| Year |
Citation |
Score |
| 2024 |
Sun S, Rodriguez G, Zhao G, Sanchez JE, Guo W, Du D, Rodriguez Moncivais OJ, Hu D, Liu J, Kirken RA, Li L. A novel approach to study multi-domain motions in JAK1's activation mechanism based on energy landscape. Briefings in Bioinformatics. 25. PMID 38446738 DOI: 10.1093/bib/bbae079 |
0.657 |
|
| 2023 |
Rodriguez Moncivais OJ, Chavez SA, Estrada Jimenez VH, Sun S, Li L, Kirken RA, Rodriguez G. Structural Analysis of Janus Tyrosine Kinase Variants in Hematological Malignancies: Implications for Drug Development and Opportunities for Novel Therapeutic Strategies. International Journal of Molecular Sciences. 24. PMID 37834019 DOI: 10.3390/ijms241914573 |
0.625 |
|
| 2023 |
Rodriguez G, Martinez GS, Negrete OD, Sun S, Guo W, Xie Y, Li L, Xiao C, Ross JA, Kirken RA. JAK3 Y841 Autophosphorylation Is Critical for STAT5B Activation, Kinase Domain Stability and Dimer Formation. International Journal of Molecular Sciences. 24. PMID 37569303 DOI: 10.3390/ijms241511928 |
0.657 |
|
| 2023 |
Sun S, Rodriguez G, Xie Y, Guo W, Hernandez AEL, Sanchez JE, Kirken RA, Li L. Phosphorylation of Tyrosine 841 Plays a Significant Role in JAK3 Activation. Life (Basel, Switzerland). 13. PMID 37109511 DOI: 10.3390/life13040981 |
0.66 |
|
| 2023 |
Grant AH, Rodriguez AC, Rodriguez Moncivais OJ, Sun S, Li L, Mohl JE, Leung MY, Kirken RA, Rodriguez G. JAK1 Pseudokinase V666G Mutant Dominantly Impairs JAK3 Phosphorylation and IL-2 Signaling. International Journal of Molecular Sciences. 24. PMID 37047778 DOI: 10.3390/ijms24076805 |
0.686 |
|
| 2023 |
Robles-Escajeda E, Mohl JE, Contreras L, Betancourt AP, Mancera BM, Kirken RA, Rodriguez G. Rapid Shift from SARS-CoV-2 Delta to Omicron Sub-Variants within a Dynamic Southern U.S. Borderplex. Viruses. 15. PMID 36992367 DOI: 10.3390/v15030658 |
0.531 |
|
| 2022 |
Gutierrez DA, Contreras L, Villanueva PJ, Borrego EA, Morán-Santibañez K, Hess JD, DeJesus R, Larragoity M, Betancourt AP, Mohl JE, Robles-Escajeda E, Begum K, Roy S, Kirken RA, Varela-Ramirez A, et al. Identification of a Potent Cytotoxic Pyrazole with Anti-Breast Cancer Activity That Alters Multiple Pathways. Cells. 11. PMID 35053370 DOI: 10.3390/cells11020254 |
0.3 |
|
| 2021 |
Ayala-Marin YM, Grant AH, Rodriguez G, Kirken RA. Quadruple and Truncated MEK3 Mutants Identified from Acute Lymphoblastic Leukemia Promote Degradation and Enhance Proliferation. International Journal of Molecular Sciences. 22. PMID 34830095 DOI: 10.3390/ijms222212210 |
0.667 |
|
| 2021 |
Estrada A, Rodriguez AC, Rodriguez G, Grant AH, Ayala-Marin YM, Arrieta AJ, Kirken RA. Phosphorylation of CrkL S114 induced by common gamma chain cytokines and T-cell receptor signal transduction. Scientific Reports. 11: 16951. PMID 34417497 DOI: 10.1038/s41598-021-96428-y |
0.681 |
|
| 2021 |
Grant AH, Estrada A, Ayala-Marin YM, Alvidrez-Camacho AY, Rodriguez G, Robles-Escajeda E, Cadena-Medina DA, Rodriguez AC, Kirken RA. The Many Faces of JAKs and STATs Within the COVID-19 Storm. Frontiers in Immunology. 12: 690477. PMID 34326843 DOI: 10.3389/fimmu.2021.690477 |
0.645 |
|
| 2021 |
Grant AH, Ayala-Marin YM, Mohl JE, Robles-Escajeda E, Rodriguez G, Dutil J, Kirken RA. The Genomic Landscape of a Restricted ALL Cohort from Patients Residing on the U.S./Mexico Border. International Journal of Environmental Research and Public Health. 18. PMID 34299796 DOI: 10.3390/ijerph18147345 |
0.552 |
|
| 2020 |
