| Year |
Citation |
Score |
| 2021 |
Perry GS, Das M, Woon ECY. Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets. Journal of Medicinal Chemistry. 64: 16974-17003. PMID 34792334 DOI: 10.1021/acs.jmedchem.1c01694 |
0.341 |
|
| 2015 |
Toh JDW, Sun L, Lau LZM, Tan J, Low JJA, Tang CWQ, Cheong EJY, Tan MJH, Chen Y, Hong W, Gao YG, Woon ECY. A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N(6)-methyladenosine demethylase FTO. Chemical Science. 6: 112-122. PMID 28553460 DOI: 10.1039/c4sc02554g |
0.41 |
|
| 2015 |
Paine HA, Nathubhai A, Woon EC, Sunderland PT, Wood PJ, Mahon MF, Lloyd MD, Thompson AS, Haikarainen T, Narwal M, Lehtiö L, Threadgill MD. Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro. Bioorganic & Medicinal Chemistry. PMID 26189030 DOI: 10.1016/j.bmc.2015.06.061 |
0.418 |
|
| 2015 |
Toh JDW, Sun L, Lau LZM, Tan J, Low JJA, Tang CWQ, Cheong EJY, Tan MJH, Chen Y, Hong W, Gao YG, Woon ECY. A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N6-methyladenosine demethylase FTO Chemical Science. 6: 112-122. DOI: 10.1039/c4sc02554g |
0.301 |
|
| 2013 |
Yeoh KK, Chan MC, Thalhammer A, Demetriades M, Chowdhury R, Tian YM, Stolze I, McNeill LA, Lee MK, Woon EC, Mackeen MM, Kawamura A, Ratcliffe PJ, Mecinović J, Schofield CJ. Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion. Organic & Biomolecular Chemistry. 11: 732-45. PMID 23151668 DOI: 10.1039/C2Ob26648B |
0.739 |
|
| 2012 |
Rose NR, Woon EC, Tumber A, Walport LJ, Chowdhury R, Li XS, King ON, Lejeune C, Ng SS, Krojer T, Chan MC, Rydzik AM, Hopkinson RJ, Che KH, Daniel M, et al. Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. Journal of Medicinal Chemistry. 55: 6639-43. PMID 22724510 DOI: 10.1021/Jm300677J |
0.733 |
|
| 2012 |
Demetriades M, Leung IK, Chowdhury R, Chan MC, McDonough MA, Yeoh KK, Tian YM, Claridge TD, Ratcliffe PJ, Woon EC, Schofield CJ. Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors. Angewandte Chemie (International Ed. in English). 51: 6672-5. PMID 22639232 DOI: 10.1002/Anie.201202000 |
0.676 |
|
| 2012 |
Woon EC, Demetriades M, Bagg EA, Aik W, Krylova SM, Ma JH, Chan M, Walport LJ, Wegman DW, Dack KN, McDonough MA, Krylov SN, Schofield CJ. Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase. Journal of Medicinal Chemistry. 55: 2173-84. PMID 22263962 DOI: 10.1021/Jm201417E |
0.646 |
|
| 2012 |
Woon EC, Tumber A, Kawamura A, Hillringhaus L, Ge W, Rose NR, Ma JH, Chan MC, Walport LJ, Che KH, Ng SS, Marsden BD, Oppermann U, McDonough MA, Schofield CJ. Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases. Angewandte Chemie (International Ed. in English). 51: 1631-4. PMID 22241642 DOI: 10.1002/Anie.201107833 |
0.697 |
|
| 2011 |
Woon EC, Zervosen A, Sauvage E, Simmons KJ, Zivec M, Inglis SR, Fishwick CW, Gobec S, Charlier P, Luxen A, Schofield CJ. Structure guided development of potent reversibly binding penicillin binding protein inhibitors. Acs Medicinal Chemistry Letters. 2: 219-23. PMID 24900305 DOI: 10.1021/Ml100260X |
0.511 |
|
| 2011 |
Contreras-Martel C, Amoroso A, Woon EC, Zervosen A, Inglis S, Martins A, Verlaine O, Rydzik AM, Job V, Luxen A, Joris B, Schofield CJ, Dessen A. Structure-guided design of cell wall biosynthesis inhibitors that overcome β-lactam resistance in Staphylococcus aureus (MRSA). Acs Chemical Biology. 6: 943-51. PMID 21732689 DOI: 10.1021/Cb2001846 |
0.441 |
|
| 2011 |
Chowdhury R, Yeoh KK, Tian YM, Hillringhaus L, Bagg EA, Rose NR, Leung IK, Li XS, Woon EC, Yang M, McDonough MA, King ON, Clifton IJ, Klose RJ, Claridge TD, et al. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. Embo Reports. 12: 463-9. PMID 21460794 DOI: 10.1038/Embor.2011.43 |
0.618 |
|
| 2011 |
Sunderland PT, Woon EC, Dhami A, Bergin AB, Mahon MF, Wood PJ, Jones LA, Tully SR, Lloyd MD, Thompson AS, Javaid H, Martin NM, Threadgill MD. 5-Benzamidoisoquinolin-1-ones and 5-(ω-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2). Journal of Medicinal Chemistry. 54: 2049-59. PMID 21417348 DOI: 10.1021/jm1010918 |
0.373 |
|
| 2011 |
Chang KH, King ON, Tumber A, Woon EC, Heightman TD, McDonough MA, Schofield CJ, Rose NR. Inhibition of histone demethylases by 4-carboxy-2,2'-bipyridyl compounds. Chemmedchem. 6: 759-64. PMID 21412984 DOI: 10.1002/Cmdc.201100026 |
0.777 |
|
| 2010 |
Rose NR, Woon EC, Kingham GL, King ON, Mecinović J, Clifton IJ, Ng SS, Talib-Hardy J, Oppermann U, McDonough MA, Schofield CJ. Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches. Journal of Medicinal Chemistry. 53: 1810-8. PMID 20088513 DOI: 10.1021/Jm901680B |
0.781 |
|
| 2010 |
Inglis SR, Woon EC, Thompson AL, Schofield CJ. Observations on the deprotection of pinanediol and pinacol boronate esters via fluorinated intermediates. The Journal of Organic Chemistry. 75: 468-71. PMID 20014787 DOI: 10.1021/Jo901930V |
0.328 |
|
| 2009 |
Inglis SR, Zervosen A, Woon EC, Gerards T, Teller N, Fischer DS, Luxen A, Schofield CJ. Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors. Journal of Medicinal Chemistry. 52: 6097-106. PMID 19731939 DOI: 10.1021/Jm9009718 |
0.465 |
|
| 2005 |
Woon EC, Threadgill MD. Poly(ADP-ribose)polymerase inhibition - where now? Current Medicinal Chemistry. 12: 2373-92. PMID 16181138 DOI: 10.2174/0929867054864778 |
0.348 |
|
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