncology. 21: vi267-vi267. DOI: 10.1093/Neuonc/Noz175.1122  0.656
2019 Moertel C, Pluhar GE, Ampudia-Mesias E, Xiong Z, Pennell CA, Rathe SK, Largaespada DA, Olin MR. IMMU-23. TARGETING THE CD200 CHECKPOINT TO ENHANCE IMMUNOTHERAPY FOR CNS TUMORS Neuro-Oncology. 21: ii97-ii98. DOI: 10.1093/Neuonc/Noz036.142  0.688
2018 Li XX, Lu XY, Zhang SJ, Chiu AP, Lo LH, Largaespada DA, Chen QB, Keng VW. Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 111: 68-75. PMID 30576936 DOI: 10.1016/J.Biopha.2018.12.019  0.329
2018 Rahrmann EP, Wolf NK, Otto GM, Heltemes Harris L, Ramsey LB, Shu J, LaRue RS, Linden MA, Rathe SK, Starr TK, Farrar MA, Moriarity BS, Largaespada DA. Sleeping Beauty Screen Identifies RREB1 and Other Genetic Drivers in Human B-cell Lymphoma. Molecular Cancer Research : McR. PMID 30355676 DOI: 10.1158/1541-7786.Mcr-18-0582  0.826
2018 Isakson SH, Rizzardi AE, Coutts AW, Carlson DF, Kirstein MN, Fisher J, Vitte J, Williams KB, Pluhar GE, Dahiya S, Widemann BC, Dombi E, Rizvi T, Ratner N, Messiaen L, ... ... Largaespada DA, et al. Genetically engineered minipigs model the major clinical features of human neurofibromatosis type 1. Communications Biology. 1: 158. PMID 30302402 DOI: 10.1038/s42003-018-0163-y  0.619
2018 Antony ML, Noble-Orcutt K, Sachs K, Khoroshilov A, Chang D, Hillesheim A, Mohei H, Pamukcuoglu M, Bergene C, Largaespada DA, Sachs Z. NRASG12V-Mediated Self-Renewal Signaling in Self-Renewing AML Stem Cells. Blood. 132: 2626-2626. DOI: 10.1182/Blood-2018-99-119448  0.354
2018 Scott M, Temiz N, Sarver A, LaRue R, Rathe S, Varshney J, Wolf N, Moriarity B, Obrien T, Spector L, Largaespada D, Modiano J, Subramanian S, Sarver A. Abstract PR14: Immune cell transcript levels, metastatic progression, and survival in osteosarcoma: A comparative transcriptome analysis Omics a Journal of Integrative Biology. 24. DOI: 10.1158/1557-3265.Sarcomas17-Pr14  0.813
2018 Reyes GLV, Koes N, Kaufmann G, Ryu E, Largaespada DA. Abstract LB-197: Transposon mutagenesis and CRISPR/Cas9 screening reveal pathways driving peripheral nerve sheath tumor development and maintenance Cancer Research. 78. DOI: 10.1158/1538-7445.Am2018-Lb-197  0.494
2018 Sarver AL, Mills L, Temiz N, Scott M, Sarver A, Spector L, Wang J, Breen M, Subramanian S, Moriarity B, Modiano J, Largaespada D. Abstract 3399: Comparative genomic analyses of osteosarcoma etiology reveal a chromosomal structural rationale for the increased incidence of osteosarcoma in dogs Cancer Research. 78: 3399-3399. DOI: 10.1158/1538-7445.Am2018-3399  0.688
2018 Camilleri ET, Beckmann PJ, Larson JD, Kurata M, Shu J, Pope E, Hudson WA, Temiz NA, Rathe SK, LaRue RS, Sarver AE, Scott MC, Varshney J, Modiano JF, Moriarity BS, ... ... Largaespada DA, et al. Abstract 2264: RNA sequencing based analysis of transposon-induced tumors reveals novel insights into cancer pathogenesis and progression Cancer Research. 78: 2264-2264. DOI: 10.1158/1538-7445.Am2018-2264  0.836
2018 Beckmann P, Larson J, Larsson A, Ostergaard J, Largaespada D. CSIG-37. FOXR2 STABILIZES MYC AND ACTIVATES FAK/SRC SIGNALING IN A DUAL MECHANISM TO PROMOTE TRANSFORMATION IN NEURAL PROGENITOR CELLS Neuro-Oncology. 20: vi51-vi51. DOI: 10.1093/Neuonc/Noy148.203  0.577
2018 Olin M, Ampudia-Mesias E, Pennell CA, Xiong Z, Rathe SK, Largaespada DA, Moertel CL, Pluhar GE. CADD-14. TARGETING THE CD200 CHECKPOINT FOR THE FIGHT AGAINST CENTRAL NERVOUS SYSTEM TUMORS Neuro-Oncology. 20: vi278-vi279. DOI: 10.1093/Neuonc/Noy148.1159  0.686
2017 Paul JA, Aich A, Abrahante JE, Wang Y, LaRue RS, Rathe SK, Kalland K, Mittal A, Jha R, Peng F, Largaespada DA, Bagchi A, Gupta K. Transcriptomic analysis of gene signatures associated with sickle pain. Scientific Data. 4: 170051. PMID 29292796 DOI: 10.1038/Sdata.2017.51  0.688
2017 Carlson M, Watson AL, Anderson L, Largaespada DA, Provenzano PP. Multiphoton fluorescence lifetime imaging of chemotherapy distribution in solid tumors. Journal of Biomedical Optics. 22: 1-9. PMID 29188660 DOI: 10.1117/1.Jbo.22.11.116010  0.637
2017 Kurata M, Yamamoto K, Moriarity BS, Kitagawa M, Largaespada DA. CRISPR/Cas9 library screening for drug target discovery. Journal of Human Genetics. PMID 29158600 DOI: 10.1038/S10038-017-0376-9  0.645
2017 Scott MC, Temiz NA, Sarver AE, LaRue RS, Rathe SK, Varshney J, Wolf NK, Moriarity BS, O'Brien TD, Spector LG, Largaespada DA, Modiano JF, Subramanian S, Sarver AL. Comparative transcriptome analysis quantifies immune cell transcript levels, metastatic progression and survival in osteosarcoma. Cancer Research. PMID 29066513 DOI: 10.1158/0008-5472.Can-17-0576  0.812
2017 Tschida BR, Temiz NA, Kuka TP, Lee LA, Riordan JD, Tierrablanca CA, Hullsiek R, Wagner S, Hudson WA, Linden MA, Amin K, Beckmann PJ, Heuer RA, Sarver AL, Yang JD, ... ... Largaespada D, et al. Sleeping Beauty insertional mutagenesis in mice identifies drivers of steatosis-associated hepatic tumor. Cancer Research. PMID 28993411 DOI: 10.1158/0008-5472.Can-17-2281  0.324
2017 Kawakami K, Largaespada DA, Ivics Z. Transposons As Tools for Functional Genomics in Vertebrate Models. Trends in Genetics : Tig. PMID 28888423 DOI: 10.1016/J.Tig.2017.07.006  0.42
2017 Than BL, Linnekamp JF, Starr TK, Largaespada DA, Rod A, Zhang Y, Bruner V, Abrahante J, Schumann A, Luczak T, Walter J, Niemczyk A, O'Sullivan MG, Medema JP, Fijneman RJ, et al. CFTR is a tumor suppressor gene in murine and human intestinal cancer. Oncogene. PMID 28192405 DOI: 10.1038/Onc.2017.3  0.317
2017 Largaespada DA, Rathe SK, Gupta K, Wang Y, Jha R, Aich A, Paul J, Abrahante JE, LaRue RS, Kalland K, Mittal A, Peng F, Bagchi A. Data from Transcriptomic analysis of gene signatures associated with sickle pain Scientific Data. 4: 170051. DOI: 10.6084/M9.Figshare.C.3491244.V1  0.677
2017 Noble-Orcutt KE, Sachs K, Navis C, Hillesheim A, Nykaza I, LaRue RS, Hansen C, Ha N, Linden MA, Largaespada DA, Sachs Z. Abstract PR09: Single-cell transcriptional profiling of acute myeloid leukemia identifies self-renewing stem cells Clinical Cancer Research. 23. DOI: 10.1158/1557-3265.Hemmal17-Pr09  0.429
2017 Williams KB, Williams RL, Rathe SK, Hawkinson J, Largaespada DA. Abstract A37: Synthetic lethality as a tool to reveal novel vulnerabilities in NF1-associated tumorigenesis Molecular Cancer Therapeutics. 16. DOI: 10.1158/1538-8514.Synthleth-A37  0.758
2017 Isakson S, Coutts A, Largaespada D, Watson A. TMOD-43. A PORCINE MODEL OF NEUROFIBROMATOSIS TYPE I-ASSOCIATED NERVOUS SYSTEM TUMORS Neuro-Oncology. 19: vi263-vi263. DOI: 10.1093/Neuonc/Nox168.1079  0.639
2017 Huang M, Zheng T, Guo J, Sperring C, Miller M, McHenry L, Zhen Q, Moriarity B, Bronner M, Conklin B, Largaespada D, Maris J, Matthay K, Weiss W. TMOD-09. HUMAN PLURIPOTENT STEM CELL-BASED MODELS OF NEUROBLASTOMA Neuro-Oncology. 19: vi256-vi256. DOI: 10.1093/Neuonc/Nox168.1048  0.709
2016 Varshney J, Scott MC, Largaespada DA, Subramanian S. Understanding the Osteosarcoma Pathobiology: A Comparative Oncology Approach. Veterinary Sciences. 3. PMID 29056713 DOI: 10.3390/Vetsci3010003  0.428
2016 Pomeroy EJ, Lee LA, Lee RD, Schirm DK, Temiz NA, Ma J, Gruber TA, Diaz-Flores E, Moriarity BS, Downing JR, Shannon KM, Largaespada DA, Eckfeldt CE. Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia. Oncogene. PMID 27991934 DOI: 10.1038/Onc.2016.471  0.673
2016 Marko TA, Shamsan GA, Edwards EN, Hazelton PE, Rathe SK, Cornax I, Overn PR, Varshney J, Diessner BJ, Moriarity BS, O'Sullivan MG, Odde DJ, Largaespada DA. Slit-Robo GTPase-Activating Protein 2 as a metastasis suppressor in osteosarcoma. Scientific Reports. 6: 39059. PMID 27966608 DOI: 10.1038/Srep39059  0.816
2016 Kurata M, Rathe SK, Bailey NJ, Aumann NK, Jones JM, Veldhuijzen GW, Moriarity BS, Largaespada DA. Using genome-wide CRISPR library screening with library resistant DCK to find new sources of Ara-C drug resistance in AML. Scientific Reports. 6: 36199. PMID 27808171 DOI: 10.1038/Srep36199  0.78
2016 Eckfeldt CE, Pomeroy EJ, Lee RD, Hazen KS, Lee LA, Moriarity BS, Largaespada DA. RALB provides critical survival signals downstream of Ras in acute myeloid leukemia. Oncotarget. PMID 27556501 DOI: 10.18632/Oncotarget.11431  0.648
2016 Kebriaei P, Singh H, Huls MH, Figliola MJ, Bassett R, Olivares S, Jena B, Dawson MJ, Kumaresan PR, Su S, Maiti S, Dai J, Moriarity B, Forget MA, Senyukov V, ... ... Largaespada DA, et al. Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells. The Journal of Clinical Investigation. PMID 27482888 DOI: 10.1172/Jci86721  0.619
2016 Kendall JJ, Chaney KE, Patel AV, Rizvi TA, Largaespada DA, Ratner N. CK2 blockade causes MPNST cell apoptosis and promotes degradation of β-catenin. Oncotarget. PMID 27448963 DOI: 10.18632/Oncotarget.10668  0.356