Valenzuela P, Oaxaca D, Di Desidero T, Parra K, Rodriguez G, Manciu M, Allegrini G, Falcone A, Bocci G, Kirken RA, Francia G. Pharmacodynamic biomarkers in metronomic chemotherapy: multiplex cytokine measurements in gastrointestinal cancer patients. Clinical and Experimental Medicine. PMID 33048259 DOI: 10.1007/s10238-020-00666-9 |
0.606 |
|
| 2019 |
Ruiz-Medina BE, Lerma D, Hwang M, Ross JA, Skouta R, Aguilera RJ, Kirken RA, Varela-Ramirez A, Robles-Escajeda E. Green barley mitigates cytotoxicity in human lymphocytes undergoing aggressive oxidative stress, via activation of both the Lyn/PI3K/Akt and MAPK/ERK pathways. Scientific Reports. 9: 6005. PMID 30979953 DOI: 10.1038/S41598-019-42228-4 |
0.318 |
|
| 2018 |
Ruiz-Medina BE, Cadena-Medina DA, Esparza E, Arrieta AJ, Kirken RA. Isoproterenol induced beta-2 adrenergic receptor activation negatively regulates interleukin-2 signaling. The Biochemical Journal. PMID 30120106 DOI: 10.1042/Bcj20180503 |
0.52 |
|
| 2017 |
Ross JA, Robles-Escajeda E, Oaxaca DM, Padilla DL, Kirken RA. The prohibitin protein complex promotes mitochondrial stabilization and cell survival in hematologic malignancies. Oncotarget. 8: 65445-65456. PMID 29029444 DOI: 10.18632/Oncotarget.18920 |
0.324 |
|
| 2017 |
Parra K, Valenzuela P, Lerma N, Gallegos A, Reza LC, Rodriguez G, Emmenegger U, Di Desidero T, Bocci G, Felder MS, Manciu M, Kirken RA, Francia G. Impact of CTLA-4 blockade in conjunction with metronomic chemotherapy on preclinical breast cancer growth. British Journal of Cancer. PMID 28056464 DOI: 10.1038/Bjc.2016.429 |
0.586 |
|
| 2017 |
Valenzuela P, Parra K, Oaxaca D, Reza L, Lopez J, Arreguin MG, Garcia D, Rodriguez G, Falcone A, Allegrini G, Desidero TD, Bocci G, Kirken R, Francia G. Abstract 784: Pharmacodynamic biomarkers in metronomic chemotherapy: Multiplex cytokine measurements in gastrointestinal cancer patients Cancer Research. 77: 784-784. DOI: 10.1158/1538-7445.Am2017-784 |
0.583 |
|
| 2016 |
Oaxaca DM, Yang-Reid SA, Ross JA, Rodriguez G, Staniswalis JG, Kirken RA. Sensitivity of imatinib-resistant T315I BCR-ABL CML to a synergistic combination of ponatinib and forskolin treatment. Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine. PMID 27444277 DOI: 10.1007/S13277-016-5179-7 |
0.604 |
|
| 2016 |
Oaxaca DM, Yang Reid SA, A Ross J, Staniswalis JG, Kirken RA. Tyrosine Kinase Inhibitors and Phosphatases: Overcoming the BCR-ABL T315I Mutation in CML with a Synergistic Combination of Ponatinib and Forskolin Journal of Clinical & Cellular Immunology. 7. DOI: 10.4172/2155-9899.1000465 |
0.383 |
|
| 2016 |
Parra K, Valenzuela P, Gallegos AE, Lerma N, Reza L, Rodriguez G, Emmenegger U, Manciu M, Desidero TD, Bocci G, Felder MS, Kirken RA, Francia G. Abstract 3261: Impact of CTLA-4 blockade in conjunction with metronomic chemotherapy on preclinical breast cancer growth Cancer Research. 76: 3261-3261. DOI: 10.1158/1538-7445.Am2016-3261 |
0.57 |
|
| 2015 |
Ruiz-Medina BE, Ross JA, Kirken RA. Interleukin-2 receptor β T450 phosphorylation is a positive regulator for receptor complex stability and activation of signaling molecules. The Journal of Biological Chemistry. PMID 26152718 DOI: 10.1074/Jbc.M115.660654 |
0.525 |
|
| 2014 |
Ross JA, Spadaro M, Rosado DC, Cavallo F, Kirken RA, Pericle F. Inhibition of JAK3 with a novel, selective and orally active small molecule induces therapeutic response in T-cell malignancies. Leukemia. 28: 941-4. PMID 24153015 DOI: 10.1038/Leu.2013.309 |
0.355 |
|
| 2014 |
Hartman LL, Farah D, Mulne AF, Storrs BB, Wilson HL, Bryson S, Oaxaca DM, Kirken RA, Ross JA. Abstract B73: Integration of a personalized molecular targeted therapy into the multimodal treatment of refractory early childhood sPNET Cancer Research. 74. DOI: 10.1158/1538-7445.Pedcan-B73 |
