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Ester M Hammond - Publications

Affiliations: 
University of Oxford, Oxford, United Kingdom 
Area:
Hypoxia
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57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Wallabregue ALD, Bolland H, Faulkner S, Hammond EM, Conway SJ. Two Color Imaging of Different Hypoxia Levels in Cancer Cells. Journal of the American Chemical Society. 145: 2572-2583. PMID 36656915 DOI: 10.1021/jacs.2c12493  0.563
2022 Koyasu S, Horita S, Saito K, Kobayashi M, Ishikita H, Chow CC, Kambe G, Nishikawa S, Menju T, Morinibu A, Okochi Y, Tabuchi Y, Onodera Y, Takeda N, Date H, ... ... Hammond EM, et al. ZBTB2 links p53 deficiency to HIF-1-mediated hypoxia signaling to promote cancer aggressiveness. Embo Reports. e202154042. PMID 36341521 DOI: 10.15252/embr.202154042  0.399
2022 Sekirnik AR, Reynolds JK, See L, Bluck JP, Scorah AR, Tallant C, Lee B, Leszczynska KB, Grimley RL, Storer RI, Malattia M, Crespillo S, Caria S, Duclos S, Hammond EM, et al. Identification of Histone Peptide Binding Specificity and Small-Molecule Ligands for the TRIM33α and TRIM33β Bromodomains. Acs Chemical Biology. PMID 36098557 DOI: 10.1021/acschembio.2c00266  0.52
2021 Suwa T, Kobayashi M, Shirai Y, Nam JM, Tabuchi Y, Takeda N, Akamatsu S, Ogawa O, Mizowaki T, Hammond EM, Harada H. SPINK1 as a plasma marker for tumor hypoxia and a therapeutic target for radiosensitization. Jci Insight. 6. PMID 34747365 DOI: 10.1172/jci.insight.148135  0.396
2021 Troelsen KS, Calder EDD, Skwarska A, Sneddon D, Hammond EM, Conway SJ. Zap-Pano: a Photocaged pro-drug of the KDAC inhibitor panobinostat. Chemmedchem. PMID 34259396 DOI: 10.1002/cmdc.202100403  0.54
2021 Brand M, Clayton J, Moroglu M, Schiedel M, Picaud S, Bluck JP, Skwarska A, Bolland H, Chan AKN, Laurin CMC, Scorah AR, See L, Rooney TPC, Andrews KH, Fedorov O, ... ... Hammond EM, et al. Controlling Intramolecular Interactions in the Design of Selective, High-Affinity Ligands for the CREBBP Bromodomain. Journal of Medicinal Chemistry. PMID 34255515 DOI: 10.1021/acs.jmedchem.1c00348  0.655
2021 Bader SB, Ma TS, Simpson CJ, Liang J, Maezono SEB, Olcina MM, Buffa FM, Hammond EM. Replication catastrophe induced by cyclic hypoxia leads to increased APOBEC3B activity. Nucleic Acids Research. PMID 34197599 DOI: 10.1093/nar/gkab551  0.688
2021 Ramachandran S, Ma TS, Griffin J, Ng N, Foskolou IP, Hwang MS, Victori P, Cheng WC, Buffa FM, Leszczynska KB, El-Khamisy SF, Gromak N, Hammond EM. Hypoxia-induced SETX links replication stress with the unfolded protein response. Nature Communications. 12: 3686. PMID 34140498 DOI: 10.1038/s41467-021-24066-z  0.481
2021 Skwarska A, Calder EDD, Sneddon D, Bolland H, Odyniec ML, Mistry IN, Martin J, Folkes LK, Conway SJ, Hammond EM. Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor. Cell Chemical Biology. PMID 33910023 DOI: 10.1016/j.chembiol.2021.04.004  0.524
2020 Bowler E, Skwarska A, Wilson JD, Ramachandran S, Bolland H, Easton A, Ostheimer C, Hwang MS, Leszczynska KB, Conway SJ, Hammond EM. Pharmacological Inhibition of ATR Can Block Autophagy through an ATR-Independent Mechanism. Iscience. 23: 101668. PMID 33134898 DOI: 10.1016/j.isci.2020.101668  0.578
2018 Collins SL, Saha J, Bouchez LC, Hammond EM, Conway SJ. Hypoxia-activated small molecule-induced gene expression. Acs Chemical Biology. PMID 30451487 DOI: 10.1021/Acschembio.8B00858  0.565
