William L. Farrar - Publications

Affiliations: 
National Cancer Institute, Rockville, MD, United States 

147 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Zhang Y, Cabarcas SM, Zheng JI, Sun L, Mathews LA, Zhang X, Lin H, Farrar WL. Cryptotanshinone targets tumor-initiating cells through down-regulation of stemness genes expression. Oncology Letters. 11: 3803-3812. PMID 27313698 DOI: 10.3892/Ol.2016.4444  0.34
2014 Crea F, Watahiki A, Quagliata L, Xue H, Pikor L, Parolia A, Wang Y, Lin D, Lam WL, Farrar WL, Isogai T, Morant R, Castori-Eppenberger S, Chi KN, Wang Y, et al. Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer. Oncotarget. 5: 764-74. PMID 24519926 DOI: 10.18632/Oncotarget.1769  0.321
2013 Sun L, Mathews LA, Cabarcas SM, Zhang X, Yang A, Zhang Y, Young MR, Klarmann KD, Keller JR, Farrar WL. Epigenetic regulation of SOX9 by the NF-κB signaling pathway in pancreatic cancer stem cells. Stem Cells (Dayton, Ohio). 31: 1454-66. PMID 23592398 DOI: 10.1002/Stem.1394  0.369
2013 Cabarcas SM, Sun L, Mathews L, Thomas S, Zhang X, Farrar WL. The differentiation of pancreatic tumor-initiating cells by vitronectin can be blocked by cilengitide. Pancreas. 42: 861-70. PMID 23462327 DOI: 10.1097/Mpa.0B013E318279D568  0.359
2013 Paolicchi E, Crea F, Farrar WL, Green JE, Danesi R. Histone lysine demethylases in breast cancer. Critical Reviews in Oncology/Hematology. 86: 97-103. PMID 23266085 DOI: 10.1016/J.Critrevonc.2012.11.008  0.3
2013 Duhagon MA, Crea F, Danesi R, Farrar WL. Embryonic stem cell pathways and chemotherapy response: an unexplored route Annals of Oncology. 24: 558-559. PMID 23233652 DOI: 10.1093/Annonc/Mds610  0.33
2012 Crea F, Sun L, Mai A, Chiang YT, Farrar WL, Danesi R, Helgason CD. The emerging role of histone lysine demethylases in prostate cancer. Molecular Cancer. 11: 52. PMID 22867098 DOI: 10.1186/1476-4598-11-52  0.309
2012 Crea F, Fornaro L, Bocci G, Sun L, Farrar WL, Falcone A, Danesi R. EZH2 inhibition: targeting the crossroad of tumor invasion and angiogenesis. Cancer Metastasis Reviews. 31: 753-61. PMID 22711031 DOI: 10.1007/S10555-012-9387-3  0.354
2012 Kim YS, Farrar W, Colburn NH, Milner JA. Cancer stem cells: potential target for bioactive food components. The Journal of Nutritional Biochemistry. 23: 691-8. PMID 22704055 DOI: 10.1016/J.Jnutbio.2012.03.002  0.345
2012 Cho YM, Kim YS, Kang MJ, Farrar WL, Hurt EM. Long-term recovery of irradiated prostate cancer increases cancer stem cells. The Prostate. 72: 1746-56. PMID 22513891 DOI: 10.1002/Pros.22527  0.301
2011 Cabarcas SM, Mathews LA, Farrar WL. The cancer stem cell niche--there goes the neighborhood? International Journal of Cancer. Journal International Du Cancer. 129: 2315-27. PMID 21792897 DOI: 10.1002/Ijc.26312  0.329
2011 Mathews LA, Cabarcas SM, Hurt EM, Zhang X, Jaffee EM, Farrar WL. Increased expression of DNA repair genes in invasive human pancreatic cancer cells. Pancreas. 40: 730-9. PMID 21633318 DOI: 10.1097/Mpa.0B013E31821Ae25B  0.315
2011 Crea F, Duhagon MA, Farrar WL, Danesi R. Pharmacogenomics and cancer stem cells: a changing landscape? Trends in Pharmacological Sciences. 32: 487-94. PMID 21529973 DOI: 10.1016/J.Tips.2011.03.010  0.315
2011 Crea F, Hurt EM, Mathews LA, Cabarcas SM, Sun L, Marquez VE, Danesi R, Farrar WL. Pharmacologic disruption of Polycomb Repressive Complex 2 inhibits tumorigenicity and tumor progression in prostate cancer. Molecular Cancer. 10: 40. PMID 21501485 DOI: 10.1186/1476-4598-10-40  0.325
2011 Mathews LA, Cabarcas SM, Farrar WL. DNA repair: the culprit for tumor-initiating cell survival? Cancer Metastasis Reviews. 30: 185-97. PMID 21340664 DOI: 10.1007/S10555-011-9277-0  0.346
2011 Crea F, Duhagon Serrat MA, Hurt EM, Thomas SB, Danesi R, Farrar WL. BMI1 silencing enhances docetaxel activity and impairs antioxidant response in prostate cancer International Journal of Cancer. 128: 1946-1954. PMID 20568112 DOI: 10.1002/Ijc.25522  0.335
2011 Sun L, Cabarcas SM, Farrar WL. Radioresistance and Cancer Stem Cells: Survival of the Fittest Journal of Carcinogenesis & Mutagenesis. 3: 1-12. DOI: 10.4172/2157-2518.S1-004  0.366
2011 Sun L, Mathews L, Cabarcas S, Zhang X, Farrar W. Abstract A58: Epigenetic regulation of CpG promoters by NF-kB pathway in invasive pancreatic cancer cells. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-A58  0.364
2010 Mathews LA, Hurt EM, Zhang X, Farrar WL. Epigenetic regulation of CpG promoter methylation in invasive prostate cancer cells. Molecular Cancer. 9: 267. PMID 20929579 DOI: 10.1186/1476-4598-9-267  0.373
2010 Crea F, Hurt EM, Farrar WL. Clinical significance of Polycomb gene expression in brain tumors. Molecular Cancer. 9: 265. PMID 20920292 DOI: 10.1186/1476-4598-9-265  0.315