0.387 |
|
| 2014 |
Parra K, Vidal C, Valenzuela P, Jallad S, Rodriguez G, Felder MS, Lerma N, Bocci G, Emmenegger U, Kirken RA, Francia G. Abstract 2987: Evaluation of CTLA-4 blockage with sequential metronomic chemotherapy for the treatment of preclinical breast cancer Cancer Research. 74: 2987-2987. DOI: 10.1158/1538-7445.Am2014-2987 |
0.586 |
|
| 2013 |
Robles-Escajeda E, Lerma D, Nyakeriga AM, Ross JA, Kirken RA, Aguilera RJ, Varela-Ramirez A. Searching in mother nature for anti-cancer activity: anti-proliferative and pro-apoptotic effect elicited by green barley on leukemia/lymphoma cells. Plos One. 8: e73508. PMID 24039967 DOI: 10.1371/Journal.Pone.0073508 |
0.382 |
|
| 2013 |
Nagy ZS, Ross JA, Rodriguez G, Balint BL, Szeles L, Nagy L, Kirken RA. Genome wide mapping reveals PDE4B as an IL-2 induced STAT5 target gene in activated human PBMCs and lymphoid cancer cells. Plos One. 8: e57326. PMID 23451206 DOI: 10.1371/Journal.Pone.0057326 |
0.712 |
|
| 2013 |
Rodriguez G, Ross JA, Nagy ZS, Kirken RA. Forskolin-inducible cAMP pathway negatively regulates T-cell proliferation by uncoupling the interleukin-2 receptor complex. The Journal of Biological Chemistry. 288: 7137-46. PMID 23341462 DOI: 10.1074/Jbc.M112.408765 |
0.747 |
|
| 2013 |
Ross JA, Rodriguez G, Kirken RA. Analysis of Janus tyrosine kinase phosphorylation and activation. Methods in Molecular Biology (Clifton, N.J.). 967: 3-20. PMID 23296718 DOI: 10.1007/978-1-62703-242-1_1 |
0.699 |
|
| 2013 |
Nagy ZS, Ross JA, Rodriguez G, Balint BL, Szeles L, Nagy L, Kirken RA. Correction: Genome wide mapping reveals PDE4B as an IL-2 induced STAT5 target gene in activated human PBMCs and lymphoid cancer cells (PLoS ONE) Plos One. 8. DOI: 10.1371/annotation/cb55d096-61f8-46de-b58f-81a872be6dd3 |
0.636 |
|
| 2012 |
Mitra A, Ross JA, Rodriguez G, Nagy ZS, Wilson HL, Kirken RA. Signal transducer and activator of transcription 5b (Stat5b) serine 193 is a novel cytokine-induced phospho-regulatory site that is constitutively activated in primary hematopoietic malignancies. The Journal of Biological Chemistry. 287: 16596-608. PMID 22442148 DOI: 10.1074/Jbc.M111.319756 |
0.748 |
|
| 2010 |
Nagy ZS, Ross JA, Rodriguez G, Bader J, Dimmock J, Kirken RA. Uncoupling JAK3 activation induces apoptosis in human lymphoid cancer cells via regulating critical survival pathways. Febs Letters. 584: 1515-20. PMID 20211620 DOI: 10.1016/J.Febslet.2010.02.071 |
0.704 |
|
| 2010 |
Ross JA, Cheng H, Nagy ZS, Frost JA, Kirken RA. Protein phosphatase 2A regulates interleukin-2 receptor complex formation and JAK3/STAT5 activation. The Journal of Biological Chemistry. 285: 3582-91. PMID 19923221 DOI: 10.1074/Jbc.M109.053843 |
0.79 |
|
| 2009 |
Nagy ZS, LeBaron MJ, Ross JA, Mitra A, Rui H, Kirken RA. STAT5 regulation of BCL10 parallels constitutive NFkappaB activation in lymphoid tumor cells. Molecular Cancer. 8: 67. PMID 19709433 DOI: 10.1186/1476-4598-8-67 |
0.433 |
|
| 2008 |
Stepkowski SM, Chen W, Ross JA, Nagy ZS, Kirken RA. STAT3: an important regulator of multiple cytokine functions. Transplantation. 85: 1372-7. PMID 18497672 DOI: 10.1097/Tp.0B013E3181739D25 |
0.479 |
|
| 2008 |
Dagvadorj A, Kirken RA, Leiby B, Karras J, Nevalainen MT. Transcription factor signal transducer and activator of transcription 5 promotes growth of human prostate cancer cells in vivo. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 1317-24. PMID 18316550 DOI: 10.1158/1078-0432.Ccr-07-2024 |
0.322 |
|
| 2008 |