2018 Carruthers RD, Ahmed SU, Ramachandran S, Strathdee K, Kurian KM, Hedley A, Gomez-Roman N, Kalna G, Neilson MP, Gilmour L, Stevenson KH, Hammond EM, Chalmers AJ. Replication stress drives constitutive activation of the DNA damage response and radioresistance in glioblastoma stem-like cells. Cancer Research. PMID 29976574 DOI: 10.1158/0008-5472.CAN-18-0569  0.424
2018 Jennings LE, Schiedel M, Hewings DS, Picaud S, Laurin CMC, Bruno PA, Bluck JP, Scorah AR, See L, Reynolds JK, Moroglu M, Mistry IN, Hicks A, Guzanov P, Clayton J, ... ... Hammond EM, et al. BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability. Bioorganic & Medicinal Chemistry. PMID 29776834 DOI: 10.1016/J.Bmc.2018.05.003  0.465
2018 Poujade FA, Mannion A, Brittain N, Theodosi A, Beeby E, Leszczynska KB, Hammond EM, Greenman J, Cawthorne C, Pires IM. WSB-1 regulates the metastatic potential of hormone receptor negative breast cancer. British Journal of Cancer. PMID 29540773 DOI: 10.1038/s41416-018-0056-3  0.532
2017 Ng N, Purshouse K, Foskolou IP, Olcina MM, Hammond EM. Challenges to DNA replication in hypoxic conditions. The Febs Journal. PMID 29288533 DOI: 10.1111/febs.14377  0.688
2017 Mistry IN, Thomas M, Calder EDD, Conway SJ, Hammond EM. Clinical Advances of Hypoxia-Activated Prodrugs in Combination With Radiation Therapy. International Journal of Radiation Oncology, Biology, Physics. 98: 1183-1196. PMID 28721903 DOI: 10.1016/J.Ijrobp.2017.03.024  0.538
2017 Foskolou IP, Jorgensen C, Leszczynska KB, Olcina MM, Tarhonskaya H, Haisma B, D'Angiolella V, Myers WK, Domene C, Flashman E, Hammond EM. Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication. Molecular Cell. PMID 28416140 DOI: 10.1016/j.molcel.2017.03.005  0.773
2017 O'Connor LJ, Mistry IN, Collins SL, Folkes LK, Brown G, Conway SJ, Hammond EM. CYP450 Enzymes Effect Oxygen-Dependent Reduction of Azide-Based Fluorogenic Dyes. Acs Central Science. 3: 20-30. PMID 28149949 DOI: 10.1021/Acscentsci.6B00276  0.513
2016 Olcina MM, Giaccia AJ, Hammond EM. Isolation of Proteins on Nascent DNA in Hypoxia and Reoxygenation Conditions. Advances in Experimental Medicine and Biology. 899: 27-40. PMID 27325260 DOI: 10.1007/978-3-319-26666-4_3  0.77
2016 Foskolou IP, Biasoli D, Olcina MM, Hammond EM. Measuring DNA Replication in Hypoxic Conditions. Advances in Experimental Medicine and Biology. 899: 11-25. PMID 27325259 DOI: 10.1007/978-3-319-26666-4_2  0.751
2016 O'Connor LJ, Cazares-Körner C, Saha J, Evans CN, Stratford MR, Hammond EM, Conway SJ. Design, synthesis and evaluation of molecularly targeted hypoxia-activated prodrugs. Nature Protocols. 11: 781-94. PMID 27010756 DOI: 10.1038/Nprot.2016.034  0.51
2016 Leszczynska KB, Göttgens EL, Biasoli D, Olcina MM, Ient J, Anbalagan S, Bernhardt S, Giaccia AJ, Hammond EM. Mechanisms and consequences of ATMIN repression in hypoxic conditions: roles for p53 and HIF-1. Scientific Reports. 6: 21698. PMID 26875667 DOI: 10.1038/Srep21698  0.783
2015 Leszczynska KB, Foskolou IP, Abraham AG, Anbalagan S, Tellier C, Haider S, Span PN, O'Neill EE, Buffa FM, Hammond EM. Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT. The Journal of Clinical Investigation. 125: 2385-98. PMID 25961455 DOI: 10.1172/JCI80402  0.319
2015 Pefani DE, Latusek R, Pires I, Grawenda AM, Yee KS, Hamilton G, van der Weyden L, Esashi F, Hammond EM, O'Neill E. RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2. Nature Cell Biology. 17: 531. PMID 25812526 DOI: 10.1038/ncb3152  0.563
2014 Olcina MM, Grand RJ, Hammond EM. ATM activation in hypoxia - causes and consequences. Molecular & Cellular Oncology. 1: e29903. PMID 27308313 DOI: 10.4161/mco.29903  0.793