2010 Sharifi N, Qi J, Bane S, Sharma S, Li R, Robey R, Figg WD, Farrar WL, Kingston DG. Survivin is not induced by novel taxanes. Molecular Pharmaceutics. 7: 2216-23. PMID 20863081 DOI: 10.1021/Mp100211K  0.337
2010 Duhagon MA, Hurt EM, Sotelo-Silveira JR, Zhang X, Farrar WL. Genomic profiling of tumor initiating prostatospheres. Bmc Genomics. 11: 324. PMID 20500816 DOI: 10.1186/1471-2164-11-324  0.352
2010 Volate SR, Kawasaki BT, Hurt EM, Milner JA, Kim YS, White J, Farrar WL. Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells. Molecular Cancer Therapeutics. 9: 461-70. PMID 20124455 DOI: 10.1158/1535-7163.Mct-09-0507  0.332
2010 Hurt EM, Chan K, Serrat MAD, Thomas SB, Veenstra TD, Farrar WL. Identification of vitronectin as an extrinsic inducer of cancer stem cell differentiation and tumor formation Stem Cells. 28: 390-398. PMID 19998373 DOI: 10.1002/Stem.271  0.341
2009 Crea F, Danesi R, Farrar WL. Cancer stem cell epigenetics and chemoresistance. Epigenomics. 1: 63-79. PMID 22122637 DOI: 10.2217/Epi.09.4  0.324
2009 Crea F, Mathews LA, Farrar WL, Hurt EM. Targeting prostate cancer stem cells. Anti-Cancer Agents in Medicinal Chemistry. 9: 1105-13. PMID 19925394 DOI: 10.2174/187152009789735053  0.35
2009 Mathews LA, Crea F, Farrar WL. Epigenetic gene regulation in stem cells and correlation to cancer. Differentiation; Research in Biological Diversity. 78: 1-17. PMID 19443100 DOI: 10.1016/J.Diff.2009.04.002  0.351
2009 Klarmann GJ, Hurt EM, Mathews LA, Zhang X, Duhagon MA, Mistree T, Thomas SB, Farrar WL. Invasive prostate cancer cells are tumor initiating cells that have a stem cell-like genomic signature. Clinical & Experimental Metastasis. 26: 433-46. PMID 19221883 DOI: 10.1007/S10585-009-9242-2  0.366
2009 Kawasaki BT, Hurt EM, Kalathur M, Duhagon MA, Milner JA, Kim YS, Farrar WL. Effects of the sesquiterpene lactone parthenolide on prostate tumor-initiating cells: An integrated molecular profiling approach. The Prostate. 69: 827-37. PMID 19204913 DOI: 10.1002/Pros.20931  0.369
2008 Kawasaki BT, Hurt EM, Mistree T, Farrar WL. Targeting cancer stem cells with phytochemicals. Molecular Interventions. 8: 174-84. PMID 18829843 DOI: 10.1124/Mi.8.4.9  0.302
2008 Qin HR, Kim HJ, Kim JY, Hurt EM, Klarmann GJ, Kawasaki BT, Duhagon Serrat MA, Farrar WL. Activation of signal transducer and activator of transcription 3 through a phosphomimetic serine 727 promotes prostate tumorigenesis independent of tyrosine 705 phosphorylation. Cancer Research. 68: 7736-41. PMID 18829527 DOI: 10.1158/0008-5472.Can-08-1125  0.381
2008 Sharifi N, Hurt EM, Thomas SB, Farrar WL. Effects of manganese superoxide dismutase silencing on androgen receptor function and gene regulation: implications for castration-resistant prostate cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 6073-80. PMID 18829485 DOI: 10.1158/1078-0432.Ccr-08-0591  0.315
2008 Kawasaki BT, Farrar WL. Cancer stem cells, CD200 and immunoevasion. Trends in Immunology. 29: 464-8. PMID 18775673 DOI: 10.1016/J.It.2008.07.005  0.32
2008 Yang XY, Wang LH, Farrar WL. A Role for PPARgamma in the Regulation of Cytokines in Immune Cells and Cancer. Ppar Research. 2008: 961753. PMID 18566687 DOI: 10.1155/2008/961753  0.303
2008 Hurt EM, Kawasaki BT, Klarmann GJ, Thomas SB, Farrar WL. CD44+ CD24(-) prostate cells are early cancer progenitor/stem cells that provide a model for patients with poor prognosis. British Journal of Cancer. 98: 756-65. PMID 18268494 DOI: 10.1038/Sj.Bjc.6604242  0.308
2008 Sharifi N, Hurt EM, Farrar WL. Androgen receptor expression in prostate cancer stem cells: is there a conundrum? Cancer Chemotherapy and Pharmacology. 62: 921-3. PMID 18075739 DOI: 10.1007/S00280-007-0659-5  0.315
2008 Sharifi N, Hurt EM, Thomas SB, Farrar WL. 162 POSTER Effects of SOD2 silencing on androgen receptor function and gene regulation: implications for castration-resistant prostate cancer Ejc Supplements. 6: 52. DOI: 10.1016/S1359-6349(08)72094-9  0.357
2007 Hodge DR, Cho E, Copeland TD, Guszczynski T, Yang E, Seth AK, Farrar WL. IL-6 enhances the nuclear translocation of DNA cytosine-5-methyltransferase 1 (DNMT1) via phosphorylation of the nuclear localization sequence by the AKT kinase. Cancer Genomics & Proteomics. 4: 387-98. PMID 18204201  0.313
2007 Varricchio L, Migliaccio A, Castoria G, Yamaguchi H, Falco Ad, Domenico MD, Giovannelli P, Farrar W, Appella E, Auricchio F. Inhibition of Estradiol Receptor/Src Association and Cell Growth by an Estradiol Receptor Tyrosine-Phosphorylated Peptide Molecular Cancer Research. 5: 1213-1221. PMID 18025264 DOI: 10.1158/1541-7786.Mcr-07-0150  0.394
2007 Sharifi N, Lechleider RJ, Farrar WL. Transforming growth factor-beta receptor III downregulation in prostate cancer: is inhibin B a tumor suppressor in prostate? Journal of Molecular Endocrinology. 39: 329-32. PMID 17975259 DOI: 10.1677/Jme-07-0084  0.316