Cheng H, Ross JA, Frost JA, Kirken RA. Phosphorylation of human Jak3 at tyrosines 904 and 939 positively regulates its activity. Molecular and Cellular Biology. 28: 2271-82. PMID 18250158 DOI: 10.1128/Mcb.01789-07 |
0.784 |
|
| 2008 |
Ross JA, Nagy ZS, Kirken RA. The PHB1/2 phosphocomplex is required for mitochondrial homeostasis and survival of human T cells. The Journal of Biological Chemistry. 283: 4699-713. PMID 18086671 DOI: 10.1074/Jbc.M708232200 |
0.405 |
|
| 2008 |
Nagy ZS, LeBaron MJ, Rui H, Kirken RA. 184 The NFκB regulator Bcl10 is a novel Stat5 target gene Cytokine. 43: 283. DOI: 10.1016/J.Cyto.2008.07.246 |
0.318 |
|
| 2007 |
Ross JA, Nagy ZS, Cheng H, Stepkowski SM, Kirken RA. Regulation of T cell homeostasis by JAKs and STATs. Archivum Immunologiae Et Therapiae Experimentalis. 55: 231-45. PMID 17659375 DOI: 10.1007/S00005-007-0030-X |
0.777 |
|
| 2007 |
Neilson LM, Zhu J, Xie J, Malabarba MG, Sakamoto K, Wagner KU, Kirken RA, Rui H. Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways. Molecular Endocrinology (Baltimore, Md.). 21: 2218-32. PMID 17550976 DOI: 10.1210/Me.2007-0173 |
0.494 |
|
| 2006 |
Nagy ZS, Rui H, Stepkowski SM, Karras J, Kirken RA. A preferential role for STAT5, not constitutively active STAT3, in promoting survival of a human lymphoid tumor. Journal of Immunology (Baltimore, Md. : 1950). 177: 5032-40. PMID 17015686 DOI: 10.4049/Jimmunol.177.8.5032 |
0.484 |
|
| 2006 |
Stepkowski SM, Kirken RA. Janus tyrosine kinases and signal transducers and activators of transcription regulate critical functions of T cells in allograft rejection and transplantation tolerance. Transplantation. 82: 295-303. PMID 16906023 DOI: 10.1097/01.Tp.0000228903.03118.Be |
0.519 |
|
| 2006 |
Qiu L, Lai R, Lin Q, Lau E, Thomazy DM, Calame D, Ford RJ, Kwak LW, Kirken RA, Amin HM. Autocrine release of interleukin-9 promotes Jak3-dependent survival of ALK+ anaplastic large-cell lymphoma cells. Blood. 108: 2407-15. PMID 16763206 DOI: 10.1182/Blood-2006-04-020305 |
0.493 |
|
| 2006 |
Zhang Y, Kirken RA, Furian L, Janczewska S, Qu X, Hancock WW, Wang M, Tejpal N, Kerman R, Kahan BD, Stepkowski SM. Allograft rejection requires STAT5a/b-regulated antiapoptotic activity in T cells but not B cells. Journal of Immunology (Baltimore, Md. : 1950). 176: 128-37. PMID 16365403 DOI: 10.4049/Jimmunol.176.1.128 |
0.378 |
|
| 2005 |
Stepkowski SM, Kirken RA. Unique advantage of Janus kinase 3 as a target for selective and nontoxic immunosuppression. Expert Review of Clinical Immunology. 1: 307-10. PMID 20476981 DOI: 10.1586/1744666X.1.3.307 |
0.376 |
|
| 2005 |
Stepkowski SM, Kao J, Wang ME, Tejpal N, Podder H, Furian L, Dimmock J, Jha A, Das U, Kahan BD, Kirken RA. The Mannich base NC1153 promotes long-term allograft survival and spares the recipient from multiple toxicities. Journal of Immunology (Baltimore, Md. : 1950). 175: 4236-46. PMID 16177063 DOI: 10.4049/Jimmunol.175.7.4236 |
0.516 |
|
| 2004 |
Nagy ZS, Ross J, Cheng H, Stepkowski SM, Kirken RA. Regulation of lymphoid cell apoptosis by Jaks and Stats. Critical Reviews in Immunology. 24: 87-110. PMID 15581392 DOI: 10.1615/Critrevimmunol.V24.I2.10 |
0.768 |
|
| 2004 |
Langer R, Wang M, Stepkowski SM, Hancock WW, Han R, Li P, Feng L, Kirken RA, Berens KL, Dupre B, Podder H, Dixon RA, Kahan BD. Selectin inhibitor bimosiamose prolongs survival of kidney allografts by reduction in intragraft production of cytokines and chemokines. Journal of the American Society of Nephrology : Jasn. 15: 2893-901. PMID 15504942 DOI: 10.1097/01.Asn.0000142425.23036.Ac |
0.38 |
|