2016 Sachs Z, Been RA, DeCoursin KJ, Nguyen HT, Mohd Hassan NA, Noble-Orcutt KE, Eckfeldt CE, Pomeroy EJ, Diaz-Flores E, Geurts JL, Diers MD, Hasz DE, Morgan KJ, MacMillan ML, Shannon KM, ... Largaespada DA, et al. Stat5 is critical for the development and maintenance of myeloproliferative neoplasm initiated by Nf1 deficiency. Haematologica. PMID 27418650 DOI: 10.3324/Haematol.2015.136002  0.809
2016 Patel AV, Chaney KE, Choi K, Largaespada DA, Kumar AR, Ratner N. An shRNA screen identifies MEIS1 as a driver of malignant peripheral nerve sheath tumors. Ebiomedicine. PMID 27333032 DOI: 10.1016/J.Ebiom.2016.06.007  0.467
2016 Watson AL, Carlson DF, Largaespada DA, Hackett PB, Fahrenkrug SC. Engineered Swine Models of Cancer. Frontiers in Genetics. 7: 78. PMID 27242889 DOI: 10.3389/Fgene.2016.00078  0.633
2016 Ho YY, Starr TK, LaRue RS, Largaespada DA. Case-oriented pathways analysis in pancreatic adenocarcinoma using data from a sleeping beauty transposon mutagenesis screen. Bmc Medical Genomics. 9: 16. PMID 27038937 DOI: 10.1186/S12920-016-0176-7  0.4
2016 Stoddart A, Qian Z, Fernald AA, Bergerson RJ, Wang J, Karrison T, Anastasi J, Bartom ET, Sarver AL, McNerney ME, Largaespada DA, Le Beau MM. Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms. Haematologica. PMID 26944478 DOI: 10.3324/Haematol.2015.139527  0.753
2016 Wu J, Keng V, Patmore DM, Kendall JJ, Patel AV, Jousma E, Jessen WJ, Choi K, Tschida BR, Silverstein KA, Fan D, Schwartz EB, Fuchs JR, Zou Y, Kim MO, ... ... Largaespada DA, et al. Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation. Cell Reports. PMID 26904939 DOI: 10.1016/J.Celrep.2016.01.074  0.341
2016 Yun YS, Kim KH, Tschida B, Sachs Z, Noble-Orcutt KE, Moriarity BS, Ai T, Ding R, Williams J, Chen L, Largaespada D, Kim DH. mTORC1 Coordinates Protein Synthesis and Immunoproteasome Formation via PRAS40 to Prevent Accumulation of Protein Stress. Molecular Cell. PMID 26876939 DOI: 10.1016/J.Molcel.2016.01.013  0.6
2016 Shu J, Li L, Sarver AE, Pope EA, Varshney J, Thayanithy V, Spector L, Largaespada DA, Steer CJ, Subramanian S. Imprinting defects at human 14q32 locus alters gene expression and is associated with the pathobiology of osteosarcoma. Oncotarget. PMID 26802029 DOI: 10.18632/Oncotarget.6965  0.368
2016 Morrissy AS, Garzia L, Shih DJ, Zuyderduyn S, Huang X, Skowron P, Remke M, Cavalli FM, Ramaswamy V, Lindsay PE, Jelveh S, Donovan LK, Wang X, Luu B, Zayne K, ... ... Largaespada DA, et al. Divergent clonal selection dominates medulloblastoma at recurrence. Nature. PMID 26760213 DOI: 10.1038/Nature16478  0.345
2016 Than BL, Linnekamp JF, Starr TK, Largaespada DA, Rod A, Zhang Y, Bruner V, Abrahante J, Schumann A, Luczak T, Niemczyk A, O'Sullivan MG, Medema JP, Fijneman RJ, Meijer GA, et al. CFTR is a tumor suppressor gene in murine and human intestinal cancer. Oncogene. PMID 26751771 DOI: 10.1038/Onc.2015.483  0.463
2016 Navis C, Noble-Orcutt K, LaRue RS, Hansen C, Ha N, Hillesheim A, Schulz R, Kim D, Largaespada DA, Sachs Z. Immunoproteasome Inhibition to Target AML with Activated RAS Pathways Blood. 128: 577-577. DOI: 10.1182/Blood.V128.22.577.577  0.424
2016 Hermanson DL, Moriarity B, Argall T, Geller MA, Largaespada D, Kaufman DS. Abstract A175: Design and evaluation of novel natural killer cell chimeric antigen receptors Cancer Immunology Research. 4. DOI: 10.1158/2326-6074.Cricimteatiaacr15-A175  0.651
2016 Wolf N, Smeester B, Weg M, Largaespada DA, Moriarity BS. Abstract A36: Validation of candidate cancer genes using the CRISPR system Cancer Research. 76. DOI: 10.1158/1538-7445.Pedca15-A36  0.718
2016 Tschida BR, Temiz NA, Yang JD, Keng VW, Largaespada DA. Abstract 63: A transposon-based forward genetic screen for steatosis-associated liver cancer drivers Cancer Research. 76: 63-63. DOI: 10.1158/1538-7445.Am2016-63  0.336
2016 Clark CR, Conboy C, Maile M, Janik C, Hatler J, Cormier R, Largaespada D, Starr TK. Abstract 3665: WAC: A candidate tumor suppressor gene in colorectal cancer Cancer Research. 76: 3665-3665. DOI: 10.1158/1538-7445.Am2016-3665  0.473
2016 LaRue RS, Noble-Orcutt KE, Hansen C, Ha N, Largaespada DA, Sachs Z. Abstract 3339: Single-cell analysis reveals molecular mechanisms of NRAS-mediated leukemia stem cell self-renewal in a murine model of AML Cancer Research. 76: 3339-3339. DOI: 10.1158/1538-7445.Am2016-3339  0.388
2016 Marko T, Shamsan G, Largaespada D. Abstract 1621: SRGAP2 expression levels may induce a biphasic metastatic phenotype in osteosarcoma cell lines Cancer Research. 76: 1621-1621. DOI: 10.1158/1538-7445.Am2016-1621  0.452
2016 Jackson P, Larsson A, Das P, Largaespada D. Abstract 1121: Validation of FOXR2 and ARHGAP36 as oncogenes in medulloblastoma Cancer Research. 76: 1121-1121. DOI: 10.1158/1538-7445.Am2016-1121  0.507
2016 Zuckermann M, Hovestadt V, Knobbe-Thomsen CB, Zapatka M, Northcott PA, Schramm K, Belic J, Jones DT, Tschida B, Moriarity B, Largaespada D, Roussel MF, Korshunov A, Reifenberger G, Pfister SM, et al. PCM-15SOMATIC CRISPR/Cas9-MEDIATED TUMOR SUPPRESSOR DISRUPTION ENABLES VERSATILE BRAIN TUMOR MODELING Neuro-Oncology. 18: iii142.2-iii142. DOI: 10.1093/Neuonc/Now080.15  0.629
2015 Wolf NK, Largaespada DA, Moriarity BS. Coping with cancer genes altered by copy number. Oncotarget. 6: 35155-6. PMID 26577648 DOI: 10.18632/Oncotarget.6215  0.699
2015 Chiu AP, Tschida BR, Lo LH, Moriarity BS, Rowlands DK, Largaespada DA, Keng VW. Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma. World Journal of Gastroenterology. 21: 12157-70. PMID 26576100 DOI: 10.3748/Wjg.V21.I42.12157  0.614
2015 Temiz NA, Moriarity BS, Wolf NK, Riordan JD, Dupuy AJ, Largaespada DA, Sarver AL. RNA sequencing of Sleeping Beauty transposon-induced tumors detect transposon-RNA fusions allowing precision analyses of forward genetic cancer screens. Genome Research. PMID 26553456 DOI: 10.1101/Gr.188649.114  0.642
2015 Heltemes-Harris LM, Larson JD, Starr TK, Hubbard GK, Sarver AL, Largaespada DA, Farrar MA. Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia. Oncogene. PMID 26500062 DOI: 10.1038/Onc.2015.405  0.659
2015 Kempema AM, Widen JC, Hexum JK, Andrews TE, Wang D, Rathe SK, Meece FA, Noble KE, Sachs Z, Largaespada DA, Harki DA. Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues. Bioorganic & Medicinal Chemistry. 23: 4737-45. PMID 26088334 DOI: 10.1016/J.Bmc.2015.05.037  0.714
2015 Mirabello L, Koster R, Moriarity BS, Spector LG, Meltzer PS, Gary J, Machiela MJ, Pankratz N, Panagiotou OA, Largaespada D, Wang Z, Gastier-Foster JM, Gorlick R, Khanna C, Caminada de Toledo SR, et al. A genome-wide scan identifies variants in NFIB associated with metastasis in patients with osteosarcoma. Cancer Discovery. PMID 26084801 DOI: 10.1158/2159-8290.Cd-15-0125  0.634
2015 Zuckermann M, Hovestadt V, Knobbe-Thomsen CB, Zapatka M, Northcott PA, Schramm K, Belic J, Jones DT, Tschida B, Moriarity B, Largaespada D, Roussel MF, Korshunov A, Reifenberger G, Pfister SM, et al. Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling. Nature Communications. 6: 7391. PMID 26067104 DOI: 10.1038/Ncomms8391  0.678
2015 Moriarity BS, Largaespada DA. Sleeping Beauty transposon insertional mutagenesis based mouse models for cancer gene discovery. Current Opinion in Genetics & Development. 30: 66-72. PMID 26051241 DOI: 10.1016/J.Gde.2015.04.007  0.7
2015 Dorr C, Janik C, Weg M, Been RA, Bader J, Kang R, Ng B, Foran L, Landman SR, O'Sullivan MG, Steinbach M, Sarver AL, Silverstein KA, Largaespada DA, Starr TK. Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor. Molecular Cancer Research : McR. 13: 1238-47. PMID 25995385 DOI: 10.1158/1541-7786.Mcr-14-0674-T  0.812
2015 Hexum JK, Becker CM, Kempema AM, Ohlfest JR, Largaespada DA, Harki DA. Parthenolide prodrug LC-1 slows growth of intracranial glioma. Bioorganic & Medicinal Chemistry Letters. 25: 2493-5. PMID 25978958 DOI: 10.1016/J.Bmcl.2015.04.058  0.361
2015 Moriarity BS, Otto GM, Rahrmann EP, Rathe SK, Wolf NK, Weg MT, Manlove LA, LaRue RS, Temiz NA, Molyneux SD, Choi K, Holly KJ, Sarver AL, Scott MC, Forster CL, ... ... Largaespada DA, et al. A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis. Nature Genetics. 47: 615-24. PMID 25961939 DOI: 10.1038/Ng.3293  0.825
2015 Larue RS, Noble KE, Hansen C, Ha N, Largaespada DA, Sachs Z. Single-Cell Analysis Reveals Molecular Mechanisms of NRAS-Mediated Leukemia Stem Cell Self-Renewal in a Murine Model of AML Blood. 126: 3060-3060. DOI: 10.1182/Blood.V126.23.3060.3060  0.407
2015 Sachs Z, LaRue RS, Noble K, Rathe SK, Sarver AL, Ha NA, Largaespada DA. Abstract B34: Single cell RNA sequencing identifies the NRASG12V-mediated AML self-renewal signature. Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Hemmal14-B34  0.743