2007 Kawasaki BT, Mistree T, Hurt EM, Kalathur M, Farrar WL. Co-expression of the toleragenic glycoprotein, CD200, with markers for cancer stem cells. Biochemical and Biophysical Research Communications. 364: 778-82. PMID 17964286 DOI: 10.1016/J.Bbrc.2007.10.067  0.361
2007 Hurt EM, Thomas SB, Peng B, Farrar WL. Molecular consequences of SOD2 expression in epigenetically silenced pancreatic carcinoma cell lines British Journal of Cancer. 97: 1116-1123. PMID 17895890 DOI: 10.1038/Sj.Bjc.6604000  0.331
2007 Wang LH, Yang XY, Zhang X, Farrar WL. Inhibition of adhesive interaction between multiple myeloma and bone marrow stromal cells by PPARgamma cross talk with NF-kappaB and C/EBP. Blood. 110: 4373-84. PMID 17785586 DOI: 10.1182/Blood-2006-07-038026  0.424
2007 Kim JY, Kim HJ, Hurt EM, Chen X, Howard OM, Farrar WL. Functional and genomic analyses of FOXP3-transduced Jurkat-T cells as regulatory T (Treg)-like cells. Biochemical and Biophysical Research Communications. 362: 44-50. PMID 17706604 DOI: 10.1016/J.Bbrc.2007.07.187  0.383
2007 Kim HJ, Kim JY, Meng Z, Wang LH, Liu F, Conrads TP, Burke TR, Veenstra TD, Farrar WL. 15-deoxy-Delta12,14-prostaglandin J2 inhibits transcriptional activity of estrogen receptor-alpha via covalent modification of DNA-binding domain. Cancer Research. 67: 2595-602. PMID 17363578 DOI: 10.1158/0008-5472.Can-06-3043  0.352
2007 Hurt EM, Thomas SB, Peng B, Farrar WL. Integrated molecular profiling of SOD2 expression in multiple myeloma Blood. 109: 3953-3962. PMID 17192397 DOI: 10.1182/Blood-2006-07-035162  0.375
2007 Hurt EM, Farrar WL. The STATus of miR-21 in apoptosis Blood. 110: 1086-1087. DOI: 10.1182/Blood-2007-05-091413  0.309
2006 Wang LH, Yang XY, Zhang X, An P, Kim HJ, Huang J, Clarke R, Osborne CK, Inman JK, Appella E, Farrar WL. Disruption of estrogen receptor DNA-binding domain and related intramolecular communication restores tamoxifen sensitivity in resistant breast cancer. Cancer Cell. 10: 487-99. PMID 17157789 DOI: 10.1016/J.Ccr.2006.09.015  0.322
2006 Sharifi N, Kawasaki BT, Hurt EM, Farrar WL. Stem cells in prostate cancer: resolving the castrate-resistant conundrum and implications for hormonal therapy. Cancer Biology & Therapy. 5: 901-6. PMID 16855379 DOI: 10.4161/Cbt.5.8.2949  0.313
2005 Hodge DR, Hurt EM, Farrar WL. The role of IL-6 and STAT3 in inflammation and cancer. European Journal of Cancer (Oxford, England : 1990). 41: 2502-12. PMID 16199153 DOI: 10.1016/J.Ejca.2005.08.016  0.418
2005 Hodge DR, Xiao W, Peng B, Cherry JC, Munroe DJ, Farrar WL. Enforced expression of superoxide dismutase 2/manganese superoxide dismutase disrupts autocrine interleukin-6 stimulation in human multiple myeloma cells and enhances dexamethasone-induced apoptosis. Cancer Research. 65: 6255-63. PMID 16024627 DOI: 10.1158/0008-5472.Can-04-4482  0.469
2005 Hodge DR, Peng B, Cherry JC, Hurt EM, Fox SD, Kelley JA, Munroe DJ, Farrar WL. Interleukin 6 supports the maintenance of p53 tumor suppressor gene promoter methylation. Cancer Research. 65: 4673-82. PMID 15930285 DOI: 10.1158/0008-5472.Can-04-3589  0.437
2005 Hodge DR, Peng B, Pompeia C, Thomas S, Cho E, Clausen PA, Marquez VE, Farrar WL. Epigenetic silencing of manganese superoxide dismutase (SOD-2) in KAS 6/1 human multiple myeloma cells increases cell proliferation. Cancer Biology & Therapy. 4: 585-92. PMID 15908783 DOI: 10.4161/Cbt.4.5.1704  0.368
2005 Wang LH, Yang XY, Zhang X, Farrar WL. Nuclear receptors as negative modulators of STAT3 in multiple myeloma. Cell Cycle (Georgetown, Tex.). 4: 242-5. PMID 15655377 DOI: 10.4161/Cc.4.2.1471  0.4
2005 Peng B, Hodge DR, Thomas SB, Cherry JM, Munroe DJ, Pompeia C, Xiao W, Farrar WL. Epigenetic silencing of the human nucleotide excision repair gene, hHR23B, in interleukin-6-responsive multiple myeloma KAS-6/1 cells. The Journal of Biological Chemistry. 280: 4182-7. PMID 15550378 DOI: 10.1074/Jbc.M412566200  0.375
2004 Xiao W, Hodge DR, Wang L, Yang X, Zhang X, Farrar WL. NF-kappaB activates IL-6 expression through cooperation with c-Jun and IL6-AP1 site, but is independent of its IL6-NFkappaB regulatory site in autocrine human multiple myeloma cells. Cancer Biology & Therapy. 3: 1007-17. PMID 15467434 DOI: 10.4161/Cbt.3.10.1141  0.408
2004 Xiao W, Hodge DR, Wang L, Yang X, Zhang X, Farrar WL. Co-operative functions between nuclear factors NFkappaB and CCAT/enhancer-binding protein-beta (C/EBP-beta) regulate the IL-6 promoter in autocrine human prostate cancer cells. The Prostate. 61: 354-70. PMID 15389813 DOI: 10.1002/Pros.20113  0.433