| 2004 |
Wang Y, Malabarba MG, Nagy ZS, Kirken RA. Interleukin 4 regulates phosphorylation of serine 756 in the transactivation domain of Stat6. Roles for multiple phosphorylation sites and Stat6 function. The Journal of Biological Chemistry. 279: 25196-203. PMID 15069079 DOI: 10.1074/Jbc.M313668200 |
0.527 |
|
| 2004 |
Stepkowski S, Zhang Y, Furian L, Janczewska S, Qu X, Wang M, Kerman R, Kirken R. STAT5A/B CONTROL SURVIVAL OF T CELLS BY REGULATING THE FUNCTION OF PRO- AND ANTI-APOPTOTIC GENES DURING ALLOGRAFT REJECTION Transplantation. 78: 549-550. DOI: 10.1097/00007890-200407271-01483 |
0.327 |
|
| 2004 |
Wang M, Stepkowski S, Furian L, Janczewska S, Zhang Y, Tejpal N, Kirken R, Dimmock J, Kahan B. SELECTIVE INHIBITION OF JANUS TYROSINE KINASE (JAK3) INDUCES APOPTOSIS OF T CELLS AND TRANSPLANTATION TOLERANCE Transplantation. 78: 526. DOI: 10.1097/00007890-200407271-01420 |
0.424 |
|
| 2004 |
Podder H, Stepkowski S, Wang M, Verani R, Dimmock J, Kirken R, Kahan B. SELECTIVE JANUS KINASE 3 (JAK3) ANTAGONIST ACTS SYNERGISTICALLY WITH CYCLOSPORINE (CSA) BUT LACKS SIDE EFFECTS ASSOCIATED WITH CSA/SIROLIMUS COMBINATION Transplantation. 78: 47. DOI: 10.1097/00007890-200407271-00134 |
0.39 |
|
| 2003 |
Behbod F, Nagy ZS, Stepkowski SM, Karras J, Johnson CR, Jarvis WD, Kirken RA. Specific inhibition of Stat5a/b promotes apoptosis of IL-2-responsive primary and tumor-derived lymphoid cells. Journal of Immunology (Baltimore, Md. : 1950). 171: 3919-27. PMID 14530308 DOI: 10.4049/Jimmunol.171.8.3919 |
0.684 |
|
| 2003 |
Kahan BD, Kirken RA, Stepkowski SM. New approaches to transplant immunosuppression Transplantation Proceedings. 35: 1621-1623. PMID 12962733 DOI: 10.1016/S0041-1345(03)00733-4 |
0.36 |
|
| 2003 |
Kirken RA, Wang YL. Molecular actions of sirolimus: sirolimus and mTor. Transplantation Proceedings. 35: 227S-230S. PMID 12742500 DOI: 10.1016/S0041-1345(03)00230-6 |
0.435 |
|
| 2002 |
Nagy ZS, Wang Y, Erwin-Cohen RA, Aradi J, Monia B, Wang LH, Stepkowski SM, Rui H, Kirken RA. Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways. Journal of Leukocyte Biology. 72: 819-28. PMID 12377952 DOI: 10.1189/Jlb.72.4.819 |
0.55 |
|
| 2002 |
Stepkowski SM, Kirken RA, Trawick BW, Wang M, Tejpal N, Wang ME, Tian L, Clark J, Kahan BD. Allochimeric class I MHC protein-induced tolerance by partial TCR engagement requires activation of both CTL4- and common gamma-chain-dependent cytokine signals. Transplantation. 73: 1227-35. PMID 11981413 DOI: 10.1097/00007890-200204270-00007 |
0.513 |
|
| 2002 |
Stepkowski SM, Erwin-Cohen RA, Behbod F, Wang ME, Qu X, Tejpal N, Nagy ZS, Kahan BD, Kirken RA. Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin. Blood. 99: 680-9. PMID 11781254 DOI: 10.1182/blood.V99.2.680 |
0.749 |
|
| 2002 |
Kirken RA, Stepkowski SM. New directions in T-cell signal transduction and transplantation tolerance Current Opinion in Organ Transplantation. 7: 18-25. DOI: 10.1097/00075200-200203000-00005 |
0.373 |
|
| 2001 |
Stepkowski SM, Kirken RA, Nagy ZS, Trawick BW, Wang M, Tejpal N, Wang ME, Tian L, Clark J, Kahan BD. The role of Stat5 in the induction of regulatory T cells in transplantation tolerance. Transplantation Proceedings. 33: 3835-6. PMID 11750634 DOI: 10.1016/S0041-1345(01)02624-0 |
0.345 |
|
| 2001 |
Stepkowski SM, Nagy ZS, Wang ME, Behbod F, Erwin-Cohen R, Kahan BD, Kirken RA. PNU156804 inhibits Jak3 tyrosine kinase and rat heart allograft rejection. Transplantation Proceedings. 33: 3272-3. PMID 11750401 DOI: 10.1016/S0041-1345(01)02390-9 |
0.689 |
|
| 2001 |