2014 Pefani DE, Latusek R, Pires I, Grawenda AM, Yee KS, Hamilton G, Van Der Weyden L, Esashi F, Hammond EM, O'Neill E. RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2 Nature Cell Biology. 16: 962-971. PMID 25218637 DOI: 10.1038/ncb3035  0.61
2014 Pires IM, Blokland NJ, Broos AW, Poujade FA, Senra JM, Eccles SA, Span PN, Harvey AJ, Hammond EM. HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion. Cancer Biology & Therapy. 15: 1350-7. PMID 25019382 DOI: 10.4161/cbt.29822  0.567
2014 Koumenis C, Hammond E, Giaccia A. Tumor microenvironment and cellular stress: signaling, metabolism, imaging, and therapeutic targets. Preface. Advances in Experimental Medicine and Biology. 772: v-viii. PMID 24765667 DOI: 10.1007/978-1-4614-5915-6  0.48
2014 Olcina MM, Hammond EM. WIP1 and senescence: oxygen matters. Cell Cycle (Georgetown, Tex.). 13: 1062. PMID 24584094 DOI: 10.4161/cc.28385  0.688
2014 Scrace S, O'Neill E, Hammond EM, Pires IM. Use of the xCELLigence system for real-time analysis of changes in cellular motility and adhesion in physiological conditions. Methods in Molecular Biology (Clifton, N.J.). 1046: 295-306. PMID 23868595 DOI: 10.1007/978-1-62703-538-5_17  0.534
2014 Fokas E, Prevo R, Hammond EM, Brunner TB, McKenna WG, Muschel RJ. Targeting ATR in DNA damage response and cancer therapeutics. Cancer Treatment Reviews. 40: 109-17. PMID 23583268 DOI: 10.1016/j.ctrv.2013.03.002  0.412
2013 Olcina MM, Foskolou IP, Anbalagan S, Senra JM, Pires IM, Jiang Y, Ryan AJ, Hammond EM. Replication stress and chromatin context link ATM activation to a role in DNA replication Molecular Cell. 52: 758-766. PMID 24268576 DOI: 10.1016/j.molcel.2013.10.019  0.801
2013 Cazares-Körner C, Pires IM, Swallow ID, Grayer SC, O'Connor LJ, Olcina MM, Christlieb M, Conway SJ, Hammond EM. CH-01 is a hypoxia-activated prodrug that sensitizes cells to hypoxia/reoxygenation through inhibition of Chk1 and Aurora A. Acs Chemical Biology. 8: 1451-9. PMID 23597309 DOI: 10.1021/cb4001537  0.784
2013 Hewings DS, Fedorov O, Filippakopoulos P, Martin S, Picaud S, Tumber A, Wells C, Olcina MM, Freeman K, Gill A, Ritchie AJ, Sheppard DW, Russell AJ, Hammond EM, Knapp S, et al. Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands. Journal of Medicinal Chemistry. 56: 3217-27. PMID 23517011 DOI: 10.1021/Jm301588R  0.739
2012 Anbalagan S, Pires IM, Blick C, Hill MA, Ferguson DJ, Chan DA, Hammond EM. Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 103: 388-93. PMID 22551566 DOI: 10.1016/j.radonc.2012.04.001  0.694
2011 Pires IM, Bencokova Z, McGurk C, Hammond EM. Exposure to acute hypoxia induces a transient DNA damage response which includes Chk1 and TLK1. Cell Cycle (Georgetown, Tex.). 9: 2502-7. PMID 20581459 DOI: 10.4161/cc.9.13.12059  0.532
2010 Chan N, Pires IM, Bencokova Z, Coackley C, Luoto KR, Bhogal N, Lakshman M, Gottipati P, Oliver FJ, Helleday T, Hammond EM, Bristow RG. Contextual synthetic lethality of cancer cell kill based on the tumor microenvironment. Cancer Research. 70: 8045-54. PMID 20924112 DOI: 10.1158/0008-5472.Can-10-2352  0.644
2010 Olcina M, Lecane PS, Hammond EM. Targeting hypoxic cells through the DNA damage response. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 5624-9. PMID 20876254 DOI: 10.1158/1078-0432.CCR-10-0286  0.688
2010 Pires IM, Bencokova Z, Milani M, Folkes LK, Li JL, Stratford MR, Harris AL, Hammond EM. Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability. Cancer Research. 70: 925-35. PMID 20103649 DOI: 10.1158/0008-5472.CAN-09-2715  0.661
2009 Rankin EB, Giaccia AJ, Hammond EM. Bringing H2AX into the angiogenesis family. Cancer Cell. 15: 459-61. PMID 19477424 DOI: 10.1016/J.Ccr.2009.05.004  0.523