2015 Eckfeldt CE, Lee RD, Pomeroy EJ, Temiz AN, Rathe SK, Ma J, Gruber TA, Diaz-Flores E, Downing JR, Shannon KM, Largaespada DA. Abstract B01: Mechanisms of treatment resistance following Ras targeted therapy in acute myeloid leukemia. Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Hemmal14-B01  0.734
2015 Zuckermann M, Hovestadt V, Knobbe-Thomsen CB, Zapatka M, Northcott PA, Schramm K, Belic J, Jones DTW, Tschida B, Moriarity B, Largaespada D, Roussel MF, Korshunov A, Reifenberger G, Pfister SM, et al. Abstract PR02: Somatic CRISPR/Cas9-mediated tumor suppressor disruption enables versatile brain tumor modeling Brain. 75. DOI: 10.1158/1538-7445.Brain15-Pr02  0.709
2015 Huang M, McHenry LK, Miller ML, Kim GE, Moriarity BS, Miyaoka Y, Bronner ME, Largaespada DA, Conklin BR, Ji HP, Maris JM, Matthay KK, Weiss WA. Abstract 3230: Human stem cell-based model of MYCN-driven neuroblastoma Cancer Research. 75: 3230-3230. DOI: 10.1158/1538-7445.Am2015-3230  0.699
2015 Das P, Jackson P, Moriarity B, Rahrmann E, LaRue R, Largaespada D. PTPS-02FOXR2: AN ONCOGENE IN MEDULLOBLASTOMA Neuro-Oncology. 17: v179.2-v179. DOI: 10.1093/Neuonc/Nov228.02  0.828
2014 Sachs Z, LaRue RS, Nguyen HT, Sachs K, Noble KE, Mohd Hassan NA, Diaz-Flores E, Rathe SK, Sarver AL, Bendall SC, Ha NA, Diers MD, Nolan GP, Shannon KM, Largaespada DA. NRASG12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia. Blood. 124: 3274-83. PMID 25316678 DOI: 10.1182/Blood-2013-08-521708  0.748
2014 Rathe SK, Moriarity BS, Stoltenberg CB, Kurata M, Aumann NK, Rahrmann EP, Bailey NJ, Melrose EG, Beckmann DA, Liska CR, Largaespada DA. Using RNA-seq and targeted nucleases to identify mechanisms of drug resistance in acute myeloid leukemia. Scientific Reports. 4: 6048. PMID 25116387 DOI: 10.1038/Srep06048  0.803
2014 Tseng YY, Moriarity BS, Gong W, Akiyama R, Tiwari A, Kawakami H, Ronning P, Reuland B, Guenther K, Beadnell TC, Essig J, Otto GM, O'Sullivan MG, Largaespada DA, Schwertfeger KL, et al. PVT1 dependence in cancer with MYC copy-number increase. Nature. 512: 82-6. PMID 25043044 DOI: 10.1038/Nature13311  0.663
2014 Li MV, Shukla D, Rhodes BH, Lall A, Shu J, Moriarity BS, Largaespada DA. HomeRun Vector Assembly System: a flexible and standardized cloning system for assembly of multi-modular DNA constructs. Plos One. 9: e100948. PMID 24959875 DOI: 10.1371/Journal.Pone.0100948  0.587
2014 Litterman AJ, Zellmer DM, LaRue RS, Jameson SC, Largaespada DA. Antigen-specific culture of memory-like CD8 T cells for adoptive immunotherapy. Cancer Immunology Research. 2: 839-45. PMID 24852944 DOI: 10.1158/2326-6066.Cir-14-0038  0.328
2014 Rahrmann EP, Moriarity BS, Otto GM, Watson AL, Choi K, Collins MH, Wallace M, Webber BR, Forster CL, Rizzardi AE, Schmechel SC, Ratner N, Largaespada DA. Trp53 haploinsufficiency modifies EGFR-driven peripheral nerve sheath tumorigenesis. The American Journal of Pathology. 184: 2082-98. PMID 24832557 DOI: 10.1016/J.Ajpath.2014.04.006  0.832
2014 Been RA, Linden MA, Hager CJ, DeCoursin KJ, Abrahante JE, Landman SR, Steinbach M, Sarver AL, Largaespada DA, Starr TK. Genetic signature of histiocytic sarcoma revealed by a sleeping beauty transposon genetic screen in mice. Plos One. 9: e97280. PMID 24827933 DOI: 10.1371/Journal.Pone.0097280  0.823
2014 Moriarity BS, Rahrmann EP, Beckmann DA, Conboy CB, Watson AL, Carlson DF, Olson ER, Hyland KA, Fahrenkrug SC, McIvor RS, Largaespada DA. Simple and efficient methods for enrichment and isolation of endonuclease modified cells. Plos One. 9: e96114. PMID 24798371 DOI: 10.1371/Journal.Pone.0096114  0.813
2014 Watson AL, Anderson LK, Greeley AD, Keng VW, Rahrmann EP, Halfond AL, Powell NM, Collins MH, Rizvi T, Moertel CL, Ratner N, Largaespada DA. Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity. Oncotarget. 5: 1502-14. PMID 24681606 DOI: 10.18632/Oncotarget.1609  0.81
2014 Tschida BR, Largaespada DA, Keng VW. Mouse models of cancer: Sleeping Beauty transposons for insertional mutagenesis screens and reverse genetic studies. Seminars in Cell & Developmental Biology. 27: 86-95. PMID 24468652 DOI: 10.1016/J.Semcdb.2014.01.006  0.375
2014 Than BL, Goos JA, Sarver AL, O'Sullivan MG, Rod A, Starr TK, Fijneman RJ, Meijer GA, Zhao L, Zhang Y, Largaespada DA, Scott PM, Cormier RT. The role of KCNQ1 in mouse and human gastrointestinal cancers. Oncogene. 33: 3861-8. PMID 23975432 DOI: 10.1038/Onc.2013.350  0.478
2014 Eckfeldt CE, Pomeroy EJ, Lee RD, Hazen KS, Moriarity BS, Largaespada DA. Ras Effector Pathways Differentially Support Proliferation and Survival of Acute Myeloid Leukemia Blood. 124: 3755-3755. DOI: 10.1182/Blood.V124.21.3755.3755  0.664
2014 Sachs Z, LaRue RS, Nguyen HT, Sachs K, Hassan NAM, Diaz-Flores E, Rathe SK, Sarver AL, Bendall SC, Ha NA, Diers MD, Nolan GP, Shannon KM, Largaespada DA. Abstract B15: NRASG12V oncogene mediates self-renewal in a murine model of acute myelogenous leukemia Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Rasonc14-B15  0.75
2014 Keng VW, Tschida BR, Kuka TP, Moriarity BS, Bell JB, Largaespada DA. Abstract 929: Identification of ZBTB20 as a novel oncogene associated with the gender bias occurrence of hepatocellular carcinoma Cancer Research. 74: 929-929. DOI: 10.1158/1538-7445.Am2014-929  0.662
2014 Jackson P, Das P, Larson J, Moriarity B, Largaespada D. PM-05 * ARHGAP36 AS A NOVEL DRIVER IN HIGH-RISK HUMAN MEDULLOBLASTOMA Neuro-Oncology. 16: v170-v170. DOI: 10.1093/Neuonc/Nou268.5  0.774
2014 Tschida BR, Lowy AR, Marek CA, Ringstrom T, Beadnell TC, Klank RL, Odde DJ, Clark HB, Wiesner SM, Largaespada DA. PM-21 * A REVERSE GENETIC SCREEN FOR DRIVERS OF GBM Neuro-Oncology. 16: v173-v173. DOI: 10.1093/Neuonc/Nou268.21  0.802
2014 Ratner N, Keng V, Patmore DM, Kendall JK, Jousma E, Choi K, Fan D, Schwartz EB, Fuchs JR, Zou Y, Kim M, Dombi E, Levy DE, Cancelas JA, Stemmer-Rachamimov A, ... ... Largaespada DA, et al. PM-18 * EGFR-STAT3 ACTIVATES  -CATENIN SIGNALING TO DRIVE NEUROFIBROMA INITIATION IN NF1, AND PLAYS A ROLE IN TUMOR MAINTENANCE Neuro-Oncology. 16: v172-v173. DOI: 10.1093/Neuonc/Nou268.18  0.417
2014 Moriarity B, Tschida B, Largaespada D. PM-14 * MODELING GBM IN MICE USING THE CRISPR NUCLEASE SYSTEM TO FUNCTIONALLY VALIDATE NOVEL CANDIDATE DRIVER GENES AND TEST NEW THERAPIES Neuro-Oncology. 16: v172-v172. DOI: 10.1093/Neuonc/Nou268.14  0.469
2013 Been RA, Ross JA, Nagel CW, Hooten AJ, Langer EK, DeCoursin KJ, Marek CA, Janik CL, Linden MA, Reed RC, Schutten MM, Largaespada DA, Johnson KJ. Perigestational dietary folic acid deficiency protects against medulloblastoma formation in a mouse model of nevoid basal cell carcinoma syndrome. Nutrition and Cancer. 65: 857-65. PMID 23909730 DOI: 10.1080/01635581.2013.804940  0.803
2013 Rathe SK, Johnson JE, Silverstein KA, Erdmann JJ, Watson AL, Popescu FE, Ohlfest JR, Largaespada DA. MMuFLR: missense mutation and frameshift location reporter. Bioinformatics (Oxford, England). 29: 2353-4. PMID 23825368 DOI: 10.1093/Bioinformatics/Btt385  0.784
2013 Rahrmann EP, Watson AL, Keng VW, Choi K, Moriarity BS, Beckmann DA, Wolf NK, Sarver A, Collins MH, Moertel CL, Wallace MR, Gel B, Serra E, Ratner N, Largaespada DA. Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis. Nature Genetics. 45: 756-66. PMID 23685747 DOI: 10.1038/Ng.2641  0.828
2013 Rahrmann EP, Largaespada DA. Retrotransposons: a new and credible source of inherited and somatically acquired hepatocellular carcinoma mutations. Journal of Hepatology. 59: 616-7. PMID 23665280 DOI: 10.1016/J.Jhep.2013.05.001  0.742
2013 Charbonneau B, Vogel RI, Manivel JC, Rizzardi A, Schmechel SC, Ognjanovic S, Subramanian S, Largaespada D, Weigel B. Expression of FGFR3 and FGFR4 and clinical risk factors associated with progression-free survival in synovial sarcoma. Human Pathology. 44: 1918-26. PMID 23664540 DOI: 10.1016/J.Humpath.2013.03.001  0.361
2013 Riordan JD, Keng VW, Tschida BR, Scheetz TE, Bell JB, Podetz-Pedersen KM, Moser CD, Copeland NG, Jenkins NA, Roberts LR, Largaespada DA, Dupuy AJ. Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis. Plos Genetics. 9: e1003441. PMID 23593033 DOI: 10.1371/Journal.Pgen.1003441  0.393
2013 Watson AL, Rahrmann EP, Moriarity BS, Choi K, Conboy CB, Greeley AD, Halfond AL, Anderson LK, Wahl BR, Keng VW, Rizzardi AE, Forster CL, Collins MH, Sarver AL, Wallace MR, ... ... Largaespada DA, et al. Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance. Cancer Discovery. 3: 674-89. PMID 23535903 DOI: 10.1158/2159-8290.Cd-13-0081  0.823
2013 Largaespada D, Ratner N. Interweaving the strands: β-catenin, an HIV co-receptor, and Schwann cell tumors. Cancer Cell. 23: 269-71. PMID 23518344 DOI: 10.1016/J.Ccr.2013.03.001  0.356
2013 Moriarity BS, Rahrmann EP, Keng VW, Manlove LS, Beckmann DA, Wolf NK, Khurshid T, Bell JB, Largaespada DA. Modular assembly of transposon integratable multigene vectors using RecWay assembly. Nucleic Acids Research. 41: e92. PMID 23444141 DOI: 10.1093/Nar/Gkt115  0.797