Yamashita H, Nevalainen MT, Xu J, LeBaron MJ, Wagner KU, Erwin RA, Harmon JM, Hennighausen L, Kirken RA, Rui H. Role of serine phosphorylation of Stat5a in prolactin-stimulated β-casein gene expression Molecular and Cellular Endocrinology. 183: 151-163. PMID 11604235 DOI: 10.1016/S0303-7207(01)00546-9 |
0.427 |
|
| 2001 |
Qu X, Kirken RA, Tian L, Wang ME, Bennett CF, Stepkowski SM. Selective inhibition of IL-2 gene expression by IL-2 antisense oligonucleotides blocks heart allograft rejection Transplantation. 72: 915-923. PMID 11571459 DOI: 10.1097/00007890-200109150-00029 |
0.404 |
|
| 2001 |
Tian L, Qu X, Wang ME, Kirken RA, Bennett FC, Stepkowski SM. Selective inhibition of IL-2 mRNA blocks allograft rejection by limiting T cell clonal expansion. Transplantation Proceedings. 33: 330. PMID 11266845 DOI: 10.1016/S0041-1345(00)02796-2 |
0.396 |
|
| 2001 |
Wang ME, Kirken R, Behbod F, Erwin-Cohen R, Stepkowski SM, Kahan BD. Inhibition of Jak3 tyrosine kinase by PNU156804 blocks rat heart allograft rejection Transplantation Proceedings. 33: 201. PMID 11266779 DOI: 10.1016/S0041-1345(00)02794-9 |
0.691 |
|
| 2001 |
Stepkowski SM, Kirken RA, Wang M, Yu J, Akioka K, Kahan BD. Tolerance induction by alteration of T cell receptor (TCR) signaling using an allochimeric donor/recipient class I MHC protein Transplantation Proceedings. 33: 131. PMID 11266741 DOI: 10.1016/S0041-1345(00)02793-7 |
0.341 |
|
| 2001 |
Kirken RA, Erwin-Cohen R, Behbod F, Wang ME, Stepkowski SM, Kahan BD. Tyrphostin AG490 selectively inhibits activation of the JAK3/STAT5/MAPK pathway and rejection of rat heart allografts Transplantation Proceedings. 33: 95. PMID 11266723 DOI: 10.1016/S0041-1345(00)02791-3 |
0.676 |
|
| 2001 |
Behbod F, Erwin-Cohen RA, Wang ME, Trawick BW, Qu X, Verani R, Kahan BD, Stepkowski SM, Kirken RA. Concomitant inhibition of Janus kinase 3 and calcineurin-dependent signaling pathways synergistically prolongs the survival of rat heart allografts. Journal of Immunology (Baltimore, Md. : 1950). 166: 3724-32. PMID 11238613 DOI: 10.4049/Jimmunol.166.6.3724 |
0.744 |
|
| 2001 |
Yen CH, Yang YC, Ruscetti SK, Kirken RA, Dai RM, Li CC. Involvement of the ubiquitin-proteasome pathway in the degradation of nontyrosine kinase-type cytokine receptors of IL-9, IL-2, and erythropoietin. Journal of Immunology (Baltimore, Md. : 1950). 165: 6372-80. PMID 11086075 DOI: 10.4049/Jimmunol.165.11.6372 |
0.445 |
|
| 2000 |
Kirken RA, Erwin RA, Wang L, Wang Y, Rui H, Farrar WL. Functional uncoupling of the Janus kinase 3-Stat5 pathway in malignant growth of human T cell leukemia virus type 1-transformed human T cells. Journal of Immunology (Baltimore, Md. : 1950). 165: 5097-104. PMID 11046040 DOI: 10.4049/Jimmunol.165.9.5097 |
0.648 |
|
| 2000 |
Stepkowski SM, Kirken RA. The role of IL-2 in allograft rejection--a lesson learned from experimental work. Transplantation. 69: 2480-2. PMID 10910265 DOI: 10.1097/00007890-200006270-00003 |
0.325 |
|
| 2000 |
Wang LH, Yang XY, Kirken RA, Resau JH, Farrar WL. Targeted disruption of Stat6 DNA binding activity by an oligonucleotide decoy blocks IL-4–driven TH2 cell response Blood. 95: 1249-1257. DOI: 10.1182/Blood.V95.4.1249.004K39_1249_1257 |
0.671 |
|
| 2000 |
Wang LH, Kirken RA, Yang XY, Erwin RA, DaSilva L, Yu C, Farrar WL. Selective disruption of interleukin 4 autocrine-regulated loop by a tyrosine kinase inhibitor restricts activity of T-helper 2 cells Blood. 95: 3816-3822. DOI: 10.1182/Blood.V95.12.3816.012K29_3816_3822 |
0.684 |
|
| 2000 |