2004 Pompeia C, Hodge DR, Plass C, Wu YZ, Marquez VE, Kelley JA, Farrar WL. Microarray analysis of epigenetic silencing of gene expression in the KAS-6/1 multiple myeloma cell line. Cancer Research. 64: 3465-73. PMID 15150099 DOI: 10.1158/0008-5472.Can-03-3970  0.308
2004 Chatti K, Farrar WL, Duhé RJ. Tyrosine phosphorylation of the Janus kinase 2 activation loop is essential for a high-activity catalytic state but dispensable for a basal catalytic state. Biochemistry. 43: 4272-83. PMID 15065871 DOI: 10.1021/Bi036109B  0.352
2004 Wang LH, Yang XY, Zhang X, Huang J, Hou J, Li J, Xiong H, Mihalic K, Zhu H, Xiao W, Farrar WL. Transcriptional inactivation of STAT3 by PPARgamma suppresses IL-6-responsive multiple myeloma cells. Immunity. 20: 205-18. PMID 14975242 DOI: 10.1016/S1074-7613(04)00030-5  0.492
2004 Matsuyama W, Wang L, Farrar WL, Faure M, Yoshimura T. Activation of discoidin domain receptor 1 isoform b with collagen up-regulates chemokine production in human macrophages: role of p38 mitogen-activated protein kinase and NF-kappa B. Journal of Immunology (Baltimore, Md. : 1950). 172: 2332-40. PMID 14764702 DOI: 10.4049/Jimmunol.172.4.2332  0.378
2004 Hodge DR, Xiao W, Wang LH, Li D, Farrar WL. Activating mutations in STAT3 and STAT5 differentially affect cellular proliferation and apoptotic resistance in multiple myeloma cells. Cancer Biology & Therapy. 3: 188-94. PMID 14726660 DOI: 10.4161/Cbt.3.2.621  0.46
2004 Wang LH, Yang XY, Zhang X, Mihalic K, Fan YX, Xiao W, Howard OM, Appella E, Maynard AT, Farrar WL. Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor. Nature Medicine. 10: 40-7. PMID 14702633 DOI: 10.1038/Nm969  0.338
2002 Duhé RJ, Clark EA, Farrar WL. Characterization of the in vitro kinase activity of a partially purified soluble GST/JAK2 fusion protein. Molecular and Cellular Biochemistry. 236: 23-35. PMID 12190118 DOI: 10.1023/A:1016186907376  0.383
2002 Yu CY, Wang L, Khaletskiy A, Farrar WL, Larner A, Colburn NH, Li JJ. STAT3 activation is required for interleukin-6 induced transformation in tumor-promotion sensitive mouse skin epithelial cells. Oncogene. 21: 3949-60. PMID 12037677 DOI: 10.1038/Sj.Onc.1205499  0.45
2002 Hodge DR, Li D, Qi SM, Farrar WL. IL-6 induces expression of the Fli-1 proto-oncogene via STAT3. Biochemical and Biophysical Research Communications. 292: 287-91. PMID 11890706 DOI: 10.1006/Bbrc.2002.6652  0.439
2002 Yang XY, Wang LH, Mihalic K, Xiao W, Chen T, Li P, Wahl LM, Farrar WL. Interleukin (IL)-4 indirectly suppresses IL-2 production by human T lymphocytes via peroxisome proliferator-activated receptor gamma activated by macrophage-derived 12/15-lipoxygenase ligands. The Journal of Biological Chemistry. 277: 3973-8. PMID 11726648 DOI: 10.1074/Jbc.M105619200  0.465
2001 Hodge DR, Xiao W, Clausen PA, Heidecker G, Szyf M, Farrar WL. Interleukin-6 regulation of the human DNA methyltransferase (HDNMT) gene in human erythroleukemia cells. The Journal of Biological Chemistry. 276: 39508-11. PMID 11551897 DOI: 10.1074/Jbc.C100343200  0.398
2001 Wang LH, Yang XY, Mihalic K, Xiao W, Li D, Farrar WL. Activation of estrogen receptor blocks interleukin-6-inducible cell growth of human multiple myeloma involving molecular cross-talk between estrogen receptor and STAT3 mediated by co-regulator PIAS3. Journal of Biological Chemistry. 276: 31839-31844. PMID 11429412 DOI: 10.1074/Jbc.M105185200  0.458
2001 Duhé RJ, Wang LH, Farrar WL. Negative regulation of Janus kinases. Cell Biochemistry and Biophysics. 34: 17-59. PMID 11394440 DOI: 10.1385/Cbb:34:1:17  0.447
2000 Kirken RA, Erwin RA, Wang L, Wang Y, Rui H, Farrar WL. Functional uncoupling of the Janus kinase 3-Stat5 pathway in malignant growth of human T cell leukemia virus type 1-transformed human T cells. Journal of Immunology (Baltimore, Md. : 1950). 165: 5097-104. PMID 11046040 DOI: 10.4049/Jimmunol.165.9.5097  0.681
2000 Yang XY, Wang LH, Chen T, Hodge DR, Resau JH, DaSilva L, Farrar WL. Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor γ (PPARγ) agonists. PPARγ co-association with transcription factor NFAT Journal of Biological Chemistry. 275: 4541-4544. PMID 10671476 DOI: 10.1074/Jbc.275.7.4541  0.489
2000 Wang LH, Yang XY, Kirken RA, Resau JH, Farrar WL. Targeted disruption of Stat6 DNA binding activity by an oligonucleotide decoy blocks IL-4–driven TH2 cell response Blood. 95: 1249-1257. DOI: 10.1182/Blood.V95.4.1249.004K39_1249_1257  0.694
2000 Wang LH, Kirken RA, Yang XY, Erwin RA, DaSilva L, Yu C, Farrar WL. Selective disruption of interleukin 4 autocrine-regulated loop by a tyrosine kinase inhibitor restricts activity of T-helper 2 cells Blood. 95: 3816-3822. DOI: 10.1182/Blood.V95.12.3816.012K29_3816_3822  0.701
2000 Wang LH, Kirken RA, Yang XY, Erwin RA, DaSilva L, Yu C, Farrar WL. Selective disruption of interleukin 4 autocrine-regulated loop by a tyrosine kinase inhibitor restricts activity of T-helper 2 cells Blood. 95: 3816-3822. DOI: 10.1182/blood.v95.12.3816  0.676