2013 Hackett PB, Largaespada DA, Switzer KC, Cooper LJ. Evaluating risks of insertional mutagenesis by DNA transposons in gene therapy. Translational Research : the Journal of Laboratory and Clinical Medicine. 161: 265-83. PMID 23313630 DOI: 10.1016/J.Trsl.2012.12.005  0.396
2013 Omidvar N, Maunakea ML, Jones L, Sevcikova S, Yin B, Himmel KL, Tennant TR, Le Beau MM, Largaespada DA, Kogan SC. PML-RARα co-operates with Sox4 in acute myeloid leukemia development in mice. Haematologica. 98: 424-7. PMID 23144197 DOI: 10.3324/Haematol.2011.057067  0.801
2013 Keng VW, Sia D, Sarver AL, Tschida BR, Fan D, Alsinet C, Solé M, Lee WL, Kuka TP, Moriarity BS, Villanueva A, Dupuy AJ, Riordan JD, Bell JB, Silverstein KA, ... ... Largaespada DA, et al. Sex bias occurrence of hepatocellular carcinoma in Poly7 molecular subclass is associated with EGFR. Hepatology (Baltimore, Md.). 57: 120-30. PMID 22899566 DOI: 10.1002/Hep.26004  0.639
2013 LaRue RS, Nguyen H, Sachs K, Mohd Hassan NA, Diaz-Flores E, Rathe SK, Sarver AG, Bendall SC, Ha NA, Diers MD, Nolan GP, Shannon K, Sachs Z, Largaespada DA. Ras-Pathway Inhibition With Targeted Therapies Abrogates Self-Renewal In Acute Myelogenous Leukemia Blood. 122: 819-819. DOI: 10.1182/Blood.V122.21.819.819  0.743
2013 Chen Z, Tan D, Zhao W, Su G, Zheng Y, He C, Diers MD, Mao Z, Singleton T, Largaespada DA, Yin B. Cellular Intrinsic Mechanism Affecting The Outcome Of AML Treatment With Ara-C In a Syngeneic Mouse Model Blood. 122: 5025-5025. DOI: 10.1182/Blood.V122.21.5025.5025  0.429
2013 Stoddart A, Fernald A, Bergerson RJ, Wang J, McNerney ME, Karrison T, Anastasi J, Bartom E, Sarver AG, Qian Z, Wolff L, Largaespada DA, Beau MMl. Retroviral Insertional Mutagenesis In Egr1+/- mice, Haploinsufficient For a Human Del(5q) Myeloid Leukemia Gene, Develop Myeloid Neoplasms With Proviral Insertions In Genes Syntenic To Human 5q Blood. 122: 1275-1275. DOI: 10.1182/Blood.V122.21.1275.1275  0.789
2013 Powell TA, Moriarity BS, Sarver AL, Largaespada DA. Abstract C3: Candidate osteosarcoma metastatic drivers identified in highly clonal metastases using transposon-mediated insertional mutagenesis Cancer Research. 73. DOI: 10.1158/1538-7445.Tim2013-C3  0.719
2013 Dorr C, Weg M, Been R, O'Sullivan MG, Sarver A, Largaespada DA, Starr TK. Abstract C43: A Sleeping Beauty forward genetic screen identifies novel cancer drivers that cooperate with Pten in lung cancer Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-C43  0.832
2013 Keng VW, Watson AL, Rahrmann EP, Li H, Tschida BR, Moriarity BS, Choi K, Rizvi TA, Collins MH, Wallace MR, Ratner N, Largaespada DA. Abstract 354: Conditional inactivation of Pten and overexpression of EGFR in Schwann cells results in early high-grade peripheral nerve sheath tumor development. Cancer Research. 73: 354-354. DOI: 10.1158/1538-7445.Am2013-354  0.824
2013 Than BLN, O'Sullivan MG, Starr T, Largaespada D, Cormier RT, Scott PM. Abstract 1970: Validation of candidate gastrointestinal cancer genes with ion channel functions, identified from Sleeping Beauty transposon-mediated mutagenesis screens in mice. Cancer Research. 73: 1970-1970. DOI: 10.1158/1538-7445.Am2013-1970  0.451
2013 Conboy CB, Tschida BR, Hu H, Burns MB, Temiz NA, Kuka T, Keng VW, Toffanin S, Harris RS, Llovet J, Starr TK, Largaespada DA. Abstract A242: R-spondin 2 drives Wnt signaling and tumor formation in breast and liver cancer. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-A242  0.411
2013 Agarwal M, Nitta R, Dovat S, Li G, Arita H, Narita Y, Fukushima S, Tateishi K, Matsushita Y, Yoshida A, Miyakita Y, Ohno M, Collins VP, Kawahara N, Shibui S, ... ... Largaespada DA, et al. CELL BIOLOGY AND SIGNALING Neuro-Oncology. 15: iii12-iii31. DOI: 10.1093/Neuonc/Not174  0.713
2013 Litterman AJ, Zellmer DM, Largaespada DA. 169 Cytokine. 63: 282-283. DOI: 10.1016/J.Cyto.2013.06.172  0.366
2012 Keng VW, Watson AL, Rahrmann EP, Li H, Tschida BR, Moriarity BS, Choi K, Rizvi TA, Collins MH, Wallace MR, Ratner N, Largaespada DA. Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST. Sarcoma. 2012: 620834. PMID 23319880 DOI: 10.1155/2012/620834  0.825
2012 Biankin AV, Waddell N, Kassahn KS, Gingras MC, Muthuswamy LB, Johns AL, Miller DK, Wilson PJ, Patch AM, Wu J, Chang DK, Cowley MJ, Gardiner BB, Song S, Harliwong I, ... ... Largaespada DA, et al. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature. 491: 399-405. PMID 23103869 DOI: 10.1038/Nature11547  0.416
2012 Solyom S, Ewing AD, Rahrmann EP, Doucet T, Nelson HH, Burns MB, Harris RS, Sigmon DF, Casella A, Erlanger B, Wheelan S, Upton KR, Shukla R, Faulkner GJ, Largaespada DA, et al. Extensive somatic L1 retrotransposition in colorectal tumors. Genome Research. 22: 2328-38. PMID 22968929 DOI: 10.1101/Gr.145235.112  0.734
2012 Seshagiri S, Stawiski EW, Durinck S, Modrusan Z, Storm EE, Conboy CB, Chaudhuri S, Guan Y, Janakiraman V, Jaiswal BS, Guillory J, Ha C, Dijkgraaf GJ, Stinson J, Gnad F, ... ... Largaespada DA, et al. Recurrent R-spondin fusions in colon cancer. Nature. 488: 660-4. PMID 22895193 DOI: 10.1038/Nature11282  0.421
2012 Maroteaux G, Loos M, van der Sluis S, Koopmans B, Aarts E, van Gassen K, Geurts A, Largaespada DA, Spruijt BM, Stiedl O, Smit AB, Verhage M. High-throughput phenotyping of avoidance learning in mice discriminates different genotypes and identifies a novel gene. Genes, Brain, and Behavior. 11: 772-84. PMID 22846151 DOI: 10.1111/J.1601-183X.2012.00820.X  0.595
2012 Larson JD, Largaespada DA. Review: In vivo models for defining molecular subtypes of the primitive neuroectodermal tumor genome: current challenges and solutions. In Vivo (Athens, Greece). 26: 487-500. PMID 22773561  0.614
2012 Keng VW, Rahrmann EP, Watson AL, Tschida BR, Moertel CL, Jessen WJ, Rizvi TA, Collins MH, Ratner N, Largaespada DA. PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors. Cancer Research. 72: 3405-13. PMID 22700876 DOI: 10.1158/0008-5472.Can-11-4092  0.834
2012 Pérez-Mancera PA, Rust AG, van der Weyden L, Kristiansen G, Li A, Sarver AL, Silverstein KA, Grützmann R, Aust D, Rümmele P, Knösel T, Herd C, Stemple DL, Kettleborough R, Brosnan JA, ... ... Largaespada DA, et al. The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Nature. 486: 266-70. PMID 22699621 DOI: 10.1038/Nature11114  0.473
2012 O'Donnell KA, Keng VW, York B, Reineke EL, Seo D, Fan D, Silverstein KA, Schrum CT, Xie WR, Mularoni L, Wheelan SJ, Torbenson MS, O'Malley BW, Largaespada DA, Boeke JD. A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer. Proceedings of the National Academy of Sciences of the United States of America. 109: E1377-86. PMID 22556267 DOI: 10.1073/Pnas.1115433109  0.438
2012 Bergerson RJ, Collier LS, Sarver AL, Been RA, Lugthart S, Diers MD, Zuber J, Rappaport AR, Nixon MJ, Silverstein KA, Fan D, Lamblin AF, Wolff L, Kersey JH, Delwel R, ... ... Largaespada DA, et al. An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model. Blood. 119: 4512-23. PMID 22427200 DOI: 10.1182/Blood-2010-04-281428  0.823
2012 Bergemann TL, Starr TK, Yu H, Steinbach M, Erdmann J, Chen Y, Cormier RT, Largaespada DA, Silverstein KA. New methods for finding common insertion sites and co-occurring common insertion sites in transposon- and virus-based genetic screens. Nucleic Acids Research. 40: 3822-33. PMID 22241771 DOI: 10.7490/F1000Research.1929.1  0.409
2012 Sachs Z, Nguyen H, Hassan NAM, Rathe SK, Sachs K, Diaz-Flores E, Bendall SC, Diers MD, Nolan GP, Shannon KM, Largaespada DA. Activated NRAS Mediates Self-Renewal Capacity in AML by Facilitating the Mll/AF9-Specified Gene Expression Signature Blood. 120: 5116-5116. DOI: 10.1182/Blood.V120.21.5116.5116  0.745
2012 Allaei R, Starr TK, Sarver A, O'Sullivan MG, Largaespada DA. Abstract 5115: Genetic signature of histiocytic sarcoma revealed by an unbiased genetic screen in mice Cancer Research. 72: 5115-5115. DOI: 10.1158/1538-7445.Am2012-5115  0.537
2012 Sachs Z, Rathe SK, Diaz-Flores E, Diers MD, Shannon K, Largaespada DA. Abstract 4176: Activated NRAS mediates self-renewal capacity in AML Cancer Research. 72: 4176-4176. DOI: 10.1158/1538-7445.Am2012-4176  0.739
2012 Shu J, Li L, Moriarity B, Thayanithy V, Spector LG, Largaespada DA, Steer CJ, Subramanian S. Abstract 4042: Loss of imprinting at the 14q32 locus contributes to osteosarcoma Cancer Research. 72: 4042-4042. DOI: 10.1158/1538-7445.Am2012-4042  0.664
2012 Wu J, Keng V, Patmore DM, Jousma E, Eaves DW, Johansson G, Schwartz EB, Fuchs JR, Dunn S, Lindquist D, Dombi E, Widemann BC, Stemmer-Rachamimov Ao, Cancelas JA, Cripe TP, ... Largaespada DA, et al. Abstract 2937: An EGFR-STAT3 pathway promotes NF1 peripheral nerve tumorigenesis and transformation Cancer Research. 72: 2937-2937. DOI: 10.1158/1538-7445.Am2012-2937  0.461