Wang LH, Kirken RA, Yang XY, Erwin RA, DaSilva L, Yu C, Farrar WL. Selective disruption of interleukin 4 autocrine-regulated loop by a tyrosine kinase inhibitor restricts activity of T-helper 2 cells Blood. 95: 3816-3822. DOI: 10.1182/blood.v95.12.3816 |
0.651 |
|
| 2000 |
Kirken RA, Erwin-Cohen R, Behbod F, Wang M, Stepkowski SM, Kahan BD. TYRPHOSTIN B42 SELECTIVELY INHIBITS ACTIVATION OF THE JAK3/STAT5/MAPK PATHWAY AND REJECTION OF RAT HEART ALLOGRAFTS.: Abstract# 1146 Transplantation. 69. DOI: 10.1097/00007890-200004271-01146 |
0.679 |
|
| 2000 |
Wang M, Kirken RA, Behbod F, Erwin-Cohen R, Stepkowski SM, Kahan BD. INHIBITION OF JAK3 TYROSINE KINASE BY PNU156804 BLOCKS RAT HEART ALLOGRAFT REJECTION. Transplantation. 69: S397. DOI: 10.1097/00007890-200004271-01093 |
0.691 |
|
| 2000 |
Wang M, Kirken RA, Yu J, Akioka K, Stepkowksi SM, Kahan BD. TOLERANCE INDUCTION BY ALTERATION OF T CELL RECEPTOR (TCR) SIGNALING USING AN ALLOCHIMERIC DONOR/RECIPIENT CLASS I MHC PROTEIN. Transplantation. 69: S245. DOI: 10.1097/00007890-200004271-00517 |
0.341 |
|
| 1999 |
Kirken RA, Erwin RA, Taub D, Murphy WJ, Behbod F, Wang L, Pericle F, Farrar WL. Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells. Journal of Leukocyte Biology. 65: 891-9. PMID 10380915 DOI: 10.1002/Jlb.65.6.891 |
0.785 |
|
| 1999 |
Kirken R, Erwin-Cohen R, Behbod F, Wang M, Ku J, Stepkowski SM, Kahan BD. TYRPHOSTIN AG490 BLOCKS ACTIVATION OF JAK3 AND REJECTION OF HEART ALLOGRAFTS IN RATS Transplantation. 67: S570. DOI: 10.1097/00007890-199905150-00135 |
0.636 |
|
| 1999 |
Wang M, Kirken R, Behbod F, Stepkowski SM, Kahan BD. INHIBITION OF JAK3 TYROSINE KINASE BY PNU 15804 BLOCKS HEART ALLOGRAFT REJECTION Transplantation. 67: S123. DOI: 10.1097/00007890-199904150-00493 |
0.696 |
|
| 1999 |
Wang M, Yu J, Akioka K, Zhang Y, Kirken R, Stepkowski SM, Kahan BD. ALTERATIONS OF T CELL SIGNALING PATHWAYS IN ALLOGENEIC RAT HOSTS RENDERED TOLERANT BY ORAL ADMINISTRATION OF ALLOCHIMERIC CLASS I MHC PROTEINS Transplantation. 67: S121. DOI: 10.1097/00007890-199904150-00487 |
0.336 |
|
| 1998 |
Dasilva L, Kirken RA, Taub DD, Evans GA, Duhé RJ, Bailey MA, Farrar WL. Molecular cloning of FKHRL1P2, a member of the developmentally regulated fork head domain transcription factor family Gene. 221: 135-142. PMID 9852958 DOI: 10.1016/S0378-1119(98)00441-7 |
0.568 |
|
| 1998 |
Yamashita H, Xu J, Erwin RA, Farrar WL, Kirken RA, Rui H. Differential control of the phosphorylation state of proline-juxtaposed serine residues Ser725 of Stat5a and Ser730 of Stat5b in prolactin-sensitive cells. The Journal of Biological Chemistry. 273: 30218-24. PMID 9804779 DOI: 10.1074/Jbc.273.46.30218 |
0.655 |
|
| 1998 |
Kirken RA, Evans GA, Duhé RJ, DaSilva L, Malabarba MG, Erwin RA, Farrar WL. Mechanisms of cytokine signal transduction: IL-2, IL-4 and prolactin as hematopoietin receptor models Veterinary Immunology and Immunopathology. 63: 27-36. PMID 9656438 DOI: 10.1016/S0165-2427(98)00079-8 |
0.678 |
|
| 1998 |
Duhé RJ, Evans GA, Erwin RA, Kirken RA, Cox GW, Farrar WL. Nitric oxide and thiol redox regulation of Janus kinase activity. Proceedings of the National Academy of Sciences of the United States of America. 95: 126-31. PMID 9419340 DOI: 10.1073/Pnas.95.1.126 |
0.56 |
|
| 1997 |
Curiel RE, Lahesmaa R, Subleski J, Cippitelli M, Kirken RA, Young HA, Ghosh P. Identification of a Stat-6-responsive element in the promoter of the human interleukin-4 gene. European Journal of Immunology. 27: 1982-7. PMID 9295035 DOI: 10.1002/Eji.1830270823 |
0.43 |
|
| 1997 |