1999 Kirken RA, Erwin RA, Taub D, Murphy WJ, Behbod F, Wang L, Pericle F, Farrar WL. Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells. Journal of Leukocyte Biology. 65: 891-9. PMID 10380915 DOI: 10.1002/Jlb.65.6.891  0.782
1998 Dasilva L, Kirken RA, Taub DD, Evans GA, Duhé RJ, Bailey MA, Farrar WL. Molecular cloning of FKHRL1P2, a member of the developmentally regulated fork head domain transcription factor family Gene. 221: 135-142. PMID 9852958 DOI: 10.1016/S0378-1119(98)00441-7  0.636
1998 Yamashita H, Xu J, Erwin RA, Farrar WL, Kirken RA, Rui H. Differential control of the phosphorylation state of proline-juxtaposed serine residues Ser725 of Stat5a and Ser730 of Stat5b in prolactin-sensitive cells. The Journal of Biological Chemistry. 273: 30218-24. PMID 9804779 DOI: 10.1074/Jbc.273.46.30218  0.646
1998 Kirken RA, Evans GA, Duhé RJ, DaSilva L, Malabarba MG, Erwin RA, Farrar WL. Mechanisms of cytokine signal transduction: IL-2, IL-4 and prolactin as hematopoietin receptor models Veterinary Immunology and Immunopathology. 63: 27-36. PMID 9656438 DOI: 10.1016/S0165-2427(98)00079-8  0.692
1998 Duhé RJ, Farrar WL. Structural and mechanistic aspects of Janus kinases: how the two-faced god wields a double-edged sword. Journal of Interferon and Cytokine Research. 18: 1-15. PMID 9475661 DOI: 10.1089/Jir.1998.18.1  0.37
1998 Duhé RJ, Evans GA, Erwin RA, Kirken RA, Cox GW, Farrar WL. Nitric oxide and thiol redox regulation of Janus kinase activity. Proceedings of the National Academy of Sciences of the United States of America. 95: 126-31. PMID 9419340 DOI: 10.1073/Pnas.95.1.126  0.589
1997 Evans GA, Farrar WL. Purification of the renaturable protein kinase PK55 by preparative isoelectric focusing and high performance electrophoretic chromatography and the generation of PK55 monoclonal antibodies by in vitro B cell stimulation. Hybridoma. 16: 497-502. PMID 9455701 DOI: 10.1089/Hyb.1997.16.497  0.391
1997 Smith MR, Duhé RJ, Liu Y, Farrar WL. Microinjected cDNA encoding JAK2 protein-tyrosine kinase induces DNA synthesis in NIH 3T3 cells Febs Letters. 408: 327-330. PMID 9188787 DOI: 10.1016/S0014-5793(97)00456-0  0.362
1997 Kirken RA, Malabarba MG, Xu J, DaSilva L, Erwin RA, Liu X, Hennighausen L, Rui H, Farrar WL. Two discrete regions of interleukin-2 (IL2) receptor beta independently mediate IL2 activation of a PD98059/rapamycin/wortmannin-insensitive Stat5a/b serine kinase. The Journal of Biological Chemistry. 272: 15459-65. PMID 9182578 DOI: 10.1074/jbc.272.24.15459  0.658
1997 Kirken RA, Malabarba MG, Xu J, Liu X, Farrar WL, Hennighausen L, Larner AC, Grimley PM, Rui H. Prolactin stimulates serine/tyrosine phosphorylation and formation of heterocomplexes of multiple Stat5 isoforms in Nb2 lymphocytes. The Journal of Biological Chemistry. 272: 14098-103. PMID 9162035 DOI: 10.1074/Jbc.272.22.14098  0.676
1997 DaSilva L, Rui H, Erwin RA, Howard OM, Kirken RA, Malabarba MG, Hackett RH, Larner AC, Farrar WL. Prolactin recruits STAT1, STAT3 and STAT5 independent of conserved receptor tyrosines TYR402, TYR479, TYR515 and TYR580. Molecular and Cellular Endocrinology. 117: 131-40. PMID 8737372 DOI: 10.1016/0303-7207(95)03738-1  0.664
1996 Malabarba MG, Rui H, Deutsch HH, Chung J, Kalthoff FS, Farrar WL, Kirken RA. Interleukin-13 is a potent activator of JAK3 and STAT6 in cells expressing interleukin-2 receptor-gamma and interleukin-4 receptor-alpha. The Biochemical Journal. 865-72. PMID 8920992 DOI: 10.1042/Bj3190865  0.663
1996 Kirken RA, Rui H, Malabarba MG, Howard OM, Kawamura M, O'Shea JJ, Farrar WL. Activation of JAK3, but not JAK1, is critical for IL-2-induced proliferation and STAT5 recruitment by a COOH-terminal region of the IL-2 receptor beta-chain. Cytokine. 7: 689-700. PMID 8580378 DOI: 10.1006/Cyto.1995.0081  0.671
1995 Malabarba MG, Kirken RA, Rui H, Koettnitz K, Kawamura M, O'Shea JJ, Kalthoff FS, Farrar WL. Activation of JAK3, but not JAK1, is critical to interleukin-4 (IL4) stimulated proliferation and requires a membrane-proximal region of IL4 receptor alpha. The Journal of Biological Chemistry. 270: 9630-7. PMID 7721895 DOI: 10.1074/jbc.270.16.9630  0.653
1995 Erwin RA, Kirken RA, Malabarba MG, Farrar WL, Rui H. Prolactin activates Ras via signaling proteins SHC, growth factor receptor bound 2, and son of sevenless. Endocrinology. 136: 3512-8. PMID 7628388 DOI: 10.1210/Endo.136.8.7628388  0.645
1995 Duhé RJ, Rui H, Greenwood JD, Garvey K, Farrar WL. Cloning Of The Gene Encoding Rat Jak2, A Protein Tyrosine Kinase Gene. 158: 281-285. PMID 7607555 DOI: 10.1016/0378-1119(95)00041-4  0.3