2009 Bencokova Z, Kaufmann MR, Pires IM, Lecane PS, Giaccia AJ, Hammond EM. ATM activation and signaling under hypoxic conditions. Molecular and Cellular Biology. 29: 526-37. PMID 18981219 DOI: 10.1128/Mcb.01301-08  0.732
2007 Hammond EM, Kaufmann MR, Giaccia AJ. Oxygen sensing and the DNA-damage response. Current Opinion in Cell Biology. 19: 680-4. PMID 18023567 DOI: 10.1016/J.Ceb.2007.10.002  0.518
2006 Krieg AJ, Hammond EM, Giaccia AJ. Functional analysis of p53 binding under differential stresses. Molecular and Cellular Biology. 26: 7030-45. PMID 16980608 DOI: 10.1128/Mcb.00322-06  0.509
2006 Hammond EM, Giaccia AJ. Hypoxia-inducible factor-1 and p53: friends, acquaintances, or strangers? Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 5007-9. PMID 16951213 DOI: 10.1158/1078-0432.Ccr-06-0613  0.436
2006 Freiberg RA, Krieg AJ, Giaccia AJ, Hammond EM. Checking in on hypoxia/reoxygenation. Cell Cycle (Georgetown, Tex.). 5: 1304-7. PMID 16760660 DOI: 10.4161/Cc.5.12.2811  0.772
2006 Hammond EM, Mandell DJ, Salim A, Krieg AJ, Johnson TM, Shirazi HA, Attardi LD, Giaccia AJ. Genome-wide analysis of p53 under hypoxic conditions Molecular and Cellular Biology. 26: 3492-3504. PMID 16611991 DOI: 10.1128/Mcb.26.9.3492-3504.2006  0.545
2006 Freiberg RA, Hammond EM, Dorie MJ, Welford SM, Giaccia AJ. DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response. Molecular and Cellular Biology. 26: 1598-609. PMID 16478982 DOI: 10.1128/Mcb.26.5.1598-1609.2006  0.769
2006 Hammond EM, Freiberg RA, Giaccia AJ. The roles of Chk 1 and Chk 2 in hypoxia and reoxygenation. Cancer Letters. 238: 161-7. PMID 16085356 DOI: 10.1016/J.Canlet.2005.06.029  0.75
2005 Hammond EM, Giaccia AJ. The role of p53 in hypoxia-induced apoptosis. Biochemical and Biophysical Research Communications. 331: 718-25. PMID 15865928 DOI: 10.1016/J.Bbrc.2005.03.154  0.547
2005 Johnson TM, Hammond EM, Giaccia A, Attardi LD. The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality Nature Genetics. 37: 145-152. PMID 15654339 DOI: 10.1038/Ng1498  0.52
2004 Hammond EM, Dorie MJ, Giaccia AJ. Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation. Cancer Research. 64: 6556-62. PMID 15374968 DOI: 10.1158/0008-5472.Can-04-1520  0.58
2004 Romero-Ramirez L, Cao H, Nelson D, Hammond E, Lee AH, Yoshida H, Mori K, Glimcher LH, Denko NC, Giaccia AJ, Le QT, Koong AC. XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Research. 64: 5943-7. PMID 15342372 DOI: 10.1158/0008-5472.Can-04-1606  0.609
2004 Hammond EM, Giaccia AJ. The role of ATM and ATR in the cellular response to hypoxia and re-oxygenation. Dna Repair. 3: 1117-22. PMID 15279800 DOI: 10.1016/J.Dnarep.2004.03.035  0.59
2003 Hammond EM, Green SL, Giaccia AJ. Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest. Mutation Research. 532: 205-13. PMID 14643437 DOI: 10.1016/J.Mrfmmm.2003.08.017  0.722
2003 Hammond EM, Dorie MJ, Giaccia AJ. ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. The Journal of Biological Chemistry. 278: 12207-13. PMID 12519769 DOI: 10.1074/Jbc.M212360200  0.586
2002 Hammond EM, Giaccia AJ. Antiangiogenic therapy and p53. Science (New York, N.Y.). 297: 471; discussion 471. PMID 12142499 DOI: 10.1126/Science.297.5581.471A  0.383
2002 Hammond EM, Denko NC, Dorie MJ, Abraham RT, Giaccia AJ. Hypoxia links ATR and p53 through replication arrest. Molecular and Cellular Biology. 22: 1834-43. PMID 11865061 DOI: 10.1128/Mcb.22.6.1834-1843.2002  0.571
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