Year |
Citation |
Score |
2019 |
Barnes L, Blaber H, Brooks DTK, Byers L, Buckley D, Byron ZC, Chilvers R, Cochrane L, Cooney E, Damian HA, Francis L, Fu He D, Grace JMJ, Green HJ, Hogarth EJP, ... ... King O, et al. Free-Wilson analysis of comprehensive data on phosphoinositide-3-kinase (PI3K) inhibitors reveals importance of -methylation for PI3Kδ activity. Journal of Medicinal Chemistry. PMID 31647659 DOI: 10.1021/Acs.Jmedchem.9B01499 |
0.307 |
|
2018 |
McAllister TE, Yeh TL, Abboud MI, Leung IKH, Hookway ES, King ONF, Bhushan B, Williams ST, Hopkinson RJ, Münzel M, Loik ND, Chowdhury R, Oppermann U, Claridge TDW, Goto Y, et al. Non-competitive cyclic peptides for targeting enzyme-substrate complexes. Chemical Science. 9: 4569-4578. PMID 29899950 DOI: 10.1039/C8Sc00286J |
0.66 |
|
2017 |
Kawamura A, Münzel M, Kojima T, Yapp C, Bhushan B, Goto Y, Tumber A, Katoh T, King ON, Passioura T, Walport LJ, Hatch SB, Madden S, Müller S, Brennan PE, et al. Highly selective inhibition of histone demethylases by de novo macrocyclic peptides. Nature Communications. 8: 14773. PMID 28382930 DOI: 10.1038/Ncomms14773 |
0.744 |
|
2014 |
Rotili D, Tomassi S, Conte M, Benedetti R, Tortorici M, Ciossani G, Valente S, Marrocco B, Labella D, Novellino E, Mattevi A, Altucci L, Tumber A, Yapp C, King ON, et al. Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities. Journal of Medicinal Chemistry. 57: 42-55. PMID 24325601 DOI: 10.1021/Jm4012802 |
0.635 |
|
2013 |
Hopkinson RJ, Tumber A, Yapp C, Chowdhury R, Aik W, Che KH, Li XS, Kristensen JB, King ON, Chan MC, Yeoh KK, Choi H, Walport LJ, Thinnes CC, Bush JT, et al. 5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation. Chemical Science (Royal Society of Chemistry : 2010). 4: 3110-3117. PMID 26682036 DOI: 10.1039/C3Sc51122G |
0.774 |
|
2013 |
Hopkinson RJ, Tumber A, Yapp C, Chowdhury R, Aik W, Che KH, Li XS, Kristensen JBL, King ONF, Chan MC, Yeoh KK, Choi H, Walport LJ, Thinnes CC, Bush JT, et al. 5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation Chemical Science. 4: 3110-3117. DOI: 10.1039/c3sc51122g |
0.731 |
|
2012 |
Rose NR, Woon EC, Tumber A, Walport LJ, Chowdhury R, Li XS, King ON, Lejeune C, Ng SS, Krojer T, Chan MC, Rydzik AM, Hopkinson RJ, Che KH, Daniel M, et al. Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. Journal of Medicinal Chemistry. 55: 6639-43. PMID 22724510 DOI: 10.1021/Jm300677J |
0.744 |
|
2011 |
Artz JD, Wernimont AK, Allali-Hassani A, Zhao Y, Amani M, Lin YH, Senisterra G, Wasney GA, Fedorov O, King O, Roos A, Lunin VV, Qiu W, Finerty P, Hutchinson A, et al. The Cryptosporidium parvum kinome. Bmc Genomics. 12: 478. PMID 21962082 DOI: 10.1186/1471-2164-12-478 |
0.325 |
|
2011 |
Chowdhury R, Yeoh KK, Tian YM, Hillringhaus L, Bagg EA, Rose NR, Leung IK, Li XS, Woon EC, Yang M, McDonough MA, King ON, Clifton IJ, Klose RJ, Claridge TD, et al. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. Embo Reports. 12: 463-9. PMID 21460794 DOI: 10.1038/Embor.2011.43 |
0.65 |
|
2011 |
Chang KH, King ON, Tumber A, Woon EC, Heightman TD, McDonough MA, Schofield CJ, Rose NR. Inhibition of histone demethylases by 4-carboxy-2,2'-bipyridyl compounds. Chemmedchem. 6: 759-64. PMID 21412984 DOI: 10.1002/Cmdc.201100026 |
0.797 |
|
2011 |
Rose NR, McDonough MA, King ON, Kawamura A, Schofield CJ. Inhibition of 2-oxoglutarate dependent oxygenases. Chemical Society Reviews. 40: 4364-97. PMID 21390379 DOI: 10.1039/C0Cs00203H |
0.74 |
|
2011 |
Fedorov O, Huber K, Eisenreich A, Filippakopoulos P, King O, Bullock AN, Szklarczyk D, Jensen LJ, Fabbro D, Trappe J, Rauch U, Bracher F, Knapp S. Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chemistry & Biology. 18: 67-76. PMID 21276940 DOI: 10.1016/J.Chembiol.2010.11.009 |
0.402 |
|
2010 |
King ON, Li XS, Sakurai M, Kawamura A, Rose NR, Ng SS, Quinn AM, Rai G, Mott BT, Beswick P, Klose RJ, Oppermann U, Jadhav A, Heightman TD, Maloney DJ, et al. Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. Plos One. 5: e15535. PMID 21124847 DOI: 10.1371/Journal.Pone.0015535 |
0.77 |
|
2010 |
Kawamura A, Tumber A, Rose NR, King ON, Daniel M, Oppermann U, Heightman TD, Schofield C. Development of homogeneous luminescence assays for histone demethylase catalysis and binding. Analytical Biochemistry. 404: 86-93. PMID 20435012 DOI: 10.1016/J.Ab.2010.04.030 |
0.742 |
|
2010 |
Rose NR, Woon EC, Kingham GL, King ON, Mecinović J, Clifton IJ, Ng SS, Talib-Hardy J, Oppermann U, McDonough MA, Schofield CJ. Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches. Journal of Medicinal Chemistry. 53: 1810-8. PMID 20088513 DOI: 10.1021/Jm901680B |
0.77 |
|
2008 |
Roos A, Barr A, King O, Ugochukwu E, Russell A, Knapp S, von Delft F. A family-wide approach to structure-based inhibitor design for protein tyrosine phosphatases Acta Crystallographica Section a Foundations of Crystallography. 64: C38-C38. DOI: 10.1107/S0108767308098796 |
0.308 |
|
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