1995 Duhé RJ, Farrar WL. Characterization of Active and Inactive Forms of the JAK2 Protein-tyrosine Kinase Produced via the Baculovirus Expression Vector System Journal of Biological Chemistry. 270: 23084-23089. PMID 7559450 DOI: 10.1074/Jbc.270.39.23084  0.377
1995 Howard OM, Kirken RA, Garcia GG, Hackett RH, Farrar WL. Structural domains of interleukin-2 receptor beta critical for signal transduction: kinase association and nuclear complex-formation. The Biochemical Journal. 306: 217-24. PMID 7532397 DOI: 10.1042/Bj3060217  0.675
1994 Rui H, Lebrun JJ, Kirken RA, Kelly PA, Farrar WL. JAK2 activation and cell proliferation induced by antibody-mediated prolactin receptor dimerization. Endocrinology. 135: 1299-306. PMID 7925093 DOI: 10.1210/Endo.135.4.7925093  0.643
1994 Kirken RA, Rui H, Howard OM, Farrar WL. Involvement of JAK-family tyrosine kinases in hematopoietin receptor signal transduction. Progress in Growth Factor Research. 5: 195-211. PMID 7919224 DOI: 10.1016/0955-2235(94)90005-1  0.628
1994 Linnekin D, Howard OMZ, Park L, Farrar W, Ferris D, Longo DL. Hck expression correlates with granulocyte-macrophage colony- stimulating factor-induced proliferation in HL-60 cells Blood. 84: 94-103. DOI: 10.1182/Blood.V84.1.94.Bloodjournal84194  0.439
1993 Evans GA, Howard OMZ, Erwin R, Farrar WL. Interleukin-2 induces tyrosine phosphorylation of the vav proto-oncogene product in human T cells: lack of requirement for the tyrosine kinase lck. Biochemical Journal. 294: 339-342. PMID 7690544 DOI: 10.1042/Bj2940339  0.493
1993 Howard OMZ, Clouse KA, Smith C, Goodwin RG, Farrar WL. Soluble tumor necrosis factor receptor: inhibition of human immunodeficiency virus activation. Proceedings of the National Academy of Sciences of the United States of America. 90: 2335-2339. PMID 7681592 DOI: 10.1073/Pnas.90.6.2335  0.33
1993 Evans GA, Rui H, Farrar WL. 3 - Identification of Intracellular Mediators of the Actions of Cytokines: Identifying Proteins Involved in Kinase Signaling Pathways Methods in Neurosciences. 16: 49-66. DOI: 10.1016/B978-0-12-185281-8.50009-0  0.396
1992 Evans GA, Wahl LM, Farrar WL. Interleukin-2-dependent phosphorylation of the retinoblastoma-susceptibility-gene product p110-115RB in human T-cells Biochemical Journal. 282: 759-764. PMID 1554358 DOI: 10.1042/Bj2820759  0.497
1992 Garcia GG, Evans GA, Michiel DF, Farrar WL. Characterization of a tyrosine kinase activity associated with the high-affinity interleukin 2 receptor complex. The Biochemical Journal. 285: 851-6. PMID 1497623 DOI: 10.1042/Bj2850851  0.45
1992 Linnekin D, Evans GA, D'Andrea A, Farrar WL. Association of the erythropoietin receptor with protein tyrosine kinase activity. Proceedings of the National Academy of Sciences of the United States of America. 89: 6237-6241. PMID 1378622 DOI: 10.1073/Pnas.89.14.6237  0.389
1992 Linnekin D, Park L, Farrar W. Dissociation of human cytokine receptor expression and signal transduction Blood. 80: 1896-1904. DOI: 10.1182/blood.v80.8.1896.bloodjournal8081896  0.383
1992 Evans G, Linnekin D, Grove S, Farrar W. Specific protein kinases modulated during T cell mitogenesis. Activity of a 55-kDa serine kinase is associated with growth arrest in human T cells. Journal of Biological Chemistry. 267: 10313-10317. DOI: 10.1016/s0021-9258(19)50019-9  0.306
1991 Michiel DF, Garcia GG, Evans GA, Farrar WL. Regulation of the interleukin 2 receptor complex tyrosine kinase activity in vitro. Cytokine. 3: 428-38. PMID 1751780 DOI: 10.1016/1043-4666(91)90047-H  0.463
1990 Farrar WL, Linnekin D. Regulation of protein kinases and gene expression by immunocytokines. Annals of the New York Academy of Sciences. 594: 240-252. PMID 2143058 DOI: 10.1111/J.1749-6632.1990.Tb40484.X  0.325
1990 Farrar WL, Garcia GG, Evans G, Michiel D, Linnekin D. Cytokine regulation of protein phosphorylation Cytokine. 2: 77-91. PMID 1966548 DOI: 10.1016/1043-4666(90)90001-A  0.358
1990 Linnekin D, Farrar WL. Signal transduction of human interleukin 3 and granulocyte-macrophage colony-stimulating factor through serine and tyrosine phosphorylation. The Biochemical Journal. 271: 317-24. PMID 1700699 DOI: 10.1042/BJ2710317  0.329
1990 Farrar WL, Ferris DK, Michiel DF, Linnekin D. Chapter 17 Induction of Protein Phosphorylation during Leukocyte Activation Current Topics in Membranes and Transport. 35: 425-467. DOI: 10.1016/S0070-2161(08)60089-1  0.378
1989 Garland JM, Ferris DK, Farrar WL. Novel characteristics of a 33KDa protein (pp33) rapidly phosphorylated in IL3 dependent cells by stimulation with IL3. Biochemical and Biophysical Research Communications. 164: 520-530. PMID 2803317 DOI: 10.1016/0006-291X(89)91750-6  0.444
1989 Harel-Bellan A, Korner M, Brini AT, Ferris D, Farrar WL. Activation of HIV-enhancer binding activity by mild detergents in human T cells. Biochemical and Biophysical Research Communications. 162: 238-43. PMID 2787635 DOI: 10.1016/0006-291X(89)91987-6  0.386