2012 Conboy CB, Hatler JM, Scott PM, Sarver AL, Silverstein KA, Seshagiri S, Adams M, Lillemoe J, Dorr CR, Cormier RT, Starr TK, Largaespada DA. Abstract 108: Functional characterization of WAC, a candidate tumor suppressor gene in colorectal cancer Cancer Research. 72: 108-108. DOI: 10.1158/1538-7445.Am2012-108  0.468
2012 Varela I, Tarpey P, Raine K, Huang D, Ong CK, Stephens P, Davies H, Jones D, Lin M, Teague J, Bignell G, Butler A, Cho J, Dalgliesh GL, Galappaththige D, ... ... Largaespada DA, et al. Erratum: Corrigendum: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma Nature. 484: 130-130. DOI: 10.1038/Nature11027  0.352
2012 Ang S, Maiti S, Moriarity B, Andrews K, Ossowski M, Tzeng K, Talbot R, Kellar D, Huls H, Kebriaei P, Kelly S, Shpall E, Largaespada D, Champlin R, Hackett P, et al. Assessing Sleeping Beauty Transpositions for T-Cell Immunotherapy by Supercomputer-Based High-Throughput Profiling of Integration Events Biology of Blood and Marrow Transplantation. 18: S219. DOI: 10.1016/J.Bbmt.2011.12.046  0.6
2011 Moriarity B, Largaespada DA. A Comprehensive Guide to Sleeping Beauty-Based Somatic Transposon Mutagenesis in the Mouse. Current Protocols in Mouse Biology. 1: 347-68. PMID 26069058 DOI: 10.1002/9780470942390.Mo110087  0.66
2011 Wilber A, Ulloa Montoya F, Hammer L, Moriarity BS, Geurts AM, Largaespada DA, Verfaillie CM, McIvor RS, Lakshmipathy U. Efficient non-viral integration and stable gene expression in multipotent adult progenitor cells. Stem Cells International. 2011: 717069. PMID 21977042 DOI: 10.4061/2011/717069  0.733
2011 Wiesner SM, Geurts JL, Diers MD, Bergerson RJ, Hasz DE, Morgan KJ, Largaespada DA. Nf1 mutant mice with p19ARF gene loss develop accelerated hematopoietic disease resembling acute leukemia with a variable phenotype. American Journal of Hematology. 86: 579-85. PMID 21681782 DOI: 10.1002/Ajh.22035  0.804
2011 McGrail M, Hatler JM, Kuang X, Liao HK, Nannapaneni K, Watt KE, Uhl JD, Largaespada DA, Vollbrecht E, Scheetz TE, Dupuy AJ, Hostetter JM, Essner JJ. Somatic mutagenesis with a Sleeping Beauty transposon system leads to solid tumor formation in zebrafish. Plos One. 6: e18826. PMID 21533036 DOI: 10.1371/Journal.Pone.0018826  0.442
2011 Starr TK, Scott PM, Marsh BM, Zhao L, Than BL, O'Sullivan MG, Sarver AL, Dupuy AJ, Largaespada DA, Cormier RT. A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 108: 5765-70. PMID 21436051 DOI: 10.1073/Pnas.1018012108  0.424
2011 Keng VW, Tschida BR, Bell JB, Largaespada DA. Modeling hepatitis B virus X-induced hepatocellular carcinoma in mice with the Sleeping Beauty transposon system. Hepatology (Baltimore, Md.). 53: 781-90. PMID 21374658 DOI: 10.1002/Hep.24091  0.358
2011 Varela I, Tarpey P, Raine K, Huang D, Ong CK, Stephens P, Davies H, Jones D, Lin ML, Teague J, Bignell G, Butler A, Cho J, Dalgliesh GL, Galappaththige D, ... ... Largaespada DA, et al. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature. 469: 539-42. PMID 21248752 DOI: 10.1038/Nature09639  0.379
2011 Carlson DF, Geurts AM, Garbe JR, Park CW, Rangel-Filho A, O'Grady SM, Jacob HJ, Steer CJ, Largaespada DA, Fahrenkrug SC. Efficient mammalian germline transgenesis by cis-enhanced Sleeping Beauty transposition. Transgenic Research. 20: 29-45. PMID 20352328 DOI: 10.1007/S11248-010-9386-5  0.584
2011 Sachs Z, Rathe SK, Diaz-Flores E, Diers MD, Shannon KM, Largaespada DA. Delineating Critical Effectors of Remission Induction in a Mouse Model of AML Blood. 118: 5232-5232. DOI: 10.1182/Blood.V118.21.5232.5232  0.758
2011 Ang SO, Maiti S, Moriarity B, Ossowski M, Andrews K, Tzeng K, Talbot R, Kellar D, Huls H, Kebriaei P, Largaespada DA, Champlin R, Hackett P, Cooper LJN. Assessing Potential Genotoxicity of Sleeping Beauty Transposition Events in T-Cell Immunotherapy by Supercomputer-Based High Throughput Profiling, Blood. 118: 4174-4174. DOI: 10.1182/Blood.V118.21.4174.4174  0.651
2011 Eckfeldt CE, Diaz-Flores E, Diers MD, Rathe SK, Shannon KM, Largaespada DA. Mechanisms of Relapse Following Targeted Therapy in An NRASG12V and Mll-AF9 Driven Mouse Model of AML Blood. 118: 2620-2620. DOI: 10.1182/Blood.V118.21.2620.2620  0.758
2011 Rathe SK, Stoltenberg CB, Largaespada DA. RNA-Sequencing of the Transcriptome of Ara-C Resistant Murine AML Cell Lines Identifies Potential Drug Targets Blood. 118: 2489-2489. DOI: 10.1182/Blood.V118.21.2489.2489  0.705
2011 Johnson KJ, Allaei R, Hooten A, Largaespada D, Ross J. Abstract 812: Maternal folic acid supplementation and risk of medulloblastoma in offspring Cancer Research. 71: 812-812. DOI: 10.1158/1538-7445.Am2011-812  0.359
2011 Starr TK, Allaei R, Sarver A, Silverstein K, O'Sullivan MG, Cormier R, Largaespada D. Abstract 2859: Identification of driver mutations in colon cancer using Sleeping Beauty mutagenesis Cancer Research. 71: 2859-2859. DOI: 10.1158/1538-7445.Am2011-2859  0.459
2011 Varela I, Tarpey P, Raine K, Huang D, Ong CK, Stephens P, Davies H, Jones D, Lin M, Teague J, Bignell G, Butler A, Cho J, Dalgliesh GL, Galappaththige D, ... ... Largaespada DA, et al. Abstract 2805: Exome sequencing identifies frequent mutation of the SWI/SNF complex genePBRM1in renal carcinoma Cancer Research. 71: 2805-2805. DOI: 10.1158/1538-7445.Am2011-2805  0.376
2010 Yin B, Tsai ML, Hasz DE, Rathe SK, LeBeau M, Largaespada DA. A microarray study of altered gene expression in Ara-C resistance in acute myeloid leukemia Leukemia. 24: 1543-1543. PMID 20703210 DOI: 10.1038/Leu.2010.59  0.708
2010 Rathe SK, Largaespada DA. Deoxycytidine kinase is downregulated in Ara-C-resistant acute myeloid leukemia murine cell lines. Leukemia. 24: 1513-5. PMID 20508618 DOI: 10.1038/Leu.2010.88  0.691
2010 Bender AM, Collier LS, Rodriguez FJ, Tieu C, Larson JD, Halder C, Mahlum E, Kollmeyer TM, Akagi K, Sarkar G, Largaespada DA, Jenkins RB. Sleeping beauty-mediated somatic mutagenesis implicates CSF1 in the formation of high-grade astrocytomas. Cancer Research. 70: 3557-65. PMID 20388773 DOI: 10.1158/0008-5472.Can-09-4674  0.661
2010 Hackett PB, Largaespada DA, Cooper LJ. A transposon and transposase system for human application. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 674-83. PMID 20104209 DOI: 10.1038/Mt.2010.2  0.375
2010 Mattison J, Kool J, Uren AG, de Ridder J, Wessels L, Jonkers J, Bignell GR, Butler A, Rust AG, Brosch M, Wilson CH, van der Weyden L, Largaespada DA, Stratton MR, Futreal PA, et al. Novel candidate cancer genes identified by a large-scale cross-species comparative oncogenomics approach. Cancer Research. 70: 883-95. PMID 20103622 DOI: 10.1158/0008-5472.Can-09-1737  0.503
2010 Sachs Z, Diaz-Flores E, Diers MD, Sachs K, Bendall SC, Fienberg HG, Rathe SK, Nolan GP, Shannon K, Largaespada D. Oncogene Withdrawal Selectively Alters Phosphoprotein States and Shifts Differentiation Status In Myeloid Leukemia Subpopulations Blood. 116: 3160-3160. DOI: 10.1182/Blood.V116.21.3160.3160  0.747
2010 Rathe SK, Largaespada D. A Screen for Drugs Showing Specific Co-Resistance or Hyper-Sensitivity Upon the Acquisition of Ara-C Resistance In AML Blood. 116: 1844-1844. DOI: 10.1182/Blood.V116.21.1844.1844  0.696
2010 Keng VW, Ryan BJ, Silverstein KAT, Sarver A, Fan D, Dupuy AJ, Jenkins NA, Copeland NG, Largaespada DA. Abstract 4182: A screen for genes that define the strong gender bias nature of hepatocellular carcinoma using a transposon mutagenesis murine model Cancer Research. 70: 4182-4182. DOI: 10.1158/1538-7445.Am10-4182  0.393
2010 Riordan JD, Keng VW, Ryan BJ, Podetz-Pedersen KM, Copeland NG, Jenkins NA, Largaespada DA, Dupuy AJ. Abstract 236: Sleeping Beauty transposon integration within the Dlk1-Dio3 imprinted domain is associated with hepatocellular carcinoma development Cancer Research. 70: 236-236. DOI: 10.1158/1538-7445.Am10-236  0.354
2010 Largaespada DA, Rahrmann EP, Keng VW, Clark HB, Dupuy AJ, Tessarollo L, Jenkins NA, Copeland NG, Ratner N. Abstract 2199: A murine insertional mutagenesis screen to identify oncogenes and tumor suppressor genes involved in Schwann cell tumorigenesis Cancer Research. 70: 2199-2199. DOI: 10.1158/1538-7445.Am10-2199  0.796
2009 Collier LS, Adams DJ, Hackett CS, Bendzick LE, Akagi K, Davies MN, Diers MD, Rodriguez FJ, Bender AM, Tieu C, Matise I, Dupuy AJ, Copeland NG, Jenkins NA, Hodgson JG, ... ... Largaespada DA, et al. Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality. Cancer Research. 69: 8429-37. PMID 19843846 DOI: 10.1158/0008-5472.Can-09-1760  0.48
2009 Dupuy AJ, Rogers LM, Kim J, Nannapaneni K, Starr TK, Liu P, Largaespada DA, Scheetz TE, Jenkins NA, Copeland NG. A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice. Cancer Research. 69: 8150-6. PMID 19808965 DOI: 10.1158/0008-5472.Can-09-1135  0.464