Kirken RA, Malabarba MG, Xu J, DaSilva L, Erwin RA, Liu X, Hennighausen L, Rui H, Farrar WL. Two discrete regions of interleukin-2 (IL2) receptor beta independently mediate IL2 activation of a PD98059/rapamycin/wortmannin-insensitive Stat5a/b serine kinase. The Journal of Biological Chemistry. 272: 15459-65. PMID 9182578 DOI: 10.1074/jbc.272.24.15459 |
0.663 |
|
| 1997 |
Kirken RA, Malabarba MG, Xu J, Liu X, Farrar WL, Hennighausen L, Larner AC, Grimley PM, Rui H. Prolactin stimulates serine/tyrosine phosphorylation and formation of heterocomplexes of multiple Stat5 isoforms in Nb2 lymphocytes. The Journal of Biological Chemistry. 272: 14098-103. PMID 9162035 DOI: 10.1074/Jbc.272.22.14098 |
0.659 |
|
| 1997 |
DaSilva L, Rui H, Erwin RA, Howard OM, Kirken RA, Malabarba MG, Hackett RH, Larner AC, Farrar WL. Prolactin recruits STAT1, STAT3 and STAT5 independent of conserved receptor tyrosines TYR402, TYR479, TYR515 and TYR580. Molecular and Cellular Endocrinology. 117: 131-40. PMID 8737372 DOI: 10.1016/0303-7207(95)03738-1 |
0.646 |
|
| 1996 |
Malabarba MG, Rui H, Deutsch HH, Chung J, Kalthoff FS, Farrar WL, Kirken RA. Interleukin-13 is a potent activator of JAK3 and STAT6 in cells expressing interleukin-2 receptor-gamma and interleukin-4 receptor-alpha. The Biochemical Journal. 865-72. PMID 8920992 DOI: 10.1042/Bj3190865 |
0.632 |
|
| 1996 |
Pericle F, Kirken RA, Epling-Burnette PK, Blanchard DK, Djeu JY. Direct killing of interleukin-2-transfected tumor cells by human neutrophils. International Journal of Cancer. Journal International Du Cancer. 66: 367-73. PMID 8621259 DOI: 10.1002/(Sici)1097-0215(19960503)66:3<367::Aid-Ijc17>3.0.Co;2-8 |
0.421 |
|
| 1996 |
Kirken RA, Rui H, Malabarba MG, Howard OM, Kawamura M, O'Shea JJ, Farrar WL. Activation of JAK3, but not JAK1, is critical for IL-2-induced proliferation and STAT5 recruitment by a COOH-terminal region of the IL-2 receptor beta-chain. Cytokine. 7: 689-700. PMID 8580378 DOI: 10.1006/Cyto.1995.0081 |
0.643 |
|
| 1995 |
Malabarba MG, Kirken RA, Rui H, Koettnitz K, Kawamura M, O'Shea JJ, Kalthoff FS, Farrar WL. Activation of JAK3, but not JAK1, is critical to interleukin-4 (IL4) stimulated proliferation and requires a membrane-proximal region of IL4 receptor alpha. The Journal of Biological Chemistry. 270: 9630-7. PMID 7721895 DOI: 10.1074/jbc.270.16.9630 |
0.623 |
|
| 1995 |
Erwin RA, Kirken RA, Malabarba MG, Farrar WL, Rui H. Prolactin activates Ras via signaling proteins SHC, growth factor receptor bound 2, and son of sevenless. Endocrinology. 136: 3512-8. PMID 7628388 DOI: 10.1210/Endo.136.8.7628388 |
0.631 |
|
| 1995 |
Howard OM, Kirken RA, Garcia GG, Hackett RH, Farrar WL. Structural domains of interleukin-2 receptor beta critical for signal transduction: kinase association and nuclear complex-formation. The Biochemical Journal. 306: 217-24. PMID 7532397 DOI: 10.1042/Bj3060217 |
0.66 |
|
| 1994 |
Johnston JA, Kawamura M, Kirken RA, Chen YQ, Blake TB, Shibuya K, Ortaldo JR, McVicar DW, O'Shea JJ. Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. Nature. 370: 151-3. PMID 8022485 DOI: 10.1038/370151a0 |
0.35 |
|
| 1994 |
Rui H, Lebrun JJ, Kirken RA, Kelly PA, Farrar WL. JAK2 activation and cell proliferation induced by antibody-mediated prolactin receptor dimerization. Endocrinology. 135: 1299-306. PMID 7925093 DOI: 10.1210/Endo.135.4.7925093 |
0.624 |
|
| 1994 |
Kirken RA, Rui H, Howard OM, Farrar WL. Involvement of JAK-family tyrosine kinases in hematopoietin receptor signal transduction. Progress in Growth Factor Research. 5: 195-211. PMID 7919224 DOI: 10.1016/0955-2235(94)90005-1 |
0.644 |
|
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