1989 Harel-Bellan A, Brini AT, Ferris DK, Robin P, Farrar WL. In situ detection of a heat-shock regulatory element binding protein using a soluble synthetic enhancer sequence. Nucleic Acids Research. 17: 4077-87. PMID 2740211 DOI: 10.1093/Nar/17.11.4077  0.307
1989 Brini AT, Harel-Bellan A, Korner M, Farrar WL. Detection of enhancer binding proteins recognizing the human immunodeficiency virus long terminal repeat by in situ gel retardation. Biochemical and Biophysical Research Communications. 160: 268-75. PMID 2565718 DOI: 10.1016/0006-291X(89)91651-3  0.366
1989 Wahl LM, Corcoran ML, Pyle SW, Arthur LO, Harel-Bellan A, Farrar WL. Human immunodeficiency virus glycoprotein (gp120) induction of monocyte arachidonic acid metabolites and interleukin 1. Proceedings of the National Academy of Sciences of the United States of America. 86: 621-5. PMID 2536171 DOI: 10.1073/Pnas.86.2.621  0.354
1989 Harel-Bellan A, Mishal Z, Willette-Brown J, Farrar WL. Detection of low and high affinity binding sites with fluoresceinated human recombinant interleukin-2 Journal of Immunological Methods. 119: 127-133. PMID 2496169 DOI: 10.1016/0022-1759(89)90389-X  0.437
1989 Ferris DK, Willette-Brown J, Martensen T, Farrar WL. Interleukin 3 and phorbol ester stimulate tyrosine phosphorylation of overlapping substrate proteins. Febs Letters. 246: 153-158. PMID 2468525 DOI: 10.1016/0014-5793(89)80273-X  0.442
1989 Farrar W, Vinocour M, Hill J. In situ hybridization histochemistry localization of interleukin-3 mRNA in mouse brain. Blood. 73: 137-140. DOI: 10.1182/Blood.V73.1.137.Bloodjournal731137  0.403
1988 Ferris DK, Harel-Bellan A, Morimoto RI, Welch WJ, Farrar WL. Mitogen and lymphokine stimulation of heat shock proteins in T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 85: 3850-4. PMID 3287377 DOI: 10.1073/Pnas.85.11.3850  0.396
1988 Farrar WL, Evans SW, Harel-Bellan A, Ferris DK. Molecular events associated with the action of haemopoietic growth factors. Journal of Cell Science. 10: 243-255. PMID 3270454 DOI: 10.1242/Jcs.1988.Supplement_10.17  0.422
1988 Ferris DK, Willet-Brown J, Martensen T, Farrar WL. Interleukin 3 stimulation of tyrosine kinase activity in FDC-P1 cells. Biochemical and Biophysical Research Communications. 154: 991-996. PMID 3261586 DOI: 10.1016/0006-291X(88)90237-9  0.471
1988 Harel‐Bellan A, Farrar WL. Regulation of proliferation in a murine colony-stimulating factor-dependent myeloid cell line: superinduction of c-fos by the growth inhibitor 8-Br-cyclic adenosine 3':5' monophosphate. Journal of Cellular Biochemistry. 38: 145-153. PMID 3068231 DOI: 10.1002/Jcb.240380302  0.357
1988 Ruscetti F, Farrar WL, Hill JM, Pert CB. Visualization of human helper T lymphocyte differentiation antigen in primate brain. Peptides. 9: 97-104. PMID 2856655 DOI: 10.1016/0196-9781(88)90231-8  0.318
1988 Bancu AC, Gherman M, Sulica A, Goto T, Farrar W, Herberman RB. Regulation of human natural cytotoxicity by IgG. II: Cyclic AMP as a mediator of monomeric IgG-induced inhibition of natural killer cell activity Cellular Immunology. 114: 246-256. PMID 2455604 DOI: 10.1016/0008-8749(88)90319-X  0.368
1987 Beckner SK, Farrar WL. Inhibition of adenylate cyclase by IL 2 in human T lymphocytes is mediated by protein kinase C Biochemical and Biophysical Research Communications. 145: 176-182. PMID 3496087 DOI: 10.1016/0006-291X(87)91303-9  0.462
1987 Evans SW, Farrar WL. Identity of common phosphoprotein substrates stimulated by interleukin 2 and diacylglycerol suggests a role of protein kinase C for IL 2 signal transduction. Journal of Cellular Biochemistry. 34: 47-59. PMID 3495544 DOI: 10.1002/JCB.240340107  0.386
1987 Evans SW, Beckner SK, Farrar WL. Stimulation of specific GTP binding and hydrolysis activities in lymphocyte membrane by interleukin-2 Nature. 325: 166-168. PMID 3100964 DOI: 10.1038/325166A0  0.479
1987 Harel-Bellan A, Farrar WL. Modulation of proto-oncogene expression by colony stimulating factors Biochemical and Biophysical Research Communications. 148: 1001-1008. PMID 2446603 DOI: 10.1016/S0006-291X(87)80231-0  0.325
1986 Pert CB, Hill JM, Ruff MR, Berman RM, Robey WG, Arthur LO, Ruscetti FW, Farrar WL. Octapeptides deduced from the neuropeptide receptor-like pattern of antigen T4 in brain potently inhibit human immunodeficiency virus receptor binding and T-cell infectivity. Proceedings of the National Academy of Sciences of the United States of America. 83: 9254-8. PMID 3097649 DOI: 10.1073/Pnas.83.23.9254  0.33
1986 Birchenall-Sparks MC, Farrar WL, Rennick D, Kilian PL, Ruscetti FW. Regulation of expression of the interleukin-2 receptor on hematopoietic cells by interleukin-3. Science (New York, N.Y.). 233: 455-8. PMID 3088729 DOI: 10.1126/SCIENCE.3088729  0.351