2009 Keng VW, Ryan BJ, Wangensteen KJ, Balciunas D, Schmedt C, Ekker SC, Largaespada DA. Efficient transposition of Tol2 in the mouse germline. Genetics. 183: 1565-73. PMID 19805821 DOI: 10.1534/Genetics.109.100768  0.334
2009 Largaespada DA. Transposon-mediated mutagenesis of somatic cells in the mouse for cancer gene identification. Methods (San Diego, Calif.). 49: 282-6. PMID 19607923 DOI: 10.1016/J.Ymeth.2009.07.002  0.397
2009 Rahrmann EP, Collier LS, Knutson TP, Doyal ME, Kuslak SL, Green LE, Malinowski RL, Roethe L, Akagi K, Waknitz M, Huang W, Largaespada DA, Marker PC. Identification of PDE4D as a proliferation promoting factor in prostate cancer using a Sleeping Beauty transposon-based somatic mutagenesis screen. Cancer Research. 69: 4388-97. PMID 19401450 DOI: 10.1158/0008-5472.Can-08-3901  0.726
2009 Largaespada DA. Transposon mutagenesis in mice. Methods in Molecular Biology (Clifton, N.J.). 530: 379-90. PMID 19266336 DOI: 10.1007/978-1-59745-471-1_20  0.401
2009 Starr TK, Allaei R, Silverstein KA, Staggs RA, Sarver AL, Bergemann TL, Gupta M, O'Sullivan MG, Matise I, Dupuy AJ, Collier LS, Powers S, Oberg AL, Asmann YW, Thibodeau SN, ... ... Largaespada DA, et al. A transposon-based genetic screen in mice identifies genes altered in colorectal cancer. Science (New York, N.Y.). 323: 1747-50. PMID 19251594 DOI: 10.1126/Science.1163040  0.425
2009 Keng VW, Villanueva A, Chiang DY, Dupuy AJ, Ryan BJ, Matise I, Silverstein KA, Sarver A, Starr TK, Akagi K, Tessarollo L, Collier LS, Powers S, Lowe SW, Jenkins NA, ... ... Largaespada DA, et al. A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma. Nature Biotechnology. 27: 264-74. PMID 19234449 DOI: 10.1038/Nbt.1526  0.384
2009 Wiesner SM, Decker SA, Larson JD, Ericson K, Forster C, Gallardo JL, Long C, Demorest ZL, Zamora EA, Low WC, SantaCruz K, Largaespada DA, Ohlfest JR. De novo induction of genetically engineered brain tumors in mice using plasmid DNA. Cancer Research. 69: 431-9. PMID 19147555 DOI: 10.1158/0008-5472.Can-08-1800  0.824
2009 Kim WI, Matise I, Diers MD, Largaespada DA. RAS oncogene suppression induces apoptosis followed by more differentiated and less myelosuppressive disease upon relapse of acute myeloid leukemia. Blood. 113: 1086-96. PMID 18952898 DOI: 10.1182/Blood-2008-01-132316  0.419
2009 Yin B, Delwel R, Valk PJ, Wallace MR, Loh ML, Shannon KM, Largaespada DA. A retroviral mutagenesis screen reveals strong cooperation between Bcl11a overexpression and loss of the Nf1 tumor suppressor gene. Blood. 113: 1075-85. PMID 18948576 DOI: 10.1182/Blood-2008-03-144436  0.483
2009 Bergerson RJ, Collier LS, Lugthart S, Allaei R, Nixon MJ, Silverstein KA, Sarver A, Fan DF, Lamblin AJ, Wolff L, Kersey JH, O'Sullivan MG, Delwel R, Kogan SC, Adams DJ, ... Largaespada D, et al. An Insertional Mutagenesis Screen for Genes That Cooperate with Mll-AF9 in Leukemogenesis. Blood. 114: 3962-3962. DOI: 10.1182/Blood.V114.22.3962.3962  0.801
2009 Poiré X, Diaz-Flores E, Bergerson RJ, Sher D, Odenike O, Shannon K, Largaespada D, Stock W. Combinations of Kinase Inhibitors May Be An Effective Therapeutic Strategy for Acute Myeloid Leukemia (AML) with MLL-AF9 Expression. Blood. 114: 1032-1032. DOI: 10.1182/Blood.V114.22.1032.1032  0.782
2009 Starr TK, Allaei R, O'Sullivan MG, Sarver AL, Dupuy AJ, Jenkins NA, Copeland NG, Largaespada DA. Abstract A14: A forward genetic screen for genes that cooperate with PTEN in lung cancer development Cancer Research. 69. DOI: 10.1158/0008-5472.Fbcr09-A14  0.411
2008 Wangensteen KJ, Wilber A, Keng VW, He Z, Matise I, Wangensteen L, Carson CM, Chen Y, Steer CJ, McIvor RS, Largaespada DA, Wang X, Ekker SC. A facile method for somatic, lifelong manipulation of multiple genes in the mouse liver. Hepatology (Baltimore, Md.). 47: 1714-24. PMID 18435462 DOI: 10.1002/Hep.22195  0.388
2008 Largaespada DA, Collier LS. Transposon-mediated mutagenesis in somatic cells: identification of transposon-genomic DNA junctions. Methods in Molecular Biology (Clifton, N.J.). 435: 95-108. PMID 18370070 DOI: 10.1007/978-1-59745-232-8_7  0.458
2008 Rathe SK, Largaespada D. A Novel Microarray Gene Expression Analysis of Murine AML Cell Lines Provides Clues to the Development of Drug Resistance to Ara-C Blood. 112: 5017-5017. DOI: 10.1182/Blood.V112.11.5017.5017  0.715
2008 Kim W, Rathe SK, Diers MD, Largaespada DA. A Murine AML Model for the Development of Resistance to NRAS(G12V) Oncogene Repression and/or Ara-C Treatment in Vivo Blood. 112: 4030-4030. DOI: 10.1182/Blood.V112.11.4030.4030  0.724
2008 Bergerson RJ, Largaespada DA. What gene have I ID'ed? Blood. 111: 417-472. DOI: 10.1182/Blood-2007-10-118067  0.798
2008 Wangensteen KJ, Wilber A, Keng VW, Chen Y, Matise I, Wangensteen L, Steer CJ, McIvor RS, Largaespada DA, Wang X, Ekker SC. A method for lifelong genetic manipulation of regenerating hepatocytes in mouse Cell Research. 18: S31-S31. DOI: 10.1038/Cr.2008.121  0.346
2007 Collier LS, Largaespada DA. Transposons for cancer gene discovery: Sleeping Beauty and beyond. Genome Biology. 8: S15. PMID 18047692 DOI: 10.1186/Gb-2007-8-S1-S15  0.349
2007 Yin B, Largaespada DA. PCR-based procedures to isolate insertion sites of DNA elements. Biotechniques. 43: 79-84. PMID 17695256 DOI: 10.2144/000112474  0.34
2007 Kim WI, Wiesner SM, Largaespada DA. Vav promoter-tTA conditional transgene expression system for hematopoietic cells drives high level expression in developing B and T cells. Experimental Hematology. 35: 1231-9. PMID 17560009 DOI: 10.1016/J.Exphem.2007.04.012  0.769
2007 Yin B, Tsai ML, Hasz DE, Rathe SK, Le Beau MM, Largaespada DA. A microarray study of altered gene expression after cytarabine resistance in acute myeloid leukemia. Leukemia. 21: 1093-7. PMID 17301810 DOI: 10.1038/Sj.Leu.2404595  0.711
2007 Morgan KJ, Rowley MA, Wiesner SM, Hasz DE, Van Ness B, Largaespada DA. The GAP-related domain of neurofibromin attenuates proliferation and downregulates N- and K-Ras activation in Nf1-negative AML cells. Leukemia Research. 31: 1107-13. PMID 17222906 DOI: 10.1016/J.Leukres.2006.11.022  0.749
2007 Kim A, Morgan K, Hasz DE, Wiesner SM, Lauchle JO, Geurts JL, Diers MD, Le DT, Kogan SC, Parada LF, Shannon K, Largaespada DA. Beta common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice. Blood. 109: 1687-91. PMID 17090653 DOI: 10.1182/Blood-2006-05-025395  0.758
2007 Bergerson RJ, Collier LS, Allaei R, Silverstein KA, Lamblin AF, Wolff L, Kogan SC, Kersey JH, Adams DJ, Largaespada DA. Novel Mll-AF9 Cooperating Genes Identified in a Leukemogenesis Screen Using Retroviral Mutagenesis. Blood. 110: 825-825. DOI: 10.1182/Blood.V110.11.825.825  0.793
2007 Johnson KJ, Largaespada DA, LeBien TW, Allaei R, Ross JA. Influence of Maternal Folic Acid Supplementation on Hematopoietic Factors in Offspring. Blood. 110: 4276-4276. DOI: 10.1182/Blood.V110.11.4276.4276  0.364
2007 Yin B, Delwel R, Valk PJ, Loh ML, Shannon KM, Largaespada DA. Bcl11a Causes p21Cip1 Down-Regulation and Transplantable Leukemia in Nf1-Deficient Mice. Blood. 110: 2657-2657. DOI: 10.1182/Blood.V110.11.2657.2657  0.449
2007 Kim W, Matise I, Diers M, Largaespada D. Continued Expression of the NRAS(G12V) Oncogene Is Required for the Maintenance of Acute Myeloid Leukemia Induced in Cooperation with MLL-AF9. Blood. 110: 1615-1615. DOI: 10.1182/Blood.V110.11.1615.1615  0.393
2006 Balciunas D, Wangensteen KJ, Wilber A, Bell J, Geurts A, Sivasubbu S, Wang X, Hackett PB, Largaespada DA, McIvor RS, Ekker SC. Harnessing a high cargo-capacity transposon for genetic applications in vertebrates. Plos Genetics. 2: e169. PMID 17096595 DOI: 10.1371/Journal.Pgen.0020169  0.622
2006 Geurts AM, Collier LS, Geurts JL, Oseth LL, Bell ML, Mu D, Lucito R, Godbout SA, Green LE, Lowe SW, Hirsch BA, Leinwand LA, Largaespada DA. Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers. Plos Genetics. 2: e156. PMID 17009875 DOI: 10.1371/Journal.Pgen.0020156  0.607
2006 Geurts AM, Wilber A, Carlson CM, Lobitz PD, Clark KJ, Hackett PB, McIvor RS, Largaespada DA. Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon. Bmc Biotechnology. 6: 30. PMID 16800892 DOI: 10.1186/1472-6750-6-30  0.613
2006 Geurts AM, Hackett CS, Bell JB, Bergemann TL, Collier LS, Carlson CM, Largaespada DA, Hackett PB. Structure-based prediction of insertion-site preferences of transposons into chromosomes. Nucleic Acids Research. 34: 2803-11. PMID 16717285 DOI: 10.1093/Nar/Gkl301  0.582
2006 Wilber A, Frandsen JL, Geurts JL, Largaespada DA, Hackett PB, McIvor RS. RNA as a source of transposase for Sleeping Beauty-mediated gene insertion and expression in somatic cells and tissues. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 625-30. PMID 16368272 DOI: 10.1016/J.Ymthe.2005.10.014  0.398