1986 Ruff MR, Farrar WL, Pert CB. Interferon gamma and granulocyte/macrophage colony-stimulating factor inhibit growth and induce antigens characteristic of myeloid differentiation in small-cell lung cancer cell lines. Proceedings of the National Academy of Sciences of the United States of America. 83: 6613-7. PMID 3018738 DOI: 10.1073/Pnas.83.17.6613  0.37
1986 Taguchi M, Thomas TP, Anderson WB, Farrar WL. Direct phosphorylation of the IL-2 receptor Tac antigen epitope by protein kinase C. Biochemical and Biophysical Research Communications. 135: 239-47. PMID 2420328 DOI: 10.1016/0006-291X(86)90968-X  0.427
1986 Evans S, Rennick D, Farrar W. Multilineage hematopoietic growth factor interleukin 3 and direct activators of protein kinase C stimulate phosphorylation of common substrates Blood. 68: 906-913. DOI: 10.1182/BLOOD.V68.4.906.BLOODJOURNAL684906  0.35
1986 Evans S, Rennick D, Farrar W. Multilineage hematopoietic growth factor interleukin 3 and direct activators of protein kinase C stimulate phosphorylation of common substrates Blood. 68: 906-913. DOI: 10.1182/blood.v68.4.906.906  0.35
1985 Farrar WL, Anderson WB. Interleukin-2 stimulates association of protein kinase C with plasma membrane. Nature. 315: 233-5. PMID 3158820 DOI: 10.1038/315233A0  0.335
1984 Burger CJ, Elgert KD, Farrar WL. Interleukin 2 (IL-2) activity during tumor growth: IL-2 production kinetics, absorption of and responses to exogenous IL-2. Cellular Immunology. 84: 228-39. PMID 6231106 DOI: 10.1016/0008-8749(84)90095-9  0.693
1983 Johnson HM, Farrar WL. The role of a gamma interferon-like lymphokine in the activation of T cells for expression of interleukin 2 receptors Cellular Immunology. 75: 154-159. PMID 6402311 DOI: 10.1016/0008-8749(83)90314-3  0.444
1982 Farrar JJ, Benjamin WR, Hilfiker ML, Howard M, Farrar WL, Fuller-Farrar J. The biochemistry, biology, and role of interleukin 2 in the induction of cytotoxic T cell and antibody-forming B cell responses. Immunological Reviews. 63: 129-66. PMID 7042543 DOI: 10.1111/J.1600-065X.1982.Tb00414.X  0.385
1982 Farrar WL, Elgert KD, Burger CJ. Tumor-induced impairment of T-cell-independent B-cell blastogenesis and DNA polymerase activity. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 169: 127-34. PMID 6461011 DOI: 10.3181/00379727-169-41320  0.656
1982 Yamamoto JK, Farrar WL, Johnson HM. Interleukin 2 regulation of mitogen induction of immune interferon (IFNγ) in spleen cells and thymocytes Cellular Immunology. 66: 333-341. PMID 6175428 DOI: 10.1016/0008-8749(82)90183-6  0.456
1981 Fuller-Farrar J, Hilfiker ML, Farrar WL, Farrar JJ. Phorbol myristic acetate enhances the production of interleukin 2. Cellular Immunology. 58: 156-64. PMID 6784931 DOI: 10.1016/0008-8749(81)90157-X  0.422
1981 Hapel AJ, Lee JC, Farrar WL, Ihle JN. Establishment of continuous cultures of Thy1.2+, Lytl+,2−T cells with purified interleukin 3 Cell. 25: 179-186. PMID 6115717 DOI: 10.1016/0092-8674(81)90242-7  0.337
1980 Mizel SB, DeLarco JE, Todaro GJ, Farrar WL, Hilfiker ML. In vitro production of immunosuppressive factors by murine sarcoma virus-transformed mouse fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 77: 2205-8. PMID 6246526 DOI: 10.1073/Pnas.77.4.2205  0.392
1979 Farrar WL, Elgert KD. In vitro immune blastogenesis during contact sensitivity in tumor-bearing mice. II. Mechanism of inhibition. Cellular Immunology. 40: 365-75. PMID 309800 DOI: 10.1016/0008-8749(78)90344-1  0.659
1979 Elgert KD, Farrar WL. In vitro immune blastogenesis during contact sensitivity in tumor-bearing mice. I. Description of progressive impairment and demonstration of splenic suppressor cells. Cellular Immunology. 40: 356-64. PMID 309799 DOI: 10.1016/0008-8749(78)90343-X  0.636
1979 Farrar JJ, Simon PL, Farrar WL, Koopman WJ, Fuller‐Bonar J. Role of mitogenic factor, lymphocyte-activating factor and immune interferon in the induction of humoral and cell-mediated immunity. Annals of the New York Academy of Sciences. 332: 303-315. PMID 161151 DOI: 10.1111/J.1749-6632.1979.Tb47125.X  0.319
1979 Connolly KM, Farrar WL, Elgert KD. Tumor-Induced Dualistic Suppressor Cell Regulation: Macrophages And Suppressor T Cells Cell Biology and Immunology of Leukocyte Function. 701-705. DOI: 10.1016/B978-0-12-569650-0.50094-2  0.664
1978 Farrar WL, Elgert KD. Inhibition of mitogen and immune blastogenesis by two distinct populations of supressor cells present in the spleens of fibrosarcoma-bearing mice: adoptive transfer of suppression. International Journal of Cancer. 22: 142-51. PMID 308934 DOI: 10.1002/Ijc.2910220207  0.658
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