2006 Score PR, Belur LR, Frandsen JL, Geurts JL, Guerts JL, Yamaguchi T, Somia NV, Hackett PB, Largaespada DA, McIvor RS. Sleeping Beauty-mediated transposition and long-term expression in vivo: use of the LoxP/Cre recombinase system to distinguish transposition-specific expression. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 617-24. PMID 16356773 DOI: 10.1016/J.Ymthe.2005.10.015  0.372
2006 Collier LS, Largaespada DA. Transforming science: cancer gene identification. Current Opinion in Genetics & Development. 16: 23-9. PMID 16326095 DOI: 10.1016/J.Gde.2005.11.001  0.463
2006 Yin B, Morgan K, Hasz DE, Mao Z, Largaespada DA. Nfl gene inactivation in acute myeloid leukemia cells confers cytarabine resistance through MAPK and mTOR pathways. Leukemia. 20: 151-4. PMID 16307021 DOI: 10.1038/Sj.Leu.2404033  0.392
2006 Yin B, Diers MD, Rathe SK, Lowe SW, Largaespada DA. Genetic Mechanisms of Cytarabine Resistance in Leukemia: Cell Culture and Mouse Transplantation Models. Blood. 108: 4374-4374. DOI: 10.1182/Blood.V108.11.4374.4374  0.745
2006 Yin B, Jeske-Geurts JL, Diers MD, Shannon KM, Largaespada DA. Bcl11a Causes Leukemia/Lymphoma in Cooperation with Nf1 Inactivation. Blood. 108: 387-387. DOI: 10.1182/Blood.V108.11.387.387  0.35
2006 Bergerson RJ, Collier LS, Cox T, Hudson WA, Allaei R, Wolff L, Kersey JH, Adams DJ, Largaespada DA. A Screen for Mll-AF9 Cooperating Mutations in Leukemogenesis Using MLV-Based Mutagenesis. Blood. 108: 1417-1417. DOI: 10.1182/Blood.V108.11.1417.1417  0.785
2006 Geurts AM, Hackett CS, Bell JB, Bergemann TL, Collier LS, Carlson CM, Largaespada DA, Hackett PB. 520. ProTIS, a Method for Prediction of Insertion-Site Preferences into Chromosomes of Vectors Used for Gene Therapy Molecular Therapy. 13: S200. DOI: 10.1016/J.Ymthe.2006.08.591  0.572
2006 Balciunas D, Wilber A, Wangensteen K, Bell J, Geurts A, Hackett PB, Largaespada DA, McIvor RS, Ekker SC. 385. Tol2 Transposon as a Gene Therapy Vector: Characterization, Optimization and Correction of Hereditary Tyrosinemia Type 1 in Mouse Molecular Therapy. 13: S147. DOI: 10.1016/J.Ymthe.2006.08.446  0.608
2006 Yin B, Largaespada DA. Models of acute myeloid leukemia: Prospects for drug development and testing Drug Discovery Today: Disease Models. 3: 137-142. DOI: 10.1016/J.Ddmod.2006.05.002  0.334
2005 Ohlfest JR, Freese AB, Largaespada DA. Nonviral vectors for cancer gene therapy: prospects for integrating vectors and combination therapies. Current Gene Therapy. 5: 629-41. PMID 16457652 DOI: 10.2174/156652305774964749  0.422
2005 Starr TK, Largaespada DA. Cancer gene discovery using the Sleeping Beauty transposon. Cell Cycle (Georgetown, Tex.). 4: 1744-8. PMID 16294016 DOI: 10.4161/Cc.4.12.2223  0.4
2005 Carlson CM, Frandsen JL, Kirchhof N, McIvor RS, Largaespada DA. Somatic integration of an oncogene-harboring Sleeping Beauty transposon models liver tumor development in the mouse. Proceedings of the National Academy of Sciences of the United States of America. 102: 17059-64. PMID 16286660 DOI: 10.1073/Pnas.0502974102  0.475
2005 Collier LS, Largaespada DA. Hopping around the tumor genome: transposons for cancer gene discovery. Cancer Research. 65: 9607-10. PMID 16266976 DOI: 10.1158/0008-5472.Can-05-3085  0.447
2005 Ohlfest JR, Demorest ZL, Motooka Y, Vengco I, Oh S, Chen E, Scappaticci FA, Saplis RJ, Ekker SC, Low WC, Freese AB, Largaespada DA. Combinatorial antiangiogenic gene therapy by nonviral gene transfer using the sleeping beauty transposon causes tumor regression and improves survival in mice bearing intracranial human glioblastoma. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 778-88. PMID 16150649 DOI: 10.1016/J.Ymthe.2005.07.689  0.417
2005 Park CW, Kren BT, Largaespada DA, Steer CJ. DNA methylation of Sleeping Beauty with transposition into the mouse genome. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 10: 763-76. PMID 16098140 DOI: 10.1111/J.1365-2443.2005.00875.X  0.313
2005 Hackett PB, Ekker SC, Largaespada DA, McIvor RS. Sleeping beauty transposon-mediated gene therapy for prolonged expression. Advances in Genetics. 54: 189-232. PMID 16096013 DOI: 10.1016/S0065-2660(05)54009-4  0.388
2005 Collier LS, Carlson CM, Ravimohan S, Dupuy AJ, Largaespada DA. Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse. Nature. 436: 272-6. PMID 16015333 DOI: 10.1038/Nature03681  0.426
2005 Dupuy AJ, Akagi K, Largaespada DA, Copeland NG, Jenkins NA. Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system. Nature. 436: 221-6. PMID 16015321 DOI: 10.1038/Nature03691  0.42
2005 Carlson CM, Largaespada DA. Insertional mutagenesis in mice: new perspectives and tools. Nature Reviews. Genetics. 6: 568-80. PMID 15995698 DOI: 10.1038/Nrg1638  0.373
2005 Wiesner SM, Jones JM, Hasz DE, Largaespada DA. Repressible transgenic model of NRAS oncogene-driven mast cell disease in the mouse. Blood. 106: 1054-62. PMID 15831708 DOI: 10.1182/Blood-2004-08-3306  0.765
2005 Liu G, Geurts AM, Yae K, Srinivasan AR, Fahrenkrug SC, Largaespada DA, Takeda J, Horie K, Olson WK, Hackett PB. Target-site preferences of Sleeping Beauty transposons. Journal of Molecular Biology. 346: 161-73. PMID 15663935 DOI: 10.1016/J.Jmb.2004.09.086  0.586
2005 Ohlfest JR, Frandsen JL, Fritz S, Lobitz PD, Perkinson SG, Clark KJ, Nelsestuen G, Key NS, McIvor RS, Hackett PB, Largaespada DA. Phenotypic correction and long-term expression of factor VIII in hemophilic mice by immunotolerization and nonviral gene transfer using the Sleeping Beauty transposon system. Blood. 105: 2691-8. PMID 15576475 DOI: 10.1182/Blood-2004-09-3496  0.414
2005 Yin B, Largaespada DA, Downing JR. Genetic Dissection of Leukemogenesis-Related Genes/Pathways Cooperating with AML1/ETO. Blood. 106: 1596-1596. DOI: 10.1182/blood.v106.11.1596.1596  0.41
2005 Wilber A, Montoya F, Geurts AM, Largaespada DA, Lakshmipathy U, McIvor RS. 193. Direct Comparison of Integration Efficiency and Stable Gene Expression Mediated by the Sleeping Beauty Transposon System and by the PhiC31 Phage Integrase System in Cultured Human Fibroblasts and in Various Stem Cell Targets Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.196  0.64
2005 Bell JB, Hackett CS, Geurts AM, Carlson CM, Collier LS, Liu G, Largaespada DA, Hackett PB. 176. Target-Site Preferences of Sleeping Beauty Transposons in an Intron of the B-raf Oncogene Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.179  0.586
2004 Ohlfest JR, Lobitz PD, Perkinson SG, Largaespada DA. Integration and long-term expression in xenografted human glioblastoma cells using a plasmid-based transposon system. Molecular Therapy : the Journal of the American Society of Gene Therapy. 10: 260-8. PMID 15294173 DOI: 10.1016/J.Ymthe.2004.05.005  0.46
2004 Yin B, Hasz DE, Kim W, Mao Z, Largaespada DA. In Vitro Derivation of ARA-C Resistant BXH-2 AML Cell Lines: Association of RAS/MAPK and P53-Regulated Pathways with Chemoresistance. Blood. 104: 4384-4384. DOI: 10.1182/Blood.V104.11.4384.4384  0.405
2004 Kogan SC, Maunakea ML, Himmel KL, Yin B, Le Beau MM, Largaespada DA. Cooperative Pathways to Acute Myeloid Leukemia Include the Combining of Transcription Factor Alterations: PML-RARα Cooperates with SOX4. Blood. 104: 3385-3385. DOI: 10.1182/Blood.V104.11.3385.3385  0.825
2004 Wiesner SM, Hasz DE, Jones JM, Largaespada DA. In Vivo Regulatable Mouse Models of NRAS(V12)-Driven Acute Systemic Mastocytosis and Acute Myeloid Leukemia. Blood. 104: 3384-3384. DOI: 10.1182/Blood.V104.11.3384.3384  0.776
2004 Yin B, Walrath J, Shannon KM, Wallace MR, Largaespada DA. Genetic Dissection of Cooperating Mutations in BXH-2 Acute Myeloid Leukemia with and without Nf1 Gene Mutation. Blood. 104: 2567-2567. DOI: 10.1182/Blood.V104.11.2567.2567  0.448
2004 Tsai ML, Yin B, Hasz DE, Largaespada DA. Expression Signature of Therapy Resistant AML: Use of In Vitro Selected Ara-C Resistant BXH-2 Strain AML Cell Lines. Blood. 104: 2032-2032. DOI: 10.1182/Blood.V104.11.2032.2032  0.414
2004 Wilber AC, Frandsen JL, Belur LR, Score PR, Geurts JL, Largaespada DA, Hackett PB, McIvor RS. 1042. RNA as a Source of Transposase for Sleeping Beauty-Mediated Transposition and Long-Term Expression in Somatic Cells and Tissues Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.987  0.391
2004 Ohlfest JR, Perkinson S, Lobitz P, Hasz D, Frandsen J, McIvor RS, Largaespada DA. 963. Development and Testing of Anti-Cancer Sleeping Beauty Transposons for Localized Tumors and Use in Metastasis Suppression Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.906  0.427
2004 Score PR, Frandsen JL, Geurts JL, Hackett PB, Largaespada DA, McIvor RS. 823. Use of a Cre Recombinase Silencing Strategy to Characterize Sleeping Beauty-Mediated Transposition In Vivo Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.720  0.388
2004 Ohlfest JR, Perkinson S, Lobitz P, Hasz D, Largaespada DA. 360. Long-Term Gene Transfer and Expression in Xenografted Human Glioblastoma by Non-Viral Gene Transfer with the Sleeping Beauty Transposon Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.291  0.453
2004 Ohlfest JR, Perkinson S, Lobitz P, Frandsen J, McIvor RS, Hackett P, Clark K, Essner J, Key N, Largaespada DA. 165. Long-term factor VIII expression and phenotypic correction in a murine model of hemophilia A achieved by immunosuppression and non-viral gene transfer using the sleeping beauty transposon Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.125  0.402
2003 Largaespada DA. Generating and manipulating transgenic animals using transposable elements. Reproductive Biology and Endocrinology : Rb&E. 1: 80. PMID 14613544 DOI: 10.1186/1477-7827-1-80  0.35
2003 Belur LR, Frandsen JL, Dupuy AJ, Ingbar DH, Largaespada DA, Hackett PB, Scott McIvor R. Gene insertion and long-term expression in lung mediated by the Sleeping Beauty transposon system. Molecular Therapy : the Journal of the American Society of Gene Therapy. 8: 501-7. PMID 12946324 DOI: 10.1016/S1525-0016(03)00211-9  0.348
2003 Largaespada DA. A bad rap: Rap1 signaling and oncogenesis. Cancer Cell. 4: 3-4. PMID 12892706 DOI: 10.1016/S1535-6108(03)00171-5  0.406
2003 Geurts AM, Yang Y, Clark KJ, Liu G, Cui Z, Dupuy AJ, Bell JB, Largaespada DA, Hackett PB. Gene transfer into genomes of human cells by the sleeping beauty transposon system. Molecular Therapy : the Journal of the American Society of Gene Therapy. 8: 108-17. PMID 12842434 DOI: 10.1016/S1525-0016(03)00099-6  0.618
2003 Roberg-Perez K, Carlson CM, Largaespada DA. MTID: a database of Sleeping Beauty transposon insertions in mice. Nucleic Acids Research. 31: 78-81. PMID 12519952 DOI: 10.1093/Nar/Gkg045  0.354
2003 Largaespada DA. Genetically modified mice in cancer research. Methods in Molecular Biology (Clifton, N.J.). 209: 311-32. PMID 12357959 DOI: 10.1385/1-59259-340-2:311  0.315
2002 Rizvi TA, Huang Y, Sidani A, Atit R, Largaespada DA, Boissy RE, Ratner N. A novel cytokine pathway suppresses glial cell melanogenesis after injury to adult nerve. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 9831-40. PMID 12427839 DOI: 10.1523/Jneurosci.22-22-09831.2002  0.315
2002 Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR, Reyes M, Lenvik T, Lund T, Blackstad M, Du J, Aldrich S, Lisberg A, Low WC, Largaespada DA, et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 418: 41-9. PMID 12077603 DOI: 10.1038/Nature00870  0.317
2002 Dupuy AJ, Clark K, Carlson CM, Fritz S, Davidson AE, Markley KM, Finley K, Fletcher CF, Ekker SC, Hackett PB, Horn S, Largaespada DA. Mammalian germ-line transgenesis by transposition. Proceedings of the National Academy of Sciences of the United States of America. 99: 4495-9. PMID 11904379 DOI: 10.1073/Pnas.062630599  0.372
2002 Himmel KL, Bi F, Shen H, Jenkins NA, Copeland NG, Zheng Y, Largaespada DA. Activation of Clg, a novel Dbl family guanine nucleotide exchange factor gene, by proviral insertion at Evi24, a common integration site in B cell and myeloid leukemias Journal of Biological Chemistry. 277: 13463-13472. PMID 11839748 DOI: 10.1074/jbc.M110981200  0.821
2001 Blaydes SM, Kogan SC, Truong BT, Gilbert DJ, Jenkins NA, Copeland NG, Largaespada DA, Brannan CI. Retroviral integration at the Epi1 locus cooperates with Nf1 gene loss in the progression to acute myeloid leukemia. Journal of Virology. 75: 9427-34. PMID 11533205 DOI: 10.1128/Jvi.75.19.9427-9434.2001  0.445
2001 Fujino T, Yamazaki Y, Largaespada DA, Jenkins NA, Copeland NG, Hirokawa K, Nakamura T. Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes Experimental Hematology. 29: 856-863. PMID 11438208 DOI: 10.1016/S0301-472X(01)00655-5  0.399
2001 Dupuy AJ, Fritz S, Largaespada DA. Transposition and gene disruption in the male germline of the mouse Genesis. 30: 82-88. PMID 11416868 DOI: 10.1002/Gene.1037  0.398
2001 Shannon KM, Le Beau MM, Largaespada DA, Killeen N. Modeling myeloid leukemia tumor suppressor gene inactivation in the mouse Seminars in Cancer Biology. 11: 191-199. PMID 11407944 DOI: 10.1006/Scbi.2001.0372  0.451
2001 Largaespada DA. Haploinsufficiency for tumor suppression: the hazards of being single and living a long time. The Journal of Experimental Medicine. 193: F15-8. PMID 11181707 DOI: 10.1084/Jem.193.4.F15  0.385
2000 Acar H, Copeland NG, Gilbert DJ, Jenkins NA, Largaespada DA. Detection of integrated murine leukemia viruses in a mouse model of acute myeloid leukemia by fluorescence in situ hybridization combined with tyramide signal amplification Cancer Genetics and Cytogenetics. 121: 44-51. PMID 10958940 DOI: 10.1016/S0165-4608(00)00232-6  0.357
2000 Britton RA, Chen SM, Wallis D, Koeuth T, Powell BS, Shaffer LG, Largaespada D, Jenkins NA, Copeland NG, Court DL, Lupski JR. Isolation and preliminary characterization of the human and mouse homologues of the bacterial cell cycle gene era. Genomics. 67: 78-82. PMID 10945472 DOI: 10.1006/Geno.2000.6243  0.401
2000 Largaespada D. Genetic heterogeneity in acute myeloid leukemia: maximizing information flow from MuLV mutagenesis studies. Leukemia. 14: 1174-1184. PMID 10914539 DOI: 10.1038/Sj.Leu.2401852  0.454
2000 Tian E, Sawyer JR, Largaespada DA, Jenkins NA, Copeland NG, Shaughnessy JD. Evi27 encodes a novel membrane protein with homology to the IL17 receptor. Oncogene. 19: 2098-109. PMID 10815801 DOI: 10.1038/Sj.Onc.1203577  0.391
2000 Nakamura T, Yamazaki Y, Saiki Y, Moriyama M, Largaespada DA, Jenkins NA, Copeland NG. Evi9 encodes a novel zinc finger protein that physically interacts with BCL6, a known human B-cell proto-oncogene product. Molecular and Cellular Biology. 20: 3178-86. PMID 10757802 DOI: 10.1128/Mcb.20.9.3178-3186.2000  0.353
1999 Li J, Shen H, Himmel KL, Dupuy AJ, Largaespada DA, Nakamura T, Shaughnessy JD, Jenkins NA, Copeland NG. Leukaemia disease genes: large-scale cloning and pathway predictions. Nature Genetics. 23: 348-53. PMID 10610183 DOI: 10.1038/15531  0.809
1999 Shaughnessy JD, Largaespada DA, Tian E, Fletcher CF, Cho BC, Vyas P, Jenkins NA, Copeland NG. Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1. Oncogene. 18: 2069-84. PMID 10321731 DOI: 10.1038/Sj.Onc.1202419  0.451
1996 Sutton J, Costa R, Klug M, Field L, Xu D, Largaespada DA, Fletcher CF, Jenkins NA, Copeland NG, Klemsz M, Hromas R. Genesis, a winged helix transcriptional repressor with expression restricted to embryonic stem cells. The Journal of Biological Chemistry. 271: 23126-33. PMID 8798505 DOI: 10.1074/Jbc.271.38.23126  0.366
1996 Taylor GA, Jeffers M, Largaespada DA, Jenkins NA, Copeland NG, Vande Woude GF. Identification of a novel GTPase, the inducibly expressed GTPase, that accumulates in response to interferon gamma. The Journal of Biological Chemistry. 271: 20399-405. PMID 8702776 DOI: 10.1074/Jbc.271.34.20399  0.327
1996 Nakamura T, Largaespada DA, Lee MP, Johnson LA, Ohyashiki K, Toyama K, Chen SJ, Willman CL, Chen IM, Feinberg AP, Jenkins NA, Copeland NG, Shaughnessy JD. Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia. Nature Genetics. 12: 154-8. PMID 8563753 DOI: 10.1038/Ng0296-154  0.353
1996 Nakamura T, Largaespada DA, Shaughnessy JD, Jenkins NA, Copeland NG. Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias. Nature Genetics. 12: 149-53. PMID 8563752 DOI: 10.1038/Ng0296-149  0.416
1996 Largaespada DA, Brannan CI, Jenkins NA, Copeland NG. Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia. Nature Genetics. 12: 137-43. PMID 8563750 DOI: 10.1038/Ng0296-137  0.402
1995 Largaespada DA, Shaughnessy JD, Jenkins NA, Copeland NG. Retroviral integration at the Evi-2 locus in BXH-2 myeloid leukemia cell lines disrupts Nf1 expression without changes in steady-state Ras-GTP levels. Journal of Virology. 69: 5095-5102. DOI: 10.1128/Jvi.69.8.5095-5102.1995  0.436
1994 Kelner GS, Kennedy J, Bacon KB, Kleyensteuber S, Largaespada DA, Jenkins NA, Copeland NG, Bazan JF, Moore KW, Schall TJ. Lymphotactin: a cytokine that represents a new class of chemokine. Science (New York, N.Y.). 266: 1395-9. PMID 7973732 DOI: 10.1126/Science.7973732  0.313
1993 Rawlings DJ, Saffran DC, Tsukada S, Largaespada DA, Grimaldi JC, Cohen L, Mohr RN, Bazan JF, Howard M, Copeland NG. Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice. Science (New York, N.Y.). 261: 358-61. PMID 8332901 DOI: 10.1126/Science.8332901  0.357
1993 Webb GC, Jenkins NA, Largaespada DA, Copeland NG, Fernandez CS, Bowtell DDL. Mammalian Homologues of the Drosophila Son of sevenless Gene Map to Murine Chromosomes 17 and 12 and to Human Chromosomes 2 and 14, Respectively Genomics. 18: 14-19. PMID 8276400 DOI: 10.1006/Geno.1993.1421  0.407
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